be_v presume_v to_o suggest_v a_o reason_n of_o a_o palsy_n than_o apoplexy_n and_o can_v hardly_o be_v make_v out_o to_o be_v the_o cause_n of_o so_o sudden_a a_o seizure_n since_o such_o a_o congestion_n must_v be_v slow_a and_o so_o the_o effect_n general_o must_v come_v gradual_o whereas_o from_o a_o perfect_a state_n of_o health_n the_o apoplexy_n on_o a_o sudden_a as_o the_o name_n import_v ordinary_o seize_v beside_o though_o the_o passage_n of_o the_o spinal_a marrow_n and_o nerve_n thence_o arise_v be_v thus_o close_v rather_o than_o obstruct_v a_o obstruction_n be_v general_o i_o conceive_v in_o the_o common_a acception_n of_o the_o word_n understand_v to_o be_v from_o some_o matter_n within_o their_o tract_n and_o not_o proper_o from_o it_o external_o compress_v they_o whereby_o the_o spirit_n can_v ready_o descend_v into_o they_o yet_o their_o motion_n in_o the_o brain_n may_v possible_o for_o some_o time_n be_v free_a enough_o and_o consequent_o the_o soul_n exercise_n may_v be_v then_o entire_a for_o a_o while_n if_o not_o indeed_o exalt_v from_o the_o confinement_n those_o have_v to_o the_o brain_n in_o that_o case_n and_o it_o be_v observe_v many_o time_n that_o in_o a_o hydrocephalus_n intellection_n and_o other_o animal_n faculty_n fail_v only_o gradual_o though_o the_o ventricles_n have_v be_v find_v upon_o dissection_n to_o have_v be_v much_o fill_v which_o they_o must_v have_v be_v long_a time_n a_o do_v withal_o what_o be_v once_o get_v into_o the_o ventricles_n have_v no_o far_a communication_n with_o the_o animal_n spirit_n be_v disterminate_v from_o the_o brain_n by_o the_o interposition_n of_o the_o membrane_n but_o galen_n seem_v not_o very_o consistent_a to_o himself_o in_o this_o notion_n as_o make_v the_o brain_n itself_o de_n loc_n affectis_fw-la lib._n 3._o cap._n 10._o to_o be_v the_o seat_n of_o it_o without_o there_o mention_v the_o ventricles_n whereas_o fore_o cap._n 7._o as_o well_o as_o in_o other_o place_n he_o only_o seat_v it_o in_o these_o exclusive_o to_o the_o substance_n of_o the_o brain_n but_o that_o hypothesis_n be_v now_o antiquate_a and_o the_o substance_n of_o the_o brain_n general_o own_v to_o be_v the_o seat_n of_o it_o anatomical_a observation_n have_v as_o i_o say_v make_v it_o apparent_a it_o must_v be_v seat_v there_o and_o though_o several_a author_n have_v diverse_o explicate_v it_o yet_o there_o be_v two_o opinion_n particular_o which_o be_v now_o adays_o most_o celebrate_v and_o perhaps_o deserve_v to_o be_v so_o both_o on_o their_o own_o account_n as_o be_v each_o of_o they_o very_o specious_a though_o somewhat_o different_a from_o each_o other_o as_o also_o of_o their_o author_n the_o famous_a wepfer_n and_o willis_n these_o indeed_o seem_v to_o agree_v in_o their_o notion_n of_o the_o particular_a seat_n of_o it_o viz._n both_o of_o they_o assign_v the_o medullar_n substance_n of_o the_o brain_n and_o cerebellum_fw-la for_o it_o but_o they_o differ_v here_o in_o that_o the_o former_a consider_v the_o whole_a compage_fw-la of_o they_o both_o under_o that_o name_n in_o contradistinction_n only_o to_o the_o ventricles_n the_o now_o receive_a distinction_n into_o cortical_a and_o medullar_n more_o proper_o so_o call_v have_v not_o be_v then_o think_v on_o and_o therefore_o he_o seem_v to_o suppose_v any_o part_n of_o the_o substance_n may_v be_v the_o seat_n whereas_o the_o latter_a suppose_n it_o to_o be_v in_o the_o corpus_fw-la callosum_fw-la or_o true_a medullar_n part_n according_a to_o that_o distinction_n but_o withal_o he_o assert_v that_o the_o morbific_a matter_n be_v transmit_v to_o it_o through_o the_o ambitus_fw-la or_o cortical_a the_o artery_n which_o be_v the_o conduit_n for_o convey_v it_o whatsoever_o it_o be_v either_o immediate_o or_o mediate_o pass_v all_o through_o it_o but_o they_o differ_v in_o their_o explication_n of_o the_o mode_n of_o production_n for_o wepfer_n suppose_v that_o the_o brain_n be_v either_o deny_v a_o sufficient_a afflux_n of_o blood_n of_o which_o he_o assign_v several_a cause_n or_o if_o it_o have_v that_o yet_o that_o the_o distribution_n of_o the_o spirit_n into_o the_o nerve_n be_v hinder_v either_o by_o a_o obstruction_n of_o they_o at_o their_o original_n or_o their_o compression_n but_o willis_n doubt_v whether_o the_o former_a of_o these_o the_o want_n of_o a_o supply_n of_o blood_n can_v have_v place_n here_o since_o it_o be_v know_v there_o be_v every_o where_o about_o the_o brain_n as_o well_o as_o in_o other_o part_n of_o the_o body_n mutual_a inosculation_n of_o the_o artery_n on_o the_o account_n of_o which_o it_o be_v not_o to_o be_v suppose_v that_o all_o the_o branch_n of_o the_o carotide_n and_o vertebral_n can_v on_o a_o sudden_a be_v obstruct_v but_o that_o if_o some_o happen_v to_o be_v so_o yet_o all_o part_n of_o the_o brain_n must_v receive_v the_o blood_n