be_v repute_v opiate_n borellus_n speak_v of_o a_o soporiferous_a aura_n that_o proceed_v from_o one_o thumb_n cure_v by_o a_o caustick_a i_o have_v read_v of_o a_o cataphora_fw-it from_o worm_n a_o soporiferous_a fume_v from_o the_o womb_n and_o very_o many_o such_o sort_n of_o instance_n which_o thing_n be_v now_o easy_o conceive_v for_o it_o be_v but_o suppose_v a_o fume_v of_o the_o nature_n of_o sem._n animale_a or_o its_o aura_n for_o i_o can_v no_o long_o doubt_v but_o it_o be_v a_o opiate_n and_o it_o will_v have_v much_o the_o same_o effect_n with_o opium_n if_o it_o be_v fit_a to_o use_v it_o after_o the_o same_o manner_n have_v show_v 1._o which_o be_v the_o predominant_a active_a principle_n in_o opium_n and_o how_o combine_v etc._n etc._n 2._o which_o of_o they_o produce_v the_o usual_a and_o laudable_a effect_n of_o opium_n and_o why_o in_o general_a i_o come_v now_o to_o the_o three_o particular_a viz._n to_o show_v iii_o which_o of_o they_o produce_v its_o ill_a effect_n and_o why_o it_o be_v ill_a effect_n be_v these_o viz._n nauseas_fw-la vomit_n which_o be_v general_o very_o dismal_a with_o great_a distress_n and_o sometime_o dangerous_a swim_v in_o the_o head_n hiccough_n distress_n anxiety_n convulsion_n faint_n leipothymy_n syncopes_fw-la etc._n etc._n 1._o note_v that_o its_o grievous_a effect_n be_v at_o or_o about_o the_o region_n of_o the_o stomach_n or_o particular_o the_o mouth_n or_o pit_n thereof_o or_o thence_o arise_v by_o consent_n 2._o note_v that_o see_v there_o be_v nothing_o so_o good_a but_o may_v cause_v evil_a effect_n in_o a_o excessive_a quantity_n this_o enquiry_n be_v more_o proper_o what_o principle_n or_o principle_n of_o opium_n do_v cause_n those_o ill_a effect_n in_o a_o ordinary_a do_v for_o what_o will_v in_o a_o moderate_a do_v will_v be_v sure_a cause_v they_o in_o a_o excessive_a do_v 3._o note_v that_o all_o the_o constant_a effect_n of_o opium_n as_o you_o may_v observe_v in_o the_o enumeration_n thereof_o in_o the_o four_o chapter_n be_v good_a and_o laudable_a effect_n it_o follow_v therefore_o that_o the_o bad_a be_v accidental_a 1._o it_o be_v not_o the_o earthy_a or_o phlegmatic_a part_n of_o opium_n that_o cause_v those_o ill_a effect_n because_o they_o be_v passive_a principle_n and_o consequent_o have_v not_o such_o a_o power_n beside_o that_o they_o be_v know_v to_o be_v innocent_a 2._o opium_n have_v all_o those_o ill_a effect_n when_o both_o the_o earthy_a and_o phlegmatic_a part_n be_v separate_v from_o it_o as_o when_o a_o extract_v of_o well_o torrefy_v opium_n be_v make_v in_o spirit_n of_o wine_n for_o by_o that_o mean_v the_o phlegmatic_a part_n be_v dry_v up_o and_o the_o earthy_a part_n subside_o and_o be_v separate_v yea_o such_o extract_v make_v by_o spirit_n of_o wine_n do_v cause_n those_o evil_a effect_n rather_o more_o than_o crude_a opium_n with_o its_o earth_n and_o phlegm_n in_o it_o as_o experience_n assure_v we_o and_o reason_n will_v plain_o confirm_v by_o and_o by_o however_o fond_a the_o world_n be_v of_o such_o preparation_n 3._o it_o be_v evident_a from_o the_o premise_n that_o the_o sal-volatile-oleosum_a of_o opium_n can_v cause_v those_o vomit_n hiccough_n etc._n etc._n for_o they_o be_v the_o effect_n of_o grievous_a sensation_n at_o stomach_n but_o the_o sal-volatile-oleosum_a cause_n a_o most_o agreeable_a and_o please_a sensation_n at_o stomach_n 4._o nothing_o quiet_v vomit_n convulsion_n â—coughs_n etc._n etc._n more_o than_o that_o sal-volatile-oleosum_a of_o opium_n 5._o experience_n inform_v we_o that_o the_o sal-volatile-oleosum_a of_o opium_n separate_v from_o all_o other_o part_n and_o principle_n thereof_o never_o cause_v such_o evil_a effect_n as_o i_o and_o another_o physician_n in_o london_n can_v testify_v as_o do_v also_o le_fw-fr mort_fw-fr in_o the_o most_o learned_a dr._n love_n collectanea_fw-la where_o he_o say_v of_o such_o a_o preparation_n thereof_o as_o contain_v only_o the_o sal-volatile-oleosum_a that_o nunquam_fw-la anxietates_fw-la circa_fw-la praecordia_fw-la aut_fw-la phantasias_fw-la conciliat_fw-la that_o be_v it_o never_o cause_v anxiety_n about_o the_o mouth_n of_o the_o stomach_n etc._n etc._n for_o that_o be_v most_o proper_o to_o be_v understand_v by_o praecordia_fw-la wedelius_n testify_v the_o like_a of_o such_o another_o preparation_n and_o so_o do_v several_a author_n though_o they_o do_v not_o in_o the_o least_o know_v why_o but_o only_o by_o experience_n 6._o it_o be_v fix_v salt_n be_v innocent_a in_o its_o nature_n and_o but_o the_o 32d_o part_n of_o opium_n which_o be_v too_o inconsiderable_a in_o a_o ordinary_a moderate_a do_v to_o cause_v any_o sensible_a effect_n it_o follow_v therefore_o that_o be_v must_v be_v the_o resinous_n part_n of_o opium_n which_o it_o have_v in_o a_o considerable_a quantity_n that_o must_v cause_v those_o ill_a effect_n this_o manifest_o appear_v 1._o because_o a_o tincture_n of_o opiam_fw-la in_o water_n which_o take_v up_o none_o of_o the_o rosin_n but_o let_v it_o fall_v into_o the_o bottom_n never_o cause_v any_o such_o ill_a effect_n which_o it_o do_v not_o also_o if_o reduce_v to_o a_o extract_v by_o evaporation_n yet_o have_v they_o all_o the_o usual_a good_a effect_n of_o opium_n 2._o wedelius_n in_o his_o opiolog_n assure_v the_o same_o of_o the_o like_a preparation_n in_o phlegm_n of_o distil_a vinegar_n l._n 2._o sect._n 1_o c._n 5._o p._n 92._o 3._o a_o extract_v of_o opium_n in_o spirit_n of_o wine_n do_v often_o cause_v those_o ill_a effect_n and_o no_o other_o preparation_n cause_v they_o as_o often_o wedelius_n ibid._n a_o laudano_n opiato_fw-it cum_fw-la spiritu_fw-la vini_n correcto_fw-la solum_fw-la ferâ—_n observavimus_fw-la ortos_fw-la vomitus_fw-la a_o nostro_fw-la vero_fw-la quod_fw-la cum_fw-la phlegmate_fw-it aceti_fw-la distillati_fw-la fieri_fw-la diximus_fw-la nunquam_fw-la vomitum_fw-la vel_fw-la nauseam_fw-la saltem_fw-la contigisse_fw-la meminimus_fw-la that_o be_v we_o have_v observe_v vomit_n almost_o only_o from_o laudanum_n prepare_v with_o spirit_n of_o wine_n but_o never_o any_o vomit_v or_o nausea_n from_o that_o prepare_v in_o phlegm_n of_o distil_a vinegar_n which_o he_o confirm_v l._n 1._o sect_n 2._o c._n 4._o p._n 62._o saying_n in_o latin_a that_o a_o curious_a observation_n be_v to_o be_v note_v by_o which_o it_o appear_v that_o a_o extract_v of_o opium_n with_o spirit_n of_o wine_n show_v more_o narcotick_a force_n by_o which_o he_o mean_v that_o it_o cause_v more_o ill_a effect_n than_o prepare_v in_o distil_a vinegar_n whereas_o that_o in_o spirit_n of_o wine_n have_v nothing_o more_o in_o it_o than_o that_o in_o vinegar_n beside_o the_o râ—sinous_n part_n therefore_o these_o do_v cause_n all_o the_o mischief_n note_v also_o that_o a_o extract_v in_o spirit_n of_o wine_n have_v in_o it_o quantity_n for_o quantity_n more_o of_o the_o râ—sinous_n part_v than_o crude_a oplum_fw-la both_o because_o the_o earthy_a part_n that_o help_v to_o make_v up_o the_o bulk_n be_v take_v away_o in_o that_o preparation_n and_o because_o the_o 〈◊〉_d of_o wine_n imbibe_v the_o rosin_n more_o greedy_o than_o other_o principle_n of_o the_o opium_n so_o that_o every_o do_v must_v in_o proportion_n have_v much_o more_o rosin_n in_o it_o than_o crude_a opium_n therefore_o it_o be_v no_o wonder_n that_o it_o cause_v those_o ill_a effect_n more_o frequent_o since_o the_o rosin_n be_v most_o certain_o the_o cause_n thereof_o as_o have_v be_v and_o shall_v be_v more_o full_o and_o beyond_o all_o contradiction_n prove_v yet_o be_v this_o the_o preparation_n boast_v of_o by_o the_o blind_a and_o inadvertent_n world_n it_o will_v amaze_v nay_o terrify_v a_o man_n to_o see_v what_o great_a care_n be_v take_v to_o be_v sure_a to_o render_v opium_n mischievous_a by_o solicitous_o use_v spirit_n of_o wine_n in_o extract_a laudanum_n and_o then_o and_o not_o till_o then_o they_o boast_v of_o the_o preparation_n as_o charas_fw-la and_o very_o many_o other_o do_v calling_z it_o not_o without_o great_a ostentation_n and_o desperate_a folly_n their_o laudanum_n may_v it_o be_v they_o and_o none_o other_o a_o turk_n will_v be_v a_o madman_n to_o use_v it_o for_o crude_a opium_n because_o it_o have_v much_o more_o of_o the_o pernicious_a principle_n in_o it_o it_o be_v the_o common_a and_o much_o esteem_v way_n first_o to_o extract_v it_o out_o of_o water_n and_o then_o it_o be_v very_o good_a laudable_a and_o innocent_a but_o think_v nothing_o worth_a till_o they_o extract_v the_o rosin_n that_o be_v all_o leave_v behind_o by_o the_o water_n in_o spirit_n of_o wine_n and_o add_v it_o to_o the_o other_o then_o do_v they_o with_o great_a authority_n praise_v it_o that_o be_v when_o they_o have_v wise_o add_v the_o poison_n to_o the_o panacea_fw-la it_o be_v as_o if_o they_o add_v ratsbane_n to_o a_o cordial_n and_o not_o think_v the_o cordial_a worthy_a commendation_n till_o they_o have_v do_v so_o 4._o it_o appear_v that_o the_o rosin_n be_v
sleep_v be_v the_o sound_a and_o that_o sleep_v gradual_o decline_v in_o degree_n as_o we_o be_v recruit_v till_o we_o awake_v the_o near_a which_o we_o be_v the_o more_o we_o dream_v the_o state_n of_o dream_v be_v a_o kind_n of_o twilight_n between_o sound_a sleep_n and_o awake_v or_o between_o a_o full_a somniferous_a relaxation_n and_o vigilative_a contraction_n and_o as_o the_o sensitive_a soul_n use_v all_o degree_n of_o contraction_n below_o that_o of_o the_o vigilative_a till_o it_o come_v to_o bare_a compression_n of_o the_o air_n so_o it_o can_v exercise_v super-vigilative_a contraction_n if_o i_o may_v so_o call_v it_o that_o be_v much_o high_a degree_n thereof_o than_o what_o be_v requisite_a ordinary_o for_o a_o state_n of_o vigilancy_n as_o in_o case_n of_o danger_n to_o the_o animal_n fright_v terror_n grievous_a passion_n and_o sensation_n by_o which_o mean_v the_o animal_n spirit_n be_v more_o compress_v than_o under_o the_o ordinary_a vigilative_a contraction_n sensation_n grow_v more_o nice_a and_o smart_a and_o motion_n more_o prompt_a and_o vigorous_a they_o always_o go_v together_o for_o the_o defence_n of_o the_o animal_n by_o extraordinary_a flight_n repulsion_n or_o otherwise_o hence_o it_o be_v upon_o fear_n terror_n grievous_a passion_n or_o sensation_n which_o manifest_o prove_v the_o be_v of_o such_o a_o extraordinary_a contraction_n upon_o such_o occasion_n that_o 1._o perspiration_n sail_v in_o a_o yet_o high_o degree_n than_o under_o bare_a or_o ordinary_a vigilative_a contraction_n as_o appear_v by_o infallible_a statick_a experiment_n and_o demonstration_n 2._o it_o be_v by_o reason_n of_o the_o say_v defensive_a contraction_n for_o so_o i_o call_v it_o because_o it_o be_v excite_v in_o a_o extraordinary_a manner_n for_o the_o defence_n of_o the_o animal_n in_o time_n of_o need_n or_o great_a exigence_n that_o in_o fright_v terror_n etc._n etc._n our_o hair_n dog_n etc._n etc._n do_v stand_v on_o end_n or_o more_o upright_o 1._o because_o the_o pore_n do_v by_o that_o violent_a contraction_n strict_o close_a about_o the_o root_n of_o the_o hair_n that_o it_o can_v swag_v incline_v or_o yield_v any_o way_n by_o reason_n of_o its_o weight_n etc._n etc._n as_o when_o the_o skin_n be_v more_o lax_n and_o soft_a and_o the_o pore_n wherein_o the_o hair_n be_v fix_v more_o open_a 2._o because_o which_o be_v the_o main_a reason_n the_o say_a contraction_n render_v the_o oblique_a pore_n more_o upright_o as_o suppose_v the_o pore_n and_o hair_n do_v natural_o stand_v oblique_o as_o they_o do_v to_o carry_v off_o wet_a etc._n etc._n as_o in_o fig._n 1._o fig_n i_o fig_n two_o and_o that_o a_o in_o fig._n 1._o be_v by_o the_o say_a contraction_n bring_v near_a to_o ay_o as_o much_o as_o be_v from_o a_o to_o o_o then_o will_v the_o pore_n and_o hair_n stand_v upright_o as_o in_o fig._n 2._o and_o the_o skin_n a_o o_o e_o i_o s_o contract_v and_o bring_v within_o the_o prick_v perpendicular_o whereas_o in_o fig._n 1._o it_o excure_v beyond_o the_o perpendicular_a n_z m_z as_o much_o as_o be_v from_o a_o to_o o._n 3._o for_o the_o same_o reason_n it_o be_v that_o the_o face_n in_o grievous_a passion_n and_o sensation_n as_o acute_a pain_n etc._n etc._n be_v contort_a and_o wring_v awry_o as_o you_o