best_a part_n of_o opium_n which_o be_v so_o much_o the_o better_a the_o more_o it_o abound_v with_o they_o 9_o if_o it_o yield_v any_o other_o tincture_n than_o red_a it_o be_v not_o right_a and_o the_o dull_a or_o pale_a the_o red_a be_v the_o worse_a or_o weak_a it_o be_v 10._o the_o best_a be_v heavy_a in_o proportion_n to_o its_o bulk_n which_o you_o may_v soon_o experiment_n thus_o weigh_v a_o ounce_n of_o each_o in_o the_o air_n then_o weigh_v they_o just_a as_o they_o be_v in_o the_o brass_n scales_n in_o water_n and_o the_o heavy_a will_n outweigh_v the_o other_o in_o water_n for_o the_o heavy_a any_o thing_n be_v the_o less_o water_n take_v from_o its_o weight_n in_o proportion_n to_o its_o bulk_n this_o be_v a_o infallible_a and_o most_o ready_a way_n to_o know_v the_o weight_n of_o any_o thing_n in_o proportion_n to_o its_o bulk_n note_v that_o my_o discourse_n be_v most_o particular_o concern_v the_o best_a sort_n of_o crude_a turkey_n opium_n that_o be_v the_o best_a that_o we_o have_v in_o common_a use_n and_o that_o its_o effect_n and_o not_o those_o of_o any_o preparation_n thereof_o be_v set_v down_o in_o the_o follow_a chapter_n chap_n iii_o the_o effect_n of_o opium_n use_v external_o opium_n use_v external_o have_v two_o sort_n of_o effect_n upon_o a_o humane_a body_n 1._o as_o a_o opiate_n to_o cause_n sleep_n take_v away_o pain_n etc._n etc._n 2._o as_o a_o alterative_a of_o the_o part_n it_o be_v apply_v to_o i._o as_o a_o opiate_n it_o be_v of_o very_o uncertain_a and_o uneven_a effect_n when_o apply_v external_o for_o sometime_o it_o cause_v sleep_n take_v away_o pain_n but_o it_o often_o fail_v therefore_o it_o be_v general_o much_o better_a safe_a more_o certain_a and_o effectual_a to_o use_v it_o internal_o i_o do_v scarce_o know_v the_o case_n wherein_o it_o be_v better_a to_o use_v it_o external_o than_o internal_o unless_o it_o be_v to_o smell_v to_o in_o some_o case_n but_o of_o these_o thing_n more_o particular_o when_o we_o come_v to_o the_o use_v of_o opium_n in_o cure_v prevent_v or_o paliate_a disease_n for_o here_o we_o only_o lie_v down_o effect_n in_o order_n to_o a_o disquisition_n of_o the_o cause_n of_o the_o operation_n of_o opium_n to_o which_o its_o internal_a effect_n will_v main_o contribute_v however_o it_o may_v be_v very_o useful_a to_o that_o end_n to_o lay_v down_o its_o alterative_a effect_n for_o thereby_o we_o shall_v in_o good_a measure_n know_v the_o prin_fw-mi ciple_n by_o which_o it_o operate_v ii_o it_o be_v external_a effect_n as_o a_o alterative_a be_v these_o viz._n 1._o it_o incides_fw-la resolve_n and_o discuss_n 2._o it_o relax_n and_o mollify_v 3._o it_o maturate_v and_o suppurate_v 4._o it_o exulcerate_v or_o cause_n blister_n if_o it_o be_v very_o strong_a and_o apply_v to_o person_n of_o a_o fine_a texture_n where_o the_o skin_n be_v tender_a but_o this_o effect_n belong_v more_o proper_o to_o the_o maslack_n or_o true_a 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d that_o drop_n from_o the_o incision_n make_v in_o the_o head_n of_o the_o poppy_n especial_o the_o theban_a which_o afford_v a_o very_a powerful_a juice_n hence_o you_o may_v observe_v that_o the_o more_o it_o exulcerates_n or_o blister_n the_o better_a be_v the_o opium_n &_o vice_fw-la versâ_fw-la 5._o it_o be_v a_o psilotherick_n for_o it_o prevent_v hair_n to_o grow_v and_o cause_v the_o shed_v thereof_o 6._o it_o be_v hurtful_a to_o the_o eye_n and_o ear_n 7._o it_o excite_v itch_n apply_v in_o a_o moderate_a manner_n to_o the_o skin_n 8._o it_o excite_v venery_n apply_v to_o the_o perinaeum_n chap._n iu._n the_o effect_n of_o opium_n use_v internal_o in_o a_o moderate_a do_v 1._o the_o moderate_a do_v in_o ordinary_a use_n to_o produce_v the_o follow_a effect_n be_v from_o one_o to_o three_o grain_n more_o or_o less_o according_a to_o the_o circumstance_n condition_n case_n constitution_n age_n &c_n &c_n of_o the_o person_n who_o take_v it_o 2._o it_o operate_v general_o in_o a_o short_a time_n after_o it_o be_v in_o the_o stomach_n that_o be_v in_o about_o half_a a_o hour_n more_o or_o less_o if_o take_v in_o a_o liquid_a form_n and_o in_o about_o a_o hour_n more_o or_o less_o if_o in_o a_o solid_a form_n drink_v a_o draught_n of_o water_n or_o some_o liquor_n after_o it_o otherwise_o it_o may_v be_v sometime_o near_o a_o hour_n and_o a_o half_a before_o it_o have_v its_o full_a effect_n but_o the_o time_n of_o its_o operation_n have_v a_o considerable_a latitude_n according_a to_o the_o disposition_n of_o the_o stomach_n and_o other_o circumstance_n as_o the_o vehicle_n it_o be_v take_v in_o etc._n etc._n the_o constant_a effect_n of_o opium_n use_v internal_o in_o a_o moderate_a do_v 1._o it_o cause_v a_o most_o agreeable_a pleasant_a and_o charm_a sensation_n about_o the_o region_n of_o the_o stomach_n which_o if_o one_o lie_v or_o sit_v still_o diffuse_v itself_o in_o a_o kind_n of_o indefinite_a manner_n seizing_z one_o not_o unlike_o the_o gentle_a sweet_a deliquium_fw-la that_o we_o find_v upon_o our_o entrance_n into_o a_o most_o agreeable_a slumber_n which_o upon_o yield_v to_o it_o general_o end_v in_o sleep_n but_o if_o the_o person_n keep_v himself_o in_o action_n discourse_n or_o business_n it_o seem_v especial_o when_o give_v in_o a_o mornning_a after_o a_o moderate_a rest_n at_o night_n like_o a_o most_o delicious_a and_o extraordinary_a refreshment_n of_o the_o spirit_n upon_o very_o good_a news_n or_o any_o other_o great_a cause_n of_o joy_n as_o the_o sight_n of_o a_o dear_o belove_a person_n etc._n etc._n thought_n to_o have_v be_v lose_v at_o sea_n or_o the_o like_a cause_v such_o a_o pleasant_a ovation_n of_o the_o spirit_n serenity_n etc._n etc._n as_o we_o find_v after_o a_o competent_a measure_n of_o generous_a wine_n ad_fw-la hilaritatem_fw-la as_o man_n use_v to_o say_v it_o be_v indeed_o so_o unexpressible_o fine_a and_o sweet_a a_o pleasure_n that_o it_o be_v very_o difficult_a for_o i_o to_o describe_v or_o any_o to_o conceive_v it_o but_o such_o as_o actual_o feel_v it_o for_o it_o be_v as_o if_o a_o good_a genius_n possess_v or_o inform_v a_o man_n therefore_o people_n do_v common_o call_v it_o a_o heavenly_a condition_n as_o if_o no_o worldly_a pleasure_n be_v to_o be_v compare_v with_o it_o helmontianus_fw-la will_v doubtless_o express_v it_o by_o the_o archaeus_n in_o his_o very_a best_a humour_n it_o have_v be_v compare_v not_o without_o good_a cause_n to_o a_o permanent_a gentle_a degree_n of_o that_o pleasure_n which_o modesty_n forbid_v the_o name_n of_o and_o it_o be_v well_o worth_a a_o remark_n that_o both_o be_v pleasure_n of_o the_o same_o sense_n viz._n that_o of_o feel_v for_o it_o can_v be_v a_o pleasure_n of_o any_o other_o sense_n since_o it_o be_v internal_a 2._o it_o cause_v a_o brisk_a gay_a and_o good_a humour_n nor_o do_v i_o doubt_v but_o it_o have_v this_o effect_n upon_o sleep_a person_n as_o far_o as_o their_o condition_n be_v capable_a of_o observe_v it_o for_o you_o shall_v have_v they_o often_o tell_v of_o pleasant_a dream_n after_o it_o when_o they_o remember_v they_o and_o speak_v of_o any_o see_v bauchin_n and_o the_o author_n mention_v below_o under_o the_o four_o effect_n of_o opium_n 3._o it_o cause_v promptitude_n serenity_n alacrity_n and_o expediteness_n in_o dispatch_v and_o manage_n of_o business_n to_o which_o end_n and_o that_o of_o a_o good_a and_o gay_a humour_n which_o be_v near_o of_o kind_n it_o be_v common_o take_v in_o the_o morning_n in_o the_o eastern_a country_n with_o most_o certain_a effect_n the_o truth_n of_o which_o wedelius_n be_v force_v to_o confess_v though_o quite_o contrary_a to_o his_o hypothesis_n of_o opium_n fix_v and_o coagulate_v the_o spirit_n give_v a_o instance_n of_o a_o certain_a serene_a person_n who_o when_o she_o have_v any_o affair_n of_o great_a moment_n to_o dispatch_v do_v beforehand_o take_v opium_n with_o great_a advantage_n for_o she_o thereby_o find_v herself_o every_o way_n better_o dispose_v for_o business_n and_o more_o enable_v to_o bear_v the_o fatigue_n thereof_o which_o be_v the_o substance_n of_o what_o he_o write_v in_o latin_n many_o other_o author_n confirm_v the_o truth_n of_o these_o effect_n but_o above_o all_o the_o constant_a experience_n of_o the_o eastern_a nation_n put_v it_o out_o of_o all_o doubt_n 4._o it_o cause_v assurance_n ovation_n of_o the_o spirit_n courage_n contempt_n of_o danger_n and_o magnanimity_n much_o after_o the_o manner_n that_o generous_a wine_n do_v instead_o of_o which_o the_o turk_n etc._n etc._n use_v opium_n before_o engagement_n desperate_a attack_n etc._n etc._n as_o be_v most_o notorious_a to_o make_v they_o courageous_a which_o it_o certain_o do_v for_o your_o satisfaction_n as_o to_o this_o and_o other_o effect_n of_o opium_n not_o so_o common_o observe_v
