Selected quad for the lemma: cause_n

Word A	Word B	Word C	Word D	Occurrence	Frequency Band	MI	MI Band	Prominent
cause_n	effect_n	necessary_a	produce_v	6,956	5	9.5140	5	true

Text snippets containing the quad

ID	Title	Author	Corrected Date of Publication (TCP Date of Publication)	STC	Words	Pages
A11334	Opiologia: or, A treatise concerning the nature, properties, true preparation and safe vse and administration of opium For the comfort and ease of all such persons as are inwardly afflicted with any extreame griefe, or languishing paine, especially such as depriue the body of all naturall rest, and can be cured by no other meanes or medicine whatsoeuer. Dedicated to the illustrious, high and mighty lords, the estates generall of the vnited prouinces in the Netherlands. By Angelus Sala Vincentinus Venitus. And done into English, and something inlarged by Tho. Bretnor. M. M.	Sala, Angelus, 1576-1637.; Bretnor, Thomas, fl. 1607-1618, tr., ed.	1618 (1618)	STC 21594; ESTC S101645	41,817	118

be_v always_o good_a see_v without_o they_o no_o man_n can_v live_v we_o may_v easy_o perceive_v the_o u●ritie_n hereof_o by_o the_o example_n of_o any_o man_n who_o have_v watch_v and_o travail_v moderate_o until_o at_o last_o he_o become_v drowsy_a and_o faint_a who_o after_o a_o little_a sleep_n and_o repose_v be_v awaken_v become_v as_o lively_a and_o frolic_a as_o at_o first_o but_o if_o this_o man_n return_v to_o his_o labour_n and_o redouble_v his_o pain_n &_o watch_v in_o such_o sort_n that_o he_o surpass_v the_o limit_n of_o his_o strength_n and_o so_o long_o until_o his_o vital_a animal_n and_o natural_a function_n be_v utter_o disband_v and_o weaken_v make_v such_o a_o exceed_a alteration_n in_o his_o body_n and_o turn_v it_o quite_o upside-down_a so_o that_o a_o dangerous_a and_o mortal_a disease_n ensue_v now_o in_o this_o case_n if_o he_o betake_v himself_o to_o this_o medicine_n for_o rest_n and_o sleep_v think_v to_o find_v like_o benefit_n and_o comfort_n as_o before_o he_o shall_v be_v so_o far_o from_o enjoy_v the_o same_o that_o quite_o contrary_a he_o must_v needs_o pay_v the_o price_n of_o his_o life_n for_o his_o vain_a excess_n and_o intemperance_n after_o the_o very_a same_o manner_n may_v we_o judge_v of_o such_o a_o sick_a person_n as_o have_v want_v sleep_n beyond_o measure_n endure_v intolerable_a pain_n take_v no_o food_n or_o nourishment_n and_o become_v extreme_a weak_a and_o at_o point_n of_o death_n who_o afterward_o fall_v into_o a_o little_a sleep_n of_o himself_o or_o by_o mean_n of_o a_o little_a laudanum_n or_o a_o spoonful_n or_o two_o of_o some_o restaurative_a liquor_n to_o comfort_v he_o instead_o of_o recover_v his_o life_n by_o any_o of_o these_o he_o doubtless_o die_v the_o cause_n of_o his_o death_n notwithstanding_o ought_v not_o to_o be_v impute_v to_o the_o little_a sleep_n he_o have_v nor_o to_o the_o take_n of_o the_o cordial_n see_v that_o sleep_n and_o nourishment_n be_v two_o necessary_a thing_n for_o the_o preservation_n of_o life_n but_o rather_o in_o regard_n that_o death_n have_v seize_v upon_o they_o these_o thing_n can_v not_o produce_v those_o good_a effect_n which_o by_o nature_n intention_n they_o be_v ordain_v and_o appoint_v for_o let_v this_o suffice_v then_o to_o confute_v the_o three_o objection_n aforesaid_a in_o defence_n of_o well_o prepare_v and_o discreet_o administer_v laudanum_n for_o if_o any_o man_n use_v opium_n as_o the_o turk_n do_v or_o henbane_n mandrake_n or_o any_o other_o narcotiall_a thing_n so_o crude_a raw_a il-prepared_n or_o uncorrect_v have_v or_o do_v commit_v any_o notable_a error_n in_o that_o behalf_n it_o be_v far_o from_o my_o scope_n or_o intention_n to_o defend_v any_o such_o abuse_n my_o desire_n be_v rather_o that_o physician_n shall_v beware_v how_o they_o deal_v with_o simple_a people_n and_o lest_o the_o art_n shall_v be_v slander_v there_o ought_v to_o be_v a_o fit_a time_n elect_v for_o the_o give_v of_o laudanum_n that_o be_v at_o the_o first_o encounter_n of_o the_o disease_n when_o there_o be_v good_a hope_n of_o cure_n consider_v that_o we_o must_v not_o only_o have_v regard_n to_o purge_v phlebomize_v prescribe_v a_o diet_n etc._n etc._n to_o our_o patient_n but_o also_o to_o comfort_v and_o restore_v to_o advance_v