see_v in_o person_n that_o cry_v because_o of_o grievance_n after_o the_o same_o manner_n as_o when_o they_o strive_v to_o lift_v up_o a_o great_a weight_n and_o that_o at_o the_o same_o time_n tear_n and_o moisture_n at_o nose_n and_o mouth_n be_v squeeze_v out_o by_o the_o same_o contraction_n which_o make_v people_n use_v the_o say_v of_o casting_n snot_n about_o when_o man_n cry_v it_o be_v for_o the_o same_o reason_n that_o people_n mouth_n water_n extreme_o when_o they_o be_v trim_v with_o a_o bad_a razor_n that_o put_v they_o to_o pain_n which_o contract_v the_o part_n and_o squeeze_v out_o the_o spital_n 4._o the_o pulse_n grow_v sensible_o narrow_a and_o hard_a by_o the_o same_o contraction_n 5._o it_o be_v by_o the_o contraction_n upon_o grievous_a sensation_n that_o our_o mouth_n water_n very_o much_o upon_o a_o nausea_n at_o stomach_n because_o of_o the_o continuity_n of_o the_o membrane_n of_o the_o mouth_n and_o stomach_n 6._o the_o same_o contraction_n be_v the_o true_a reason_n why_o people_n upon_o hunger_n which_o be_v a_o grievous_a sensation_n at_o stomach_n have_v so_o much_o moisture_n or_o spital_n in_o their_o mouth_n and_o so_o much_o the_o more_o when_o they_o see_v good_a victual_n and_o can_v have_v it_o because_o the_o grievance_n which_o cause_v the_o contraction_n that_o squeeze_v it_o out_o be_v by_o so_o much_o the_o great_a this_o be_v the_o cause_n why_o the_o mouth_n water_n when_o hungry_a people_n see_v or_o smell_v good_a victual_n by_o the_o same_o contraction_n moisture_n be_v squeeze_v out_o into_o the_o oesophagus_n or_o gullet_n and_o the_o menstruum_fw-la into_o the_o stomach_n at_o the_o same_o time_n where_o observe_v god_n good_a and_o wise_a providence_n that_o hunger_n which_o call_v for_o meat_n at_o the_o same_o time_n provide_v spital_n to_o lubricate_v it_o for_o swollow_v and_o to_o help_v digestion_n render_v the_o gullet_n slippery_a and_o distensible_a and_o cause_v the_o menstruum_fw-la to_o flow_v more_o abundant_o into_o the_o stomach_n and_o all_o this_o when_o most_o need_v and_o that_o exact_o in_o proportion_n to_o the_o hunger_n or_o grievous_a sensation_n that_o cause_v the_o contraction_n it_o be_v well_o worth_a your_o nothing_o that_o god_n wisdom_n do_v always_o cause_v the_o want_n of_o what_o be_v necessary_a in_o sensile_a creature_n to_o be_v the_o solicit_v and_o urge_v cause_n for_o supply_v that_o a_o due_a proportion_n may_v be_v observe_v between_o the_o supply_n and_o the_o want_n which_o may_v upon_o the_o tell_n of_o it_o appear_v so_o plain_a a_o case_n that_o it_o be_v scarce_o worth_a the_o mention_v but_o believe_v i_o it_o be_v so_o little_o observe_v as_o plain_a as_o it_o may_v seem_v to_o be_v that_o people_n have_v and_o do_v err_v extravagant_o for_o want_n of_o note_v it_o which_o if_o they_o have_v note_v they_o can_v never_o have_v say_v that_o vapour_n or_o the_o retire_n of_o spirit_n into_o the_o brain_n etc._n etc._n be_v the_o cause_n or_o call_v of_o natural_a sleep_n nor_o feign_v menstruum_n to_o be_v the_o cause_n of_o hunger_n but_o will_v have_v due_o consider_v what_o be_v main_o supply_v by_o eat_v or_o recruit_v by_o sleep_v etc._n etc._n and_o then_o have_v nothing_o to_o do_v but_o to_o conclude_v the_o defect_n of_o that_o to_o have_v be_v the_o cause_n that_o solicit_v for_o the_o supply_n in_o proportion_n to_o the_o defect_n which_o if_o observe_v will_v most_o natural_o and_o easy_o lead_v you_o to_o the_o true_a knowledge_n of_o the_o cause_n of_o all_o appetite_n in_o a_o animal_n upon_o a_o few_o minute_n consideration_n for_o want_v of_o which_o most_o plain_a and_o one_o will_v think_v very_o obvious_a method_n the_o deviate_a world_n have_v sad_o puzzle_v itself_o about_o the_o cause_n of_o hunger_n thirst_v sleep_v and_o the_o like_a to_o this_o day_n and_o still_o be_v in_o dispute_n about_o they_o of_o which_o though_o my_o advertent_fw-la reader_n may_v well_o prevent_v i_o by_o use_v that_o natural_a method_n i_o shall_v god_n will_v give_v a_o account_n in_o my_o tract_n of_o animal_n mechanism_n only_a note_n here_o that_o i_o do_v not_o mean_v bare_a privative_a defect_n as_o such_o to_o be_v the_o positive_a cause_n but_o that_o the_o defect_n of_o what_o keep_v or_o guard_v the_o stomach_n etc._n etc._n from_o the_o grievance_n cause_v other_o matter_n to_o grieve_v it_o cause_n hunger_n etc._n etc._n without_o which_o mean_n no_o proportion_n can_v be_v observe_v between_o hunger_n and_o what_o take_v it_o away_o or_o our_o food_n 7._o the_o same_o defensive_a contraction_n do_v upon_o grievous_a sensation_n as_o pain_n cold_a terror_n etc._n etc._n cause_n a_o corrugation_n of_o the_o scrotum_fw-la contract_v the_o skin_n into_o little_a tubercle_n like_o that_o of_o a_o goose-skin_n etc._n etc._n 8._o by_o it_o upon_o grievous_a sensation_n as_o by_o squeeze_v the_o nose_n very_o hard_o pull_v the_o hair_n sand_n or_o any_o such_o thing_n in_o the_o eye_n or_o a_o grievance_n by_o the_o volatile_a particle_n of_o onion_n mustard_n horse-radish-root_n etc._n etc._n the_o part_n and_o membrane_n about_o the_o eye_n contract_v squeeze_v out_o tear_n that_o what_o grieve_v the_o eye_n may_v thereby_o be_v wash_v away_o or_o qualify_v as_o much_o as_o the_o tear_n can_v do_v it_o 9_o by_o this_o contraction_n repel_v the_o blood_n the_o skin_n grow_v pale_a by_o cold_a fear_v pain_n etc._n etc._n which_o also_o close_v the_o pore_n stop_v sweat_n as_o in_o a_o moment_n you_o will_v have_v a_o account_n hereafter_o how_o contraction_n may_v cause_v sweat_n
that_o when_o people_n be_v in_o a_o untoward_a condition_n or_o as_o they_o call_v it_o out_o of_o sod_n the_o next_o day_n after_o drink_v man_n often_o advise_v take_v the_o hair_n of_o the_o same_o dog_n that_o be_v drink_v some_o of_o the_o same_o wine_n or_o liquor_n it_o be_v best_o for_o they_o to_o use_v it_o as_o i_o just_a now_o direct_v for_o their_o case_n upon_o the_o good_a effect_n of_o the_o wine_n cease_v be_v much_o like_a that_o upon_o the_o go_n off_o of_o the_o operation_n of_o opium_n which_o may_v also_o in_o this_o case_n be_v use_v instead_o of_o wine_n to_o procure_v a_o better_a and_o blither_n condition_n for_o that_o day_n that_o use_v to_o be_v very_o troublesome_a to_o drinker_n 3._o note_v that_o good_a preparation_n of_o opium_n may_v be_v convenient_o use_v to_o horse_n to_o prevent_v their_o be_v tire_v or_o take_v off_o their_o weariness_n and_o cause_v they_o to_o go_v on_o but_o i_o will_v not_o advise_v any_o preparation_n in_o this_o case_n but_o the_o liquid_a panacea_fw-la in_o good_a ale_n or_o beer_n and_o that_o only_a in_o the_o same_o quantity_n as_o be_v use_v to_o man_n till_o far_a experience_n embolden_v the_o practice_n by_o such_o mean_n i_o can_v doubt_v it_o any_o jade_n may_v be_v make_v to_o appear_v lively_a go_v well_o etc._n etc._n chap._n xxxii_o of_o the_o use_n of_o the_o panacea_fw-la etc._n etc._n to_o compose_v the_o sensitive_a soul_n spirit_n etc._n etc._n i_o have_v show_v how_o and_o why_o it_o compose_v and_o quiet_v the_o sensitive_a soul_n spirit_n blood_n stomach_n etc._n etc._n and_o by_o that_o mean_n allay_v all_o the_o fury_n commotion_n perturbation_n and_o turbulent_a exorbitance_n thereof_o and_o that_o often_o without_o sleep_n but_o much_o better_a with_o it_o it_o follow_v therefore_o 1._o that_o it_o prevent_v and_o take_v off_o all_o fret_n and_o turbulent_a passion_n of_o the_o sensitive_a soul_n as_o anger_n uneasy_a agitation_n and_o toss_v of_o the_o mind_n peevishness_n fretfulness_n discontent_n disquietude_n dissatisfaction_n murmur_n turmoiling_n and_o vexatious_a thought_n anxiety_n solicitude_n etc._n etc._n and_o all_o the_o evil_a effect_n thereof_o as_o watch_n waste_v of_o spirit_n or_o strength_n lossitude_n hypochondriacal_a melancholy_n cachexy_n scurvy_n etc._n etc._n but_o these_o last_o belong_v most_o proper_o to_o its_o alterative_a faculty_n or_o virtue_n 2._o all_o involuntary_a furious_a agitation_n of_o the_o sensitive_a soul_n and_o spirit_n as_o madness_n more_o especial_o melancholy_a madness_n or_o such_o as_o proceed_v from_o grievous_a thought_n or_o apprehension_n loss_n cross_n despair_n fear_n terror_n or_o the_o like_a but_o they_o be_v not_o so_o good_a in_o merry_a madness_n as_o those_o from_o joy_n venereal_a fury_n and_o suchlike_a which_o answer_v the_o great_a dispute_n about_o opiate_n in_o madness_n delirium_n epileptical_a fit_n convulsion_n general_a and_o particular_a as_o those_o of_o the_o head_n rise_v of_o the_o light_n vomit_n hiccough_n sabbing_n kecking_n convulsive_a asthma_n palpitation_n and_o tremble_n of_o the_o heart_n shake_v and_o shivering_n upon_o fear_n terror_n cold_a pain_n ague-fits_a convulsive_a colick_n hysterick_n fit_v iliack_a passion_n etc._n etc._n 3._o all_o fever_n and_o fret_n of_o humour_n that_o happen_v from_o any_o of_o the_o aforesaid_a cause_n or_o from_o any_o violent_a motion_n voluntary_a or_o involuntary_a as_o labour_n run_v hew_v fight_a or_o any_o vehement_a exercise_n ratling_n toss_n concussion_n in_o coach_n wagon_n boat_n in_o stormy_a wether_n violent_a ride_v etc._n etc._n or_o from_o heat_n of_o fire_n sun_n bath_n hothouse_n bagnio_n crowd_n lie_v too_o many_o in_o one_o bed_n or_o with_o too_o much_o clothes_n or_o from_o grievous_a sensation_n irritation_n or_o pain_n as_o fever_n upon_o inflammation_n abscess_n bubo_n stone_n colic_n cardialgia_n wound_n fracture_n dislocation_n confusion_n amputation_n lithotomy_n paracentesis_n or_o any_o painful_a operation_n of_o the_o noble_a art_n of_o chirurgery_n agony_n or_o pain_n of_o the_o smallpox_n as_o its_o second_o fever_n and_o the_o like_a or_o from_o flux_n as_o tedious_a and_o turbulent_a vomit_n diarrheas_n dysentery_n cholera_n iliack_a passion_n artificial_a purge_v and_o all_o symptomatick_a or_o immaterial_a fever_n whatsoever_o which_o either_o never_o have_v any_o matter_n but_o proceed_v from_o such_o agitate_a cause_n as_o i_o mention_v or_o remain_v as_o some_o do_v after_o the_o grieve_v matter_n be_v carry_v off_o by_o vomit_v purge_v etc._n etc._n i_o forbear_v mention_v pleurisy_n and_o peripneumonia_n among_o the_o fever_n that_o it_o prevent_v or_o take_v off_o because_o there_o be_v great_a dispute_n whether_o opiate_n be_v convenient_a in_o those_o case_n which_o i_o hope_v to_o determine_v unless_o it_o be_v when_o the_o say_v distemper_n be_v come_v to_o that_o pass_n that_o it_o be_v dangerous_a to_o cause_v sleep_n or_o take_v away_o any_o of_o the_o sense_n of_o the_o irritation_n of_o the_o matter_n to_o be_v expectorate_v lest_o it_o shall_v be_v too_o much_o amass_v in_o the_o bronchias_n or_o windpipe_n and_o so_o choke_v the_o person_n i_o see_v no_o cause_n to_o forbid_v they_o any_o more_o than_o sleep_v or_o opiate_n in_o other_o inflammation_n wherein_o they_o be_v high_o beneficial_a to_o give_v ease_n cause_n sleep_n compose_v the_o spirit_n and_o take_v off_o or_o at_o least_o moderate_a the_o fever_n but_o i_o see_v many_o good_a reason_n to_o use_v they_o 1._o because_o as_o a_o sal-volatile-oleosum_a they_o reserate_v and_o resolve_v clammy_a humour_n and_o be_v so_o agreeable_a in_o principle_n as_o menstraums_n shall_v be_v to_o the_o thing_n to_o be_v resolve_v i_o can_v doubt_v but_o red_a poppy_n be_v upon_o experience_n state_v a_o specific_a in_o those_o case_n for_o that_o reason_n 2._o because_o these_o distemper_n as_o hypocrates_n speak_v be_v from_o a_o segregation_n of_o humour_n by_o agitation_n etc._n etc._n and_o opiate_n excellent_a composer_n thereof_o 3._o because_o they_o be_v such_o great_a discusser_n and_o 4._o open_v the_o pore_n to_o let_v the_o discuss_v matter_n quite_o out_o of_o the_o body_n 5._o because_o it_o may_v be_v that_o by_o its_o relaxation_n upon_o such_o resolution_n the_o lodge_v matter_n may_v be_v cause_v to_o flow_v off_o and_o circulate_v again_o and_o so_o be_v gradue_v discuss_v and_o carry_v off_o by_o the_o open_a pore_n 6._o because_o it_o envigorate_v nature_n to_o perform_v those_o thing_n and_o 7._o give_v ease_n and_o recruit_v of_o the_o spirit_n by_o sleep_n so_o that_o all_o thing_n consider_v i_o think_v as_o