often_o cause_v most_o dismal_a and_o tedious_a vomit_n and_o when_o they_o fall_v to_o relieve_v by_o reject_v the_o grieve_v matter_n hiccough_v anxiety_n distress_n syncopes_fw-la and_o sometime_o fatal_a succumbency_n nature_n and_o all_o endeavour_n fail_v to_o work_v any_o far_o for_o the_o animal_n relief_n these_o thing_n happen_v most_o common_o when_o indigeslible_a rosin_n stick_v to_o the_o stomach_n especial_o if_o they_o be_v join_v with_o any_o pungent_a volatile_a or_o acrimonious_a particle_n hence_o it_o be_v that_o resinous_n vomit_n be_v quite_o banish_v out_o of_o the_o practice_n of_o physic_n and_o it_o be_v well_o if_o resinous_n purger_n be_v so_o also_o especial_o such_o as_o have_v considerable_a acrimony_n unless_o give_v with_o the_o yolk_n of_o a_o egg_n lixivial_n or_o in_o tincture_n with_o spirituous_a thing_n to_o keep_v the_o resinous_n particle_n from_o coalescence_n and_o adhere_v to_o the_o stomach_n etc._n etc._n 1._o note_v for_o we_o shall_v have_v some_o occasion_n for_o it_o that_o resinous_n thing_n join_v with_o volatile_a irritate_v particle_n have_v all_o the_o ill_a quality_n aforemention_v viz._n hardness_n of_o digestion_n aptitude_n to_o stick_v to_o the_o stomach_n and_o volatile_a particle_n to_o irritate_fw-la and_o tear_v its_o coat_n all_o the_o time_n they_o so_o stick_v to_o it_o and_o therefore_o such_o thing_n have_v dismal_a effect_n especial_o in_o weak_a stomach_n that_o can_v digest_v they_o 2._o note_v that_o the_o distress_n at_o stomach_n cause_v by_o a_o grievous_a sensation_n be_v of_o two_o sort_n 1._o such_o as_o be_v the_o endeavour_n of_o nature_n or_o the_o sensitive_a soul_n in_o defence_n of_o the_o animal_n as_o all_o vomit_n purge_n convulsion_n hiccough_n throw_n struggle_n agitation_n contraction_n watch_n etc._n etc._n which_o be_v accompany_v with_o melancholy_a fretfulness_n ill_a humour_n etc._n etc._n because_o of_o the_o grievance_n 2._o such_o as_o follow_v the_o yield_v and_o succumbency_n of_o nature_n or_o the_o sensitive_a soul_n after_o be_v tire_v and_o overbear_v by_o the_o fatigue_n of_o defensive_a contraction_n as_o faint_n distress_n agony_n syncopes_fw-la and_o leipothymy_n 3._o note_v that_o syncopes_fw-la or_o leipothymy_n be_v cause_v by_o the_o sensitive_a soul_n be_v overbear_v as_o be_v say_v tire_v and_o spend_v and_o give_v over_o his_o fruitless_a contraction_n defensive_a and_o vigilative_a upon_o a_o sudden_a as_o be_v to_o no_o purpose_n as_o he_o do_v gentle_o and_o gradual_o give_v over_o vigilative_a contraction_n to_o cause_n sleep_n so_o that_o syncopes_fw-la be_v only_o great_a sudden_a and_o more_o absolute_a dereliction_n of_o the_o whole_a concern_v of_o contraction_n hence_o it_o be_v that_o perspiration_n be_v great_a in_o syncopes_fw-la or_o leipothymy_n than_o in_o sleep_n the_o laxity_n of_o the_o cornea_n and_o the_o whole_a body_n great_a the_o feel_v less_o or_o quite_o go_v that_o all_o motion_n become_v much_o slow_a or_o none_o by_o the_o want_n of_o compression_n of_o the_o animal_n spirit_n and_o dismal_a dereliction_n of_o all_o contraction_n by_o the_o sensitive_a soul_n hence_o it_o be_v that_o all_o the_o effect_n of_o sleep_n be_v yet_o great_a in_o syncopes_fw-la 4._o note_v that_o therefore_o it_o seem_v all_o the_o difference_n between_o sleep_n and_o a_o leipothymy_n be_v that_o in_o this_o the_o sensitive_a soul_n quite_o throw_v the_o reins_o of_o contraction_n away_o and_o in_o sleep_n keep_v hold_v thereof_o and_o only_o let_v they_o loose_a and_z as_o refection_n be_v make_v straighten_v they_o more_o and_o more_o till_o they_o come_v to_o the_o degree_n of_o vigilative_a contraction_n which_o perfect_o awake_v they_o therefore_o sleep_n grow_v slight_a towards_o morning_n because_o contraction_n gradual_o come_v on_o here_o you_o may_v see_v but_o i_o must_v stop_v lest_o i_o run_v too_o far_o why_o every_o thing_n that_o cause_v contraction_n of_o the_o sensile_a part_n as_o pain_n and_o all_o grievance_n be_v apt_a to_o awake_a people_n and_o keep_v they_o so_o as_o relaxer_n cause_v sleep_n and_o continue_v it_o 5._o note_v that_o though_o i_o have_v particular_o speak_v of_o the_o somach_n as_o be_v most_o concern_v and_o the_o best_a example_n of_o any_o membrane_n yet_o do_v not_o i_o exclude_v any_o membrane_n from_o be_v capable_a of_o pleasure_n by_o the_o like_a thing_n as_o for_o the_o effect_n of_o pleasure_n upon_o the_o sensitive_a soul_n i_o have_v upon_o several_a occasion_n say_v or_o intimate_v enough_o concern_v they_o and_o even_o the_o vulgar_a know_v that_o pleasure_n or_o be_v please_v make_v people_n good_a and_o gay_a humour_a that_o it_o elevate_v the_o spirit_n raise_v courage_n as_o wine_n do_v and_o enable_v every_o animal_n to_o labour_n or_o travel_v the_o better_a as_o horse_n by_o the_o sound_n of_o bell_n especial_o if_o tuneable_a and_o in_o company_n with_o another_o horse_n that_o they_o have_v a_o kindness_n for_o how_o soldier_n march_v more_o easy_o with_o merry_a comrade_n that_o be_v full_a of_o jest_n and_o pleasant_a story_n or_o with_o drum_n trumpets_z kettle_z drums_z 〈◊〉_d and_o other_o music_n that_o please_v the_o ear_n how_o much_o more_o briâ—k_n and_o blithe_a be_v we_o in_o a_o fair_a sunshine_n which_o please_v the_o eye_n than_o at_o other_o time_n some_o â—ink_n according_a to_o the_o vulgar_a error_n that_o iâ—_n be_v the_o goodness_n of_o the_o air_n do_v it_o but_o it_o be_v plain_o otherwise_o for_o you_o find_v the_o change_n most_o remarkable_a in_o yourself_o just_a upon_o go_v out_o of_o door_n into_o the_o sunshine_n whereas_o you_o have_v the_o same_o air_n in_o your_o chamber_n nor_o be_v that_o fine_a lightness_n of_o humour_n to_o be_v find_v if_o it_o be_v cloudy_a though_o the_o air_n be_v better_o as_o may_v be_v observe_v by_o the_o barometer_n and_o other_o weather-glass_n nor_o in_o the_o night_n time_n nor_o where_o the_o sun_n do_v not_o come_v nor_o be_v blind_a people_n so_o affect_v therefore_o it_o be_v the_o pleasure_n of_o the_o bright_a sunshine_n that_o cause_v it_o if_o mean_a 'slight_o transient_a and_o external_n pleasure_n cause_v such_o effect_n how_o much_o more_o than_o will_v a_o intense_a internal_a and_o continue_a pleasure_n upon_o the_o most_o exquisite_o dispose_v part_n for_o sensation_n of_o all_o the_o whole_a body_n which_o be_v main_o design_v for_o those_o purpose_n of_o please_a and_o comfort_v to_o invite_v we_o to_o nourish_v ourselves_o and_o to_o satisfy_v the_o grievous_a sensation_n of_o hunger_n and_o thirst_n by_o the_o pleasure_n of_o meat_n and_o drink_n such_o pleasant_a effect_n thus_o the_o fretfulness_n peevishness_n ill_a humour_n melancholy_n pusillanimity_n inaptitude_n and_o listnesness_n that_o attend_v the_o grievous_a sensation_n of_o hunger_n be_v take_v off_o and_o cure_v by_o the_o pleasant_a sensation_n that_o a_o good_a meal_n or_o some_o glass_n of_o wine_n do_v cause_n hence_o it_o be_v that_o we_o can_v sleep_v when_o hungry_a because_o grievous_a sensation_n contract_v the_o sensile_a part_n and_o be_v apt_a to_o it_o after_o meal_n the_o pleasure_n of_o which_o relax_n we_o if_o we_o sit_v or_o lie_v quiet_o and_o silent_o but_o if_o we_o do_v not_o we_o be_v more_o lively_a and_o fit_a for_o business_n instance_n of_o this_o kind_a be_v so_o numerous_a and_o notorious_a that_o i_o need_v say_v no_o more_o of_o the_o effect_n of_o pleasure_n in_o cause_v a_o good_a humour_n elevation_n of_o the_o spirit_n satisfaction_n content_a composure_n etc._n etc._n be_v it_o possible_a that_o one_o shall_v be_v high_o please_v and_o not_o take_v comfort_n therein_o take_v comfort_n and_o not_o be_v elevate_v in_o spirit_n well_o satisfy_v and_o content_v therefore_o it_o be_v strange_a and_o very_o strange_a that_o people_n shall_v leave_v wine_n cordial_n meat_n spirit_n etc._n etc._n actual_o and_o sensible_o please_v satisfy_a and_o comfort_v we_o at_o stomach_n where_o there_o be_v a_o membrane_n most_o exquisite_o dispose_v for_o sensation_n and_o run_v after_o fume_n and_o effluvias_fw-la that_o be_v never_o in_o our_o case_n in_o be_v to_o the_o brain_n or_o blood_n that_o have_v no_o sense_n to_o entertain_v they_o and_o consequent_o can_v receive_v no_o sensible_a comfort_n by_o they_o if_o this_o be_v not_o seek_v a_o needle_n in_o a_o bottle_n of_o hay_n where_o it_o never_o be_v when_o it_o stick_v most_o sensible_o in_o their_o finger_n nothing_o be_v we_o shall_v think_v it_o a_o strange_a ridiculous_a action_n in_o a_o child_n or_o natural_a fool_n but_o great_a be_v the_o privilege_n and_o authority_n of_o the_o learned_a so_o much_o may_v suffice_v as_o to_o the_o effect_n of_o pleasure_n upon_o the_o sensitive_a soul_n as_o for_o the_o effect_n of_o pleasure_n upon_o the_o body_n it_o be_v relaxation_n of_o all_o the_o sensile_a part_n thereof_o as_o appear_v 1._o because_o it_o be_v contrary_a viz._n displeasure_n or_o sensitive_a
be_v repute_v opiate_n borellus_n speak_v of_o a_o soporiferous_a aura_n that_o proceed_v from_o one_o thumb_n cure_v by_o a_o caustick_a i_o have_v read_v of_o a_o cataphora_fw-it from_o worm_n a_o soporiferous_a fume_v from_o the_o womb_n and_o very_o many_o such_o sort_n of_o instance_n which_o thing_n be_v now_o easy_o conceive_v for_o it_o be_v but_o suppose_v a_o fume_v of_o the_o nature_n of_o sem._n animale_a or_o its_o aura_n for_o i_o can_v no_o long_o doubt_v but_o it_o be_v a_o opiate_n and_o it_o will_v have_v much_o the_o same_o effect_n with_o opium_n if_o it_o be_v fit_a to_o use_v it_o after_o the_o same_o manner_n have_v show_v 1._o which_o be_v the_o predominant_a active_a principle_n in_o opium_n and_o how_o combine_v etc._n etc._n 2._o which_o of_o they_o produce_v the_o usual_a and_o laudable_a effect_n of_o opium_n and_o why_o in_o general_a i_o come_v now_o to_o the_o three_o particular_a viz._n to_o show_v iii_o which_o of_o they_o produce_v its_o ill_a effect_n and_o why_o it_o be_v ill_a effect_n be_v these_o viz._n nauseas_fw-la vomit_n which_o be_v general_o very_o dismal_a with_o great_a distress_n and_o sometime_o dangerous_a swim_v in_o the_o head_n hiccough_n distress_n anxiety_n convulsion_n faint_n leipothymy_n syncopes_fw-la etc._n etc._n 1._o note_v that_o its_o grievous_a effect_n be_v at_o or_o about_o the_o region_n of_o the_o stomach_n or_o particular_o the_o mouth_n or_o pit_n thereof_o or_o thence_o arise_v by_o consent_n 2._o note_v that_o see_v there_o