quick_o enough_o from_o those_o which_o be_v free_a by_o mean_n of_o these_o anastomosis_n and_o so_o the_o nerve_n may_v be_v ready_o enough_o supply_v or_o if_o these_o artery_n chance_v to_o be_v total_o obstruct_v he_o think_v the_o consequent_a distemper_n will_v not_o be_v proper_o a_o apoplexy_n but_o a_o lipothymy_n or_o hysterical_a affect_v from_o which_o consideration_n he_o deduce_v that_o what_o make_v a_o apoplexy_n must_v be_v something_o in_o the_o brain_n itself_o that_o cause_v either_o a_o solution_n of_o continuity_n in_o it_o or_o insinuate_v itself_o into_o the_o meditullium_fw-la cerebri_fw-la or_o original_n of_o the_o nerve_n and_o there_o either_o obstruct_v the_o passage_n of_o the_o spirit_n into_o they_o or_o else_o on_o the_o account_n of_o some_o narcotick_a or_o other_o disagreeable_a quality_n dissipate_v or_o depress_n they_o both_o these_o notion_n may_v with_o much_o great_a advantage_n be_v have_v from_o the_o learned_a author_n than_o a_o short_a abstract_n for_o which_o too_o under_o this_o head_n i_o shall_v apologise_v this_o relate_n to_o the_o cause_n but_o that_o withal_o it_o conduce_v to_o determine_v the_o seat_n but_o though_o dr._n willis_n have_v so_o specious_o urge_v against_o that_o tenant_n of_o the_o non-admission_n of_o blood_n to_o the_o brain_n to_o produce_v a_o apoplexy_n yet_o i_o suppose_v that_o with_o all_o deference_n to_o his_o great_a judgement_n his_o opinion_n that_o the_o proper_a medullar_n part_n of_o it_o be_v the_o only_a or_o at_o least_o most_o frequent_a seat_n of_o it_o be_v somewhat_o too_o contract_v not_o to_o say_v precarious_a and_o that_o on_o the_o other_o side_n though_o a_o apoplexy_n may_v perhaps_o sometime_o begin_v in_o the_o corpus_fw-la callosum_fw-la yet_o rather_o and_o much_o more_o frequent_o in_o the_o cortical_a than_o there_o or_o among_o the_o nerve_n at_o their_o original_n for_o though_o it_o be_v probable_a the_o meditullium_fw-la cerebri_fw-la be_v the_o place_n where_o the_o soul_n principal_o act_n and_o from_o whence_o she_o dispense_v her_o influence_n to_o the_o rest_n of_o the_o body_n and_o therefore_o she_o can_v be_v say_v to_o be_v disturb_v in_o her_o act_n and_o so_o a_o distemper_n be_v introduce_v till_o that_o part_n be_v disaffect_v yet_o i_o conceive_v that_o part_n be_v proper_o to_o be_v reckon_v the_o seat_n of_o a_o distemper_n where_o the_o cause_n that_o influential_o occasion_n the_o defection_n of_o nature_n due_a act_n first_o fix_v it_o self_n otherwise_o i_o see_v no_o reason_n but_o that_o wepfer_v denegation_n of_o spirit_n which_o willis_n oppugnes_fw-la may_v be_v sufficient_a both_o to_o make_v and_o denominate_v a_o apoplexy_n and_o indeed_o that_o the_o cortical_a be_v most_o apt_a to_o receive_v the_o morbific_n matter_n seem_v obvious_a from_o hence_o that_o in_o it_o the_o artery_n be_v most_o numerous_a and_o it_o most_o lax_n and_o yield_a so_o that_o when_o from_o any_o occasion_n the_o blood_n be_v apt_a to_o get_v out_o of_o or_o at_o least_o distend_a its_o vessel_n or_o indeed_o but_o to_o exude_v out_o of_o they_o it_o be_v probable_a this_o may_v be_v do_v more_o easy_o here_o than_o in_o the_o corpus_fw-la callosum_fw-la it_o be_v true_a it_o must_v be_v grant_v that_o the_o artery_n be_v disseminated_a through_o all_o part_n of_o it_o even_o to_o the_o inmost_a otherwise_o they_o can_v neither_o receive_v due_a heat_n nor_o nourishment_n if_o at_o least_o nourishment_n come_v immediate_o from_o the_o blood_n to_o any_o part_n but_o the_o root_n of_o the_o nerval_a tree_n numerous_o disperse_v through_o the_o cortex_fw-la which_o vessel_n though_o penetrate_a ever_o so_o deep_a if_o they_o chance_v either_o to_o open_v be_v break_v or_o become_v relax_v whereby_o they_o may_v let_v go_v some_o of_o the_o substance_n they_o carry_v after_o the_o manner_n by_o and_o by_o to_o be_v allege_v it_o be_v obvious_a must_v soon_o supply_v the_o matter_n of_o a_o considerable_a inundation_n if_o i_o may_v so_o call_v it_o of_o the_o blood_n or_o those_o
blood_n even_o in_o the_o vessel_n for_o any_o considerable_a time_n necessary_o kill_v both_o from_o what_o appear_v upon_o dissection_n not_o only_o wepfer_v before_o mention_v but_o other_o observation_n evince_v it_o and_o i_o myself_o happen_v to_o observe_v the_o same_o in_o the_o dissection_n of_o a_o very_a worthy_a lady_n the_o lady_n pakington_n the_o relation_n whereof_o be_v publish_v in_o the_o philosophical_a transaction_n num._n 173._o a._n d._n 1675._o as_o also_o in_o regard_n it_o seem_v difficult_a to_o make_v out_o how_o from_o a_o slow_a congestion_n if_o viscous_a matter_n be_v the_o cause_n or_o from_o a_o exudation_n of_o serum_fw-la the_o diffusion_n whereof_o though_o somewhat_o more_o speedy_a than_o in_o the_o supposition_n of_o viscosity_n be_v yet_o comparative_o slow_a