experience_n assure_v we_o that_o red_a poppy_n or_o opiate_n in_o due_a quantity_n be_v the_o very_o best_a remedy_n that_o can_v be_v use_v hence_o it_o be_v that_o wedelius_n call_v opium_n a_o antipleuritick_n specific_a he_o have_v observe_v as_o i_o and_o other_o have_v do_v that_o the_o whole_a course_n of_o the_o disease_n and_o expectoration_n will_v succeed_v much_o better_a by_o their_o use._n he_o add_v also_o that_o he_o have_v very_o often_o cure_v they_o by_o its_o help_n without_o let_v of_o blood_n which_o be_v a_o infallible_a sign_n of_o their_o good_a effect_n since_o the_o pleurisy_n can_v hardly_o be_v cure_v without_o bleed_v i_o can_v see_v how_o a_o effect_n that_o bear_v such_o analogy_n to_o sleep_n can_v do_v any_o more_o harm_n than_o sleep_n etmuller_n also_o advise_v the_o give_v of_o opiate_n not_o only_o in_o the_o beginning_n but_o also_o during_o the_o increase_n of_o the_o pleurisy_n or_o peripneumoniae_fw-la so_o that_o i_o conclude_v that_o they_o be_v of_o excellent_a use_n in_o those_o disease_n unless_o it_o be_v when_o sleep_n or_o they_o may_v cause_v too_o much_o insensibleness_n of_o the_o bronchias_n and_o so_o retard_v expectoration_n when_o the_o case_n be_v such_o that_o the_o want_v thereof_o may_v endanger_v the_o person_n be_v be_v choke_v we_o have_v also_o many_o history_n of_o person_n cure_v in_o other_o fever_n by_o large_a dose_n of_o opiate_n i_o suppose_v that_o resinous_a opiate_n cause_v vomit_v and_o great_a disturbance_n by_o reason_n of_o ill_a digestion_n in_o those_o case_n may_v be_v one_o great_a cause_n of_o people_n fear_n and_o jeolousy_n in_o give_v opiate_n which_o be_v easy_o prevent_v by_o give_v liquid_a opiate_n void_a of_o any_o resinous_a particle_n as_o the_o liquid_a panacea_fw-la etc._n etc._n 4._o it_o do_v by_o compose_v quiet_v and_o appease_v the_o motion_n and_o perturbation_n of_o the_o blood_n conduce_v much_o to_o the_o stop_n of_o its_o efflux_n in_o hemorrhage_n or_o bleeding_n that_o be_v unnatural_a as_o at_o nose_n in_o spit_v and_o vomit_v of_o blood_n bleed_v at_o the_o hemorrhoid_v in_o dysentery_n piss_v of_o blood_n etc._n etc._n and_o sometime_o in_o profuse_a menses_fw-la when_o they_o happen_v from_o a_o fever_n or_o too_o much_o motion_n of_o the_o blood_n and_o
why_o then_o do_v they_o write_v and_o trouble_v the_o world_n to_o peruse_v their_o book_n when_o they_o be_v so_o far_o from_o explain_v the_o property_n of_o opium_n that_o they_o scarce_o ever_o dare_v mention_v they_o nor_o set_v their_o hypothesise_n and_o they_o as_o much_o as_o in_o view_n of_o one_o another_o be_v not_o this_o a_o tacit_n confession_n of_o the_o incompetency_n of_o their_o supposition_n i_o beg_v pardon_n for_o call_v they_o they_o though_o they_o themselves_o do_v for_o i_o can_v offer_v they_o a_o great_a abuse_n than_o lay_v their_o spurious_a and_o lame_a brat_n at_o their_o door_n though_o one_o scarce_o need_v say_v any_o more_o of_o they_o yet_o lest_o i_o be_v think_v presumptuous_a or_o saucy_a for_o so_o much_o as_o offer_v to_o suspect_v the_o general_a foundation_n of_o all_o the_o famous_a author_n that_o ever_o live_v as_o galen_n avicenna_n etc._n etc._n among_o the_o ancient_n etmuller_n willis_n etc._n etc._n among_o the_o modern_n 1._o i_o will_v show_v you_o very_o just_a cause_n to_o suspect_v the_o insufficiency_n of_o the_o general_a foundation_n viz._n that_o opium_n diminish_v or_o disable_v the_o spirit_n 2._o i_o will_v prove_v that_o it_o do_v not_o do_v it_o by_o a_o cold_a quality_n 3._o that_o it_o do_v not_o do_v it_o by_o vapour_n fume_n aura_n or_o any_o such_o way_n 4._o that_o it_o diminish_v or_o disable_v the_o spirit_n by_o no_o mean_n whatsoever_o which_o diminish_v or_o disable_n of_o the_o spirit_n cold_a quality_n and_o fume_n or_o aura_n comprehend_v the_o foundation_n of_o all_o opinion_n concern_v opium_n that_o ever_o i_o read_v or_o hear_v of_o and_o consequent_o if_o those_o two_o fundamental_a opinion_n be_v refute_v all_o the_o superstructure_n that_o have_v be_v in_o this_o case_n must_v fall_v to_o the_o ground_n chap._n viii_o the_o author_n show_v just_a cause_n of_o his_o suspicion_n that_o all_o author_n have_v go_v upon_o a_o wrong_a foundation_n in_o their_o disquisition_n of_o the_o cause_n of_o the_o operation_n of_o opium_n i_o have_v show_v you_o that_o the_o general_a foundation_n of_o both_o ancient_n and_o modern_a author_n be_v that_o opium_n do_v diminish_v or_o disable_v the_o spirit_n and_o now_o i_o will_v plain_o show_v just_a cause_n of_o my_o suspicion_n of_o its_o insufficiency_n which_o be_v these_o 1._o i_o observe_v that_o all_o learned_a man_n be_v to_o this_o day_n high_o dissatisfy_v as_o to_o the_o cause_n and_o manner_n of_o the_o operation_n of_o opium_n notwithstanding_o all_o that_o have_v be_v write_v concern_v it_o and_o that_o it_o be_v the_o common_a cry_n on_o all_o hand_n that_o none_o have_v illustrate_v the_o operation_n of_o opium_n to_o any_o purpose_n or_o give_v any_o satisfaction_n therein_o and_o therefore_o learned_a physician_n be_v still_o as_o much_o upon_o the_o enquiry_n as_o ever_o they_o be_v it_o be_v much_o more_o civil_a and_o reasonable_a to_o suspect_v the_o foundation_n that_o all_o former_a author_n have_v build_v upon_o than_o a_o general_a failure_n in_o all_o the_o most_o judicious_a master_n builder_n that_o ever_o endeavour_v to_o build_v thereon_o for_o if_o all_o the_o best_a architect_n of_o the_o whole_a world_n fail_v to_o erect_v a_o firm_a superstructure_n upon_o any_o one_o foundation_n what_o can_v we_o think_v but_o that_o the_o foundation_n be_v infirm_a especial_o when_o as_o in_o our_o case_n no_o way_n that_o care_n judgement_n perspicacity_n and_o wit_n can_v invent_v or_o think_v of_o have_v be_v leave_v untried_a to_o build_v thereon_o so_o that_o though_o i_o modest_o call_v it_o a_o cause_n of_o suspicion_n it_o amount_v almost_o if_o not_o altogether_o to_o a_o demonstration_n that_o the_o foundation_n that_o all_o author_n have_v go_v upon_o be_v naught_o will_v not_o any_o consider_a man_n when_o he_o see_v all_o the_o judicious_a architect_n of_o the_o world_n fail_v to_o erect_v a_o firm_a building_n upon_o a_o certain_a foandation_n seek_v for_o another_o therefore_o who_o can_v blame_v i_o if_o i_o do_v and_o not_o blame_v they_o that_o do_v not_o the_o mean_a bricklayer_n or_o carpenter_n that_o shall_v be_v guilty_a of_o such_o stupidity_n as_o to_o attempt_v to_o build_v upon_o such_o a_o foundation_n as_o always_o deceive_v the_o builder_n will_v be_v think_v too_o great_a a_o blockhead_n to_o be_v employ_v in_o building_n 2._o i_o observe_v that_o most_o man_n do_v notwithstanding_o that_o foundation_n be_v agree_v upon_o think_v it_o impossible_a to_o explain_v the_o intricate_a various_a contradictory_n phenomena_n and_o mysterious_a effect_n of_o opium_n sit_v content_v and_o persuade_v that_o it_o operate_v by_o a_o occult_a quality_n whole_o unexplicable_a and_o particular_o reserve_v from_o the_o knowledge_n of_o mankind_n but_o nature_n work_v mechanical_o in_o weight_n measure_n etc._n etc._n therefore_o it_o be_v more_o than_o probable_a that_o it_o be_v only_o their_o be_v upon_o a_o wrong_a bottom_n make_v it_o seem_v absolute_o occult_a for_o it_o be_v impossible_a to_o find_v a_o thing_n where_o it_o be_v not_o or_o to_o build_v firm_o upon_o a_o insufficient_a foundation_n whereas_o have_v it_o be_v right_o and_o true_a it_o be_v not_o to_o be_v imagine_v but_o some_o or_o other_o will_v have_v thereupon_o do_v something_o that_o will_v have_v stand_v against_o all_o wind_n and_o storm_n which_o none_o have_v do_v 3._o i_o observe_v that_o none_o dare_v venture_v to_o lay_v the_o whole_a no_o nor_o one_o half_a of_o the_o burden_n of_o the_o phinomena_n or_o effect_n of_o opium_n upon_o that_o foundation_n foresee_v doubtless_o that_o it_o can_v not_o bear_v they_o and_o that_o if_o they_o lay_v any_o more_o weight_n thereon_o the_o whole_a will_v totter_v and_o fall_v to_o the_o ground_n the_o project_n in_o every_o hypothesis_n be_v to_o persuade_v man_n of_o the_o truth_n thereof_o and_o the_o only_a way_n to_o do_v it_o be_v to_o solve_v all_o phenomena_n thereby_o for_o if_o it_o fail_v but_o in_o one_o it_o be_v a_o infallible_a sign_n of_o its_o insufficiency_n there_o be_v no_o reason_n to_o omit_v any_o of_o the_o phenomena_n if_o they_o can_v have_v discern_v that_o the_o hypothesis_n will_v have_v bear_v they_o therefore_o as_o have_v be_v intimate_v it_o imply_v a_o confession_n of_o its_o incompetency_n 4._o i_o observe_v that_o ancient_a author_n write_v of_o opium_n before_o it_o come_v to_o be_v of_o common_a and_o general_a use_n in_o the_o daytime_n with_o healthy_a person_n as_o it_o since_o be_v in_o many_o nation_n to_o cause_v a_o gay_a pleasant_a and_o good_a humour_n take_v off_o sadness_n melancholy_a and_o anxiety_n to_o cause_n assurance_n boldness_n courage_n bravery_n magnanimity_n euphory_n or_o easy_a undergo_n of_o labour_n journey_n promptitude_n in_o business_n expediteness_n and_o serenity_n to_o excite_v to_o venery_n etc._n etc._n which_o effect_n can_v be_v explain_v by_o that_o supposition_n of_o disable_n the_o spirit_n and_o that_o they_o use_v opium_n only_a medicinally_n for_o the_o sake_n of_o such_o other_o effect_n as_o may_v be_v tolerable_o well_o explicate_v by_o that_o hypothesis_n so_o that_o they_o have_v not_o any_o occasion_n nor_o inducement_n to_o look_v any_o far_o the_o effect_n they_o give_v it_o for_o be_v only_o 1._o to_o cause_v sleep_n 2._o to_o take_v off_o pain_n 3._o to_o stop_v flux_n 4._o to_o compose_v the_o spirit_n 5._o to_o cause_v perspiration_n and_o sweat_n all_o which_o be_v not_o inconsistent_a with_o the_o hypothesis_n of_o diminish_v or_o disable_n the_o spirit_n as_o the_o other_o be_v and_o therefore_o may_v well_o deceive_v they_o for_o first_o sleep_n be_v cause_v by_o diminish_v the_o spirit_n by_o labour_n watch_v etc._n etc._n as_o be_v most_o notorious_a over_o the_o whole_a world_n so_o other_o thing_n that_o diminish_v the_o spirit_n as_o bleed_v vomit_v purge_v and_o many_o other_o cause_n of_o diminish_v thereof_o do_v incline_v we_o to_o sleep_v second_o indolence_n or_o exemption_n from_o pain_n be_v cause_v by_o nothing_o more_o than_o want_v of_o spirit_n as_o in_o paralytical_a case_n stuporâ—_n obstruction_n or_o compression_n of_o the_o nerve_n syncopes_fw-la leipothymy_n deliquium_n faint_n after_o bleed_v and_o sleep_v which_o as_o be_v say_v be_v so_o much_o cause_v by_o loss_n of_o spirit_n etc._n etc._n three_o flux_n be_v stop_v or_o moderate_v by_o nothing_o better_a than_o sleep_n which_o general_o as_o be_v say_v proceed_v from_o loss_n of_o spirit_n what_o also_o stop_v or_o moderate_v flux_n more_o than_o want_v of_o the_o sense_n of_o the_o irritation_n of_o humour_n and_o what_o take_v away_o sense_n more_o than_o want_v of_o spirit_n thus_o want_v of_o sense_n by_o the_o absence_n of_o the_o spirit_n in_o paralytical_a intestine_n stop_v flux_n thus_o fail_v a_o paralytical_a bladder_n to_o express_v the_o urine_n so_o a_o palsy_n of_o the_o membrane_n