be_v nothing_o so_o good_a but_o may_v cause_v evil_a effect_n in_o a_o excessive_a quantity_n this_o enquiry_n be_v more_o proper_o what_o principle_n or_o principle_n of_o opium_n do_v cause_n those_o ill_a effect_n in_o a_o ordinary_a do_v for_o what_o will_v in_o a_o moderate_a do_v will_v be_v sure_a cause_v they_o in_o a_o excessive_a do_v 3._o note_v that_o all_o the_o constant_a effect_n of_o opium_n as_o you_o may_v observe_v in_o the_o enumeration_n thereof_o in_o the_o four_o chapter_n be_v good_a and_o laudable_a effect_n it_o follow_v therefore_o that_o the_o bad_a be_v accidental_a 1._o it_o be_v not_o the_o earthy_a or_o phlegmatic_a part_n of_o opium_n that_o cause_v those_o ill_a effect_n because_o they_o be_v passive_a principle_n and_o consequent_o have_v not_o such_o a_o power_n beside_o that_o they_o be_v know_v to_o be_v innocent_a 2._o opium_n have_v all_o those_o ill_a effect_n when_o both_o the_o earthy_a and_o phlegmatic_a part_n be_v separate_v from_o it_o as_o when_o a_o extract_v of_o well_o torrefy_v opium_n be_v make_v in_o spirit_n of_o wine_n for_o by_o that_o mean_v the_o phlegmatic_a part_n be_v dry_v up_o and_o the_o earthy_a part_n subside_o and_o be_v separate_v yea_o such_o extract_v make_v by_o spirit_n of_o wine_n do_v cause_n those_o evil_a effect_n rather_o more_o than_o crude_a opium_n with_o its_o earth_n and_o phlegm_n in_o it_o as_o experience_n assure_v we_o and_o reason_n will_v plain_o confirm_v by_o and_o by_o however_o fond_a the_o world_n be_v of_o such_o preparation_n 3._o it_o be_v evident_a from_o the_o premise_n that_o the_o sal-volatile-oleosum_a of_o opium_n can_v cause_v those_o vomit_n hiccough_n etc._n etc._n for_o they_o be_v the_o effect_n of_o grievous_a sensation_n at_o stomach_n but_o the_o sal-volatile-oleosum_a cause_n a_o most_o agreeable_a and_o please_a sensation_n at_o stomach_n 4._o nothing_o quiet_v vomit_n convulsion_n â—coughs_n etc._n etc._n more_o than_o that_o sal-volatile-oleosum_a of_o opium_n 5._o experience_n inform_v we_o that_o the_o sal-volatile-oleosum_a of_o opium_n separate_v from_o all_o other_o part_n and_o principle_n thereof_o never_o cause_v such_o evil_a effect_n as_o i_o and_o another_o physician_n in_o london_n can_v testify_v as_o do_v also_o le_fw-fr mort_fw-fr in_o the_o most_o learned_a dr._n love_n collectanea_fw-la where_o he_o say_v of_o such_o a_o preparation_n thereof_o as_o contain_v only_o the_o sal-volatile-oleosum_a that_o nunquam_fw-la anxietates_fw-la circa_fw-la praecordia_fw-la aut_fw-la phantasias_fw-la conciliat_fw-la that_o be_v it_o never_o cause_v anxiety_n about_o the_o mouth_n of_o the_o stomach_n etc._n etc._n for_o that_o be_v most_o proper_o to_o be_v understand_v by_o praecordia_fw-la wedelius_n testify_v the_o like_a of_o such_o another_o preparation_n and_o so_o do_v several_a author_n though_o they_o do_v not_o in_o the_o least_o know_v why_o but_o only_o by_o experience_n 6._o it_o be_v fix_v salt_n be_v innocent_a in_o its_o nature_n and_o but_o the_o 32d_o part_n of_o opium_n which_o be_v too_o inconsiderable_a in_o a_o ordinary_a moderate_a do_v to_o cause_v any_o sensible_a effect_n it_o follow_v therefore_o that_o be_v must_v be_v the_o resinous_n part_n of_o opium_n which_o it_o have_v in_o a_o considerable_a quantity_n that_o must_v cause_v those_o ill_a effect_n this_o manifest_o appear_v 1._o because_o a_o tincture_n of_o opiam_fw-la in_o water_n which_o take_v up_o none_o of_o the_o rosin_n but_o let_v it_o fall_v into_o the_o bottom_n never_o cause_v any_o such_o ill_a effect_n which_o it_o do_v not_o also_o if_o reduce_v to_o a_o extract_v by_o evaporation_n yet_o have_v they_o all_o the_o usual_a good_a effect_n of_o opium_n 2._o wedelius_n in_o his_o opiolog_n assure_v the_o same_o of_o the_o like_a preparation_n in_o phlegm_n of_o distil_a vinegar_n l._n 2._o sect._n 1_o c._n 5._o p._n 92._o 3._o a_o extract_v of_o opium_n in_o spirit_n of_o wine_n do_v often_o cause_v those_o ill_a effect_n and_o no_o other_o preparation_n cause_v they_o as_o often_o wedelius_n ibid._n a_o laudano_n opiato_fw-it cum_fw-la spiritu_fw-la vini_n correcto_fw-la solum_fw-la ferâ—_n observavimus_fw-la ortos_fw-la vomitus_fw-la a_o nostro_fw-la vero_fw-la quod_fw-la cum_fw-la phlegmate_fw-it aceti_fw-la distillati_fw-la fieri_fw-la diximus_fw-la nunquam_fw-la vomitum_fw-la vel_fw-la nauseam_fw-la saltem_fw-la contigisse_fw-la meminimus_fw-la that_o be_v we_o have_v observe_v vomit_n almost_o only_o from_o laudanum_n prepare_v with_o spirit_n of_o wine_n but_o never_o any_o vomit_v or_o nausea_n from_o that_o prepare_v in_o phlegm_n of_o distil_a vinegar_n which_o he_o confirm_v l._n 1._o sect_n 2._o c._n 4._o p._n 62._o saying_n in_o latin_a that_o a_o curious_a observation_n be_v to_o be_v note_v by_o which_o it_o appear_v that_o a_o extract_v of_o opium_n with_o spirit_n of_o wine_n show_v more_o narcotick_a force_n by_o which_o he_o mean_v that_o it_o cause_v more_o ill_a effect_n than_o prepare_v in_o distil_a vinegar_n whereas_o that_o in_o spirit_n of_o wine_n have_v nothing_o more_o in_o it_o than_o that_o in_o vinegar_n beside_o the_o râ—sinous_n part_n therefore_o these_o do_v cause_n all_o the_o mischief_n note_v also_o that_o a_o extract_v in_o spirit_n of_o wine_n have_v in_o it_o quantity_n for_o quantity_n more_o of_o the_o râ—sinous_n part_v than_o crude_a oplum_fw-la both_o because_o the_o earthy_a part_n that_o help_v to_o make_v up_o the_o bulk_n be_v take_v away_o in_o that_o preparation_n and_o because_o the_o 〈◊〉_d of_o wine_n imbibe_v the_o rosin_n more_o greedy_o than_o other_o principle_n of_o the_o opium_n so_o that_o every_o do_v must_v in_o proportion_n have_v much_o more_o rosin_n in_o it_o than_o crude_a opium_n therefore_o it_o be_v no_o wonder_n that_o it_o cause_v those_o ill_a effect_n more_o frequent_o since_o the_o rosin_n be_v most_o certain_o the_o cause_n thereof_o as_o have_v be_v and_o shall_v be_v more_o full_o and_o beyond_o all_o contradiction_n prove_v yet_o be_v this_o the_o preparation_n boast_v of_o by_o the_o blind_a and_o inadvertent_n world_n it_o will_v amaze_v nay_o terrify_v a_o man_n to_o see_v what_o great_a care_n be_v take_v to_o be_v sure_a to_o render_v opium_n mischievous_a by_o solicitous_o use_v spirit_n of_o wine_n in_o extract_a laudanum_n and_o then_o and_o not_o till_o then_o they_o boast_v of_o the_o preparation_n as_o charas_fw-la and_o very_o many_o other_o do_v calling_z it_o not_o without_o great_a ostentation_n and_o desperate_a folly_n their_o laudanum_n may_v it_o be_v they_o and_o none_o other_o a_o turk_n will_v be_v a_o madman_n to_o use_v it_o for_o crude_a opium_n because_o it_o have_v much_o more_o of_o the_o pernicious_a principle_n in_o it_o it_o be_v the_o common_a and_o much_o esteem_v way_n first_o to_o extract_v it_o out_o of_o water_n and_o then_o it_o be_v very_o good_a laudable_a and_o innocent_a but_o think_v nothing_o worth_a till_o they_o extract_v the_o rosin_n that_o be_v all_o leave_v behind_o by_o the_o water_n in_o spirit_n of_o wine_n and_o add_v it_o to_o the_o other_o then_o do_v they_o with_o great_a authority_n praise_v it_o that_o be_v when_o they_o have_v wise_o add_v the_o poison_n to_o the_o panacea_fw-la it_o be_v as_o if_o they_o add_v ratsbane_n to_o a_o cordial_n and_o not_o think_v the_o cordial_a worthy_a commendation_n till_o they_o have_v do_v so_o 4._o it_o appear_v that_o the_o rosin_n be_v
and_o motion_n fail_v together_o of_o the_o great_a perspiration_n and_o all_o other_o effect_n of_o relaxation_n in_o such_o syncopes_fw-la or_o leipothymy_n in_o a_o yet_o high_o degree_n than_o in_o sleep_n wherein_o the_o sensitive_a soul_n do_v not_o quite_o let_v go_v the_o reign_v of_o contraction_n as_o appear_v by_o the_o motion_n that_o remain_v as_o of_o the_o heart_n intestine_n etc._n etc._n though_o far_o more_o remiss_a in_o sleep_n than_o in_o a_o wake_v state_n note_v that_o such_o leipothymy_n be_v as_o be_v hint_v of_o the_o same_o nature_n as_o sleep_n be_v but_o that_o they_o be_v sudden_a more_o profound_a and_o not_o so_o usual_a natural_a and_o of_o course_n as_o sleep_n be_v which_o make_v they_o more_o amaze_a and_o surprise_v therefore_o it_o follow_v that_o they_o be_v as_o sleep_n be_v a_o mean_n of_o recruit_v when_o all_o work_n and_o tug_v by_o defensive_a contraction_n fail_v and_o so_o the_o last_o refuge_n of_o the_o sensitive_a soul_n when_o overtired_n in_o order_n to_o recover_v strength_n for_o a_o fresh_a engagement_n with_o the_o enemy_n as_o be_v tire_v at_o night_n the_o sensitive_a soul_n loosen_v the_o rign_n of_o contraction_n to_o enable_v he_o the_o better_a to_o fall_v to_o his_o work_n the_o next_o day_n this_o you_o will_v find_v by_o all_o reason_n and_o experience_n to_o be_v the_o true_a state_n of_o leipothymy_n upon_o grievance_n and_o fatigue_n though_o not_o hitherto_o mind_v that_o i_o know_v of_o many_o true_a and_o useful_a consequence_n do_v hence_o follow_v as_o that_o we_o be_v not_o always_o to_o disturb_v they_o or_o put_v they_o out_o of_o these_o recruit_v leipothymy_n by_o grievous_a mean_n as_o pricking_n pinch_n etc._n etc._n but_o only_o by_o cordial_n and_o refresh_a thing_n as_o you_o will_v treat_v a_o person_n much_o tire_v or_o by_o let_v they_o take_v their_o nap_n if_o i_o may_v so_o call_v it_o if_o there_o be_v not_o very_o eminent_a danger_n but_o it_o be_v endless_a and_o beside_o my_o purpose_n to_o make_v a_o particular_a discourse_n of_o this_o matter_n which_o will_v belong_v more_o proper_o to_o my_o tract_n of_o animal_n mechanism_n 14._o death_n happen_v sometime_o though_o