and_o bring_v they_o to_o their_o natural_a rest_n and_o to_o cease_v and_o qualify_v their_o torment_n moreover_o we_o shall_v omit_v no_o occasion_n at_o any_o time_n to_o ease_v and_o succour_v our_o neighbour_n even_o until_o the_o point_n of_o death_n in_o all_o thing_n we_o may_v or_o can_v possible_o even_o as_o we_o will_v be_v serve_v ourselves_o in_o the_o like_a ●ase_n and_o that_o with_o all_o convenient_a exception_n and_o protestation_n for_o the_o reason_n aforesaid_a and_o this_o shall_v suffice_v for_o conclusion_n of_o this_o present_a treatise_n now_o i_o protest_v to_o every_o one_o that_o shall_v read_v this_o same_o that_o i_o have_v no_o pretention_n in_o this_o discourse_n to_o injure_v or_o detract_v from_o those_o which_o worthy_o make_v profession_n of_o physic_n but_o only_o desire_v to_o amplify_v the_o knowledge_n of_o this_o medicine_n for_o the_o benefit_n of_o such_o person_n as_o be_v ignorant_a thereof_o as_o i_o have_v before_o say_v in_o my_o preface_n and_o also_o to_o manifest_v the_o pain_n which_o i_o take_v and_o the_o diligence_n i_o bestow_v to_o find_v out_o the_o property_n preparation_n and_o true_a use_n of_o such_o thing_n as_o be_v especial_o convenient_a and_o necessary_a in_o physic_n and_o consequent_o to_o make_v it_o appear_v that_o those_o which_o move_v with_o their_o own_o proper_a passion_n shall_v speak_v any_o thing_n against_o i_o deceive_v themselves_o and_o derogate_v from_o that_o noble_a name_n whence_o they_o be_v call_v christian_n think_v it_o no_o wrong_n to_o detract_v from_o another_o honour_n so_o they_o may_v by_o that_o mean_n or_o any_o other_o augment_v their_o own_o which_o i_o will_v have_v construe_v with_o all_o modest_a exception_n intend_v not_o to_o touch_v any_o one_o man_n name_n more_o than_o another_o if_o their_o own_o tongue_n be_v not_o their_o own_o accusor_n whereby_o if_o they_o chance_v to_o manifest_v themselves_o they_o shall_v have_v no_o occasion_n to_o blame_v i_o and_o therefore_o i_o commit_v my_o right_n to_o he_o which_o only_o know_v the_o heart_n of_o man_n and_o who_o administer_v justice_n equity_n mercy_n and_o grace_n unto_o all_o his_o creature_n to_o who_o be_v glory_n for_o ever_o and_o ever_o amen_n finis_fw-la fault_n escape_v in_o the_o print_n in_o the_o epistle_n dedicatory_a pag._n 12._o line_n 10._o read_v calcining_n in_o the_o author_n preface_n p._n 12._o l._n 6._o r._n iucundé_v in_o the_o treatise_n p._n 2._o l._n 1._o r._n dioscorides_n p._n 11._o l._n 12._o r_o nuisance_n p._n 15._o l._n 1._o r._n complicentur_fw-la p._n 19_o l._n 17._o for_o among_o r._n against_o p._n 49._o l._n 16._o r._n mellis_n license_v feb._n 21._o 1669._o roger_n l'estrange_n

ingenerall_n become_v not_o only_o more_o able_a body_v and_o strong_a thereby_o but_o also_o more_o apt_a and_o able_a to_o eat_v and_o digest_v diverse_a thing_n which_o the_o tender_a and_o nice_a christian_n can_v iudure_v and_o that_o the_o truth_n be_v so_o let_v we_o but_o consider_v a_o little_a the_o difference_n of_o natural_a toughness_n and_o strength_n between_o a_o christian_a paysant_n or_o carle_n here_o among_o we_o and_o a_o gentleman_n or_o citizen_n do_v not_o we_o see_v i_o pray_v you_o that_o the_o paysant_n can_v more_o easy_o endure_v a_o purgation_n make_v of_o white_a hellebore_n tithymall_n euphorbium_n or_o colocynthis_fw-la which_o be_v account_v violent_a and_o venomous_a medicine_n than_o these_o tender_a spark_n aforesaid_a can_v brook_v rheubarbe_n mechoacan_n sena_n aloe_n or_o the_o damask_n rise_v but_o why_o the_o turk_n devour_v opium_n on_o this_o fashion_n ought_v rather_o to_o be_v impute_v unto_o a_o ordinary_a custom_n and_o common_a usage_n among_o they_o then_o to_o any_o other_o cause_n whatsoever_o even_o as_o the_o indian_n be_v accustom_v to_o take_v tobacco_n which_o be_v a_o plant_n not_o only_o narcoticke_a and_o stupefactive_a but_o of_o a_o violent_a and_o extreme_a vomitive_a quality_n also_o notwithstanding_o we_o see_v that_o christian_n all_o europe_n over_o by_o little_a and_o little_o have_v bring_v themselves_o into_o such_o a_o custom_n and_o habit_n thereunto_o that_o they_o feel_v no_o alteration_n or_o prejudice_n at_o all_o as_o they_o think_v by_o the_o use_n