that_o include_v the_o glandule_n must_v as_o in_o sleep_n which_o relax_n they_o stop_v or_o moderate_v all_o defluxion_n catarrh_n etc._n etc._n because_o they_o be_v not_o sensible_a oâ—_n the_o irritation_n of_o the_o humour_n by_o quantity_n or_o quality_n which_o irritation_n cause_v the_o defluxion_n or_o catarrh_n by_o exciting_a the_o membrane_n to_o contract_v and_o thereby_o to_o squeeze_v out_o the_o humour_n contain_v in_o the_o glandule_n four_o the_o composure_n of_o the_o spirit_n be_v procure_v main_o by_o sleep_n which_o all_o loss_n of_o spirit_n as_o be_v show_v incline_v we_o to_o so_o bleed_v which_o diminish_v the_o spirit_n compose_v their_o fury_n in_o fever_n delirium_n madness_n etc._n etc._n five_o perspiration_n be_v cause_v by_o nothing_o more_o than_o sleep_v for_o we_o perspire_v twice_o as_o much_o in_o sleep_n as_o when_o we_o watch_v as_o be_v most_o manifest_o demonstrable_a by_o the_o statick_a experiment_n of_o weigh_v people_n nor_o be_v perspiration_n ever_o so_o great_a as_o in_o deliquium_n syncopes_fw-la leipothymy_n and_o such_o like_a deadish_fw-mi case_n which_o be_v cause_v by_o diminish_v or_o disable_n of_o the_o spirit_n nay_o it_o be_v so_o in_o animal_n quite_o dead_a for_o a_o little_a time_n while_o they_o be_v hot_a as_o be_v evident_a by_o like_a statick_a demonstration_n the_o true_a cause_n of_o which_o be_v relaxation_n of_o the_o pore_n skin_n etc._n etc._n for_o want_n of_o spirit_n to_o contract_n and_o constringe_v they_o as_o shall_v be_v full_o prove_v hereafter_o by_o god_n help_n these_o thing_n be_v doubtless_o the_o occasion_n of_o that_o hypothesis_n of_o diminish_v or_o disable_n the_o spirit_n by_o opium_n but_o how_o likely_a be_v they_o to_o err_v by_o establish_v it_o without_o any_o consideration_n of_o its_o enliven_a encourage_v and_o brisk_a effect_n as_o ovation_n of_o the_o spirit_n gaity_n bravery_n magnanimity_n euphory_n promptitude_n to_o venery_n etc._n etc._n which_o can_v never_o be_v solve_v by_o diminution_n or_o disability_n of_o the_o spirit_n till_o depression_n and_o elevation_n thereof_o be_v reconcilable_a and_o consistent_a at_o the_o same_o time_n in_o the_o same_o subject_n which_o can_v never_o be_v till_o disable_n and_o not_o disable_n be_v the_o same_o thing_n have_v not_o we_o then_o good_a reason_n to_o suspect_v that_o general_a foundation_n of_o diminish_v or_o disable_n the_o spirit_n by_o opium_n which_o be_v lay_v by_o such_o as_o never_o consider_v any_o thing_n of_o its_o generous_a and_o sprightly_a effect_n which_o as_o have_v be_v show_v be_v its_o constant_a and_o therefore_o most_o proper_a and_o genuine_a effect_n who_o can_v doubt_v then_o but_o they_o must_v err_v in_o lay_v a_o foundation_n quite_o contrary_a to_o the_o very_a property_n of_o opium_n 5._o i_o observe_v that_o all_o our_o modern_a author_n and_o physician_n receive_v the_o knowledge_n of_o opium_n its_o effect_n and_o uses_n from_o those_o ancient_n do_v use_v it_o only_o for_o the_o same_o end_n and_o purpose_v as_o they_o do_v and_o that_o our_o modern_a author_n live_v in_o these_o western_a part_n of_o the_o world_n very_o remote_a from_o the_o eastern_a country_n where_o it_o be_v use_v common_o and_o in_o large_a dose_n by_o people_n in_o health_n in_o the_o daytime_n to_o enliven_v invigorate_a and_o encourage_v they_o and_o cause_v the_o brave_a generous_a and_o magnanimous_a effect_n aforemention_v viz._n courage_n euphory_n etc._n etc._n and_o find_v no_o physician_n that_o go_v before_o they_o to_o mention_v these_o noble_a cordial_a and_o glorious_a effect_n and_o if_o they_o do_v at_o any_o time_n slight_o touch_v they_o to_o do_v it_o with_o all_o imaginable_a disregard_n neglect_v and_o contempt_n as_o if_o there_o be_v no_o heed_n to_o be_v take_v of_o they_o but_o as_o idle_a tale_n and_o improbable_a story_n be_v contrary_a and_o utter_o as_o they_o think_v inconsistent_a and_o irreconcilable_a with_o the_o daily_a and_o most_o notorious_a effect_n of_o opium_n observe_v among_o we_o and_o to_o the_o universal_a opinion_n of_o all_o author_n who_o state_v opium_n to_o be_v a_o diminisher_n or_o disabler_n of_o the_o spirit_n which_o can_v not_o produce_v as_o they_o conclude_v such_o contradictory_n and_o therefore_o to_o they_o utter_o incredible_a effect_n and_o fabulons_a flam_n arise_v as_o they_o fancy_v from_o some_o silly_a error_n as_o want_v of_o due_a observation_n in_o traveller_n mistake_a discourse_n and_o the_o like_a so_o that_o as_o the_o say_n be_v they_o let_v they_o in_o at_o one_o ear_n and_o out_o at_o the_o other_o there_o be_v no_o such_o contrary_a effect_n of_o any_o one_o thing_n to_o be_v observe_v in_o the_o whole_a creation_n and_o they_o be_v well_o assure_v of_o the_o other_o effect_n by_o daily_a experience_n and_o have_v never_o observe_v those_o lively_a effect_n for_o the_o several_a plain_a reason_n that_o you_o will_v meet_v in_o the_o follow_a paragraph_n have_v no_o cause_n to_o alter_v their_o opinion_n when_o all_o thing_n seem_v to_o they_o to_o make_v for_o their_o hypothesis_n for_o want_v of_o a_o notion_n of_o those_o brisk_a effect_n 6._o i_o observe_v that_o those_o brisk_a effect_n of_o opium_n be_v not_o take_v notice_n of_o by_o our_o physician_n nor_o indeed_o all_o thing_n consider_v do_v i_o well_o see_v how_o they_o shall_v without_o get_v out_o of_o the_o common_a road_n of_o observe_v which_o be_v sometime_o as_o i_o have_v find_v very_o useful_a upon_o such_o occasion_n for_o first_o opium_n be_v seldom_o if_o ever_o give_v in_o these_o western_a nation_n but_o to_o sick_a people_n as_o the_o ancient_n do_v who_o be_v utter_o incapable_a of_o those_o brisk_a effect_n or_o at_o least_o to_o any_o remarkable_a degree_n that_o may_v call_v for_o a_o particular_a or_o special_a advertency_n or_o attention_n without_o which_o they_o pass_v off_o as_o they_o come_v without_o any_o reflection_n thereupon_o and_o so_o signify_v nothing_o as_o if_o they_o have_v never_o happen_v second_o we_o as_o the_o ancient_n do_v general_o give_v opium_n when_o people_n be_v go_v to_o bed_n by_o which_o mean_v all_o opportunity_n of_o observation_n be_v lose_v because_o darkness_n and_o be_v alone_o hide_v or_o hinder_v the_o show_v of_o any_o such_o effect_n and_o the_o physician_n who_o only_a business_n it_o be_v to_o be_v more_o curious_a in_o such_o matter_n be_v go_v to_o his_o own_o rest_n though_o if_o he_o be_v present_a not_o likely_a to_o take_v any_o observation_n of_o such_o matter_n whereof_o he_o have_v least_o thought_n or_o belief_n as_o be_v in_o his_o opinion_n contrary_a to_o all_o reason_n sense_n experience_n and_o the_o opinion_n of_o all_o author_n of_o the_o stupefactive_a quality_n of_o opium_n in_o which_o they_o all_o agree_v three_o opium_n be_v as_o be_v say_v give_v in_o these_o country_n to_o cause_n sleep_n or_o such_o effect_n to_o which_o sleep_n conduce_v as_o compose_v the_o spirit_n cause_v indolence_n stop_v flux_n and_o promote_a perspiration_n and_o therefore_o always_o give_v with_o all_o careful_a direction_n and_o injunction_n that_o may_v conduce_v to_o that_o end_n as_o go_v to_o bed_n lie_v still_o put_v out_o light_n keep_v silence_n etc._n etc._n which_o concur_v with_o the_o opium_n cause_n sleep_n which_o be_v utter_o inconsistent_a with_o show_v any_o of_o those_o lively_a effect_n that_o belong_v only_o to_o a_o wake_a person_n to_o do_v so_o that_o all_o opportunity_n of_o observation_n be_v utter_o preclude_v now_o all_o the_o premise_n consider_v it_o can_v be_v conceive_v that_o such_o as_o set_v their_o mind_n upon_o contrary_a effect_n and_o expect_v no_o other_o much_o less_o contrary_a one_o against_o which_o also_o they_o be_v high_o prejudice_v by_o their_o reason_n experience_n and_o read_v shall_v observe_v such_o brisk_a effect_n if_o they_o do_v happen_v and_o how_o can_v a_o brisk_a humour_n courage_n easy_a undergo_n of_o labour_n promptitude_n to_o venus_n etc._n etc._n be_v observe_v in_o sick_a and_o infirm_a people_n lie_v in_o bed_n alone_z and_o in_o the_o dark_a or_o which_o render_v it_o utter_o impossible_a while_o they_o be_v asleep_a and_o the_o thing_n itself_o disbelieved_a and_o esteem_v contrary_a to_o common_a sense_n and_o the_o universal_a sentiment_n of_o the_o learned_a and_o all_o other_o therefore_o 7._o if_o after_o all_o any_o such_o brisk_a effect_n do_v ever_o happen_v it_o must_v be_v either_o not_o regard_v or_o if_o observe_v which_o be_v no_o way_n likely_a as_o be_v show_v you_o may_v be_v sure_a for_o the_o many_o plain_a reason_n and_o cause_n aforesaid_a that_o it_o be_v not_o impute_v to_o stupify_a opium_n as_o all_o esteem_v it_o but_o to_o any_o other_o cause_n or_o accident_n rather_o than_o to_o a_o thing_n well_o know_v to_o have_v quite_o contrary_a effect_n for_o instance_n if_o the_o sick_a person_n happen_v to_o be_v
increase_v more_o and_o more_o and_o make_v one_o more_o and_o more_o remote_a from_o wake_v 4._o why_o shall_v warm_a bath_n fomentation_n feetwash_n head-washes_a warm_a moist_a wether_n the_o act_n of_o venery_n the_o pleasure_n of_o sweet_a melody_n gentle_a rub_v of_o the_o head_n in_o a_o pleasant_a manner_n scratch_v the_o back_n where_o it_o itch_v and_o all_o gentle_a pleasure_n that_o be_v consistent_a with_o lie_v or_o sit_v still_o which_o do_v all_o cause_n a_o very_a free_a perspiration_n of_o fume_n at_o the_o pore_n that_o be_v then_o most_o certain_o open_v by_o all_o those_o cause_n as_o may_v be_v prove_v by_o statick_a demonstration_n magnify_v glass_n etc._n etc._n cause_n sleep_n see_v they_o all_o cause_n a_o spend_v of_o the_o fume_n obj._n some_o half-witted_a unthinking_a caviller_n may_v say_v that_o such_o thing_n stir_v up_o the_o vapour_n etc._n etc._n answ._n what_o such_o mean_a by_o vapour_n stir_v be_v not_o easy_o determinable_a but_o this_o i_o know_v that_o all_o stir_n of_o humour_n or_o any_o other_o thing_n hinder_v sleep_n and_o that_o the_o long_o such_o cause_n of_o open_v the_o pore_n and_o consequent_o of_o perspire_a fume_n do_v last_o the_o more_o we_o be_v incline_v by_o they_o to_o sleep_n so_o that_o the_o more_o our_o fume_n have_v be_v spend_v the_o more_o we_o be_v incline_v to_o sleep_v which_o be_v a_o strange_a contradiction_n if_o fume_n be_v the_o cause_n of_o sleep_n i_o can_v but_o smile_v to_o think_v how_o most_o physician_n come_v to_o call_v several_a thing_n vapour_n first_o they_o say_v that_o sleep_n be_v from_o vapour_n then_o call_v every_o thing_n vapour_n right_a or_o wrong_n that_o incline_v we_o to_o sleep_v by_o reason_n of_o that_o false_a supposition_n how_o then_o come_v camphire_n not_o to_o be_v a_o great_a causer_n of_o sleep_n that_o be_v so_o apt_a to_o evaporate_v 5._o fear_v sorrow_n grief_n melancholy_n depression_n of_o spirit_n cold_a etc._n etc._n do_v most_o certain_o close_v the_o pore_n as_o appear_v by_o statick_a experiment_n by_o which_o mean_v vapour_n be_v much_o crowd_v in_o the_o body_n yet_o all_o such_o grievance_n do_v hinder_v sleep_n as_o they_o also_o do_v the_o effect_n of_o opium_n and_o drunkenness_n therefore_o they_o do_v not_o proceed_v from_o fume_n as_o the_o world_n imagine_v for_o then_o these_o thing_n that_o crowd_v in_o the_o fume_n and_o vapour_n will_v promote_v not_o hinder_v sleep_n 6._o if_o fume_n be_v the_o cause_n of_o sleep_n then_o be_v the_o cause_n of_o sleep_n and_o vertigo_n as_o the_o vaporanians_n allow_v the_o same_o it_o follow_v then_o that_o we_o can_v never_o sleep_v without_o a_o vertigo_n 7._o many_o as_o dr._n willis_n say_v eat_v their_o meat_n take_v their_o drink_n etc._n etc._n as_o other_o people_n yet_o do_v not_o sleep_v at_o all_o for_o many_o week_n together_o which_o be_v impossible_a if_o the_o fume_n of_o meat_n and_o drink_v cause_v sleep_n for_o they_o by_o eat_v and_o drink_v must_v have_v those_o fume_n and_o consequent_o sleep_v as_o other_o people_n if_o that_o be_v true_a three_o they_o suppose_v and_o take_v it_o for_o grant_v which_o i_o do_v not_o for_o i_o know_v the_o contrary_a that_o opium_n while_o it_o be_v at_o stomach_n can_v affect_v the_o brain_n etc._n etc._n no_o other_o way_n but_o by_o fume_n which_o be_v a_o most_o groundless_a supposition_n for_o 1._o how_o shall_v a_o lump_n of_o curd_n at_o stomach_n or_o the_o have_v of_o a_o knife_n swallow_v and_o many_o such_o thing_n which_o can_v send_v no_o fume_n to_o the_o head_n cause_n convulsion_n headache_n vertigo_n syncopes_fw-la leipothymy_n of_o the_o whole_a man_n manias_fw-la furor_n etc._n etc._n if_o there_o be_v not_o another_o way_n for_o thing_n to_o affect_v the_o nervosum_fw-la genus_fw-la etc._n etc._n while_n at_o stomach_n beside_o send_v up_o vapour_n to_o do_v it_o but_o of_o this_o matter_n to_o show_v how_o a_o thing_n at_o stomach_n may_v affect_v the_o brain_n and_o the_o whole_a system_n of_o the_o nerve_n etc._n etc._n and_o how_o opium_n do_v it_o without_o fume_n the_o 17_o 18_o 19_o 20_o etc._n etc._n chapter_n will_v show_v you_o at_o large_a therefore_o i_o shall_v say_v no_o more_o of_o this_o at_o present_a for_o it_o be_v fit_a for_o we_o first_o to_o overthrow_v that_o supposition_n of_o fume_n and_o vapour_n before_o we_o