to_o the_o sodainness_n of_o the_o invasion_n much_o more_o from_o so_o very_o slow_a a_o congestion_n as_o must_v produce_v a_o fleshy_a substance_n as_o the_o polypus_fw-la be_v unless_o on_o the_o occasion_n of_o its_o dislodging_n even_o now_o mention_v all_o the_o animal_n function_n from_o a_o perfect_a exercise_n of_o they_o as_o be_v most_o usual_o observable_a shall_v so_o instantaneous_o be_v destroy_v whereas_o the_o effusion_n of_o the_o blood_n out_o of_o its_o vessel_n may_v rational_o yield_v a_o account_n of_o this_o defection_n with_o as_o great_a swiftness_n as_o can_v be_v imagine_v the_o blood_n as_o i_o say_v before_o once_o get_v out_o of_o its_o channel_n be_v propel_v by_o mean_n of_o the_o impulse_n from_o the_o heart_n so_o as_o to_o diffuse_v itself_o immediate_o over_o the_o whole_a substance_n of_o the_o brain_n so_o far_o as_o the_o invest_n membrane_n will_v permit_v and_o though_o only_o one_o lobe_n of_o it_o chance_v to_o be_v disaffect_v yet_o the_o commerce_n be_v break_v off_o betwixt_o the_o spirit_n in_o this_o and_o the_o rest_n it_o seem_v probable_a though_o from_o the_o disproportion_n of_o our_o organ_n to_o discern_v those_o extreme_o small_a passage_n not_o autoptical_o demonstrable_a that_o there_o be_v a_o constant_a one_o by_o some_o small_a meatus_fw-la through_o the_o whole_a brain_n the_o action_n of_o the_o whole_a must_v cease_v since_o it_o be_v observable_a that_o for_o preform_v regular_o the_o action_n which_o be_v the_o province_n of_o any_o organ_n all_o the_o part_n of_o that_o organ_n must_v be_v due_o constitute_v and_o therefore_o much_o more_o ought_v this_o to_o be_v observe_v in_o the_o brain_n who_o action_n be_v so_o much_o more_o considerable_a and_o nice_a than_o any_o of_o the_o rest_n as_o influence_v the_o whole_a body_n as_o well_o as_o its_o texture_n be_v more_o curious_a and_o substance_n more_o tender_a the_o four_o thing_n propose_v to_o be_v consider_v be_v the_o disposition_n of_o the_o part_n where_o the_o distemper_n be_v seat_v to_o be_v affect_v which_o have_v endeavour_v to_o make_v out_o to_o be_v the_o brain_n we_o be_v to_o reflect_v that_o much_o of_o the_o invasion_n of_o the_o distemper_n as_o be_v before_o insinuate_v be_v owe_v to_o the_o vitiate_a organization_n of_o it_o and_o not_o all_o to_o the_o perluent_fw-la liquor_n for_o if_o it_o be_v firm_a in_o its_o tone_n and_o otherwise_o right_o constitute_v there_o be_v reason_n to_o suppose_v it_o may_v caeteris_fw-la paribus_fw-la much_o resist_v morbific_a impression_n whereas_o if_o it_o have_v be_v before_o weaken_v it_o be_v obvious_a it_o will_v easy_o yield_v to_o they_o we_o see_v in_o fever_n that_o the_o blood_n run_v rapid_o enough_o through_o it_o and_o in_o a_o anasarca_fw-la and_o cachectical_a habit_n the_o serum_fw-la make_v up_o much_o the_o great_a part_n of_o the_o blood_n which_o may_v therefore_o be_v presume_v apt_a to_o overflow_v that_o tender_a part_n so_o also_o it_o be_v observable_a that_o the_o blood_n many_o time_n appear_v extreme_o viscous_a as_o in_o pleurisy_n rheumatisme_n etc._n etc._n yet_o in_o none_o of_o these_o case_n ordinary_o be_v the_o person_n incline_v to_o apoplexy_n so_o that_o though_o the_o irregularity_n of_o the_o liquor_n may_v sometime_o occasion_v they_o without_o this_o predisposition_n oft_o he_o brain_n yet_o when_o it_o appear_v they_o invade_v more_o frequent_o than_o otherwise_o they_o use_v to_o do_v there_o seem_v considerable_a reason_n to_o suppose_v that_o it_o deflect_v some_o way_n or_o other_o in_o its_o organization_n from_o what_o be_v natural_a to_o it_o this_o defect_n i_o deny_v not_o may_v perhaps_o sometime_o consist_v in_o too_o great_a a_o closeness_n of_o its_o texture_n whereby_o a_o partial_a obstruction_n of_o its_o vessel_n may_v be_v make_v by_o degree_n from_o the_o adhesion_n of_o some_o viscouse_n matter_n deposit_v by_o little_a and_o little_a by_o the_o circulate_v blood_n about_o the_o capillary_a artery_n and_o so_o the_o blood_n behind_o come_v indeed_o only_o to_o be_v retard_v here_o whilst_o no_o disturbance_n happen_v to_o it_o but_o take_v its_o course_n to_o some_o other_o region_n of_o the_o body_n but_o if_o it_o once_o come_v to_o be_v more_o than_o ordinary_o exagitated_a it_o may_v become_v so_o determine_v in_o its_o motion_n as_o at_o last_o to_o flow_v impetuous_o hither_o too_o but_o not_o be_v able_a to_o get_v through_o its_o usual_a channel_n must_v produce_v the_o effect_n before_o suggest_v of_o a_o irruption_n into_o the_o substance_n of_o the_o brain_n but_o yet_o ordinary_o i_o conceive_v it_o depend_v upon_o too_o great_a laxity_n of_o it_o whereby_o when_o any_o forcible_a impulse_n happen_v it_o may_v too_o ready_o yield_v to_o it_o and_o so_o be_v sudden_o overwhelm_v this_o laxity_n may_v be_v consider_v to_o consist_v not_o