thereof_o i_o make_v no_o question_n but_o a_o man_n may_v find_v a_o number_n of_o people_n among_o christian_n that_o if_o they_o can_v already_o can_v easy_o accustom_v themselves_o to_o eat_v opium_n as_o familiar_o as_o they_o take_v tobacco_n although_o they_o can_v not_o use_v ●t_z in_o such_o quantity_n nor_o so_o often_o in_o regard_n it_o be_v a_o pure_a essence_n and_o extract_n which_o nature_n have_v separate_v from_o its_o plant_n for_o essential_a thing_n be_v always_o far_o more_o effectual_a than_o gross_a be_v for_o confirmation_n whereof_o we_o need_v not_o doubt_v that_o if_o a_o man_n shall_v separate_v the_o rosinous_a and_o sulphurous_a substance_n of_o tobaccao_n and_o bring_v it_o into_o such_o a_o consistence_n as_o opium_n be_v and_o afterward_o give_v it_o unto_o such_o as_o usual_o take_v tobacco_n they_o can_v not_o possible_o endure_v the_o ten_o part_n so_o much_o of_o this_o as_o of_o the_o leaf_n as_o have_v be_v already_o practise_v and_o try_v there_o be_v some_o empiric_n i_o know_v which_o give_v crude_a opium_n to_o their_o patiens_fw-la in_o as_o great_a or_o great_a quantity_n at_o a_o time_n than_o discorides_n have_v limit_v and_o that_o without_o any_o great_a danger_n or_o hazard_n of_o life_n at_o all_o only_o correct_v it_o a_o little_a with_o the_o powder_n of_o carawayseed_n and_o in_o case_n of_o necessity_n i_o myself_o will_v not_o stick_v or_o make_v any_o scruple_n to_o use_v it_o yea_o i_o dare_v if_o need_n be_v take_v two_o or_o three_o grain_n thereof_o at_o a_o time_n myself_o for_o although_o i_o never_o do_v eat_v thereof_o hitherto_o indeed_o yet_o have_v i_o often_o taste_v the_o same_o and_o also_o receive_v great_a quantity_n of_o the_o sulphurous_a vapour_n both_o into_o my_o stomach_n and_o head_n in_o time_n of_o the_o preparation_n thereof_o without_o any_o perceivance_n or_o the_o least_o touch_n of_o any_o offence_n in_o the_o world_n nevertheless_o it_o be_v not_o my_o counsel_n that_o any_o physician_n shall_v use_v it_o crude_a in_o this_o manner_n see_v we_o have_v art_n and_o mean_n to_o prepare_v it_o otherwise_o the_o second_o assurance_n that_o we_o have_v concern_v the_o use_n of_o opium_n be_v in_o that_o we_o find_v and_o see_v that_o the_o most_o expert_a and_o wise_a physician_n of_o old_a find_v it_o good_a and_o therefore_o prescribe_v this_o medicine_n as_o a_o principal_a ingredient_n and_o as_o one_o of_o the_o most_o important_a base_n in_o their_o chief_a composition_n alexitery_n diaphoreticke_n anodynes_n cordial_n which_o natural_o resist_v the_o most_o grievous_a and_o violent_a disease_n that_o can_v any_o way_n happen_v to_o human_a body_n for_o which_o cause_n they_o usual_o call_v they_o opiate_n confection_n as_o that_o of_o their_o treacle_n of_o andromachus_n their_o mithridate_n of_o danocrates_n their_o triphera_n magna_fw-la aurea_fw-la alexandrina_n philomuim_n romanum_fw-la requies_fw-la nicholai_n and_o other_o which_o they_o have_v use_v as_o principal_a medicine_n for_o these_o many_o hundred_o year_n and_o yet_o do_v for_o they_o be_v indeed_o the_o most_o precious_a and_o necessary_a composition_n their_o ordinary_a apothecary_n have_v the_o cause_n which_o move_v ancient_a physician_n to_o put_v opium_n unto_o the_o foresay_a confection_n be_v not_o few_o see_v that_o its_o property_n be_v to_o assuage_v all_o inward_a pain_n strengthen_v the_o passage_n &_o conduit_n which_o be_v open_a loose_a &_o disband_v precipitate_v disperse_v and_o consume_v these_o venomous_a vapour_n which_o be_v raise_v from_o one_o part_n to_o another_o incrassat_fw-la and_o thicken_v all_o subtle_a corrosive_n &_o humour_n by_o correct_v their_o malignity_n and_o acrimonie_n stop_v and_o stay_v all_o flux_n as_o well_o dysenterick_n as_o menstrual_a appease_v and_o extinguish_v all_o extremity_n in_o burn_a fever_n provoke_v natural_a rest_n and_o sleep_v to_o distress_a and_o lunatic_n person_n and_o final_o like_o a_o balm_n defend_v the_o part_n from_o corruption_n which_o operation_n and_o effect_n be_v require_v in_o all_o composition_n which_o be_v general_o ordain_v to_o resist_v the_o violence_n of_o diverse_a disease_n in_o appease_v and_o repel_v whereof_o some_o of_o these_o property_n before_o name_v