establish_v our_o own_o for_o far_a satisfaction_n then_o as_o to_o that_o general_a supposition_n of_o fume_n let_v we_o due_o and_o full_o consider_v thing_n for_o it_o be_v not_o a_o slight_a matter_n to_o proceed_v against_o a_o general_n opinion_n that_o have_v continue_v through_o all_o age_n or_o to_o wipe_v off_o the_o prejudices_fw-la acquire_v thereby_o observe_v 1._o that_o the_o brain_n be_v a_o principal_a part._n 2._o that_o it_o be_v very_o soft_a tender_a and_o next_o to_o a_o fluid_a 3._o that_o very_o small_a fine_a and_o gentle_a thing_n do_v high_o offend_v it_o as_o the_o effluvia_n of_o sweet_a or_o ill-scented_n thing_n cause_v hysterick_a and_o epileptical_a fit_n syncopes_fw-la faint_n etc._n etc._n it_o be_v also_o notorious_a among_o we_o physician_n that_o a_o little_a fume_v scarce_o sensible_a as_o to_o quantity_n or_o quality_n rise_v from_o a_o toe_n finger_n &c_n &c_n and_o arrive_v at_o the_o brain_n cause_v dreadful_a epileptical_a fit_n vertigo_n &c._n &c._n 4._o that_o our_o wise_a and_o provident_a creator_n have_v therefore_o secure_v and_o fortify_v all_o the_o avenue_n of_o the_o brain_n in_o a_o more_o particular_a manner_n by_o several_a circumvallation_n viz._n first_o with_o the_o pia_fw-la mater_fw-la second_o with_o the_o dura_n mater_n call_v so_o from_o its_o hardness_n solidity_n and_o strength_n three_o with_o a_o strong_a skull_n of_o a_o round_a or_o arch_a figure_n four_o with_o the_o pericranium_n all_o which_o belong_v to_o it_o particular_o beside_o other_o integument_n common_a to_o it_o with_o other_o part_n as_o 1._o the_o skin_n 2._o the_o cuticle_n 3._o the_o membrana_fw-la carnosa_fw-la 4._o the_o periostium_fw-la all_o which_o do_v surround_v it_o and_o after_o all_o it_o be_v thatch_v as_o it_o be_v with_o hair_n 5._o that_o the_o same_o providence_n have_v take_v care_n which_o be_v very_o observable_a that_o none_o of_o the_o object_n of_o sensation_n nor_o probable_o any_o particle_n or_o effluvium_fw-la that_o fly_v from_o they_o shall_v ever_o reach_v the_o brain_n but_o only_o bare_a impulse_n and_o they_o not_o immediate_o convey_v but_o by_o the_o intervention_n of_o a_o fine_a tenuious_a soft_a gentle_a and_o most_o agreeable_a aura_n viz._n the_o animal_n spirit_n lest_o any_o offence_n shall_v be_v give_v in_o the_o least_o manner_n to_o this_o most_o tender_a delicate_a principal_a part_n and_o royal_a seat_n of_o the_o soul_n all_o which_o care_n have_v never_o be_v without_o necessity_n for_o god_n and_o nature_n do_v nothing_o in_o vain_a and_o if_o you_o will_v due_o consider_v the_o organ_n of_o sensation_n that_o be_v near_o the_o brain_n you_o will_v find_v that_o they_o be_v contrive_v as_o shutter_n to_o exclude_v all_o extraneous_a particle_n from_o the_o brain_n for_o impulse_n may_v have_v be_v contrive_v without_o their_o intervention_n because_o they_o do_v not_o alter_v or_o improve_v the_o impulse_n receive_v from_o object_n for_o if_o they_o do_v we_o shall_v not_o have_v true_a notice_n of_o thing_n and_o see_v they_o do_v not_o alter_v or_o improve_v the_o impulse_n of_o what_o use_n shall_v they_o be_v but_o to_o exclude_v extraneous_a particle_n eume_n effluvia_n &c._n &c._n for_o instance_n the_o tremulous_a motion_n of_o the_o air_n in_o the_o case_n of_o sound_n will_v have_v as_o true_o hit_v the_o auditory_a nerve_n or_o membrane_n without_o the_o tympan_n and_o very_o often_o much_o true_a without_o it_o because_o of_o the_o several_a fault_n and_o disorder_n that_o it_o be_v liable_a to_o yet_o so_o necessary_a be_v it_o think_v by_o the_o best_a of_o judge_n who_o can_v err_v that_o it_o be_v rather_o to_o be_v place_v there_o with_o all_o its_o inconvenience_n that_o may_v follow_v than_o any_o way_n expose_v the_o brain_n though_o to_o the_o most_o gentle_a of_o body_n viz._n the_o air_n by_o which_o in_o all_o probability_n the_o animal_n spirit_n themselves_o be_v nourish_v or_o sustain_v be_v it_o not_o that_o extraneous_a particle_n or_o air_n will_v offend_v the_o brain_n what_o need_n be_v there_o of_o the_o tympan_n when_o we_o know_v as_o well_o by_o experience_n as_o by_o the_o aforesaid_a reason_n that_o a_o dog_n etc._n etc._n can_v hear_v as_o well_o without_o it_o upon_o the_o first_o take_v it_o off_o but_o that_o the_o hear_v will_v afterward_o decay_v because_o the_o brain_n etc._n etc._n be_v expose_v will_v be_v injure_v what_o be_v evident_a in_o the_o case_n of_o the_o ear_n may_v be_v make_v so_o
impossible_a it_o shall_v be_v without_o such_o disturbance_n as_o i_o mention_v will_v follow_v if_o they_o pass_v in_o the_o road_n of_o the_o spirit_n it_o be_v not_o common_a sense_n that_o such_o câ—de_a blast_n shall_v meliorate_v or_o enliven_v the_o spirit_n to_o cause_v briskness_n bravery_n serenity_n courage_n magnanimity_n as_o opium_n do_v much_o less_o if_o those_o fume_n stop_v and_o crowd_v in_o the_o brain_n and_o any_o way_n hinder_v the_o generation_n of_o animal_n spirit_n as_o the_o common_a assertion_n be_v the_o like_a be_v to_o be_v say_v of_o their_o pass_v between_o the_o pia_fw-la mater_fw-la and_o the_o medullary_a part_n of_o the_o nerve_n which_o can_v be_v allow_v because_o of_o its_o close_a adherence_n thereto_o with_o this_o addition_n that_o they_o will_v constant_o cause_v a_o violent_a headache_n which_o opium_n and_o meal_n to_o which_o fume_n be_v particular_o attribute_v do_v often_o cure_v so_o if_o they_o get_v up_o to_o the_o head_n between_o the_o pia_n and_o dura_n mater_n it_o be_v headache_n and_o not_o the_o symptom_n of_o opium_n that_o they_o will_v produce_v which_o headache_n as_o be_v say_v opium_n and_o meal_n do_v cure_v 21._o last_o if_o they_o pass_v by_o any_o mean_n quite_o on_o the_o outside_n of_o the_o nerve_n and_o their_o membrane_n viz._n the_o pia_n and_o dura_n mater_n then_o must_v they_o take_v their_o lodgement_n if_o within_o the_o skull_n between_o the_o dura_n mater_n and_o the_o skull_n and_o produce_v no_o other_o symptom_n but_o a_o headache_n which_o as_o be_v say_v opium_n and_o meal_n rather_o cure_v than_o produce_v and_o if_o without_o the_o skull_n it_o be_v quite_o beside_o the_o cushion_n and_o the_o vaporarian_n own_o intention_n for_o in_o all_o these_o last_o case_n they_o can_v not_o affect_v the_o animal_n spirit_n for_o good_a or_o evil_n many_o and_o very_o many_o thing_n may_v be_v add_v to_o show_v the_o impossibility_n inconvenience_n incoherence_n absurdity_n etc._n etc._n that_o attend_v the_o passage_n of_o the_o fume_n and_o vapour_n into_o the_o brain_n head_n etc._n etc._n 22._o i_o have_v forgotâ—_n mention_v the_o absurdity_n of_o its_o pass_v up_o at_o gullet_n and_o so_o to_o the_o head_n because_o i_o can_v not_o imagine_v that_o any_o one_o will_v be_v so_o beastly_a a_o animal_n as_o to_o belch_v up_o a_o argument_n of_o that_o kind_n consider_v our_o very_a sense_n tell_v we_o that_o what_o come_v up_o that_o way_n pass_v out_o at_o mouth_n or_o nostril_n and_o because_o if_o it_o be_v so_o the_o operation_n of_o opium_n etc._n etc._n will_v be_v in_o proportion_n to_o our_o belch_a which_o be_v ridiculous_a 23._o the_o great_a comfort_n of_o a_o cordial_n be_v at_o first_o or_o soon_o after_o it_o be_v take_v but_o if_o '_o its_o comfort_n be_v by_o fume_n or_o essluvia_n pass_v to_o the_o blood_n or_o any_o where_o beside_o the_o comfort_n will_v as_o their_o cause_n of_o fume_n do_v increase_v for_o a_o long_a time_n and_o be_v more_o after_o a_o good_a while_n than_o at_o first_o so_o 24._o if_o opium_n operate_v by_o fume_n while_o at_o stomach_n which_o must_v gradual_o increase_v continual_o how_o come_v opium_n to_o be_v at_o the_o height_n of_o its_o operation_n in_o a_o short_a time_n viz._n in_o about_o half_a a_o hour_n after_o it_o begin_v sensible_o to_o operate_v or_o a_o hour_n at_o far_a and_o not_o increase_v continual_o in_o its_o operation_n as_o their_o pretend_a cause_n the_o fume_n must_v do_v by_o continual_a steam_a 25._o if_o opium_n operate_v by_o send_v fume_n by_o passage_n etc._n etc._n from_o the_o stomach_n to_o the_o brain_n i_o shall_v think_v that_o when_o it_o have_v get_v out_o of_o the_o stomach_n as_o into_o the_o intestine_n lacteal_v vein_n etc._n etc._n there_o shall_v be_v a_o kind_n of_o interval_n of_o its_o operation_n which_o be_v never_o observe_v till_o it_o get_v into_o the_o blood_n again_o therefore_o it_o do_v not_o operate_v by_o fume_n for_o the_o pylorus_n be_v always_o shut_v but_o when_o somewhat_o be_v send_v downward_o which_o will_v hinder_v the_o mount_a of_o the_o vapour_n into_o the_o stomach_n in_o order_n to_o pass_v to_o the_o brain_n 26._o if_o vapour_n be_v the_o cause_n of_o sleep_n after_o meal_n than_o shall_v we_o be_v more_o sleepy_a two_o or_o three_o hour_n after_o meal_n because_o of_o the_o abundance_n of_o the_o fume_n that_o will_v be_v crowd_v into_o the_o brain_n by_o that_o time_n but_o we_o be_v more_o sleepy_a present_o after_o meal_n and_o if_o we_o indulge_v it_o but_o for_o a_o quarter_n of_o a_o hour_n we_o be_v refresh_v and_o far_o from_o sleepiness_n afterward_o though_o the_o fume_n if_o that_o hypothesis_n be_v true_a will_v be_v much_o more_o at_o brain_n two_o or_o three_o hour_n after_o the_o meal_n so_o it_o be_v in_o the_o case_n of_o wine_n if_o one_o take_v a_o short_a nap_n after_o some_o glass_n he_o may_v drink_v a_o great_a many_o afterward_o without_o be_v sleepy_a which_o plain_o prove_v that_o it_o be_v not_o the_o fume_n of_o the_o wine_n be_v the_o cause_n of_o the_o sleep_n because_o he_o be_v not_o at_o all_o sleepy_a when_o there_o must_v be_v more_o fume_n 27._o all_o allow_v that_o hot_a fume_n assault_v the_o brain_n cause_n frenzy_n if_o that_o be_v true_a than_o the_o fume_n of_o wine_n and_o opium_n which_o be_v both_o very_a hot_a must_v always_o do_v so_o but_o opium_n and_o wine_n also_o do_v often_o cause_v composure_n good_a humour_n sleep_v etc._n etc._n which_o be_v contrary_a to_o frenzy_n therefore_o they_o do_v not_o operate_v by_o fume_n 28._o if_o sleep_n say_v helmont_n the_o only_a man_n that_o i_o have_v read_v who_o be_v against_o vapour_n be_v cause_v by_o vapour_n ascend_v from_o the_o stomach_n to_o the_o head_n obstruct_v and_o intercept_n all_o the_o passage_n of_o sensation_n motion_n speech_n judgement_n etc._n etc._n as_o the_o school_n say_v than_o a_o disease_n will_v have_v be_v before_o the_o fall_n of_o adam_n because_o sleep_n will_v have_v be_v a_o disease_n that_o be_v a_o flatulent_a and_o vaporous_a palsy_n 29._o all_o allow_v vomitives_n and_o purger_n to_o operate_v by_o irritation_n or_o a_o grievous_a sensation_n of_o the_o membrane_n of_o the_o stomach_n why_o not_o wine_n cordial_n opium_n etc._n etc._n by_o a_o pleasant_a sensation_n cujus_fw-la est_fw-la dolour_n aut_fw-la gravamen_fw-la ejusdem_fw-la est_fw-la voluptas_fw-la and_o as_o a_o grievous_a sensation_n or_o pain_n cause_v melancholy_a depression_n of_o spirit_n fretfulness_n lassitude_n etc._n etc._n so_o a_o pleasant_a sensation_n cause_v comfort_n elevation_n of_o the_o spirit_n euphory_n etc._n etc._n but_o we_o have_v not_o clear_v the_o way_n sufficient_o for_o these_o matter_n yet_o which_o will_v in_o due_a time_n be_v solemn_o consider_v obj._n it_o may_v be_v say_v that_o both_o vomitives_n and_o purgative_n take_v some_o time_n before_o they_o operate_v unless_o a_o nausea_n upon_o aversion_n cause_v they_o to_o work_v soon_o for_o thing_n must_v have_v time_n to_o insinuate_v themselves_o or_o soak_v through_o the_o crusta_fw-la carnosa_fw-la of_o the_o stomach_n and_o afterward_o to_o affect_v its_o sensile_a coat_n which_o argue_v that_o wine_n and_o cordial_n which_o operate_v immediate_o do_v not_o operate_v that_o way_n but_o by_o fume_n or_o effuvium_n pass_v into_o the_o brain_n or_o blood_n answ._n i_o doubt_v indeed_o that_o this_o difference_n may_v be_v a_o occasion_n of_o refer_v the_o effect_n of_o cordial_n and_o those_o of_o emittick_n and_o cathartic_o to_o different_a cause_n but_o it_o be_v very_o strange_a that_o they_o shall_v go_v so_o far_o as_o the_o blood_n or_o brain_n to_o seek_v for_o the_o cause_n of_o the_o operation_n of_o cordial_n which_o operate_v in_o a_o moment_n and_o go_v no_o far_o than_o the_o stomach_n for_o the_o cause_n of_o the_o operation_n of_o vomatives_n and_o purgative_n which_o take_v more_o time_n to_o operate_v especial_o see_v the_o blood_n and_o brain_n have_v no_o sensation_n and_o that_o all_o sensitive_a comfort_n happen_v by_o that_o mean_n i_o think_v it_o be_v much_o more_o proper_a first_o to_o consider_v the_o immediate_a part_n upon_o which_o they_o insist_v when_o at_o stomach_n especial_o see_v it_o be_v so_o very_o sensible_a before_o we_o run_v rove_a i_o know_v not_o whither_o to_o seek_v for_o the_o cause_n of_o a_o thing_n that_o work_v please_v and_o comfort_v the_o stomach_n as_o soon_o as_o it_o be_v down_o i_o take_v myself_o run_v off_o the_o proper_a subject_a matter_n of_o this_o chapter_n and_o anticipate_v that_o of_o another_o therefore_o i_o will_v be_v short_a and_o deliver_v my_o opinion_n in_o this_o case_n by_o way_n of_o position_n with_o a_o familiar_a instance_n to_o illustrate_v it_o which_o may_v in_o some_o measure_n prepare_v you_o for_o the_o proof_n