only_o in_o a_o great_a inteneration_n of_o its_o substance_n than_o usual_a and_o thence_o its_o easiness_n to_o yield_v to_o the_o force_n of_o the_o impel_v blood_n to_o which_o in_o its_o due_a constitution_n it_o bear_v a_o proportion_n but_o likewise_o in_o the_o great_a openness_n of_o its_o pore_n than_o be_v natural_a though_o the_o fibre_n that_o constitute_v it_o have_v their_o due_a degree_n of_o firmness_n whereby_o it_o become_v capable_a of_o receive_v other_o and_o more_o bulky_a particle_n than_o usual_a as_o be_v consequential_a upon_o that_o texture_n so_o deprave_v which_o may_v possible_o as_o in_o too_o serous_a and_o acrimonious_a a_o dyscrasy_a of_o the_o blood_n proceed_v from_o the_o abrasion_n of_o some_o of_o the_o loose_a particle_n that_o constitute_v the_o habit_n of_o the_o part_n by_o the_o perluent_fw-la juice_n supply_v by_o such_o blood_n and_o i_o suppose_v may_v be_v the_o case_n of_o the_o lady_n before_o mention_v who_o be_v endue_v with_o a_o extraordinary_a acumen_n a_o great_a evidence_n of_o a_o exquisite_a constitution_n of_o the_o brain_n yet_o abound_v with_o exceed_o sharp_a substance_n in_o her_o blood_n or_o other_o liquor_n as_o many_o of_o her_o symptom_n declare_v which_o pore_n likewise_o may_v acquire_v other_o figure_n than_o be_v proper_a for_o they_o these_o concur_v particular_o to_o determine_v almost_o any_o of_o the_o secretion_n whether_o simple_a or_o mix_v that_o happen_v in_o our_o body_n so_o that_o when_o the_o brain_n happen_v to_o have_v its_o organization_n thus_o vitiate_v and_o the_o other_o cause_n concur_v a_o apoplexy_n may_v in_o probability_n easy_o enough_o be_v produce_v so_o that_o to_o recapitulate_v i_o conceive_v the_o part_n effect_v may_v either_o be_v the_o whole_a brain_n or_o any_o considerable_a part_n of_o it_o and_o either_o the_o cortical_a or_o medullar_n but_o especial_o or_o at_o lest_o first_o the_o cortical_a from_o whence_o the_o disaffect_v matter_n be_v transmit_v to_o the_o part_n of_o it_o which_o lie_v deep_o where_o the_o animal_n spirit_n principal_o exert_v themselves_o the_o nature_n of_o the_o distemper_n to_o consist_v in_o the_o sudden_a abolition_n of_o the_o due_a excrasie_n and_o distribution_n of_o they_o thence_o the_o immediate_a cause_n 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considerable_a number_n of_o its_o particle_n at_o once_o and_o so_o undergo_v a_o strong_a impression_n which_o may_v easy_o enough_o be_v conceive_v to_o be_v propagate_v to_o the_o brain_n partly_o by_o disturb_v their_o regular_a tonic_a motion_n which_o must_v from_o their_o tensity_n be_v continue_v up_o to_o their_o original_n partly_o by_o the_o ingress_n of_o too_o many_o of_o the_o lancinate_a particle_n of_o it_o into_o they_o which_o beside_o the_o fix_v or_o dissipate_v the_o animal_n spirit_n which_o i_o conceive_v to_o be_v much_o of_o the_o nature_n of_o volatill_a salt_n may_v disorder_v the_o tone_n of_o these_o nerve_n first_o and_o then_o by_o the_o continuance_n of_o the_o impulse_n of_o those_o behind_o which_o have_v the_o same_o ground_n to_o attempt_v a_o entrance_n that_o of_o the_o brain_n itself_o which_o be_v more_o tender_a than_o the_o nerve_n must_v therefore_o when_o the_o cause_n of_o the_o disaffection_n reach_v it_o be_v proportional_o injure_v a_o 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a_o physico-medical_a essay_n concern_v the_o late_a frequency_n of_o apoplexy_n together_o with_o a_o general_a method_n of_o their_o prevention_n and_o cure._n in_o a_o letter_n to_o a_o physician_n by_o william_n cole_n m.d._n oxford_z print_v at_o the_o theater_n 1689._o imprimatur_fw-la gilb_n ironside_n vicecan_a oxon_n feb._n 20._o 1689._o to_o my_o much_o esteem_a friend_n samuel_n kimberley_n dr._n in_o physic_n dear_a sir._n though_o i_o must_v look_v on_o your_o request_n to_o have_v my_o thought_n of_o the_o cause_n of_o the_o great_a frequency_n of_o apoplexy_n these_o late_a year_n than_o former_o as_o only_o a_o instance_n of_o your_o modesty_n in_o give_v a_o deference_n to_o the_o judgement_n of_o other_o when_o i_o doubt_v not_o your_o own_o notion_n if_o you_o please_v to_o draw_v they_o forth_o can_v better_o satisfy_v both_o yourself_o and_o all_o man_n else_o than_o any_o i_o can_v produce_v yet_o that_o i_o may_v not_o be_v want_v to_o the_o friendship_n i_o 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vertigo_n or_o a_o great_a oppression_n and_o pain_n in_o the_o head_n upon_o which_o present_o follow_v stupidness_n somnolency_n dazzle_v of_o the_o eye_n a_o relaxation_n of_o all_o part_n of_o the_o body_n and_o the_o like_a all_o which_o be_v so_o evident_o deducible_a from_o the_o consideration_n of_o the_o nerve_n affect_v at_o their_o original_n that_o it_o be_v time_n lose_v far_a to_o prove_v it_o but_o since_o it_o