be_v ordinary_o desire_v as_o quercetanus_n in_o his_o pharmacop●a_n entreat_v of_o the_o vetues_fw-la of_o opium_n affirm_v in_o these_o word_n say_v pauci_fw-la en●m_fw-la sunt_fw-la morbi_fw-la qui_fw-la non_fw-la simul_fw-la complacentur_fw-la vel_fw-la ardoribus_fw-la vel_fw-la inflammationibus_fw-la vel_fw-la inquietudinibus_fw-la commotiomibus_fw-la la●guoribus_fw-la oppressionibus_fw-la vigilijs_fw-la de●luxionibus_fw-la vel_fw-la var●●_n generis_fw-la doloribus_fw-la capitis_fw-la pectoris_fw-la ventricul●_n ventris_fw-la vel_fw-la cu●scunque_fw-la alterius_fw-la patris_fw-la ad_fw-la quorum_fw-la omnium_fw-la symptomatum_fw-la ferociam_fw-la compescendam_fw-la opium_n specificam_fw-la &_o peculiarem_fw-la quandam_fw-la habet_fw-la proprietatem_fw-la qua_fw-la vel_fw-la unum_fw-la exhis_fw-la symptomatis_n seorsim_fw-la vel_fw-la plura_fw-la cum_fw-la malo_fw-la coniuncta_fw-la simul_fw-la cum_fw-la admirabili_fw-la astantium_fw-la &_o ipsorum_fw-la aegrorum_fw-la admiratione_n evincit_fw-la ac_fw-la subigit_fw-la unde_fw-la saepeumerò_fw-la in_o e●usmodi_fw-la casibus_fw-la tam_fw-la mirandos_fw-la sanationum_fw-la effectus_fw-la prodere_fw-la videmus_fw-la theriacam_n muhridatium_fw-la antidotos_fw-la esdrae_fw-la &_o simile_n quae_fw-la opium_n exciiunt_fw-la etc._n etc._n for_o there_o be_v very_o few_o disease_n which_o be_v not_o either_o accompany_v with_o heat_n inflammation_n inquietude_n perturbation_n languish_v oppression_n watch_v flux_n etc._n etc._n for_o mitigate_a and_o ●epressing_v of_o which_o symptom_n opium_n have_v a_o specifical_a and_o a_o certain_a peculiar_a propriety_n etc._n etc._n and_o this_o may_v serve_v to_o assure_v we_o that_o we_o may_v bold_o use_v opium_n inward_o without_o any_o prejudice_n to_o life_n yea_o rather_o for_o its_o better_a conservation_n be_v administer_v with_o judgement_n and_o discretion_n as_o all_o other_o medicine_n whatsoever_o ought_v to_o be_v chap._n iii_o concern_v the_o good_a and_o evil_a affect_n which_o opium_n may_v produce_v in_o man_n body_n that_o opium_n as_o aforesaid_a be_v wise_o administer_v to_o the_o disease_a produce_v in_o they_o many_o good_a effect_n and_o contrariwise_o abuse_v excit_v diverse_a dangerous_a and_o mortal_a accident_n be_v in_o no_o sort_n doubt_v among_o discreet_a physician_n but_o touch_v the_o cause_n why_o opium_n do_v work_v these_o effect_n in_o man_n body_n be_v disputable_a for_o most_o physician_n impute_v it_o to_o that_o extremity_n of_o the_o four_o degree_n of_o coldness_n wherewith_o it_o be_v endow_v and_o for_o proof_n and_o confirmation_n hereof_o they_o produce_v a_o argument_n draw_v from_o the_o effect_n of_o its_o operation_n in_o this_o manner_n opium_n say_v they_o provoke_v a_o vigilant_a or_o watchful_a man_n to_o sleep_v and_o incrass_v thin_a and_o subtle_a humour_n vigilancy_n then_o proceed_v for_o the_o most_o part_n from_o a_o hot_a and_o dry_a cause_n with_o matter_n or_o without_o and_o the_o dissolution_n also_o of_o the_o humour_n from_o the_o like_a distemperature_n opium_n therefore_o contrary_v and_o impugn_v the_o cause_n of_o these_o effect_n must_v needs_o be_v of_o the_o quality_n aforesaid_a and_o for_o the_o further_a confirmation_n hereof_o they_o allege_v galen_n plini●_n and_o other_o who_o in_o like_a manner_n witness_n that_o when_o opium_n be_v undiscreet_o use_v it_o cause_v lethargic_a sleep_n privation_n of_o sense_n stupe●_n faction_n of_o

substance_n of_o the_o body_n as_o all_o other_o vegetable_a and_o animal_n medicine_n may_v easy_o do_v in_o regard_n of_o that_o symbolisation_n they_o have_v with_o the_o foresay_a substance_n so_o that_o the_o stomach_n may_v reduce_v they_o into_o chyle_n at_o pleasure_n which_o be_v the_o cause_n also_o that_o the_o poison_n of_o evil_a plant_n serpent_n and_o other_o venomous_a creature_n be_v more_o active_a sudden_a and_o pierce_a then_o arsink_n itself_o or_o realgar_n mineral_n i_o can_v produce_v a_o number_n of_o other_o reason_n to_o demonstrate_v that_o chemical_a medicine_n of_o a_o vehement_a nature_n as_o principal_o the_o two_o before_o name_v against_o which_o all_o this_o controversy_n do_v particular_o arise_v be_v more_o gentle_a than_o any_o violent_a vomitive_a medicine_n which_o