very_o rare_o and_o that_o in_o very_o weak_a people_n that_o take_v little_a or_o no_o sustenance_n because_o either_o when_o fall_v into_o such_o syncopes_fw-la they_o never_o come_v out_o of_o they_o by_o reason_n that_o they_o have_v not_o within_o they_o wherewith_o to_o recruit_v their_o spirit_n or_o that_o opium_n take_v they_o much_o spend_v and_o tire_v with_o distemper_n cause_n as_o in_o weak_a and_o weary_a people_n a_o most_o profound_a sopor_fw-la which_o not_o recruit_v they_o who_o take_v or_o digest_v no_o sustenance_n they_o must_v rather_o grow_v weak_a and_o weak_a for_o somewhat_o be_v spend_v while_o we_o live_v and_o consequent_o the_o sleep_n or_o sopor_fw-la more_o and_o more_o profound_a till_o they_o sleep_v their_o last_o for_o want_v of_o some_o recruit_v which_o be_v the_o very_a thing_n that_o natural_o lessen_v sleep_n and_o awake_v we_o when_o there_o be_v no_o other_o apparent_a cause_n for_o as_o the_o be_v tire_v and_o want_v of_o recruit_v cause_n sleep_v so_o the_o have_v it_o cause_v wake_v or_o which_o be_v the_o same_o in_o effect_n no_o far_o need_v of_o relaxation_n for_o recruit_n sake_n so_o that_o the_o sensitive_a soul_n fall_v to_o his_o useful_a work_n of_o vigilative_a contraction_n for_o sense_n and_o motion_n sake_n 15._o it_o sometime_o cause_n purge_v which_o happen_v as_o far_o as_o i_o have_v observe_v or_o can_v learn_v only_o when_o it_o be_v give_v in_o a_o good_a quantity_n to_o person_n of_o a_o strong_a digestion_n or_o canine_a appetite_n the_o case_n be_v thus_o when_o person_n that_o be_v of_o a_o strong_a digestion_n take_v a_o resinous_n opiate_n in_o good_a quantity_n they_o do_v in_o great_a measure_n by_o their_o fix_a salt_n at_o stomach_n and_o strong_a digestion_n subdue_v the_o volatility_n of_o the_o opium_n and_o dissolve_v its_o rosin_n which_o then_o as_o acrimonious_a rosin_n or_o vomit_n subdue_v by_o fix_a salt_n use_v to_o do_v cause_v purge_v hence_o it_o be_v that_o it_o general_o if_o not_o always_o purge_v dog_n and_o people_n of_o a_o high_a canine_a appetite_n and_o that_o sometime_o meet_v such_o fix_a salt_n it_o purge_v the_o consumptive_a bartholine_n say_v that_o mandrake_n juice_n purge_v when_o it_o meet_v with_o acrimonious_a fix_a salt_n erastus_n and_o quercelan_n do_v agree_v that_o it_o have_v a_o purgative_n quality_n but_o that_o it_o do_v not_o always_o exert_v it_o 1._o because_o it_o take_v away_o the_o sense_n of_o irritation_n 2._o because_o it_o be_v give_v in_o too_o small_a a_o quantity_n the_o reason_n be_v just_a and_o right_a and_o not_o only_o consistent_a with_o but_o confirm_v what_o i_o say_v note_v that_o this_o be_v not_o intend_v of_o the_o purge_v that_o happen_v after_o the_o declination_n of_o its_o operation_n which_o be_v as_o you_o will_v find_v from_o another_o cause_n therefore_o this_o do_v not_o smell_v of_o the_o opium_n as_o the_o other_o do_v because_o it_o be_v past_a and_o go_v before_o that_o in_o the_o declination_n happen_v of_o which_o more_o in_o its_o proper_a place_n 16._o it_o raise_v and_o revive_v some_o person_n that_o be_v almost_o expire_a in_o two_o case_n one_o be_v when_o such_o as_o have_v be_v use_v to_o take_v it_o be_v even_o expire_a for_o want_n of_o it_o of_o which_o more_o hereafter_o the_o other_o case_n be_v when_o violent_a contraction_n as_o from_o pain_n cold_a vomit_n and_o grievous_a passion_n as_o terror_n etc._n etc._n be_v the_o cause_n that_o people_n be_v almost_o expire_a for_o it_o take_v off_o the_o contraction_n by_o relax_v etc._n etc._n 17._o it_o stay_v very_o long_o at_o stomach_n when_o the_o rosin_n thereof_o stick_v to_o the_o stomach_n and_o be_v there_o detain_v beside_o that_o the_o stomach_n be_v relax_v and_o have_v little_a sense_n or_o motion_n as_o in_o sleep_n do_v not_o soon_o digest_v it_o or_o discharge_v it_o it_o be_v fine_a in_o this_o case_n and_o all_o other_o to_o observe_v how_o sensation_n and_o motion_n go_v hand_n in_o hand_n keep_v equal_a pace_n and_o equal_a proportion_n as_o it_o plain_o must_v be_v by_o the_o principle_n of_o relaxation_n and_o contraction_n which_o i_o have_v state_v and_o prove_v 18._o it_o cause_v stoppage_n of_o urine_n sometime_o especial_o in_o old_a people_n by_o over_o relax_v and_o cause_v a_o kind_n of_o a_o temporary_a palsy_n of_o the_o bladder_n as_o be_v show_v and_o take_v away_o the_o sense_n of_o the_o irritation_n of_o the_o urine_n which_o shall_v contract_v the_o bladder_n to_o squeeze_v it_o out_o by_o which_o mean_v it_o happen_v sometime_o that_o the_o bladder_n come_v to_o be_v so_o over_o extend_v beyond_o its_o due_a tone_n that_o they_o can_v contract_v it_o to_o make_v water_n in_o all_o which_o case_n strong_a contracter_n as_o cold_a terror_n etc._n etc._n immediate_o cure_v they_o the_o very_a put_v the_o scrotum_fw-la to_o the_o edge_n of_o a_o cold_a chamberpot_n have_v effect_v it_o several_a time_n by_o my_o advice_n though_o if_o need_v be_v you_o must_v come_v to_o dash_v of_o cold_a water_n upon_o the_o region_n of_o the_o bladder_n or_o pump_v on_o it_o or_o dip_v in_o it_o etc._n etc._n so_o terror_n and_o cause_v a_o very_a smart_n pain_n especial_o near_o those_o part_n will_v do_v much_o but_o cold_a be_v the_o ready_a and_o best_a remedy_n 19_o it_o sometime_o prove_v dangerous_a after_o great_a hemorrbage_n or_o evacuation_n as_o tapping_n in_o dropsy_n etc._n etc._n because_o the_o relaxation_n hinder_v the_o part_n due_o to_o contract_v upon_o what_o remain_v which_o may_v cause_v great_a mischief_n as_o discontinuation_n of_o motion_n etc._n etc._n thus_o have_v you_o all_o the_o constant_a frequent_a and_o rare_a effect_n of_o opium_n take_v internal_o in_o a_o moderate_a do_v so_o natural_o easy_o plain_o and_o mechanical_o explicate_v that_o people_n may_v in_o my_o judgement_n more_o admire_v how_o all_o fail_v of_o discover_v the_o manner_n of_o their_o production_n than_o that_o i_o find_v it_o as_o man_n be_v apt_a to_o think_v of_o the_o circulation_n of_o the_o blood_n which_o now_o as_o i_o hope_v the_o effect_n of_o opium_n do_v seem_v very_o obvious_a both_o which_o case_n be_v to_o i_o very_o strong_a argument_n of_o a_o be_v that_o rule_n and_o dispose_n darken_v and_o illuminate_v etc._n etc._n as_o he_o please_v when_o i_o consider_v that_o both_o the_o circulation_n of_o the_o blood_n and_o the_o cause_n of_o the_o operation_n of_o opium_n viz._n pleasure_n at_o stomach_n etc._n etc._n fall_v under_o the_o sense_n of_o many_o million_o who_o in_o one_o case_n see_v the_o blood_n move_v and_o in_o the_o other_o feel_v
which_o look_v not_o unlike_o a_o apoplexy_n make_v author_n say_v that_o opium_n cause_v apoplexy_n such_o as_o escape_v death_n do_v so_o general_o by_o 34._o plentiful_a purge_v which_o be_v occasion_v by_o a_o great_a quantity_n of_o the_o rosin_n of_o opium_n meet_v a_o strong_a digestion_n and_o fix_a salt_n as_o have_v beeâ—_n say_v 35._o sweat_v that_o smell_n of_o the_o opium_n be_v cause_v 1._o by_o the_o openness_n of_o the_o pore_n by_o relaxation_n 2._o by_o plenty_n or_o at_o least_o sufficiency_n of_o moisture_n for_o that_o end_n for_o otherwise_o as_o be_v show_v it_o will_v be_v only_o insensible_a perspiration_n 3._o by_o the_o great_a quantity_n of_o volatile_a salt_n attenuate_v the_o humour_n 4._o by_o the_o strict_a intimate_a and_o even_o indissoluble_a specific_a union_n or_o combination_n of_o the_o volatile_a salt_n and_o oily_a part_n which_o make_v it_o hold_v its_o specific_a smell_n to_o the_o last_o 36._o violent_a itch_n in_o the_o skin_n must_v of_o necessity_n follow_v a_o great_a quantity_n of_o opium_n since_o it_o cause_v such_o itch_n as_o be_v show_v in_o a_o small_a quantity_n by_o the_o titillation_n of_o its_o volatile_a salt_n note_v that_o these_o effect_n do_v not_o all_o happen_v to_o all_o man_n that_o take_v it_o in_o a_o excessive_a do_v but_o some_o to_o one_o and_o some_o to_o other_o as_o be_v intimate_v in_o chap._n 5._o according_a as_o they_o be_v more_o or_o less_o trouble_v with_o the_o rosin_n quantity_n relaxation_n etc._n etc._n chap._n xxii_o the_o explication_n of_o the_o effect_n of_o a_o long_a and_o lavish_a use_n of_o opium_n as_o a_o excessive_a do_v of_o opium_n be_v intemperance_n for_o one_o time_n so_o a_o long_a and_o lavish_a use_n of_o it_o be_v a_o habitual_a intemperance_n for_o a_o long_a time_n therefore_o if_o you_o can_v not_o rational_o expect_v good_a effâ—s_n in_o that_o case_n any_o more_o than_o from_o the_o best_a wine_n take_v sudden_o in_o a_o vast_a quantity_n it_o follow_v that_o you_o can_v expect_v good_a effect_n from_o a_o habitual_a intemperate_a take_v of_o it_o any_o more_o than_o from_o a_o long_a and_o lavish_a drink_v of_o wine_n though_o both_o be_v excellent_o good_a in_o their_o kind_a but_o that_o the_o opium_n have_v the_o pernicious_a resinous_a part_n join_v with_o it_o there_o be_v nothing_o so_o good_a whereof_o a_o intemperate_a use_n be_v not_o mischievous_a god_n have_v so_o order_v it_o to_o deter_v from_o and_o punish_v intemperance_n and_o the_o abuse_n of_o his_o creature_n therefore_o ill_a effect_n be_v not_o always_o to_o be_v impute_v to_o the_o viciousness_n of_o the_o thing_n use_v but_o frequent_o of_o the_o person_n that_o imprudent_o use_v they_o 1._o relaxation_n and_o debility_n of_o all_o part_n be_v contract_v by_o the_o habitual_a over-relaxing_a thereof_o by_o the_o lavish_a use_n of_o opium_n 2._o a_o inhability_n of_o do_v any_o thing_n without_o it_o be_v contract_v by_o the_o habitual_a pleasure_n comfort_n promptitude_n and_o euphory_n it_o cause_v when_o