by_o diminish_v or_o disable_n the_o spirit_n except_o it_o be_v that_o the_o pernicious_a rosin_n may_v do_v something_o of_o that_o kind_n by_o its_o aforesaid_a ill_a effect_n but_o by_o pleasant_o affect_v the_o membrane_n at_o stomach_n venereal_a part_n etc._n etc._n 2._o that_o sleep_n be_v cause_v by_o relaxation_n and_o quiet_v the_o spirit_n 3._o that_o pleasure_n especial_o if_o intense_a and_o last_a as_o that_o by_o opium_n comfort_n enlivens_fw-la encourage_v and_o cause_v a_o ovation_n of_o the_o sensitive_a soul_n and_o spirit_n and_o displeasure_n cause_v sadness_n dejection_n etc._n etc._n 4._o how_o pleasure_n must_v cause_v complacency_n satisfaction_n content_a acquiescence_n and_o composure_n of_o the_o sensitive_a soul_n and_o spirit_n as_o grievance_n cause_v the_o contrary_n 5._o how_o pleasure_n elevate_a and_o keep_v up_o the_o spirit_n and_o cause_v a_o entire_a relaxation_n of_o the_o defensive_a and_o a_o great_a relaxation_n of_o the_o vigilative_a contraction_n which_o tire_v the_o sensitive_a soul_n must_v cause_v euphory_n or_o easy_a undergo_n of_o labour_n journey_n etc._n etc._n without_o lassitude_n as_o experience_n show_v 6._o how_o pleasure_n cause_v relaxation_n of_o all_o the_o sensile_a part_n 7._o how_o the_o say_a relaxation_n as_o in_o sleep_n do_v by_o suffer_v the_o animal_n spirit_n to_o expand_v and_o thereby_o make_v they_o unfit_a to_o carry_v impression_n smart_o which_o be_v necessary_a to_o convey_v a_o sense_n of_o pain_n for_o a_o smart_a impression_n be_v the_o very_a cause_n of_o it_o take_v away_o pain_n to_o which_o you_o may_v add_v that_o the_o sensitive_a soul_n attend_v willing_o to_o the_o sense_n of_o pleasure_n be_v divert_v from_o pain_n and_o that_o a_o sense_n of_o pain_n can_v be_v in_o the_o same_o subject_a with_o pleasure_n which_o be_v therefore_o once_o excite_v pain_n must_v disappear_v but_o that_o of_o take_v away_o all_o smartness_n of_o impression_n by_o relaxation_n be_v a_o plain_a mechanical_a cause_n 8._o how_o therefore_o all_o flux_n that_o be_v cause_v by_o or_o require_v a_o grievous_a sensation_n or_o irritation_n by_o quantity_n or_o quality_n to_o maintain_v and_o continue_v they_o by_o cause_v a_o contraction_n of_o the_o part_n to_o squeeze_v out_o the_o humour_n must_v be_v moderate_v for_o want_v of_o sensation_n upon_o such_o relaxation_n to_o irritate_fw-la the_o part_n as_o it_o happen_v in_o sleep_n or_o in_o any_o case_n where_o relaxation_n and_o thereby_o expansion_n of_o the_o animal_n spirit_n incapacitates_fw-la they_o to_o carry_v impression_n smart_o which_o be_v of_o the_o essence_n of_o pain_n as_o have_v be_v show_v 9_o how_o perspiration_n must_v be_v promote_v by_o relaxation_n which_o open_v the_o pore_n 10._o how_o that_o by_o the_o same_o mean_n sweat_v also_o must_v be_v promote_v if_o the_o body_n be_v full_a of_o moisture_n 11._o how_o opium_n or_o semen_n animale_a be_v of_o the_o same_o principle_n and_o of_o like_a principle_n with_o cantharides_n pismire_n bee_n garlick_n etc._n etc._n must_v excite_v to_o venery_n cause_n itch_n of_o the_o skin_n etc._n etc._n 12._o how_o opium_n may_v by_o too_o high_a a_o ovation_n of_o the_o spirit_n cause_n watch_v while_o pleasure_n cause_v relaxation_n etc._n etc._n may_v take_v away_o pain_n for_o relaxation_n as_o in_o sleep_n syncopes_fw-la etc._n etc._n be_v enough_o to_o take_v away_o pain_n but_o to_o sleep_v quietness_n of_o the_o spirit_n be_v also_o require_v as_o well_o as_o their_o expansion_n by_o relaxation_n so_o that_o pain_n may_v very_o well_o be_v take_v off_o without_o sleep_n as_o it_o often_o be_v by_o opium_n that_o always_o relax_n 13._o how_o the_o pleasure_n that_o opium_n cause_n be_v as_o be_v say_v by_o the_o same_o principle_n and_o therefore_o of_o the_o same_o nature_n with_o that_o which_o animal_n seed_n cause_v upon_o the_o membrane_n but_o that_o animal_n seed_n cause_v it_o only_o upon_o one_o part_n and_o opium_n upon_o the_o membrane_n of_o the_o stomach_n venereal_a part_n and_o all_o other_o in_o general_n and_o that_o only_a for_o a_o moment_n but_o this_o of_o opium_n for_o many_o hour_n by_o which_o mean_v the_o effect_n of_o relaxtion_n by_o pleasure_n come_v to_o be_v more_o remarkable_a as_o after_o much_o wine_n who_o effect_n be_v somewhat_o last_v and_o internal_a as_o that_o of_o opium_n be_v 14._o how_o the_o rosin_n of_o opium_n cause_v its_o ill_a effect_n by_o its_o indigestibleness_n adhere_v quality_n and_o tedious_a sting_a of_o the_o exquisite_o nice_a coat_n of_o the_o stomach_n by_o continual_o teaze_v and_o urge_v it_o by_o its_o actimony_n and_o acute_a volatile_a point_n or_o spiculâ—_n therefore_o have_v 1._o a_o most_o perfect_a and_o complete_a sol-volatile-oleosum_a in_o opium_n of_o the_o same_o please_a principle_n as_o to_o all_o membrane_n as_o animal_n seed_n be_v to_o the_o membrane_n of_o venus_n whereby_o they_o must_v be_v please_v tickle_v and_o relax_v 2._o a_o pernicious_a rosin_n indigestible_a stick_v and_o arm_v with_o acrimonious_a and_o sting_a point_n which_o must_v high_o offend_v the_o most_o sensile_a coat_n at_o the_o stomach_n i_o be_o now_o ready_a by_o god_n assistance_n to_o explain_v every_o phenomenon_n or_o effect_v of_o opium_n however_o amaze_a and_o mysterious_a hope_v they_o will_v not_o remain_v long_o so_o chap._n xvi_o the_o explication_n of_o the_o effect_n of_o opium_n use_v external_o its_o effect_n external_o use_v be_v of_o two_o sort_n either_o i._o as_o a_o opiate_n or_o please_a tickler_n of_o the_o membrane_n or_o ii_o as_o a_o alterative_a of_o the_o part_n that_o it_o be_v apply_v to_o first_o as_o a_o opiate_n or_o pleaser_n of_o the_o membrane_n it_o have_v the_o same_o effect_n as_o opium_n use_v internal_o and_o for_o the_o same_o reason_n therefore_o the_o cause_n of_o its_o operation_n in_o this_o case_n will_v be_v better_o see_v by_o the_o explication_n of_o its_o internal_a effect_n which_o be_v far_o more_o perfect_a complete_a and_o certain_a second_o as_o a_o alterative_a of_o the_o part_n that_o it_o be_v apply_v to_o which_o be_v the_o follow_v viz._n 1._o it_o incides_fw-la resolve_n and_o discuss_n by_o its_o point_a penetrate_a and_o volatile_a salt_n insinuate_v itself_o into_o the_o part_n and_o humour_n of_o the_o animal_n because_o its_o particle_n be_v fine_a minute_n and_o agreeable_a thereto_o as_o menstruum_n to_o the_o thing_n to_o be_v dissolve_v then_o by_o its_o volatility_n it_o discuss_n what_o it_o have_v so_o incide_v and_o resolve_v 2._o it_o mollefy_v and_o relax_n by_o its_o sal-volatile-oleosum_a so_o resolve_v the_o part_n and_o humour_n and_o thereby_o kindly_a loosen_a they_o thus_o opiate_n as_o solanum_fw-la lethale_n or_o deadly_a night_n shade_n hemlock_n mandrake_n etc._n etc._n come_v to_o be_v of_o excellent_a use_n in_o hard_a tumor_n of_o the_o spleen_n tophousness_n etc._n etc._n 3._o it_o maturate_v and_o suppurate_v for_o the_o aforesaid_a reason_n for_o nothing_o can_v better_v dispose_n towards_o maturation_n and_o suppuration_n than_o relax_v mollefy_a and_o resolve_v 4._o it_o exulcerate_v or_o cause_n blister_n or_o at_o least_o rubify_v tender_a skin_n if_o it_o be_v very_o strong_a because_o of_o its_o volatile_a salt_n as_o cantharides_n spearwort_n and_o other_o thing_n do_v upon_o the_o same_o account_n but_o this_o effect_n belong_v main_o to_o the_o true_a mastack_n or_o 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d that_o drop_n from_o the_o incision_n make_v in_o the_o head_n of_o the_o poppy_n more_o especial_o the_o theban_a which_o afford_v a_o most_o powerful_a juice_n for_o exulcerate_v or_o blister_v be_v but_o a_o strong_a full_a and_o therefore_o painful_a resolution_n as_o you_o see_v by_o the_o cuticle_n upon_o blister_n resolve_v into_o a_o kind_n of_o jelly_n 5._o it_o be_v psilothrick_n for_o the_o same_o reason_n for_o while_o it_o so_o resolve_v the_o part_n it_o loosen_v the_o root_n of_o the_o hair_n and_o so_o cause_v its_o shed_n 6._o it_o hurt_v the_o eye_n because_o of_o its_o acrimony_n by_o reason_n of_o the_o volatile_a salt_n 7._o it_o cause_v itch_a in_o the_o skin_n by_o the_o titillation_n of_o the_o same_o volatile_a salt_n as_o you_o find_v by_o the_o application_n of_o squill_n and_o the_o like_a 8._o it_o excite_v venery_n by_o the_o same_o titillation_n on_o the_o veneral_a membrane_n chap._n xvii_o the_o explication_n of_o the_o effect_n of_o opium_n use_v internal_o in_o a_o moderate_a do_v note_v that_o because_o opium_n have_v be_v general_o hitherto_o use_v either_o crude_a or_o with_o its_o rosin_n in_o it_o the_o effect_n of_o opium_n be_v according_o consider_v as_o common_a experience_n thereupon_o have_v give_v opportunity_n of_o observe_v they_o but_o as_o i_o proceed_v i_o shall_v show_v you_o where_o the_o resinous_n part_n of_o opium_n be_v concern_v in_o the_o effect_n 1._o it_o be_v manifest_a why_o opium_n may_v well_o
part_n by_o its_o relax_v the_o pore_n of_o the_o kidney_n and_o render_v the_o humour_n more_o penetrate_v in_o some_o measure_n by_o the_o volatile_a salt_n 20._o it_o cause_v a_o nausea_n by_o its_o rosin_n stick_v to_o and_o teaze_v the_o sensile_a coat_n of_o the_o stomach_n the_o reason_n why_o it_o be_v general_o so_o long_o before_o it_o cause_v a_o nausea_n or_o vomit_v be_v that_o its_o pleasure_n do_v at_o first_o prevent_v it_o till_o at_o last_o the_o stick_a rosin_n urge_v it_o by_o its_o long_a stay_n and_o vexatious_a adherence_n 21._o it_o cause_v swimmings_n in_o the_o head_n by_o consent_n when_o the_o stomach_n be_v grieve_v by_o that_o rosin_n as_o you_o find_v upon_o nauseas_fw-la before_o vomit_v or_o when_o any_o thing_n do_v much_o offend_v the_o stomach_n as_o much_o drink_n or_o wine_n which_o when_o they_o have_v vomit_v those_o swimming_n cease_v 22._o it_o cause_v watch_v in_o some_o person_n who_o be_v of_o very_o movable_a spirit_n by_o actuate_a and_o stir_v their_o spirit_n by_o its_o active_a volatile_a salt_n though_o it_o do_v at_o the_o same_o time_n please_v the_o membrane_n and_o consequent_o relax_v the_o sensile_a part_n and_o thereby_o cause_n indolence_n the_o effect_n of_o relaxation_n which_o it_o also_o do_v when_o people_n keep_v themselves_o from_o sleep_n by_o voluntary_a motion_n and_o therefore_o take_v away_o pain_n even_o when_o man_n travel_v etc._n etc._n beside_o there_o be_v some_o sort_n of_o person_n that_o upon_o joy_n good_a news_n pleasure_n or_o the_o like_a be_v too_o much_o elevate_v or_o have_v a_o restless_a ovation_n of_o the_o spirit_n which_o will_v not_o suffer_v they_o to_o sleep_n though_o they_o be_v in_o a_o pleasant_a condition_n all_o the_o time_n this_o may_v be_v the_o case_n of_o some_o that_o can_v sleep_v after_o opium_n though_o they_o be_v all_o the_o time_n as_o they_o call_v it_o in_o a_o heavenly_a condition_n for_o as_o i_o have_v say_v a_o quietness_n of_o the_o spirit_n be_v requisite_a to_o cause_v sleep_n as_o well_o as_o relaxation_n but_o relaxation_n alone_o and_o thereby_o expansion_n of_o the_o spirit_n so_o that_o they_o can_v carry_v impression_n smart_o