be_v not_o satisfactory_a enough_o to_o assert_v in_o general_a that_o the_o brain_n which_o be_v a_o accurate_o organise_v part_n in_o which_o there_o be_v a_o great_a variety_n of_o cell_n and_o vessel_n and_o a_o considerable_a difformity_n of_o part_n one_o from_o another_o be_v the_o seat_n of_o this_o distemper_n without_o determine_v whether_o the_o whole_a or_o any_o particular_a region_n or_o part_n of_o it_o be_v especial_o affect_v author_n have_v employ_v themselves_o in_o this_o search_n the_o most_o celebrate_a opinion_n and_o which_o most_o have_v follow_v till_o this_o age_n be_v that_o of_o galen_n who_o assign_v the_o ventricles_n for_o the_o particular_a seat_n and_o suppose_v a_o viscous_a matter_n get_v into_o they_o to_o be_v the_o cause_n of_o it_o this_o opinion_n though_o it_o may_v give_v some_o account_n of_o the_o interception_n of_o the_o animal_n spirit_n which_o according_a to_o the_o ancient_a doctrine_n be_v to_o actuate_v the_o body_n by_o be_v distribute_v along_o the_o nerve_n on_o the_o account_n of_o the_o compression_n these_o must_v so_o undergo_v near_o their_o original_n which_o distribution_n fail_v all_o animal_n motion_n in_o the_o part_n influence_v by_o the_o nerve_n which_o labour_n under_o this_o compression_n must_v cease_v yet_o with_o all_o deference_n to_o the_o memory_n of_o the_o great_a author_n as_o well_o as_o to_o the_o abettor_n of_o it_o i_o conceive_v may_v rather_o
but_o from_o which_o of_o they_o it_o be_v requisite_a we_o inquire_v to_o consider_v first_o the_o passive_a quality_n of_o the_o air_n dryness_n and_o moisture_n it_o may_v perhaps_o seem_v probable_a that_o they_o may_v in_o order_n to_o produce_v this_o as_o well_o as_o some_o other_o distemper_n indispose_v the_o brain_n the_o former_a by_o harden_v the_o tone_n of_o the_o sanguiferous_a vessel_n in_o general_a and_o consequent_o contract_v their_o tube_n and_o so_o cause_v a_o acceleration_n of_o the_o motion_n of_o the_o blood_n through_o they_o which_o must_v if_o propel_v with_o the_o same_o force_n at_o its_o original_n run_v more_o swift_o through_o vessel_n when_o thus_o straighten_a than_o whilst_o have_v their_o usual_a dilatation_n whereby_o it_o may_v be_v presume_v that_o when_o cast_v forth_o of_o the_o artery_n into_o the_o interstice_n between_o they_o and_o the_o vein_n at_o their_o extremity_n it_o may_v make_v its_o way_n into_o the_o more_o yield_a substance_n it_o be_v any_o where_o to_o pass_v through_o and_o the_o brain_n be_v confess_o more_o so_o than_o any_o other_o part_n of_o the_o body_n be_v therefore_o most_o likely_a to_o be_v affect_v on_o such_o occasion_n the_o latter_a which_o be_v countenance_v by_o the_o great_a hypocrates_n sect._n 3_o aph._n 16._o by_o intenerate_v the_o brain_n so_o much_o beyond_o its_o usual_a constitution_n that_o it_o may_v thence_o become_v more_o than_o natural_o susceptible_a of_o the_o always_o brisk_o circulate_v blood_n next_o as_o to_o the_o most_o efficacious_a of_o the_o active_a one_o heat_v it_o may_v perhaps_o be_v urge_v that_o the_o blood_n though_o otherwise_o well_o enough_o constitute_v be_v much_o heat_v and_o rarify_v by_o that_o excess_n of_o the_o ambient_fw-la may_v be_v incline_v to_o make_v its_o way_n out_o of_o the_o vessel_n in_o the_o brain_n especial_o on_o the_o account_n of_o its_o forementioned_a tenderness_n but_o beside_o that_o experience_n warrant_v none_o of_o these_o supposition_n perhaps_o it_o can_v hardly_o be_v make_v out_o 1_o st_z that_o so_o great_a a_o dryness_n as_o must_v effect_v this_o can_v be_v introduce_v into_o our_o body_n which_o be_v continual_o irrigate_v not_o only_o by_o the_o circulate_v blood_n but_o other_o secondary_a liquor_n 2_o dly_a that_o a_o great_a excess_n of_o moisture_n in_o the_o air_n shall_v produce_v apoplexy_n unless_o those_o more_o rare_a one_o as_o i_o suppose_v they_o be_v from_o the_o serum_fw-la and_o that_o general_o after_o other_o distemper_n which_o have_v weaken_v the_o crasis_n of_o the_o blood_n as_o well_o as_o the_o tone_n of_o the_o brain_n since_o such_o a_o dyscrasy_a impress_v on_o the_o blood_n seem_v to_o make_v it_o more_o torpid_a by_o clog_a the_o spirit_n in_o it_o and_o so_o less_o apt_a to_o inundation_n and_o beside_o relax_n the_o vessel_n as_o well_o as_o the_o substance_n of_o the_o brain_n and_o so_o favour_v its_o ready_a passage_n along_o they_o and_o 3_o dly_z that_o the_o excess_n of_o outward_a heat_n shall_v cause_v this_o eruption_n since_o by_o it_o the_o solid_a part_n may_v be_v as_o well_o presume_v to_o be_v invigorate_v to_o resist_v as_o the_o blood_n excite_v to_o attempt_v it_o beside_o that_o the_o transpiration_n that_o be_v occasion_v by_o this_o heat_n may_v sufficient_o compensate_a for_o the_o accelerate_a motion_n of_o the_o blood_n its_o quantity_n which_o may_v in_o