take_v without_o which_o the_o sensitive_a soul_n become_v lazy_a listless_a and_o averse_a to_o all_o action_n it_o be_v as_o iâ—_n a_o man_n use_v to_o dance_n to_o excellent_a music_n be_v require_v to_o do_v it_o without_o any_o music_n at_o all_o nor_o as_o much_o as_o thought_n of_o it_o or_o mumble_v it_o within_o himself_o or_o that_o one_o who_o drink_v nothing_o but_o wine_n and_o eat_v the_o best_a shall_v be_v sudden_o deny_v both_o and_o force_v to_o live_v upon_o bread_n and_o water_n or_o that_o such_o as_o always_o take_v tobacco_n at_o their_o study_n shall_v be_v sudden_o debar_v thereof_o and_o require_v to_o study_v without_o it_o how_o very_o listless_a will_v a_o man_n be_v in_o such_o case_n though_o hardly_o any_o of_o the_o comparison_n come_v up_o to_o that_o of_o opium_n because_o of_o the_o charm_a pleasure_n mighty_a euphory_n and_o promptitude_n that_o it_o cause_n it_o be_v as_o if_o one_o be_v support_v and_o whole_o depend_v upon_o cordial_n and_o sudden_o deny_v they_o etc._n etc._n 3._o a_o inhability_n of_o get_v up_o in_o the_o morning_n till_o it_o be_v take_v and_o begin_v to_o operate_v proceed_v from_o the_o same_o cause_n a_o mechanical_a reason_n may_v be_v expect_v here_o also_o as_o to_o these_o matter_n but_o it_o will_v hardly_o bear_v it_o any_o more_o than_o how_o the_o will_n or_o appetite_n cause_v the_o first_o impulse_n towards_o voluntary_a moti_fw-la n_o all_o that_o can_v be_v say_v be_v that_o without_o the_o opium_n the_o sensitive_a soul_n be_v when_o he_o do_v any_o thing_n to_o act_v under_o the_o toil_n and_o difficulty_n of_o a_o full_a vigilative_a contraction_n as_o be_v awake_a intentive_a contraction_n as_o act_v and_o defensive_a contraction_n as_o be_v grieve_v when_o the_o operation_n of_o opium_n be_v over_o as_o after_o veneral_a pleasure_n etc._n etc._n so_o that_o now_o he_o labour_v under_o the_o great_a disadvantage_n and_o drudgery_n of_o all_o the_o three_o contraction_n whereas_o by_o the_o pleasure_n fine_a titillation_n of_o opium_n and_o relaxation_n consequential_a thereunto_o he_o be_v ease_v of_o all_o the_o defensive_a contraction_n which_o be_v the_o most_o grievous_a and_o in_o great_a measure_n of_o the_o vigilative_a as_o have_v be_v show_v which_o make_v work_v journey_a etc._n etc._n very_o easy_a to_o he_o therefore_o it_o be_v as_o if_o one_o that_o delight_v in_o music_n dance_v to_o charm_a melody_n in_o belove_a company_n with_o please_a refection_n of_o wine_n etc._n etc._n and_o in_o the_o other_o case_n as_o if_o one_o labour_v in_o grief_n or_o pain_n now_o suppose_v that_o one_o use_v never_o to_o act_n or_o work_n without_o such_o mighty_a pleasant_a advantage_n and_o cause_n of_o euphory_n be_v require_v to_o act_v under_o the_o pressure_n of_o the_o three_o contraction_n or_o in_o grief_n or_o pain_n how_o listless_a will_v he_o be_v to_o act_n work_n get_v up_o etc._n etc._n 4._o a_o dull_a moapish_a and_o heavy_a disposition_n must_v be_v the_o effect_n unless_o it_o be_v while_o they_o please_v comfort_n and_o enliven_v themselves_o by_o the_o opium_n because_o their_o brain_n be_v habitual_o over_o relax_v which_o be_v the_o very_a case_n of_o old_a drunkard_n who_o have_v as_o it_o be_v say_v drink_v away_o their_o part_n by_o such_o a_o habitual_a relaxation_n of_o the_o brain_n which_o overmuch_o sleep_v cause_n also_o upon_o the_o account_n of_o the_o like_a relaxation_n therefore_o they_o must_v be_v moapish_a till_o the_o please_a titillation_n of_o opium_n enlivens_fw-la they_o 5._o diminution_n of_o appetite_n be_v cause_v by_o a_o habitual_a relaxation_n of_o the_o stomach_n take_v away_o its_o sensation_n and_o suspend_v the_o menstruum_fw-la from_o flow_v to_o it_o as_o free_o as_o it_o shall_v and_o will_v if_o there_o be_v a_o due_a contraction_n to_o squeeze_v it_o out_o 6._o weakness_n of_o digestion_n happen_v from_o the_o same_o cause_n 7._o dropsy_n be_v cause_v by_o the_o relaxation_n weaken_v the_o part_n and_o make_v they_o thereby_o susceptible_a of_o humour_n as_o also_o by_o diminution_n of_o appetite_n and_o digestion_n as_o in_o old_a drunkard_n 8._o decay_n of_o part_n or_o wit_n happen_v from_o habitual_a relaxation_n of_o the_o brain_n and_o its_o membrane_n as_o in_o old_a drunkard_n 9_o weakness_n of_o memory_n proceed_v from_o the_o same_o cause_n as_o in_o old_a drunkard_n 10._o stoop_v in_o the_o back_n be_v cause_v by_o the_o habitual_a relaxation_n of_o the_o part_n which_o weaken_v and_o cause_v they_o to_o comply_v with_o our_o tendency_n and_o use_v of_o bend_v forward_o and_o yield_v to_o the_o great_a weight_n that_o be_v general_o speak_v on_o the_o foreside_n of_o the_o backbone_n or_o perpendicular_a so_o that_o stoop_v must_v gradual_o follow_v those_o conspire_a cause_n as_o it_o do_v in_o habitual_a drunkard_n who_o part_n be_v relax_v 11._o early_o decrepiteness_n must_v proceed_v from_o the_o aforesaid_a relaxation_n spoil_v the_o tone_n of_o part_n and_o cause_v want_n of_o appetite_n digestion_n etc._n etc._n in_o the_o manner_n before_o show_v 12._o shortness_n of_o life_n must_v be_v the_o effect_n of_o the_o same_o cause_n 13._o acrimony_n of_o blood_n proceed_v from_o the_o abundance_n of_o acrimonious_a volatile_a salt_n take_v in_o the_o opium_n wherein_o it_o be_v much_o more_o acrimonious_a than_o our_o natural_a volatile_a salt_n and_o in_o great_a quantity_n proportionable_o therefore_o it_o can_v be_v no_o wonder_n that_o 14._o it_o excite_v inclination_n to_o venery_n by_o that_o acrimonious_a salt_n which_o be_v analogous_a to_o that_o of_o cantharides_n aunt_n bee_n etc._n etc._n 15._o frequent_a inclination_n to_o make_v water_n be_v also_o a_o know_a and_o common_a effect_n of_o such_o a_o salt_n by_o its_o irritate_v and_o solicit_v the_o bladder_n etc._n etc._n 16._o priapism_n
principle_n of_o motion_n by_o which_o all_o ill_a matter_n be_v effective_o subdue_v when_o they_o act_v with_o alacrity_n and_o vigour_n they_o be_v the_o principal_a agent_n and_o we_o physician_n but_o as_o be_v say_v minister_n or_o as_o handmaid_n to_o offer_v or_o hand_n good_a matter_n medicament_n or_o instrument_n to_o those_o principal_a agent_n of_o nature_n and_o that_o this_o sal-volatile-oleosum_a of_o opium_n be_v the_o most_o proper_a matter_n or_o medicament_n we_o can_v put_v into_o nature_n hand_n so_o invigorate_v appear_v manifest_o in_o that_o 5._o its_o principle_n be_v the_o most_o agreeable_a to_o the_o best_a noble_a most_o active_a and_o predominant_a principle_n of_o our_o body_n as_o have_v be_v prove_v most_o evident_o plene_fw-la &_o plane_n nor_o be_v it_o only_o agreeable_a but_o 6._o more_o vigorous_a and_o powerful_a to_o actuate_v reduce_v alter_v or_o exalt_v our_o principle_n according_a to_o the_o direction_n of_o our_o invigorated_a nature_n or_o sensitive_a soul_n and_o spirit_n which_o have_v so_o convenient_a a_o instrument_n and_o high_o qualify_v a_o matter_n will_v soon_o alter_v the_o perverse_a renew_v the_o decay_a acuate_v the_o dull_a and_o elevate_v the_o depress_v effete_a and_o pall_a humour_n of_o our_o body_n especial_o see_v 7._o that_o the_o sal-volatile-oleosum_a of_o opium_n be_v so_o agreeable_a and_o powerful_a must_v be_v the_o great_a resolver_n of_o humour_n that_o can_v be_v imagine_v for_o all_o resolution_n be_v by_o a_o agreement_n of_o particle_n which_o make_v they_o easy_o miscible_a insinuate_v into_o and_o penetrate_v each_o other_o especial_o if_o one_o be_v somewhat_o more_o vigorous_a and_o penetrate_a than_o the_o other_o as_o the_o sal-volatile-oleosum_a have_v be_v plain_o prove_v to_o be_v thus_o it_o be_v that_o all_o menstruum_n do_v so_o resolve_v thing_n of_o their_o own_o nature_n and_o so_o purify_v and_o cleanse_v they_o by_o take_v to_o themselves_o what_o be_v mere_o and_o pure_o of_o the_o same_o nature_n and_o reject_v or_o let_v go_v their_o hold_n of_o what_o be_v otherwise_o where_o it_o be_v worth_a note_n how_o upon_o the_o account_n of_o the_o intimate_a combination_n and_o union_n of_o the_o volatile_a salt_n and_o oily_a part_n in_o our_o panacea_fw-la it_o be_v dissolvable_a in_o all_o menstruum_n and_o consequent_o a_o universal_a resolvent_fw-la of_o all_o the_o humour_n of_o our_o body_n which_o its_o external_a resolve_v of_o all_o humour_n and_o tumor_n do_v also_o prove_v now_o if_o it_o be_v such_o a_o resolver_n of_o which_o there_o be_v no_o place_n to_o doubt_v then_o as_o claudius_n de_fw-fr la_fw-fr courvee_n say_v it_o must_v excel_v all_o thing_n in_o alter_v and_o reduce_v all_o the_o humour_n of_o our_o body_n to_o a_o good_a and_o agreeable_a condition_n nor_o do_v it_o only_o thus_o resolve_v they_o and_o thereby_o separate_v as_o be_v say_v the_o good_a from_o the_o bad_a but_z 8._o when_o it_o have_v so_o do_v it_o by_o the_o amicable_a agreeableness_n of_o its_o sal-volatile-oleosum_a compose_v faculty_n strict_a combination_n of_o its_o principle_n join_v to_o concentrate_n congregate_n and_o as_o it_o be_v cement_v the_o best_a and_o most_o agreeable_a into_o a_o close_a union_n and_o firm_a texture_n by_o as_o be_v say_v the_o direction_n of_o invigorated_a nature_n which_o be_v of_o itself_o the_o good_a be_v once_o separate_v from_o the_o bad_a high_o sufficient_a without_o any_o other_o help_v to_o unite_v part_n so_o agreeable_a and_o of_o themselves_o incline_v to_o unite_v and_o combine_v though_o all_o tho_o part_n of_o opium_n like_o those_o of_o the_o great_a dissolvent_a be_v go_v and_o when_o that_o be_v do_v 9_o the_o high_a discussive_a quality_n of_o the_o sal-volatile-oleosum_a must_v be_v very_o