our_o ancient_n prescribe_v yea_o far_o more_o safe_a than_o any_o vomitorie_n under_o hellebore_n or_o any_o above_o name_v but_o to_o avoid_v long_a discourse_n let_v these_o suffice_v at_o this_o time_n now_o let_v we_o come_v to_o resolve_v ourselves_o whether_o those_o ordinary_a medicine_n which_o be_v natural_o gentle_a and_o without_o any_o offensive_a quality_n after_o chemical_a preparation_n change_v their_o natural_a mildness_n into_o that_o which_o be_v evil_a and_o so_o become_v vehement_a and_o dangerous_a concern_v which_o point_n we_o have_v in_o this_o discourse_n already_o speak_v some_o thing_n in_o defence_n of_o purgative_a medicine_n as_o those_o of_o more_o frequent_a use_n than_o other_o among_o disease_a person_n and_o therefore_o will_v be_v content_v to_o determine_v the_o whole_a matter_n in_o the_o general_a defence_n of_o diaphoreticke_n diuretic_n alexitery_n etc._n etc._n chemical_o prepare_v first_o therefore_o it_o must_v of_o necessity_n be_v grant_v of_o all_o opponent_n that_o every_o medicine_n ingenerall_n bereave_v of_o its_o earthiness_n and_o seculencie_n and_o make_v pure_a clean_o and_o well_o digest_v by_o fire_n must_v of_o consequence_n be_v less_o hurtful_a less_o dangerous_a and_o less_o offensive_a and_o be_v also_o far_o more_o apt_a to_o work_v ci●òtutò_fw-la &_o miundè_fw-la as_o the_o physician_n wish_v than_o any_o crude_a earthy_a impure_a or_o ill_o prepare_v medicine_n may_v or_o can_v do_v by_o any_o mean_n '_o possible_a the_o reason_n be_v that_o when_o such_o ill-prepared_n stuff_n be_v once_o get_v into_o the_o stomach_n of_o any_o disease_a person_n nature_n already_o struggle_v against_o the_o disease_n become_v thereby_o more_o weary_v over-cloyed_n and_o oppress_v in_o concoct_v and_o separate_n the_o pureness_n from_o the_o impurenesse_n of_o such_o drug_n than_o it_o be_v before_o and_o therefore_o can_v receive_v very_o little_a or_o no_o comfort_n at_o all_o by_o such_o medicine_n whereas_o on_o the_o contrary_a part_n other_o medicine_n make_v subtle_a active_a pure_a and_o well_o prepare_v by_o art_n do_v begin_v to_o disperse_v and_o dilate_v themselves_o gentle_o into_o all_o part_n of_o the_o body_n as_o soon_o as_o they_o be_v receive_v thereinto_o and_o be_v never_o so_o little_a exagitated_a or_o move_v by_o natural_a heat_n assist_v nature_n herself_o without_o any_o alteration_n or_o disturbance_n at_o all_o and_o like_o a_o good_a friend_n aid_n and_o promone_v she_o whereas_o the_o other_o weari_v and_o torment_v the_o body_n like_o a_o tyrant_n moreover_o we_o may_v consider_v that_o chemical_a medicine_n be_v pure_a and_o neat_a as_o aforesaid_a leave_v no_o feculent_a residence_n or_o corruption_n in_o the_o body_n at_o all_o as_o other_o common_o do_v but_o if_o it_o come_v to_o pass_v as_o it_o be_v not_o unlikely_a that_o some_o shall_v deny_v these_o reason_n object_v that_o chemical_a medicine_n be_v subtle_a and_o pure_a can_v more_o easy_o disturb_v nature_n and_o move_v the_o body_n more_o sudden_o than_o other_o medicine_n do_v to_o who_o we_o answer_v that_o although_o among_o our_o chemical_a medicine_n there_o be_v some_o of_o a_o subtle_a nature_n as_o our_o distil_a oil_n the_o quintessence_n of_o wine_n and_o other_o vegetable_n and_o as_o there_o be_v diverse_a liquor_n we_o acknowledge_v very_o sharp_a and_o pierce_a so_o in_o like_a manner_n be_v there_o some_o disease_n wherein_o such_o medicine_n be_v very_o requisite_a and_o necessary_a whereas_o other_o of_o a_o cross_n seculent_a and_o clammy_a substance_n can_v yield_v no_o ease_n or_o comfort_n at_o all_o in_o regard_n whereof_o we_o ought_v not_o to_o account_v they_o dangerous_a or_o hurtful_a but_o rather_o very_o beneficial_a and_o wholesome_a especial_o be_v well_o apply_v and_o use_v a●_n all_o medicine_n of_o what_o nature_n soever_o aught_o to_o be_v but_o under_o colour_n of_o these_o no_o man_n ought_v to_o comprehend_v other_o chemical_a medicine_n or_o proclaim_v they_o to_o be_v of_o such_o a_o pierce_a nature_n for_o come_v to_o purgative_a medicine_n extract_v be_v of_o a_o sappy_a thick_a and_o condense_a form_n we_o know_v well_o that_o they_o be_v not_o nor_o can_v be_v so_o subtle_a or_o pierce_a as_o oil_n nor_o be_v call_v