that_o case_n be_v principal_o dangerous_a be_v thence_o diminish_v it_o remain_v then_o to_o attribute_v this_o frequency_n of_o apoplexy_n to_o the_o coldness_n of_o the_o air_n as_o the_o most_o adequate_a occasion_n which_o when_o it_o happen_v to_o be_v intense_o so_o may_v i_o conceive_v be_v make_v out_o to_o give_v a_o probable_a reason_n of_o it_o that_o cold_a be_v a_o great_a enemy_n to_o the_o brain_n be_v both_o the_o general_a sense_n and_o confirm_v by_o the_o authority_n of_o hypocrates_n sect._n 5._o aph._n 18._o and_o all_o physician_n since_o and_o therefore_o we_o may_v possible_o infer_v that_o the_o great_a architect_n fence_v this_o part_n with_o so_o strong_a a_o wall_n scarce_o more_o to_o protect_v it_o from_o other_o injury_n than_o this_o to_o which_o it_o will_v otherwise_o be_v expose_v but_o how_o cold_a affect_v it_o so_o injurious_o may_v require_v a_o little_a explication_n in_o order_n to_o it_o give_v i_o leave_v sir_n to_o consider_v without_o pretend_v to_o discuss_v it_o so_o minutely_o as_o man_n of_o more_o philosophical_a head_n and_o better_o accomplish_v in_o such_o speculation_n might_n the_o nature_n of_o cold_a as_o be_v requisite_a to_o be_v know_v in_o some_o measure_n to_o the_o understanding_n its_o relative_a effect_n which_o attempt_n indeed_o may_v appear_v very_o presumptuous_a after_o that_o the_o exquisite_a mr._n boyle_n have_v not_o think_v fit_a to_o determine_v in_o the_o matter_n but_o that_o you_o may_v perhaps_o find_v that_o the_o short_a deduction_n i_o make_v however_o unartificial_o be_v either_o take_v from_o or_o i_o conceive_v reducible_a to_o what_o he_o have_v deliver_v and_o so_o far_o from_o be_v positive_o assert_v that_o they_o be_v only_o submit_v to_o the_o censure_n of_o your_o and_o other_o better_a judgement_n to_o which_o purpose_n three_o or_o four_o general_a consideration_n seem_v not_o unfit_a so_o far_o as_o belong_v to_o our_o present_a disquisition_n to_o be_v take_v notice_n of_o to_o give_v a_o account_n of_o its_o manner_n of_o affect_v we_o in_o the_o first_o place_n than_o it_o may_v be_v consider_v that_o though_o neither_o cold_a nor_o heat_n nor_o any_o of_o the_o rest_n of_o the_o sensible_a quality_n have_v any_o real_a be_v but_o only_o in_o relation_n to_o our_o perception_n insomuch_o that_o be_v there_o no_o sensitive_a being_n there_n can_v be_v no_o such_o thing_n yet_o they_o must_v be_v found_v on_o something_o that_o do_v real_o exist_v as_o all_o accident_n beside_o be_v so_o that_o though_o they_o can_v be_v reckon_v among_o the_o general_a affection_n of_o matter_n as_o motion_n though_o they_o depend_v upon_o it_o or_o its_o contrary_a rest_v bulk_n figure_n etc._n etc._n be_v which_o will_v still_o be_v where_o matter_n be_v though_o there_o be_v no_o sensitive_a being_n yet_o be_v consequent_a upon_o it_o but_o determine_v by_o these_o and_o associate_v to_o somewhat_o that_o have_v perception_n second_o that_o it_o be_v evident_a our_o sensory_n be_v affect_v by_o cold_a that_o be_v have_v some_o impression_n make_v on_o they_o now_o nothing_o can_v affect_v but_o by_o approach_v to_o that_o which_o it_o do_v so_o affect_v and_o to_o approach_v require_v motion_n it_o must_v follow_v that_o motion_n must_v go_v to_o constitute_v the_o nature_n of_o cold._n which_o though_o it_o may_v seem_v not_o so_o evident_a since_o cold_a be_v reckon_v contrary_a to_o heat_n and_o this_o consist_v obvious_o in_o motion_n it_o may_v be_v urge_v that_o shall_v in_o rest_n yet_o it_o may_v be_v return_v that_o though_o it_o be_v necessary_o to_o be_v infer_v there_o be_v motion_n where_o there_o be_v heat_n yet_o not_o always_o that_o there_o be_v heat_n where_o motion_n so_o that_o it_o be_v not_o motion_n simple_o but_o consider_v with_o some_o adjunct_n viz._n motion_n in_o such_o or_o such_o a_o degree_n and_o with_o relation_n to_o sensitive_a being_n that_o constitute_v heat_v and_o consequent_o that_o it_o be_v not_o to_o be_v infer_v that_o cold_a consist_v in_o absolute_a rest_n because_o contrary_a to_o heat_n but_o in_o a_o different_a degree_n of_o motion_n though_o other_o mechanical_a affection_n must_v concur_v to_o determine_v it_o which_o recede_v on_o one_o hand_n from_o a_o middle_a degree_n of_o it_o in_o our_o sensory_a as_o that_o which_o make_v heat_n do_v on_o the_o other_o which_o too_o may_v be_v evince_v from_o hence_o that_o each_o of_o they_o have_v a_o great_a latitude_n of_o degree_n must_v be_v found_v in_o what_o admit_v of_o degree_n which_o motion_n do_v but_o rest_v not_o three_o that_o motion_n here_o be_v not_o to_o be_v consider_v abstract_o but_o together_o with_o the_o subject_n of_o it_o and_o as_o occasion_v by_o and_o produce_v in_o some_o body_n we_o may_v take_v notice_n that_o as_o it_o be_v evident_a the_o body_n without_o we_o which_o excite_v our_o sensation_n be_v move_v so_o our_o organ_n which_o be_v design_v to_o receive_v the_o impression_n of_o these_o extraneous_a object_n and_o transmit_v they_o to_o the_o soul_n can_v hardly_o be_v presume_v to_o do_v it_o any_o more_o indeed_o than_o prove_v a_o fit_a mansion_n for_o she_o without_o have_v their_o particle_n whether_o consistent_a or_o fluid_a for_o both_o be_v necessary_a to_o their_o construction_n in_o motion_n and_o not_o only_o so_o but_o endue_v with_o a_o determinate_a degree_n of_o it_o this_o degree_n ought_v not_o to_o be_v violent_a for_o so_o the_o