effectual_a for_o the_o difflation_n and_o discussion_n of_o the_o sever_a effete_a particle_n which_o must_v be_v high_o assist_v and_o improve_v by_o the_o brisk_a and_o cheerful_a motion_n of_o nature_n viz._n the_o sensitive_a soul_n and_o spirit_n so_o as_o be_v aforesaid_a invigorate_v nor_o be_v this_o all_o but_o to_o complete_a and_o perfect_a the_o operation_n 10._o it_o lay_v open_a all_o the_o pore_n of_o the_o body_n as_o have_v be_v demonstrate_v 〈◊〉_d they_o out_o and_o give_v the_o ill_a particle_n their_o â—inal_n exit_fw-la by_o the_o most_o natural_a and_o plentiful_a way_n of_o evacuation_n leave_v the_o body_n free_a from_o all_o miasm_n and_o impurity_n 11._o i_o have_v sufficient_o show_v how_o unalterable_a it_o be_v in_o itself_o chap._n 15._o so_o that_o like_o the_o liquor_n alcahest_fw-mi it_o be_v not_o make_v to_o be_v subdue_v but_o to_o subdue_v and_o resolve_v humour_n now_o what_o can_v be_v require_v more_o in_o a_o medicament_n and_o how_o can_v the_o sensitive_a soul_n and_o spirit_n or_o nature_n so_o invigorate_v and_o endue_v with_o all_o euphory_n and_o cheerfulness_n by_o this_o glorious_a medicament_n who_o principle_n be_v not_o only_o agreeable_a to_o our_o noble_a one_o but_o more_o powerful_a and_o intimate_o combine_v so_o resolve_v of_o humour_n ready_a to_o unite_v the_o good_a and_o to_o discuss_v the_o bad_a and_o carry_v they_o off_o by_o the_o pore_n ever_o fail_v be_v due_o administer_v of_o good_a effect_n in_o alter_v all_o the_o humour_n of_o our_o body_n hypocrates_n in_o his_o book_n de_fw-fr nature_n hominis_fw-la state_n the_o cause_n of_o disease_n to_o be_v a_o disgregation_n of_o humour_n by_o which_o he_o seem_v to_o imply_v that_o the_o power_n of_o congregate_a and_o concentrate_v of_o humour_n be_v sufficient_a to_o accomplish_v a_o panacea_fw-la which_o be_v but_o one_o single_a qualification_n in_o eleven_o of_o our_o sal-volatile-oleosum_a though_o this_o alone_a as_o be_v experience_v even_o in_o common_a preparation_n of_o opium_n suffice_v very_o often_o to_o cure_v disease_n by_o compose_v commotion_n as_o in_o diary_n fever_n from_o perturbation_n etc._n etc._n thus_o the_o bitter_a and_o firm_a texture_v cortex_fw-la as_o i_o have_v show_v in_o my_o book_n de_fw-fr febribus_fw-la intermittentibus_fw-la take_v off_o ague_n fit_v by_o re-combining_a the_o segregated_a humour_n with_o the_o blood_n which_o it_o sudden_o do_v leave_v a_o disposition_n in_o the_o blood_n when_o ever_o it_o meet_v with_o a_o segregate_a cause_n as_o purge_v violent_a motion_n insolation_n intemperate_a drink_v etc._n etc._n to_o a_o relapse_n by_o a_o second_o separation_n of_o the_o morbid_v matter_n from_o it_o as_o you_o have_v it_o more_o at_o large_a in_o my_o say_a book_n p._n 166_o 167_o etc._n etc._n 242_o 243_o etc._n etc._n where_o you_o may_v see_v how_o opiate_n conduce_v very_o much_o to_o a_o speedy_a cure_n by_o the_o cortex_fw-la by_o compose_v etc._n etc._n martianus_n say_v coâ—m_fw-la de_fw-fr locis_fw-la in_o homine_fw-la p._n 76._o opium_n sist_z it_o &_o prohibet_fw-la humorum_fw-la disgregationem_fw-la that_o be_v opium_n hinder_v disgregation_n of_o humour_n now_o you_o may_v perceive_v the_o true_a qualification_n of_o a_o sal-volatile-oleosum_a so_o much_o seek_v for_o by_o the_o learned_a as_o a_o panacea_fw-la and_o how_o far_o the_o common_a one_o that_o be_v sell_v in_o the_o apothecary_n shop_n be_v from_o be_v such_o silvius_n indeed_o have_v a_o excellent_a one_o with_o which_o he_o do_v many_o and_o great_a cure_n which_o be_v consider_v have_v he_o not_o confess_v his_o ignorance_n of_o the_o cause_n of_o the_o effect_n of_o opium_n and_o the_o narrative_a he_o make_v of_o its_o virtue_n and_o performance_n in_o his_o preface_n to_o the_o first_o book_n of_o his_o praxis_fw-la and_o that_o he_o delight_v so_o much_o in_o the_o use_n of_o opium_n even_o when_o he_o be_v young_a that_o he_o be_v call_v by_o the_o name_n of_o doctor_n opiatus_fw-la and_o that_o he_o declare_v no_o oil_n be_v add_v in_o its_o preparation_n and_o that_o it_o be_v intimate_v that_o the_o oil_n and_o volatile_a part_n be_v strict_o combine_v will_v have_v make_v i_o suspect_n that_o it_o be_v the_o sal-volatile-oleosum_a of_o opium_n that_o he_o use_v which_o if_o it_o be_v not_o i_o dare_v be_v confident_a that_o notwithstanding_o all_o its_o excellency_n it_o be_v not_o as_o good_a i_o be_o very_a well_o satisfy_v that_o a_o true_a and_o consummate_v sal-volatile-oleosum_a be_v not_o to_o be_v make_v bare_o by_o art_n enquirer_n may_v have_v better_a success_n if_o they_o seek_v it_o among_o the_o natural_a tribe_n of_o bitter_a plant_n that_o be_v agreeable_a to_o the_o stomach_n which_o have_v all_o in_o they_o a_o sal-volatile-oleosum_a but_o how_o to_o pick_v and_o cull_v be_v i_o think_v best_o see_v by_o the_o requisite_a qualification_n of_o a_o panacea_fw-la that_o i_o have_v state_v there_o have_v be_v many_o in_o who_o hand_n bitter_a thing_n have_v be_v as_o a_o panacea_fw-la one_o in_o germany_n cure_v most_o disease_n with_o wild_a sage_n some_o have_v do_v great_a thing_n with_o agrimony_n other_o
vagina_n in_o which_o case_n it_o be_v of_o neat_a use_n both_o by_o relax_v and_o take_v away_o pain_n during_o the_o operation_n it_o may_v be_v also_o of_o use_n when_o the_o strictness_n of_o the_o collum_n uteri_fw-la hinder_v the_o admission_n of_o sem._n viril_n both_o as_o a_o general_a relaxer_n and_o as_o cause_v great_a pleasure_n of_o those_o part_n and_o a_o proportionable_a relaxation_n thereof_o for_o it_o be_v by_o the_o pleasure_n in_o coition_n that_o the_o collum_n uteri_fw-la be_v open_v or_o relax_v as_o be_v observe_v which_o immediate_o close_v again_o when_o the_o sense_n of_o pleasure_n be_v end_v yea_o and_o so_o much_o the_o strict_a because_o the_o loss_n of_o pleasure_n be_v as_o be_v show_v a_o kind_a of_o grievance_n hence_o it_o be_v that_o omne_fw-la animal_n post_fw-la coitum_fw-la est_fw-la triste_fw-fr and_o not_o because_o of_o loss_n of_o spirit_n as_o be_v vulgar_o imagine_v for_o we_o can_v lose_v little_a or_o no_o spirit_n by_o that_o which_o be_v so_o separate_v for_o excretion_n before_o hand_n as_o the_o semen_n be_v 5._o to_o enlarge_v any_o part_n for_o the_o due_a reception_n of_o what_o be_v convenient_a or_o necessary_a as_o the_o breast_n to_o receive_v milk_n by_o which_o mean_v it_o come_v to_o be_v such_o great_a increaser_n of_o milk_n the_o seminal_a vessel_n as_o sem._n virile_a do_v upon_o puberty_n to_o receive_v the_o semen_n thus_o it_o cause_v the_o penis_n to_o grow_v as_o the_o semen_n upon_o puberty_n cause_v it_o and_o cock_n comb_n turkeycock_n red_a bag_n at_o the_o neck_n proboscis_n etc._n etc._n to_o grow_v as_o the_o time_n they_o be_v fit_a for_o or_o begin_v to_o tread_v for_o the_o relaxation_n cause_v by_o the_o pleasure_n of_o the_o semen_n make_v the_o party_n more_o capable_a of_o the_o nutriment_n thus_o it_o be_v that_o sleep_v cause_n the_o growth_n fatten_v and_o thrive_a of_o animal_n and_o red_a nose_n to_o grow_v so_o large_a by_o frequent_a relaxation_n upon_o the_o pleasure_n of_o wine_n ale_z etc._n etc._n as_o be_v say_v to_o which_o quantity_n distend_v the_o part_n may_v in_o the_o last_o mention_v case_n contribute_v i._o the_o form_n of_o opiate_n in_o this_o case_n may_v be_v either_o solid_a or_o liquid_a as_o you_o think_v â—it_a ii_o the_o dose_n must_v be_v proportion_v to_o the_o relaxation_n that_o you_o desire_v for_o more_o relax_n more_o and_o less_o less_o so_o must_v it_o be_v also_o proportion_v to_o the_o contraction_n that_o it_o be_v to_o take_v away_o therefore_o very_o grievous_a passion_n or_o sensation_n which_o cause_n proportionable_a contraction_n require_v great_a dose_n because_o their_o grievance_n and_o contraction_n do_v strong_o oppose_v the_o pleasure_n and_o relaxation_n that_o opiate_n cause_n therefore_o great_a pain_n as_o you_o will_v find_v in_o its_o due_a place_n require_v a_o extraordinary_a do_v iii_o the_o vehicle_n in_o contraction_n from_o grievous_a passion_n shall_v be_v wine_n or_o some_o comfortable_a cordial_n except_o they_o be_v the_o more_o turbulent_a passion_n as_o anger_n fury_n etc._n etc._n where_o composer_n as_o emulsion_n milk_n and_o water_n etc._n etc._n be_v best_a in_o all_o other_o case_n emollient_a and_o supply_a vehicles_n be_v most_o proper_a as_o soft_a smooth_a and_o slippery_a 〈◊〉_d broth_n etc._n etc._n iv_o the_o time_n to_o give_v they_o be_v at_o the_o due_a distance_n before_o bed_n time_n when_o the_o intention_n be_v consistent_a with_o sleep_n which_o itself_o be_v a_o great_a relaxer_n otherwise_o any_o time_n will_v serve_v as_o occasion_n or_o the_o intention_n of_o the_o physician_n require_v it_o v._o the_o regimen_n 1._o as_o to_o meat_n and_o drink_n be_v use_v moist_a emollient_a and_o lubricate_a thing_n as_o smooth_a broth_n somewhat_o â—at_a butter_v root_n herb_n sauce_n 〈◊〉_d milk-meat_n young_a flesh_n as_o of_o roast_a pig_n 〈◊〉_d lamb_n etc._n etc._n smooth_a drink_n as_o alc_n 〈◊〉_d etc._n etc._n 2._o as_o to_o sleep_v and_o wake_v that_o relax_n and_o this_o contract_n therefore_o that_o conduce_v this_o hinder_v 3._o as_o to_o rest_n and_o motion_n that_o relax_n and_o this_o contract_n 4._o as_o to_o the_o passion_n of_o the_o mind_n the_o pleasant_a as_o 〈◊〉_d joy_n pleasure_n comfort_n and_o all_o such_o do_v relax_v and_o the_o grievous_a as_o terror_n fear_v grief_n melancholy_n etc._n etc._n contract_n as_o pain_n do_v 5._o as_o to_o air_n the_o warm_a and_o moist_a or_o that_o when_o the_o quicksilver_n be_v low_a in_o