subtle_a in_o regard_n of_o their_o penetrative_a virtue_n but_o rather_o because_o they_o be_v far_o more_o easy_o convert_v into_o liquor_n than_o the_o substance_n from_o whence_o they_o be_v extract_v and_o therefore_o ought_v in_o no_o ease_n to_o be_v call_v irritative_n experience_n herself_o teach_v we_o that_o the_o extract_n of_o mechoacan_n rheubarbe_n or_o sena_n be_v gentle_a medicine_n due_o administer_v show_v themselves_o far_o more_o mild_a gentle_a and_o effectual_a then_o when_o they_o be_v exhibit_v after_o a_o entire_a and_o gross_a preparation_n but_o what_o need_v many_o word_n do_v we_o not_o plain_o see_v that_o our_o chemical_a art_n bring_v colocynthis_fw-la and_o scammony_n acrimonious_a and_o venomous_a purgative_n ●o_o be_v so_o gentle_a and_o mild_a in_o operation_n that_o a_o man_n may_v as_o safe_o and_o free_o administer_v they_o as_o rheubarbe_n have_v only_a regard_n to_o the_o quality_n of_o the_o disease_n and_o the_o humour_n they_o natural_o purge_v as_o namely_o that_o of_o scammony_n whereof_o a_o man_n may_v bold_o give_v to_o one_o of_o a_o strong_a constitution_n twenty_o grain_n at_o a_o time_n in_o sugar_n rosat_n or_o any_o other_o conserve_v and_o this_o will_v work_v easy_o and_o well_o without_o any_o touch_n of_o pain_n perturbance_n or_o inflammation_n in_o the_o bowel_n as_o otherwise_o it_o will_v sure_o do_v and_o this_o be_v a_o maxim_n that_o not_o only_a scammony_n but_o every_o other_o purgative_a medicine_n of_o such_o venomous_a and_o vehement_a nature_n as_o hellebore_n tithymall_n etc._n etc._n lose_v their_o acrimonie_n and_o malign_a quality_n and_o by_o mean_n of_o this_o art_n become_v gentle_a and_o effectual_a in_o the_o extirpation_n of_o all_o such_o disease_n as_o they_o natural_o concern_v or_o respect_n without_o any_o inconvenience_n or_o danger_n at_o all_o and_o this_o be_v no_o vain_a conjecture_n of_o my_o own_o brain_n for_o i_o can_v produce_v a_o hundred_o sage_a and_o learned_a physician_n which_o can_n &_o will_v testify_v and_o make_v this_o good_a as_o well_o as_o myself_o and_o this_o be_v all_o which_o i_o purpose_v to_o speak_v at_o this_o time_n in_o defence_n of_o chemical_a medicine_n against_o the_o suggestion_n of_o scandalous_a tongue_n not_o meaning_n or_o intendeng_v hereby_o to_o disgrace_n or_o vilipend_v those_o ordinary_a medicine_n wherewith_o the_o world_n be_v and_o have_v be_v furnish_v and_o serve_v for_o so_o many_o age_n together_o for_o both_o the_o one_o and_o the_o other_o may_v be_v find_v good_a or_o evil_n according_a to_o the_o diversity_n of_o their_o usage_n notwithstanding_o i_o have_v at_o all_o time_n indevor_v myself_o to_o the_o uttermost_a of_o my_o power_n to_o amplify_v and_o illustrate_v the_o art_n of_o physic_n for_o the_o comfort_n of_o the_o disease_a as_o every_o one_o ought_v without_o any_o passion_n or_o malice_n in_o condemn_a thing_n new_o invent_v for_o paradox_n and_o heresy_n before_o due_a examination_n and_o trial_n ad_fw-la authorem_fw-la excuse_v i_o worthy_a sala_n if_o i_o chance_v for_o want_v of_o judgement_n thy_o intent_n to_o miss_v in_o fit_v that_o for_o england_n which_o for_o france_n thou_o pain_n haste_v take_v and_o labour_n to_o iwis_o for_o which_o and_o other_o thou_o deserve_v bliss_n i_o wish_v i_o be_v thy_o neighbour_n or_o that_o i_o with_o such_o a_o one_o may_v spend_v my_o day_n and_o die_v but_o now_o the_o world_n be_v such_o we_o can_v find_v a_o man_n with_o who_o we_o free_o may_v converse_v some_o proud_a some_o stately_a other_o so_o unkind_a that_o it_o grieve_v my_o heart_n their_o manner_n to_o rehearse_v or_o talk_v of_o such_o selfe-lover_n in_o my_o verse_n when_o man_n by_o nature_n friendly_a creature_n bear_v dote_v on_o themselves_o and_o other_o foul_o scorn_v but_o thou_o patavian-like_a i_o hear_v do_v joy_n to_o do_v poor_a scholar_n good_a and_o to_o