many_o contumacious_a distemper_n which_o by_o calm_v instead_o of_o exagitate_v the_o blood_n a_o little_a disturb_v will_v quick_o have_v go_v of_o so_o it_o be_v fit_v that_o those_o shall_v be_v admonish_v of_o the_o ill_a consequence_n of_o such_o a_o method_n who_o i_o will_v believe_v out_o of_o charity_n which_o yet_o will_v be_v more_o fit_o employ_v otherways_o adventure_v upon_o it_o especial_o near_o the_o begin_n of_o feverish_a indisposition_n before_o the_o morbific_a matter_n be_v digest_v and_o fit_v to_o secede_v as_o well_o as_o the_o multitude_n of_o pretender_n to_o physic_n who_o without_o a_o due_a knowledge_n of_o the_o ground_n of_o physic_n which_o those_o that_o industrious_o study_v it_o know_v be_v not_o easy_a to_o be_v attain_v make_v this_o their_o sacred_a anchor_n when_o they_o know_v not_o what_o to_o do_v another_o sort_n of_o evacuation_n for_o prevention_n may_v be_v propose_v viz._n by_o fontanell_n but_o though_o these_o look_v specious_o and_o many_o be_v fond_a of_o they_o and_o indeed_o they_o may_v be_v possible_o useful_a to_o such_o who_o have_v escape_v out_o of_o one_o fit_a as_o a_o constant_a drain_v to_o divert_v some_o humour_n from_o the_o brain_n which_o by_o too_o much_o relax_v or_o otherwise_o indispose_v it_o may_v occasion_v return_n this_o part_n require_v thence_o as_o i_o have_v deduce_v a_o long_a time_n and_o diligent_a regulation_n to_o recover_v its_o native_a tone_n and_o so_o may_v need_v all_o manner_n of_o diversion_n as_o well_o as_o other_o assistance_n yet_o to_o person_n free_a from_o other_o indisposition_n that_o require_v they_o i_o shall_v think_v they_o if_o not_o in_o some_o degree_n prejudicial_a by_o draw_v away_o some_o part_n of_o what_o shall_v be_v retain_v at_o least_o superfluous_a the_o humour_n evacuate_v at_o they_o bear_v usual_o but_o a_o small_a proportion_n to_o the_o daily_o supply_v bring_v into_o the_o blood_n which_o therefore_o may_v become_v much_o deprave_v for_o all_o the_o assistance_n these_o can_v give_v especial_o in_o regard_n the_o evacuation_n be_v not_o of_o a_o peccant_a humour_n in_o general_a but_o make_v up_o of_o any_o sort_n of_o particle_n that_o can_v get_v out_o of_o the_o aperture_n of_o the_o divide_a vessel_n and_o much_o different_a from_o what_o be_v of_o nature_n designation_n in_o part_n fit_o by_o she_o organise_v upon_o the_o first_o construction_n for_o i_o can_v conceive_v it_o otherwise_o elective_a than_o as_o those_o aperture_n which_o on_o the_o score_n of_o the_o incision_n or_o erosion_n of_o the_o vessel_n must_v be_v large_a can_v only_o discharge_v some_o such_o sufficient_o for_o the_o most_o part_n complex_fw-la substance_n from_o the_o blood_n as_o be_v of_o a_o bulk_n and_o figure_n commensurate_n to_o they_o or_o less_o without_o any_o relation_n to_o they_o as_o disagreeable_a to_o the_o rest_n of_o the_o mass_n and_o so_o from_o that_o largeness_n of_o the_o aperture_n there_o must_v be_v transmit_v a_o much_o great_a number_n of_o useful_a than_o true_o excrementitious_a substance_n to_o say_v nothing_o of_o the_o disturbance_n which_o the_o pain_n must_v occasion_v in_o a_o body_n otherwise_o sound_a whereas_o most_o of_o the_o useful_a evacuate_a administration_n except_o phlebotomy_n which_o produce_v its_o effect_n main_o by_o the_o quantity_n it_o be_v use_v in_o make_v or_o presuppose_v a_o laxity_n and_o separation_n of_o part_n in_o the_o substance_n from_o whence_o the_o evacuation_n be_v to_o be_v have_v as_o well_o as_o effect_v it_o at_o emissary_n fit_o frame_v and_o dispose_v to_o let_v go_v such_o or_o such_o determinate_a humour_n second_o as_o to_o the_o corroborate_n the_o crasis_n of_o the_o blood_n though_o those_o who_o be_v in_o perfect_a health_n need_v it_o not_o and_o medecine_n of_o that_o tendency_n may_v perhaps_o make_v it_o ferment_n too_o high_o and_o so_o perhaps_o occasional_o introduce_v the_o distemper_n which_o the_o pretext_n of_o give_v they_o be_v to_o prevent_v yet_o to_o valetudinary_a person_n or_o those_o who_o blood_n upon_o emission_n appear_v viscous_a or_o be_v otherwise_o deprave_a i_o suppose_v such_o administration_n be_v very_o necessary_a and_o to_o such_o i_o will_v universals_z premise_a propose_v a_o course_n