be_v sufficient_a to_o cause_v indolence_n and_o the_o pleasure_n to_o cause_v a_o heavenly_a or_o very_o pleasant_a condition_n sanctor_n stat._n med._n sect._n 7._o aph._n 28._o say_v that_o laetitia_n perseverans_fw-la per_fw-la multos_fw-la dies_fw-la somnum_fw-la impedit_fw-la persevere_v pleasure_n may_v do_v the_o same_o by_o like_a reason_n that_o be_v too_o much_o 〈◊〉_d or_o ovation_n of_o the_o spirit_n sometime_o too_o large_a a_o do_v cause_n watch_v by_o over-actuating_a and_o exciting_a the_o spirit_n medicum_fw-la vini_fw-la generosi_fw-la &_o allium_fw-la say_v sanctorius_n conciliant_fw-la somnum_fw-la &_o perspirationem_fw-la si_fw-la vero_fw-la plus_fw-la justo_fw-la sumantur_fw-la utrumque_fw-la prohibent_fw-la perspirabile_fw-la tamen_fw-la in_o sudorem_fw-la convertunt_fw-la that_o be_v a_o little_a generous_a wine_n and_o garlic_n will_v cause_v sleep_n and_o perspiration_n but_o too_o much_o hinder_v both_o yet_o they_o convert_v the_o perspirable_a matter_n to_o a_o sweat_n which_o wine_n and_o garlick_n have_v the_o nature_n of_o opiate_n and_o the_o reason_n why_o they_o sweat_v be_v the_o quantity_n of_o the_o wine_n afford_v more_o moisture_n hypocrates_n say_v 23._o a_o dubious_a state_n between_o sleep_v and_o wake_v be_v cause_v when_o the_o relaxation_n upon_o the_o pleasure_n of_o opium_n incline_v to_o sleep_v but_o the_o irreâ—uiete_a ovation_n of_o the_o spirit_n by_o the_o pleasure_n and_o titillation_n will_v hardly_o suffer_v it_o yet_o high_o please_v and_o put_v they_o in_o a_o sweet_a agreeable_a condition_n chap._n xix_o the_o explication_n of_o the_o rare_a effect_n of_o opium_n in_o a_o moderate_a do_v 1._o it_o cause_v temporary_a pulse_n of_o the_o 〈◊〉_d and_o sometime_o of_o other_o part_n by_o its_o over_o relax_v the_o part_n and_o cause_v thereby_o a_o expansion_n of_o the_o elastic_a spirit_n which_o as_o be_v demonstrate_v weaken_v their_o motion_n 2._o falter_v of_o the_o tongue_n do_v as_o in_o relaxation_n by_o drunkenness_n proceed_v from_o the_o same_o cause_n 3._o looseness_n of_o the_o low_a jaw_n as_o you_o see_v in_o the_o drowsy_a and_o drunken_a people_n be_v from_o the_o same_o relaxation_n 4._o it_o sometime_o prevent_v sweat_n by_o cause_v a_o very_a liberal_a perspiration_n as_o be_v show_v for_o as_o sanctorius_n say_v who_o shall_v know_v it_o much_o insensible_a perspiration_n and_o sweat_n can_v consist_v especial_o in_o a_o temperate_a person_n who_o eat_v and_o drink_v moderate_o therefore_o if_o you_o keep_v a_o person_n that_o sweat_v much_o at_o night_n in_o a_o free_a perspiration_n all_o day_n by_o the_o help_n of_o a_o opiate_n you_o will_v much_o lessen_v or_o total_o prevent_v the_o sweat_n at_o night_n as_o in_o consumptive_a person_n etc._n etc._n 5._o it_o cause_v abortion_n by_o relax_v the_o neck_n of_o the_o womb_n which_o also_o the_o pleasure_n of_o coition_n sometime_o do_v for_o the_o like_a reason_n and_o will_v be_v much_o more_o apt_a to_o cause_v it_o if_o it_o continue_v long_o as_o that_o of_o opium_n do_v note_v the_o inconvenience_n of_o coition_n after_o impregnation_n this_o be_v the_o great_a cause_n that_o whore_n be_v not_o apt_a to_o bear_v child_n because_o frequency_n of_o pleasure_n do_v over-relax_a the_o collum_n 〈◊〉_d 6._o it_o prevent_v abortion_n when_o fear_n terror_n or_o any_o contract_a cause_n as_o grief_n grievous_a passion_n or_o sensation_n do_v threaten_v it_o by_o its_o take_n off_o the_o contraction_n and_o grievance_n that_o cause_v it_o 7_o intumescence_n of_o the_o lip_n be_v from_o their_o relaxation_n admit_v the_o blood_n and_o humour_n into_o they_o in_o a_o plentiful_a manner_n beside_o that_o their_o laxity_n and_o the_o inadvertency_n occasion_v by_o the_o divert_v pleasure_n or_o drowsiness_n that_o follow_v let_v the_o low_a lip_n hang_v down_o careless_o as_o be_v usual_a in_o such_o case_n may_v by_o expose_v much_o more_o of_o that_o lip_n which_o be_v most_o concern_v in_o this_o effect_n make_v it_o seem_v large_a as_o a_o hang_a lip_n do_v 8._o it_o may_v cure_v a_o dropsy_n as_o dr._n wâ—llis_n do_v instance_n 1._o by_o cause_v a_o free_a perspiration_n which_o be_v much_o want_v in_o those_o case_n 2._o by_o relax_v the_o pore_n and_o make_v way_n for_o the_o humour_n to_o 〈◊〉_d 3._o by_o cause_v much_o urine_n as_o cantharides_n millepedes_n &c_n &c_n do_v upon_o the_o account_n of_o their_o volatile-salt_n with_o which_o opium_n abound_v 9_o it_o cure_v stupor_n that_o proceed_v from_o contraction_n as_o by_o cold_a etc._n etc._n by_o relax_v all_o part_n 10._o it_o cause_v anxiety_n and_o distress_n by_o the_o rosin_n stick_v and_o teaze_v the_o stomach_n 11._o vomit_n and_o hiccough_n proceed_v from_o the_o same_o cause_n 12._o convulsion_n be_v cause_v by_o the_o same_o rosin_n while_o it_o continual_o urge_v the_o stomach_n to_o grievous_a vomit_n which_o at_o last_o draw_v other_o part_n as_o the_o stomach_n usual_o do_v when_o under_o great_a grievance_n into_o violent_a contraction_n or_o convulsion_n by_o consent_n to_o endeavour_v its_o assistance_n because_o the_o defensive_a contraction_n grow_v very_o high_a by_o the_o almost_o intolerable_a and_o tedious_a grievance_n at_o stomach_n cause_v a_o mighty_a compression_n of_o the_o springy_a animal_n spirit_n by_o which_o mean_v they_o grow_v very_o forcible_a irrequiete_a and_o violent_o springy_a under_o the_o urgency_n of_o a_o enormous_a compressure_n which_o cause_v such_o convulsive_a motion_n note_v that_o such_o a_o violent_a compression_n of_o the_o animal_n spirit_n into_o a_o great_a springiness_n be_v the_o cause_n of_o the_o strength_n of_o convulsive_a motion_n so_o that_o sometime_o a_o strong_a man_n can_v hardly_o hold_v a_o child_n limb_n in_o such_o case_n 13._o syncopes_fw-la leipothymy_n and_o faint_n follow_v when_o the_o sensitive_a soul_n be_v quite_o tire_v and_o overbear_v by_o the_o fatigue_n of_o such_o distress_n vomit_n and_o defensive_a contraction_n to_o reject_v and_o excuss_v the_o say_v adhere_v and_o teaze_v rosin_n yield_v itself_o to_o rest_n and_o let_v we_o go_v the_o reign_v of_o contraction_n as_o be_v fruitless_a and_o no_o long_o endurable_a whereupon_o all_o the_o sensile_a part_n be_v relax_v in_o the_o high_a degree_n they_o thereby_o grow_v unfit_a for_o sensation_n and_o the_o animal_n spirit_n expand_v as_o far_o as_o the_o atmospherical_a compressure_n permit_v they_o so_o that_o they_o grow_v incapable_a to_o convey_v impression_n by_o which_o mean_v sense_n fail_v and_o motion_n also_o for_o the_o same_o reason_n because_o the_o animal_n spirit_n loose_v their_o springy_a endeavour_n for_o want_n of_o a_o sufficient_a compression_n to_o render_v they_o flippant_a for_o the_o purpose_n which_o be_v the_o cause_n as_o in_o sleep_n that_o sense_n
and_o motion_n fail_v together_o of_o the_o great_a perspiration_n and_o all_o other_o effect_n of_o relaxation_n in_o such_o syncopes_fw-la or_o leipothymy_n in_o a_o yet_o high_o degree_n than_o in_o sleep_n wherein_o the_o sensitive_a soul_n do_v not_o quite_o let_v go_v the_o reign_v of_o contraction_n as_o appear_v by_o the_o motion_n that_o remain_v as_o of_o the_o heart_n intestine_n etc._n etc._n though_o far_o more_o remiss_a in_o sleep_n than_o in_o a_o wake_v state_n note_v that_o such_o leipothymy_n be_v as_o be_v hint_v of_o the_o same_o nature_n as_o sleep_n be_v but_o that_o they_o be_v sudden_a more_o profound_a and_o not_o so_o usual_a natural_a and_o of_o course_n as_o sleep_n be_v which_o make_v they_o more_o amaze_a and_o surprise_v therefore_o it_o follow_v that_o they_o be_v as_o sleep_n be_v a_o mean_n of_o recruit_v when_o all_o work_n and_o tug_v by_o defensive_a contraction_n fail_v and_o so_o the_o last_o refuge_n of_o the_o sensitive_a soul_n when_o overtired_n in_o order_n to_o recover_v strength_n for_o a_o fresh_a engagement_n with_o the_o enemy_n as_o be_v tire_v at_o night_n the_o sensitive_a soul_n loosen_v the_o rign_n of_o contraction_n to_o enable_v he_o the_o better_a to_o fall_v to_o his_o work_n the_o next_o day_n this_o you_o will_v find_v by_o all_o reason_n and_o experience_n to_o be_v the_o true_a state_n of_o leipothymy_n upon_o grievance_n and_o fatigue_n though_o not_o hitherto_o mind_v that_o i_o know_v of_o many_o true_a and_o useful_a consequence_n do_v hence_o follow_v as_o that_o we_o be_v not_o always_o to_o disturb_v they_o or_o put_v they_o out_o of_o these_o recruit_v leipothymy_n by_o grievous_a mean_n as_o pricking_n pinch_n etc._n etc._n but_o only_o by_o cordial_n and_o refresh_a thing_n as_o you_o will_v treat_v a_o person_n much_o tire_v or_o by_o let_v they_o take_v their_o nap_n if_o i_o may_v so_o call_v it_o if_o there_o be_v not_o very_o eminent_a danger_n but_o it_o be_v endless_a and_o beside_o my_o purpose_n to_o make_v a_o particular_a discourse_n of_o this_o matter_n which_o will_v belong_v more_o proper_o to_o my_o tract_n of_o animal_n mechanism_n 14._o death_n happen_v sometime_o though_o very_o rare_o and_o that_o in_o very_o weak_a people_n that_o take_v little_a or_o no_o sustenance_n because_o either_o when_o fall_v into_o such_o syncopes_fw-la they_o never_o come_v out_o of_o they_o by_o reason_n that_o they_o have_v not_o within_o they_o wherewith_o to_o recruit_v their_o spirit_n or_o that_o opium_n take_v they_o much_o spend_v and_o tire_v with_o distemper_n cause_n as_o in_o weak_a and_o weary_a people_n a_o most_o profound_a sopor_fw-la which_o not_o recruit_v they_o who_o take_v or_o digest_v no_o sustenance_n they_o must_v rather_o grow_v weak_a and_o weak_a for_o somewhat_o be_v spend_v while_o we_o live_v and_o consequent_o the_o sleep_n or_o sopor_fw-la more_o and_o more_o profound_a till_o they_o sleep_v their_o last_o for_o want_v of_o some_o recruit_v which_o be_v the_o very_a thing_n that_o natural_o lessen_v sleep_n and_o awake_v we_o when_o there_o be_v no_o other_o apparent_a cause_n for_o as_o the_o be_v tire_v and_o want_v of_o recruit_v cause_n sleep_v so_o the_o have_v it_o cause_v wake_v or_o which_o be_v the_o same_o in_o effect_n no_o far_o need_v of_o relaxation_n for_o recruit_n sake_n so_o that_o the_o sensitive_a soul_n fall_v to_o his_o useful_a work_n of_o vigilative_a contraction_n for_o sense_n and_o motion_n sake_n 15._o it_o sometime_o cause_n purge_v which_o happen_v as_o far_o as_o i_o have_v observe_v or_o can_v learn_v only_o when_o it_o be_v give_v in_o a_o good_a quantity_n to_o person_n of_o a_o strong_a digestion_n or_o canine_a appetite_n the_o case_n be_v thus_o when_o person_n that_o be_v of_o a_o strong_a digestion_n take_v a_o resinous_n opiate_n in_o good_a quantity_n they_o do_v in_o great_a measure_n by_o their_o fix_a salt_n at_o stomach_n and_o strong_a digestion_n subdue_v the_o volatility_n of_o the_o opium_n and_o dissolve_v its_o rosin_n which_o then_o as_o acrimonious_a rosin_n or_o vomit_n subdue_v by_o fix_a salt_n use_v to_o do_v cause_v purge_v hence_o it_o be_v that_o it_o general_o if_o not_o always_o purge_v dog_n and_o people_n of_o a_o high_a canine_a appetite_n and_o that_o sometime_o meet_v such_o fix_a salt_n it_o purge_v the_o consumptive_a bartholine_n say_v that_o mandrake_n juice_n purge_v when_o it_o meet_v with_o acrimonious_a fix_a salt_n erastus_n and_o quercelan_n do_v agree_v that_o it_o have_v a_o purgative_n quality_n but_o that_o it_o do_v not_o always_o exert_v it_o 1._o because_o it_o take_v away_o the_o sense_n of_o irritation_n 2._o because_o it_o be_v give_v in_o too_o small_a a_o quantity_n the_o reason_n be_v just_a and_o right_a and_o not_o only_o consistent_a with_o but_o confirm_v what_o i_o say_v note_v that_o this_o be_v not_o intend_v of_o the_o purge_v that_o happen_v after_o the_o declination_n of_o its_o operation_n which_o be_v as_o you_o will_v find_v from_o another_o cause_n therefore_o this_o do_v not_o smell_v of_o the_o opium_n as_o the_o other_o do_v because_o it_o be_v past_a and_o go_v before_o that_o in_o the_o declination_n happen_v of_o which_o more_o in_o its_o proper_a place_n 16._o it_o raise_v and_o revive_v some_o person_n that_o be_v almost_o expire_a in_o two_o case_n one_o be_v when_o such_o as_o have_v be_v use_v to_o take_v it_o be_v