of_o they_o in_o manner_n as_o follow_v the_o objection_n 1_o first_o that_o laudanum_n be_v principal_o compose_v of_o opium_n and_o still_o retain_v its_o somniferous_a property_n may_v consequent_o suffocate_v natural_a heat_n and_o benumb_v and_o stupefy_v all_o the_o sense_n 2_o see_v laudanum_n do_v incrassate_fw-it &_o thicken_v the_o subtle_a humour_n it_o follow_v that_o although_o it_o do_v cease_v pain_n for_o the_o time_n yet_o afterward_o it_o make_v the_o cause_n of_o the_o sickness_n malignant_a fix_v and_o incurable_a 3_o that_o it_o have_v be_v observe_v that_o some_o sick_a people_n have_v die_v some_o few_o hour_n after_o the_o take_n of_o laudanun_n inconsideration_n whereof_o we_o shall_v abstain_v from_o its_o use_n altogether_o the_o answer_n concern_v the_o first_o objection_n i_o be_o of_o opinion_n that_o if_o such_o man_n as_o go_v about_o to_o propose_v any_o such_o thing_n will_v either_o give_v place_n to_o the_o authority_n of_o great_a physician_n or_o experience-self_n both_o which_o assure_v we_o that_o c●ude_a opium_n take_v in_o small_a quantity_n neither_o suffocate_v natural_a hea●e_n nor_o dull_v the_o sense_n as_o have_v be_v already_o sufficient_o prove_v in_o the_o begin_n of_o this_o discourse_n they_o will_v neither_o blame_v nor_o so_o base_o esteem_v of_o it_o but_o suppose_v that_o a_o very_a small_a do_v of_o crude_a opium_n do_v produce_v such_o effect_n must_v it_o therefore_o do_v the_o same_o when_o it_o be_v deprive_v of_o the_o superfluity_n of_o its_o narcotical_a sulphur_n his_o acrimonie_n correct_v and_o after_o mix_v with_o such_o bezoardick_n and_o cordial_a thing_n as_o aforesaid_a no_o man_n of_o judgement_n or_o of_o any_o experience_n in_o the_o mystery_n of_o nature_n can_v deny_v that_o opium_n the_o principal_a ingredience_n or_o basis_n of_o laudanum_n be_v thus_o alter_v both_o in_o form_n and_o substance_n become_v likewise_o change_v in_o its_o virtue_n and_o operation_n and_o therefore_o can_v with_o no_o reason_n censure_v so_o hardly_o thereof_o as_o when_o it_o be_v crude_a and_o notwithstanding_o that_o laudanun_n do_v provoke_v the_o disease_a to_o sleep_v yet_o daily_a experience_n teach_v we_o that_o it_o do_v not_o suffocate_v natural_a heat_n but_o rather_o preserve_v it_o when_o it_o be_v about_o to_o consume_v and_o in_o danger_n to_o be_v sudden_o extinct_a by_o reason_n of_o its_o violent_a motion_n extreme_a pain_n and_o extraordinary_a watch_v whereby_o it_o be_v as_o rude_o handle_v as_o a_o lamp_n or_o burning-torch_n be_v in_o a_o mighty_a tempest_n which_o cause_v a_o great_a waste_n of_o oil_n and_o loss_n of_o light_n than_o it_o will_v do_v if_o it_o be_v defend_v from_o such_o a_o accident_n 2_o for_o the_o second_o objection_n laudanum_n be_v so_o far_o from_o aggravate_v impair_n or_o make_v worse_o the_o cause_n of_o the_o disease_n by_o reason_n of_o its_o incrassate_a faculty_n that_o quite_o contrary_a it_o prepare_v some_o offend_a humour_n and_o make_v they_o far_o more_o apt_a and_o easy_a to_o be_v expel_v as_o in_o the_o 21._o passage_n before_o concern_v gout_n we_o have_v something_o declare_v for_o be_v it_o not_o the_o consent_n and_o verdict_n of_o the_o best_a physician_n in_o the_o world_n that_o the_o preparation_n of_o humour_n before_o purgation_n do_v chief_o consist_v in_o two_o operation_n that_o be_v in_o subtilize_v and_o attenuate_v of_o those_o which_o be_v viscouse_n thick_a and_o clammy_a and_o incrassate_v and_o thicken_a indifferent_o those_o which_o be_v too_o subtle_a virulent_a windy_a &_o vagant_fw-la in_o the_o body_n now_o the_o great_a part_n of_o extreme_a pain_n and_o inward_a heat_n proceed_v from_o some_o dissolve_a matter_n that_o be_v either_o salt_n sharp_a or_o corrode_a or_o from_o such_o as_o do_v excoriate_v inflame_v and_o alter_v the_o member_n affect_v whereby_o malignant_a vapour_n arise_v which_o pass_v unto_o the_o adjoin_v part_n do_v by_o consent_n produce_v sundry_a torment_n &_o many_o evil_a accident_n as_o by_o experience_n be_v manifest_a what_o better_a course_n can_v a_o man_n observe_v then_o by_o mean_n of_o laudanum_n to_o thicken_v and_o digest_v the_o say_v humour_n &_o sequester_v &_o consume_v the_o aforesaid_a vapour_n in_o such_o sort_n that_o they_o can_v by_o no_o mean_n exercise_v their_o cruelty_n as_o before_o and_o in_o case_n of_o superfluity_n if_o it_o be_v any_o way_n requisite_a to_o be_v purge_v a_o man_n may_v do_v it_o afterward_o far_o more_o wary_o and_o safe_o then_o in_o the_o former_a estate_n be_v not_o this_o represent_v to_o any_o man_n understanding_n by_o sundry_a outward_a ulcer_n