the_o barometer_n or_o weatherglass_n do_v relax_v as_o do_v warm_a bath_n fomentation_n etc._n etc._n especial_o if_o emollient_a dry_v and_o cold_a air_n and_o that_o when_o the_o quicksilver_n be_v high_a do_v cause_n contraction_n 6._o as_o to_o excretion_n and_o retention_n general_o excretion_n do_v make_v room_n and_o way_n for_o thing_n to_o pass_v through_o or_o into_o the_o relaxed_a part_n as_o clyster_v for_o passage_n of_o the_o stone_n child_n reduction_n of_o hernias_fw-la etc._n etc._n but_o be_v sure_a not_o to_o make_v the_o excretion_n grievous_a because_o all_o grievous_a sensation_n cause_v contraction_n chap._n xxxiv_o of_o the_o use_n of_o the_o panacea_fw-la of_o opium_n etc._n etc._n to_o take_v away_o pain_n or_o grievous_a sensation_n this_o it_o do_v as_o be_v show_v by_o divert_v the_o sensitive_a soul_n and_o introduce_v a_o sense_n of_o pleasure_n which_o be_v contrary_a to_o grievous_a sensation_n or_o pain_n can_v be_v in_o the_o same_o subject_a with_o pain_n but_o chief_o and_o mechanical_o by_o relax_v all_o part_n and_o permit_v the_o springy_a animal_n spirit_n to_o expand_v and_o so_o become_v unfit_a to_o carry_v impression_n smart_o which_o be_v requisite_a to_o cause_v a_o sense_n of_o pain_n as_o have_v be_v prove_v therefore_o it_o be_v of_o most_o happy_a and_o glorious_a use_n in_o all_o pain_n but_o especial_o to_o be_v use_v 1._o in_o such_o as_o be_v not_o for_o any_o benefit_n to_o the_o person_n pain_v in_o order_n to_o alter_v or_o evacuate_v the_o grieve_v cause_n as_o in_o pocky_a scorbutical_a or_o hypochondriacal_a pain_n or_o such_o as_o proceed_v from_o any_o ill_a habit_n of_o body_n etc._n etc._n 2._o where_o pain_n hinder_v the_o take_v away_o of_o its_o cause_n or_o some_o benefit_n as_o when_o the_o pain_n of_o the_o stone_n do_v by_o contract_v the_o part_n hinder_v its_o own_o passage_n that_o of_o a_o tenesmus_n hinder_v go_v to_o stool_n that_o of_o the_o sphincter_n of_o the_o bladder_n hinder_v its_o open_n to_o let_v out_o urine_n clod_v blood_n phlegm_n matter_n or_o any_o such_o thing_n when_o that_o of_o the_o neck_n of_o the_o wâ—mb_n hinder_v delivery_n of_o a_o child_n afterbirth_n mole_n clod_v blood_n etc._n etc._n that_o of_o the_o mouth_n of_o the_o stomach_n hinder_v vomit_v when_o requisite_a or_o that_o of_o the_o pylorus_n hinder_v the_o detrusion_n of_o chyle_n or_o that_o of_o the_o intestine_n as_o by_o a_o inflammation_n etc._n etc._n stop_v the_o passage_n of_o the_o ordure_n and_o cause_v a_o iliack_a passion_n or_o that_o of_o the_o guilet_n hinder_v swollow_v of_o the_o larynx_n breathe_v or_o that_o of_o any_o part_n hinder_v perspiration_n or_o desire_a sweat_n or_o that_o of_o the_o venereal_a part_n stop_v the_o menses_fw-la or_o lochia_n etc._n etc._n in_o all_o which_o case_n it_o be_v and_o must_v in_o all_o reason_n be_v of_o excellent_a and_o if_o due_o manage_v of_o almost_o if_o not_o altogether_o infallible_a effect_n by_o take_v away_o the_o pain_n which_o cause_v the_o part_n to_o contract_v and_o make_v the_o stop_n etc._n etc._n 3._o where_o the_o cause_n of_o the_o pain_n can_v be_v remove_v but_o by_o perspiration_n sweat_v menses_fw-la lochia_n or_o urine_n â—s_n in_o pain_n in_o the_o habit_n of_o the_o body_n limb_n etc._n etc._n from_o cold_a wind_n or_o vapour_n gout_n rheumatism_n stitch_n pleurisy_n inflammation_n and_o many_o of_o the_o case_n aforemention_v it_o be_v excellent_a as_o it_o be_v 4._o where_o the_o pain_n irritation_n or_o grievous_a sensation_n cause_v nature_n to_o work_v irregular_o as_o in_o iliack_n â—_z hysterick_a fit_n fruitless_a convulsion_n canine_a apâ—_n etc._n etc._n in_o which_o case_n it_o excel_v all_o other_o mean_n for_o many_o reason_n 5._o where_o the_o pain_n be_v not_o likely_a to_o have_v a_o timely_a effect_n for_o good_a till_o people_n may_v be_v too_o much_o wear_v out_o 6._o in_o all_o pain_n that_o have_v not_o any_o material_a cause_n from_o the_o â—_z &c._n &c._n of_o the_o body_n as_o such_o as_o happen_v from_o passion_n wound_n prick_v of_o nerve_n tendon_n fracture_n dislocation_n amputation_n severe_a chirurgical_a operation_n etc._n etc._n 7._o in_o all_o pain_n from_o inflammation_n suppuration_n abseess_n tumour_n where_o repulsion_n be_v not_o convenient_a or_o possible_a 8._o in_o all_o pain_n that_o be_v more_o likely_a to_o cause_v fever_n than_o any_o
from_o the_o college_n of_o physician_n oct._n 5._o 1700._o mr._n smith_n i_o have_v read_v the_o book_n you_o send_v i_o which_o for_o the_o great_a discovery_n contain_v therein_o be_v just_o entitle_v the_o mystery_n of_o opium_n reveal_v it_o have_v no_o need_n of_o i_o nor_o of_o any_o other_o approbation_n for_o such_o extraordinary_a performance_n as_o this_o be_v be_v more_o secure_a of_o a_o kind_a reception_n in_o the_o world_n by_o their_o own_o great_a worth_n and_o usefulness_n to_o the_o public_a than_o by_o any_o other_o recommendation_n whatsoever_o you_o thomas_n burwell_n the_o mystery_n of_o opium_n reveal_v by_o dr._n john_n jones_n chancellor_n of_o landaff_n a_o member_n of_o the_o college_n of_o physician_n in_o london_n and_o former_o fellow_n of_o jesus-college_n in_o oxford_n who_o i._o give_v a_o account_n of_o the_o name_n make_v choice_n effect_n etc._n etc._n of_o opium_n ii_o prove_v all_o former_a opinion_n of_o its_o operation_n to_o be_v mere_a chimera_n iii_o demonstrate_v what_o its_o true_a cause_n be_v by_o which_o he_o easy_o and_o mechanical_o explain_v all_o even_o its_o most_o mysterious_a effect_n iv_o show_v its_o noxious_a principle_n and_o how_o to_o separate_v it_o thereby_o render_v it_o a_o safe_a and_o noble_a panacea_fw-la whereof_o v._o he_o show_v the_o palliative_a and_o curative_fw-it use._n a_o deo_fw-la lux_fw-la london_n print_v for_o richard_n smith_n at_o the_o angel_n and_o bible_n without_o temple-bar_n mdcc_o to_o the_o king_n most_o excellent_a majesty_n william_n iii_o etc._n etc._n may_v it_o please_v your_o majesty_n have_v no_o mean_n to_o atone_v for_o my_o bold_a essay_n to_o express_v your_o majesty_n glorious_a act_n and_o virtue_n upon_o a_o small_a pillar_n as_o much_o too_o narrow_a to_o contain_v as_o my_o pen_n be_v too_o short_a to_o reach_v they_o but_o by_o this_o poor_a sacrifice_n make_v one_o presumption_n the_o advocate_n of_o the_o other_o as_o if_o offence_n bear_v no_o proportion_n to_o your_o royal_a notice_n and_o clemency_n without_o accumulate_v they_o i_o humble_o implore_v god_n representative_a in_o mercy_n as_o well_o as_o power_n to_o be_v a_o saviour_n in_o pardon_v as_o well_o as_o preserve_n i_o confess_v my_o attempt_n as_o dare_v and_o assume_v as_o that_o of_o the_o arrogant_a and_o sturdy_n giant_n to_o scale_v heaven_n be_v too_o great_a a_o taskâ—or_a â—or_z a_o general_n consult_v of_o the_o most_o exalted_a wit_n on_o earth_n if_o not_o of_o angel_n and_o refine_a separate_a soul_n of_o who_o number_n i_o by_o frequent_a ecstasy_n of_o thanks_o and_o praise_n for_o the_o wonder_v your_o majesty_n have_v wrought_v for_o we_o seem_v as_o it_o be_v ambitious_a to_o be_v one_o as_o well_o know_v that_o such_o miraculous_a exploit_n far_o transcend_v the_o conception_n and_o high_a flight_n of_o those_o that_o be_v clog_v with_o body_n which_o have_v quite_o balk_v my_o endeavour_n to_o describe_v they_o but_o that_o those_o uncontrollable_a rapture_n use_v violence_n upon_o my_o modesty_n and_o a_o long_o defeat_v expectation_n of_o better_a pen_n render_v my_o impatience_n outrageous_a to_o find_v man_n silent_a where_o they_o can_v be_v loud_o enough_o as_o if_o the_o impracticableness_n of_o adequate_a thanks_o have_v pall_a their_o spirit_n or_o the_o vast_a cataract_n of_o blessing_n your_o majesty_n pour_v upon_o we_o have_v overwhelm_v or_o the_o consequent_a ease_n and_o security_n lull_v they_o asleep_o or_o our_o exuberant_a prosperity_n overgrow_v the_o memory_n of_o its_o brave_a and_o generous_a author_n the_o thought_n of_o which_o ingratitude_n what_o loyal_a or_o moral_a heart_n can_v bear_v without_o the_o high_a indignation_n the_o fret_v and_o ferment_n whereof_o will_v have_v even_o burst_v its_o vessel_n without_o the_o vent_n i_o give_v it_o in_o express_v my_o thought_n upon_o that_o pillar_n to_o mind_v the_o forgetful_a excite_v the_o lethargic_a and_o give_v all_o a_o model_n by_o my_o paper-building_n to_o erect_v more_o sumptuous_a and_o permanent_a monument_n of_o what_o god_n and_o your_o majesty_n unparalleled_a magnanimity_n courage_n and_o conduct_v have_v do_v for_o we_o since_o that_o be_v my_o design_n gratitude_n my_o motive_n deed_n and_o qualification_n that_o have_v no_o commensurate_a word_n my_o theme_n i_o hope_v defect_n in_o expression_n will_v not_o intercept_v a_o gracious_a aspect_n if_o the_o book_n afford_v any_o thing_n new_a or_o useful_a your_o majesty_n be_v the_o author_n as_o preserver_n of_o our_o life_n and_o establisher_n of_o the_o necessary_a tranquillity_n for_o thoughtful_a study_n and_o invention_n therefore_o i_o humble_o present_v it_o to_o your_o most_o sacred_a majesty_n as_o man_n do_v oblation_n to_o the_o deity_n from_o who_o they_o receive_v they_o make_o it_o as_o far_o as_o in_o i_o lie_v double_o you_o as_o be_v royal_a sir_n your_o majesty_n most_o humble_a obedient_a thankful_a subject_a and_o servant_n john_n jones_n the_o mystery_n of_o opium_n reveal_v chap._n i._o show_v how_o opium_n have_v its_o name_n how_o it_o be_v make_v whence_o it_o come_v etc._n etc._n the_o opium_n that_o be_v in_o use_n in_o ancient_a time_n be_v make_v thus_o when_o the_o poppy_n which_o be_v general_o the_o