even_o expire_a for_o want_n of_o it_o of_o which_o more_o hereafter_o the_o other_o case_n be_v when_o violent_a contraction_n as_o from_o pain_n cold_a vomit_n and_o grievous_a passion_n as_o terror_n etc._n etc._n be_v the_o cause_n that_o people_n be_v almost_o expire_a for_o it_o take_v off_o the_o contraction_n by_o relax_v etc._n etc._n 17._o it_o stay_v very_o long_o at_o stomach_n when_o the_o rosin_n thereof_o stick_v to_o the_o stomach_n and_o be_v there_o detain_v beside_o that_o the_o stomach_n be_v relax_v and_o have_v little_a sense_n or_o motion_n as_o in_o sleep_n do_v not_o soon_o digest_v it_o or_o discharge_v it_o it_o be_v fine_a in_o this_o case_n and_o all_o other_o to_o observe_v how_o sensation_n and_o motion_n go_v hand_n in_o hand_n keep_v equal_a pace_n and_o equal_a proportion_n as_o it_o plain_o must_v be_v by_o the_o principle_n of_o relaxation_n and_o contraction_n which_o i_o have_v state_v and_o prove_v 18._o it_o cause_v stoppage_n of_o urine_n sometime_o especial_o in_o old_a people_n by_o over_o relax_v and_o cause_v a_o kind_n of_o a_o temporary_a palsy_n of_o the_o bladder_n as_o be_v show_v and_o take_v away_o the_o sense_n of_o the_o irritation_n of_o the_o urine_n which_o shall_v contract_v the_o bladder_n to_o squeeze_v it_o out_o by_o which_o mean_v it_o happen_v sometime_o that_o the_o bladder_n come_v to_o be_v so_o over_o extend_v beyond_o its_o due_a tone_n that_o they_o can_v contract_v it_o to_o make_v water_n in_o all_o which_o case_n strong_a contracter_n as_o cold_a terror_n etc._n etc._n immediate_o cure_v they_o the_o very_a put_v the_o scrotum_fw-la to_o the_o edge_n of_o a_o cold_a chamberpot_n have_v effect_v it_o several_a time_n by_o my_o advice_n though_o if_o need_v be_v you_o must_v come_v to_o dash_v of_o cold_a water_n upon_o the_o region_n of_o the_o bladder_n or_o pump_v on_o it_o or_o dip_v in_o it_o etc._n etc._n so_o terror_n and_o cause_v a_o very_a smart_n pain_n especial_o near_o those_o part_n will_v do_v much_o but_o cold_a be_v the_o ready_a and_o best_a remedy_n 19_o it_o sometime_o prove_v dangerous_a after_o great_a hemorrbage_n or_o evacuation_n as_o tapping_n in_o dropsy_n etc._n etc._n because_o the_o relaxation_n hinder_v the_o part_n due_o to_o contract_v upon_o what_o remain_v which_o may_v cause_v great_a mischief_n as_o discontinuation_n of_o motion_n etc._n etc._n thus_o have_v you_o all_o the_o constant_a frequent_a and_o rare_a effect_n of_o opium_n take_v internal_o in_o a_o moderate_a do_v so_o natural_o easy_o plain_o and_o mechanical_o explicate_v that_o people_n may_v in_o my_o judgement_n more_o admire_v how_o all_o fail_v of_o discover_v the_o manner_n of_o their_o production_n than_o that_o i_o find_v it_o as_o man_n be_v apt_a to_o think_v of_o the_o circulation_n of_o the_o blood_n which_o now_o as_o i_o hope_v the_o effect_n of_o opium_n do_v seem_v very_o obvious_a both_o which_o case_n be_v to_o i_o very_o strong_a argument_n of_o a_o be_v that_o rule_n and_o dispose_n darken_v and_o illuminate_v etc._n etc._n as_o he_o please_v when_o i_o consider_v that_o both_o the_o circulation_n of_o the_o blood_n and_o the_o cause_n of_o the_o operation_n of_o opium_n viz._n pleasure_n at_o stomach_n etc._n etc._n fall_v under_o the_o sense_n of_o many_o million_o who_o in_o one_o case_n see_v the_o blood_n move_v and_o in_o the_o other_o feel_v
opium_n extract_v out_o of_o spirit_n of_o wine_n to_o make_v it_o worse_o than_o when_o crude_a therefore_o have_v sometime_o ill_a effect_n especial_o when_o use_v alone_o in_o the_o form_n of_o a_o pill_n in_o a_o large_a do_v as_o be_v say_v 10._o philonium_fw-la magistrale_fw-la be_v also_o to_o be_v reject_v because_o the_o opium_n be_v prepare_v in_o spirit_n of_o wine_n and_o benjamin_n add_v which_o be_v resinous_a 11._o philon._n rom._n &_o persic_a be_v tolerable_a because_o the_o opium_n be_v disgregated_a and_o mix_v as_o galen_n will_v have_v it_o among_o much_o and_o several_a other_o thing_n which_o keep_v its_o resinous_a part_n from_o coalescence_n ii_o as_o to_o its_o form_n 1._o a_o pilular_a form_n of_o crude_a opium_n or_o any_o resinous_a preparation_n thereof_o wherein_o the_o rosin_n be_v not_o due_o subdue_v segregated_a alter_v or_o correct_v be_v as_o have_v be_v show_v the_o most_o pernicious_a 2._o the_o form_n of_o a_o electuary_n be_v commendable_a it_o be_v in_o small_a quantity_n mix_v therein_o with_o many_o or_o much_o other_o thing_n that_o prevent_v the_o coalescence_n of_o the_o râ—sin_n we_o particle_n 3._o a_o liquid_a form_n be_v general_o good_a because_o the_o part_n as_o in_o a_o tincture_n of_o opium_n in_o spirit_n of_o wine_n be_v sever_v and_o segiegated_a yet_o it_o be_v not_o so_o very_o safe_a where_o the_o râ—sin_n be_v not_o separate_v because_o if_o care_n be_v not_o take_v as_o have_v be_v direct_v the_o resinous_a particle_n may_v be_v precipitate_v at_o stomach_n and_o so_o coalesce_v and_o stick_v to_o it_o 4._o the_o operation_n of_o opium_n be_v quick_a in_o a_o liquid_a form_n but_o more_o last_a in_o a_o solid_a form_n especial_o if_o the_o opium_n be_v resinous_a which_o though_o noxious_a in_o general_n yet_o have_v the_o advantage_n of_o duration_n where_o it_o may_v be_v bear_v as_o in_o person_n of_o a_o robu_v texture_n and_o good_a digestion_n or_o where_o custom_n have_v take_v off_o its_o grievounsess_n as_o you_o find_v in_o habitual_a tobaco-taking_a etc._n etc._n 5._o the_o liquid_a panacea_fw-la of_o opium_n be_v better_a for_o alteration_n because_o it_o be_v the_o first_o fruit_n of_o the_o opium_n and_o more_o sincere_a and_o unaltered_a by_o fire_n than_o the_o solid_a but_o 6._o the_o solid_a panacea_fw-la be_v better_a where_o a_o stay_n at_o stomach_n and_o the_o intestine_n be_v convenient_a as_o in_o stop_v of_o vomit_v looseness_n etc._n etc._n to_o be_v brief_a 7._o liquid_a form_n shall_v be_v always_o give_v in_o foul_a stomach_n where_o the_o digestion_n be_v weak_a in_o fever_n and_o when_o a_o nimble_a operation_n be_v requisite_a iii_o as_o to_o its_o dose_n 1._o the_o mean_a or_o middle_n do_v be_v general_o to_o be_v use_v and_o where_o there_o be_v no_o direction_n to_o the_o contrary_n 2._o the_o mean_a dose_n may_v serve_v except_o in_o violent_a pain_n or_o where_o much_o of_o the_o opiate_n be_v lose_v as_o it_o happen_v very_o often_o in_o vomit_v or_o looseness_n or_o to_o excite_v venery_n because_o those_o part_n be_v remote_a and_o require_v a_o very_a sensible_a titillation_n but_o as_o to_o these_o matter_n you_o will_v have_v particular_a direction_n in_o the_o respective_a case_n in_o the_o follow_a chapter_n that_o treat_v thereof_o in_o a_o special_a manner_n 3._o the_o do_v must_v be_v proportionable_o less_o in_o the_o fine_a and_o lax-textured_n child_n woman_n warm_a and_o moist_a wether_n weak_a stomach_n person_n much_o debilitate_a or_o overtired_n with_o work_n labour_n disease_n etc._n etc._n iv_o as_o to_o its_o vehicle_n 1._o it_o shall_v general_o unless_o there_o be_v particular_a cause_n to_o the_o contrary_a be_v pleasant_a and_o agreeable_a to_o the_o taste_n and_o stomach_n that_o it_o may_v rather_o conspire_v with_o the_o opiate_n to_o please_v the_o membrane_n etc._n etc._n than_o contradict_v the_o sensitive_a pleasure_n that_o it_o cause_n 2._o it_o shall_v not_o be_v a_o acid_n because_o it_o infringe_n the_o volatile_a nature_n of_o opium_n except_o some_o particular_a case_n require_v it_o which_o will_v be_v see_v hereafter_o 3._o it_o shall_v not_o be_v a_o volatilo-saline_a especial_o to_o cause_v sleep_n or_o because_o that_o may_v render_v it_o too_o acrimonious_a or_o pungent_a and_o so_o hinder_v sleep_n composure_n etc._n etc._n 4._o it_o shall_v not_o be_v lixivial_a because_o its_o fix_a nature_n oppose_v the_o volatile_a except_o it_o be_v where_o the_o opiate_n be_v resinous_a to_o help_v its_o dissolution_n therefore_o 5._o wine_n or_o ferment_v liquor_n cordial_n water_n or_o smooth_a and_o pleasant_a liquid_n as_o emulsion_n milk_n and_o water_n water_n and_o sugar_n etc._n etc._n will_v be_v the_o most_o proper_a general_o speak_v 6._o the_o resinous_a opiate_n shall_v be_v always_o give_v in_o sulphureous_a spirit_n wâ—ne_n or_o strong_a liquor_n or_o in_o a_o lixivial_a vehicle_n or_o rather_o in_o both_o mix_v or_o in_o a_o rear_n yolk_n of_o a_o egg_n or_o fine_o powder_v and_o well_o mix_v with_o electuary_n bolus_n conserve_n thick_a syrup_n pulp_n or_o any_o thing_n that_o be_v innocent_a and_o of_o a_o good_a consistence_n to_o keep_v the_o resinous_a particle_n asunder_o and_o to_o prevent_v their_o coalescence_n for_o which_o end_n i_o judge_v that_o good_a white_a sâ—p_n must_v be_v because_o of_o the_o alkali_n its_o slipp'riness_n and_o aptitude_n to_o join_v with_o the_o rosin_n a_o good_a vehicle_n the_o opium_n and_o scrape_n of_o the_o soap_n be_v mix_v with_o a_o little_a rose-water_n and_o what_o else_o you_o think_v fit_a to_o render_v they_o more_o acceptable_a by_o pound_v they_o in_o a_o mortar_n for_o a_o good_a while_n to_o a_o intimate_a mixture_n v._o as_o to_o time_n 1._o give_v the_o liquid_a form_n half_a a_o hour_n at_o least_o or_o a_o hour_n before_o the_o time_n you_o will_v have_v they_o operate_v 2._o give_v the_o solid_a form_n a_o hour_n or_o a_o hour_n and_o a_o half_a before_o you_o will_v have_v they_o operate_v it_o be_v very_o silly_a not_o to_o give_v they_o till_o the_o very_a time_n that_o they_o shall_v operate_v as_o it_o be_v usual_a at_o bedtime_n when_o they_o shall_v be_v then_o operate_a and_o cause_v sleepiness_n that_o the_o rest_n and_o ease_n of_o lie_v down_o may_v concur_v with_o it_o whereas_o if_o people_n be_v unapt_a to_o sleep_v as_o general_o they_o be_v who_o take_v opium_n they_o not_o take_v it_o till_o bedtime_n lie_v toss_v and_o tumble_v grow_v uneasy_a and_o restless_a and_o the_o bed_n hard_o and_o in_o a_o great_a part_n of_o the_o year_n too_o hot_a before_o the_o opium_n operate_v so_o that_o the_o opium_n can_v take_v effect_n by_o reason_n of_o disquietude_n so_o the_o person_n lie_v all_o or_o most_o part_n of_o the_o night_n without_o any_o sleep_n whereas_o if_o it_o be_v so_o give_v as_o to_o cause_v a_o great_a sleepiness_n by_o the_o time_n they_o go_v to_o bed_n their_o lie_v still_o a_o very_a little_a time_n which_o they_o be_v then_o apt_a to_o and_o the_o bed_n be_v soft_a easy_a cool_a and_o pleasant_a they_o immediate_o sleep_v and_o their_o spirit_n be_v compose_v continue_v their_o sleep_n all_o or_o most_o part_n of_o the_o night_n therefore_o i_o have_v often_o come_v where_o people_n have_v not_o sleep_v though_o they_o take_v a_o opiate_n at_o bedtime_n and_o give_v they_o the_o very_a same_o a_o convenient_a time_n before_o and_o they_o have_v sweet_o sleep_v to_o their_o heart_n desire_n and_o refreshment_n 4._o give_v opiate_n as_o to_o meal_n at_o least_o 3_o hour_n before_o and_o after_o they_o or_o about_o the_o middle_a time_n between_o they_o if_o it_o be_v in_o the_o daytime_n or_o when_o the_o stomach_n be_v near_o empty_a or_o but_o little_a or_o light_a matter_n in_o it_o which_o if_o gentle_a and_o agreeable_a will_v help_v man_n to_o sleep_v but_o great_a repletion_n and_o perfect_a emptiness_n or_o hunger_n which_o be_v a_o grievous_a sensation_n do_v disturb_v or_o hinder_v sleep_n 5._o opiate_n may_v and_o have_v prove_v inconvenient_a before_o or_o after_o let_v of_o blood_n and_o hemorrhage_n especial_o if_o the_o evacuation_n be_v large_a and_o sudden_a the_o reason_n be_v because_o though_o person_n be_v very_o dispirited_a and_o so_o much_o incline_v to_o sleep_n of_o themselves_o may_v sleep_v too_o much_o and_o dangerous_o and_o because_o opium_n relax_v hinder_v the_o vessel_n due_o to_o contract_v upon_o the_o remain_a blood_n which_o may_v cause_v a_o discontinuance_n of_o its_o stream_n by_o reason_n that_o the_o diminish_v blood_n may_v not_o suffice_v to_o fill_v up_o the_o relaxed_a vessel_n though_o this_o may_v seldom_o happen_v because_o the_o compressure_n of_o the_o air_n be_v appoint_v by_o most_o wise_a providence_n to_o close_v all_o our_o vessel_n in_o such_o case_n but_o it_o must_v be_v better_a do_v when_o the_o