of_o bitter_a medicine_n both_o at_o spring_n and_o fall_v if_o they_o be_v of_o cold_a and_o phlegmatic_a constitution_n as_o i_o will_v advise_v other_o who_o blood_n be_v too_o apt_a on_o light_a occasion_n to_o be_v exagitated_a the_o familiar_a use_n of_o appropriate_a calm_v medicine_n but_o to_o all_o chalybeates_n to_o be_v diversify_v and_o give_v with_o different_a vehicle_n according_a to_o the_o several_a constitution_n of_o person_n may_v be_v of_o most_o extensive_a use_n and_o have_v this_o to_o recommend_v they_o that_o they_o need_v no_o strict_a regulation_n nay_o their_o effect_n be_v depress_v by_o confinement_n stir_v and_o change_v the_o air_n both_o actuate_a they_o and_o exciting_a and_o ferment_a the_o blood_n as_o also_o strengthen_v the_o tone_n of_o the_o part_n of_o these_o the_o chalybeat_a water_n as_o those_o of_o tunbridge_n astrap_n and_o which_o i_o believe_v be_v second_o to_o none_o ilmington_n in_o your_o neighbourhood_n and_o the_o like_a drink_v in_o summer_n and_o perhaps_o at_o other_o season_n but_o that_o custom_n have_v not_o authorize_v it_o here_o though_o henricus_fw-la ab_fw-la here_o be_v as_o great_a a_o judge_n of_o that_o as_o any_o man_n in_o his_o spadacrene_n prescribe_v they_o with_o as_o good_a success_n in_o the_o midst_n of_o winter_n as_o at_o any_o time_n beside_o for_o a_o month_n or_o long_o be_v as_o the_o most_o familiar_a and_o confirm_v by_o the_o practice_n of_o the_o great_a physician_n of_o many_o age_n so_o perhaps_o the_o most_o efficacious_a of_o any_o preparation_n of_o steel_n as_o be_v take_v up_o by_o the_o water_n run_v through_o the_o minera_n whilst_o the_o metal_n be_v yet_o in_o solutis_fw-la principiis_fw-la as_o the_o chemist_n speak_v and_o so_o most_o subtle_a and_o active_a if_o so_o be_v the_o brain_n happen_v not_o before_o to_o have_v be_v too_o much_o intenerate_v in_o which_o case_n perhaps_o the_o water_n itself_o symbolise_v with_o the_o indisposition_n especial_o the_o quantity_n consider_v may_v predominate_v over_o the_o power_n of_o the_o vitriol_n dissolve_v in_o it_o to_o constringe_v the_o before_o weaken_a part_n and_o the_o diversion_n to_o be_v use_v at_o the_o well_n may_v not_o a_o little_a conduce_v to_o the_o effect_n of_o rectify_v the_o blood_n by_o exciting_a the_o spirit_n but_o as_o to_o the_o several_a chalybeate_a preparation_n give_v i_o leave_v so_o much_o to_o digress_v if_o you_o will_v call_v it_o a_o digression_n as_o to_o say_v that_o i_o think_v if_o the_o part_n of_o our_o body_n and_o crasis_n of_o the_o blood_n be_v only_o to_o be_v strengthen_v and_o no_o store_n of_o acid_n abound_v those_o of_o they_o that_o have_v be_v open_v 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of_o those_o that_o immoderate_o use_v it_o and_o more_o perhaps_o then_o the_o apoplectic_a balsam_n because_o both_o the_o matter_n of_o it_o be_v more_o gross_a and_o thence_o apt_a to_o lie_v long_o about_o the_o extremity_n of_o the_o olfactory_a nerve_n and_o so_o continual_o to_o affect_v they_o and_o also_o the_o custom_n of_o many_o be_v as_o i_o have_v often_o observe_v ever_o and_o anon_o to_o be_v supply_v more_o whereby_o the_o pore_n of_o those_o nerve_n be_v keep_v continual_o open_a and_o i_o must_v suspect_v that_o shall_v any_o pestilential_a season_n invade_v which_o god_n avert_v such_o person_n as_o much_o accustom_v themselves_o to_o these_o powder_n will_v caeteris_fw-la paribus_fw-la be_v in_o more_o danger_n of_o receive_v infection_n than_o other_o since_o from_o the_o symptom_n deliver_v by_o author_n the_o pestilence_n appear_v to_o seize_v the_o brain_n particular_o and_o the_o sudden_a fate_n record_v of_o those_o that_o without_o any_o precede_a 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feed_n and_o want_v of_o due_a exercise_n may_v possible_o at_o some_o time_n be_v considerable_o increase_v and_o withal_o how_o that_o many_o not_o only_o live_v under_o great_a fasting_n for_o many_o day_n whether_o for_o want_v of_o appetite_n or_o constraint_n which_o evacuation_n proceed_v notwithstanding_o at_o least_o that_o of_o transpiration_n which_o according_a to_o the_o observation_n of_o the_o accurate_a sanctorius_n be_v much_o the_o great_a of_o they_o all_o must_v necessary_o diminish_v the_o quantity_n of_o blood_n much_o below_o the_o proportion_n that_o any_o physician_n by_o bleed_a dare_v though_o for_o reason_n not_o so_o proper_a for_o this_o place_n and_o the_o brevity_n of_o a_o letter_n already_o swell_v too_o much_o the_o advantage_n thence_o result_v in_o many_o case_n equal_v not_o those_o of_o a_o free_a phlebotomy_n and_o yet_o afterward_o recover_v to_o as_o good_a a_o state_n of_o health_n as_o ever_o they_o enjoy_v we_o ought_v to_o lay_v aside_o 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always_o to_o be_v dread_v