which_o be_v inflame_v and_o distil_a from_o some_o subtle_a and_o corrosive_n humour_n cause_n great_a prick_a dolour_n and_o pain_n and_o oftentimes_o by_o consent_n a_o fever_n to_o the_o patient_n so_o that_o the_o true_a remedy_n in_o such_o a_o case_n to_o take_v away_o such_o accident_n be_v some_o excellent_a anodyne_n which_o may_v mitigate_v and_o assuage_v that_o unnatural_a heat_n and_o sudden_o ripen_v and_o indifferent_o thicken_v the_o offend_a humour_n which_o be_v so_o subtle_a and_o corrosive_n which_o be_v do_v all_o other_o symptom_n cease_v whatsoever_o laudanum_n then_o not_o only_o produce_v these_o effect_n by_o its_o natural_a property_n but_o also_o mundify_v resist_a putrefaction_n and_o heal_v and_o comfort_v the_o weaken_a part_n as_o it_o be_v balsam_n may_v by_o good_a consequence_n take_v away_o or_o extinguish_v the_o cause_n of_o many_o evil_a symptom_n rather_o than_o impair_v and_o make_v they_o incurable_a for_o although_o it_o do_v moderate_o incrassate_fw-it yet_o notwithstanding_o it_o do_v not_o coagulate_v the_o blood_n nor_o fix_v the_o substance_n which_o in_o their_o own_o proper_a nature_n be_v liquid_a in_o stone_n nor_o solder_v or_o glue_v the_o part_n together_o as_o gypsum_fw-la do_v for_o which_o cause_n only_a man_n shall_v blame_v it_o in_o such_o manner_n as_o before_o 3_o three_o we_o will_v not_o deny_v but_o that_o some_o sick_a person_n may_v chance_v to_o die_v soon_o after_o the_o receipt_n of_o laudanum_n but_o that_o laudanum_n be_v the_o cause_n of_o their_o death_n &_o that_o in_o regard_n thereof_o its_o use_n be_v utter_o to_o be_v abandon_v and_o forsake_v be_v the_o matter_n now_o in_o question_n first_o therefore_o it_o be_v very_o apparent_a by_o our_o former_a discourse_n that_o laudanum_n be_v not_o a_o thing_n of_o such_o a_o venomous_a quality_n as_o will_v cause_v death_n to_o the_o receiver_n for_o albeit_o the_o observation_n be_v true_a that_o some_o have_v die_v soon_o after_o the_o take_n thereof_o yet_o that_o ought_v not_o to_o supersede_n all_o other_o reason_n attestation_n &_o experience_n concern_v the_o good_a effect_n and_o safe_a use_n of_o laudanum_n for_o as_o it_o be_v a_o absurd_a and_o foolish_a thing_n for_o a_o man_n to_o say_v ●_o do_v see_v certain_a grain_n of_o bezoar-stone_n vnicornes-horne_n pearl_n or_o such_o like_a precious_a cordial_n give_v to_o a_o sick_a person_n who_o die_v not_o long_o after_o ergo_fw-la that_o be_v the_o cause_n of_o his_o death_n and_o therefore_o take_v heed_n of_o use_v any_o such_o thing_n hereafter_o or_o i_o see_v one_o give_v a_o clyster_n to_o such_o a_o sick_a person_n who_o die_v soon_o after_o ergo_fw-la clyster_n be_v dangerous_a remedy_n and_o ought_v not_o to_o be_v use_v as_o many_o simple_a people_n be_v accustom_v to_o argue_v even_o so_o it_o be_v as_o absurd_a a_o thing_n to_o hold_v laudanum_n in_o suspicion_n because_o such_o a_o one_o take_v it_o &_o after_o dy●d_v for_o although_o it_o do_v principal_o and_o speedy_o cause_v all_o torment_n to_o cease_v and_o provoke_v the_o disease_a to_o sleep_v yet_o that_o be_v no_o consequence_n that_o it_o can_v preserve_v a_o man_n from_o death_n when_o by_o god_n his_o secret_a decree_n his_o hour_n be_v come_v for_o neither_o that_o nor_o no_o other_o medicine_n in_o the_o world_n can_v do_v sleep_n and_o exemption_n from_o pain_n be_v necessary_a thing_n as_o well_o for_o sound_v as_o sick_a man_n the_o one_o with_o distinction_n the_o other_o without_o all_o exception_n but_o that_o these_o two_o do_v sometime_o serve_v for_o the_o maintenance_n and_o strengthen_n of_o man_n life_n and_o other_o sometime_o be_v unnecessary_a and_o of_o no_o use_n this_o proceed_v not_o through_o any_o fault_n in_o themselves_o but_o in_o nature_n which_o do_v not_o receive_v they_o for_o her_o own_o good_a and_o benefit_n as_o other_o time_n she_o use_v to_o do_v which_o thing_n be_v lively_o represent_v unto_o we_o by_o the_o use_n of_o meat_n drink_n and_o all_o other_o thing_n call_v medicine_n not_o natural_a which_o sometime_o be_v good_a and_o profitable_a to_o the_o body_n and_o sometime_o quite_o contrary_a even_o as_o nature_n dispose_v of_o they_o for_o our_o good_a or_o evil_a howsoever_o in_o themselves_o they_o