white_a and_o sow_v then_o only_o in_o garden_n and_o small_a enclosure_n be_v come_v to_o its_o full_a growth_n and_o most_o turgid_a of_o milky_a juice_n which_o be_v in_o the_o hot_a country_n in_o may_n and_o june_n they_o do_v as_o soon_o as_o the_o dew_n be_v up_o in_o the_o morning_n make_v several_a incision_n transvers_o or_o athwart_o the_o head_n of_o the_o poppy_n yet_o not_o direct_o horizontal_a but_o somewhat_o oblique_o take_v care_n not_o to_o make_v they_o quite_o through_o into_o the_o cavity_n thereof_o hold_v the_o knife_n or_o instrument_n with_o which_o the_o incision_n be_v make_v with_o its_o edge_n slope_v upward_o while_o it_o wound_v the_o head_n and_o convenient_o place_v certain_a shell_n to_o receive_v the_o milky_a drop_n that_o issue_v out_o of_o the_o incision_n and_o go_v backward_o among_o the_o poppy_n as_o they_o proceed_v in_o this_o work_n 1._o they_o choose_v the_o time_n when_o the_o poppy_n head_n be_v most_o turgid_a of_o milk_n to_o take_v it_o in_o the_o best_a condition_n for_o their_o purpose_n for_o if_o they_o gather_v it_o soon_o it_o be_v not_o so_o mature_a and_o if_o afterward_o some_o of_o its_o virtue_n expire_v and_o the_o quantity_n of_o the_o juice_n be_v less_o because_o dry_v up_o in_o some_o measure_n if_o not_o take_v timely_o 2._o they_o make_v several_a incision_n in_o every_o poppy_n head_n to_o have_v the_o great_a plenty_n of_o juice_n 3._o they_o make_v they_o immediate_o after_o the_o dew_n be_v up_o to_o prevent_v its_o be_v taint_v with_o any_o of_o the_o dew_n and_o because_o the_o great_a heat_n of_o the_o day_n in_o those_o country_n will_v much_o diminish_v the_o quantity_n of_o the_o milky_a juice_n and_o so_o thicken_v it_o that_o it_o will_v not_o run_v out_o as_o free_o as_o in_o the_o morning_n 4._o they_o make_v the_o incision_n transvers_o thereby_o to_o cut_v and_o lay_v open_a more_o of_o the_o milky_a vessel_n 5._o they_o make_v they_o somewhat_o oblique_o that_o the_o drop_n may_v the_o better_o follow_v and_o overtake_v one_o the_o other_o and_o thereby_o coalesce_v and_o grow_v more_o considerable_a in_o bulk_n and_o that_o the_o oblique_a wound_n may_v the_o better_a conduct_v they_o into_o the_o same_o part_n of_o the_o shell_n that_o they_o may_v find_v all_o together_o in_o a_o mass_n when_o it_o be_v sufficient_o dry_v or_o inspissated_a by_o the_o heat_n of_o the_o sun_n 6._o they_o do_v not_o make_v the_o incision_n quite_o through_o if_o they_o can_v avoid_v it_o lest_o any_o of_o the_o juice_n shall_v run_v into_o the_o cavity_n of_o the_o head_n and_o so_o be_v lose_v among_o the_o seed_n contain_v therein_o 7._o they_o sloap_v the_o edge_n of_o the_o knife_n or_o instrument_n upward_o as_o they_o make_v the_o incision_n that_o the_o juice_n may_v the_o easy_a slide_n outward_o especial_o in_o case_n they_o happen_v to_o make_v the_o incision_n quite_o through_o which_o they_o can_v not_o always_o avoid_v notwithstanding_o all_o the_o care_n they_o use_v 8._o they_o go_v backward_o as_o they_o do_v it_o to_o avoid_v go_v by_o the_o shell_n and_o incise_v head_n lest_o they_o shall_v disorder_v or_o discompose_v or_o throw_v they_o down_o or_o wipe_v off_o any_o of_o the_o juice_n with_o their_o clothes_n this_o be_v do_v they_o leave_v the_o milky_a juice_n in_o the_o shell_n to_o inspissate_fw-it by_o the_o heat_n of_o the_o sun_n into_o a_o pilular_a consistence_n i_o have_v be_v the_o more_o particular_a to_o show_v man_n how_o to_o make_v opium_n of_o english_a poppy_n which_o you_o will_v find_v of_o good_a use_n the_o milky_a juice_n as_o it_o dry_v
all_o such_o do_v depend_v and_o that_o the_o particular_a enumeration_n of_o its_o effect_n in_o disease_n belong_v to_o its_o curative_fw-it and_o paliative_fw-it virtue_n which_o will_v be_v handle_v hereafter_o the_o rare_a effect_n of_o opium_n take_v in_o a_o moderate_a do_v 1._o temporary_a palsy_n as_o of_o the_o bladder_n and_o sometime_o of_o other_o part_n though_o very_o rare_o 2._o falter_v of_o the_o tongue_n 3._o looseness_n of_o the_o low_a jaw_n as_o in_o the_o drowsy_a drunkard_n etc._n etc._n 4._o prevention_n of_o sweat_n in_o such_o as_o sweat_v too_o much_o for_o want_v of_o perspiration_n 5._o abortion_n 6._o prevention_n of_o abortion_n in_o some_o case_n 7._o intumescence_n of_o the_o li_n 8._o cure_v of_o the_o dropsy_n of_o which_o dr._n willis_n give_v a_o instance_n 9_o cure_v of_o stupor_n of_o some_o sort_n as_o those_o from_o cold_n etc._n etc._n 10._o anxiety_n and_o distress_n 11._o vomit_n and_o hiccough_n 12._o convulsion_n 13._o syncopes_fw-la leipothimy_n and_o faint_n 14._o death_n though_o very_o rare_o and_o that_o in_o very_o weak_a people_n 15._o purge_v 16._o raise_v and_o revive_v some_o person_n that_o be_v just_a expire_a 17._o a_o long_a stay_n thereof_o at_o stomach_n sometime_o 18._o stoppage_n of_o urine_n 19_o it_o sometime_o prove_v dangerous_a after_o hemorrhage_n and_o large_a evacuation_n 1._o note_v that_o the_o first_o class_n of_o effect_n be_v the_o most_o constant_a be_v the_o most_o proper_a genuine_a and_o principal_a effect_n upon_o which_o all_o other_o effect_n depend_v unless_o they_o be_v accidental_a it_o must_v therefore_o be_v that_o these_o shall_v best_a guide_v we_o in_o the_o disquisition_n of_o the_o cause_n of_o the_o operation_n of_o opium_n 2._o note_v that_o the_o second_o class_n though_o not_o so_o constant_a be_v natural_a effect_n of_o opium_n and_o will_v be_v also_o good_a guide_n for_o the_o same_o purpose_n 3._o note_v that_o there_o be_v but_o little_a notice_n to_o be_v take_v of_o the_o rare_a effect_n for_o that_o purpose_n because_o most_o accidental_a the_o effect_n of_o the_o go_v off_o or_o declination_n of_o the_o operation_n of_o opium_n take_v internal_o in_o a_o moderate_a do_v 1._o a_o general_a return_n of_o all_o the_o disease_n and_o disaster_n that_o opium_n paliate_v during_o its_o operation_n unless_o it_o happen_v that_o some_o be_v cure_v thereby_o which_o iâ—_n they_o be_v be_v general_o by_o the_o benefit_n of_o sweat_n or_o insensible_a perspiration_n as_o cold_n pain_n from_o wind_n or_o humour_n that_o shall_v have_v pass_v by_o the_o pore_n as_o in_o cough_n toothache_n etc._n etc._n from_o construction_n of_o the_o pore_n or_o by_o compose_v the_o fury_n of_o the_o spirit_n or_o blood_n which_o it_o very_o often_o yea_o general_o cure_v with_o one_o single_a do_v but_o of_o these_o thing_n more_o in_o the_o curative_fw-it part._n 2._o sweat_v though_o not_o constant_o 3._o frequent_v make_v of_o water_n sometime_o 4._o a_o looseness_n sometime_o even_o when_o there_o be_v none_o before_o the_o give_v of_o the_o opium_n 5._o disease_n seem_v worse_a than_o before_o the_o take_n of_o it_o 6._o a_o melancholy_a and_o sad_a depression_n of_o spirit_n 7._o a_o narrow_a pulse_n 8._o itch_a of_o the_o skin_n chap._n v._o the_o effect_n of_o opium_n take_v in_o a_o excessive_a quantity_n 1._o a_o heat_n at_o stomach_n 2._o a_o sense_n of_o weight_n at_o stomach_n sometime_o 3._o gaity_n of_o humour_n at_o first_o aâ—_n after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 4._o sardonick_a laughter_n afterward_o as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 5._o laxity_n and_o debility_n of_o all_o part_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 6._o alienation_n of_o the_o mind_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 7._o loss_n of_o memory_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 8._o darkness_n of_o the_o eye_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 9_o laxity_n of_o the_o cornea_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 10._o appearance_n of_o divers_a colour_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 11._o deadness_n of_o the_o eye_n to_o the_o view_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 12._o falter_v of_o the_o tongue_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 13._o a_o sopor_fw-la as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 14._o a_o slow_a and_o wide_a pulse_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 15._o a_o high_a colour_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 16._o looseness_n of_o the_o jaw_n and_o li_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 17._o intumescence_n of_o the_o li_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 18._o difficulty_n of_o breathe_v as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 19_o fury_n and_o madness_n as_o after_o drink_v a_o great_a quantity_n of_o wine_n in_o a_o short_a time_n 20._o venereal_a fury_n 21._o priapism_n 22._o violent_a itch_n 23._o nausea_n 24._o swimmings_n in_o the_o head_n 25._o vertigo_n 26._o vomit_n 27._o hiccough_n 28._o a_o turbulent_a pulse_n 29._o convulsion_n and_o cold_a sweat_v 30._o faint_n and_o leipothymy_n 31._o cold_a breath_n 32._o death_n such_o as_o escape_v it_o general_o have_v 33._o plentiful_a purge_v 34._o sweat_v that_o smell_n of_o the_o opium_n 35._o violent_a itch_n in_o the_o skin_n 1._o note_v that_o all_o these_o effect_n do_v not_o happen_v to_o all_o but_o some_o to_o one_o and_o some_o to_o other_o 2._o that_o these_o effect_n be_v great_a or_o less_o according_a to_o the_o do_v constitution_n of_o the_o person_n and_o other_o circumstance_n 3._o that_o they_o be_v most_o endanger_v thereby_o that_o have_v a_o lax_n and_o fine_a texture_n and_o a_o weak_a digestion_n 4._o that_o a_o looseness_n upon_o it_o be_v a_o good_a sign_n 5._o that_o it_o affect_v some_o by_o make_v they_o furious_a as_o wine_n do_v and_o other_o stupid_a general_o the_o furious_a be_v most_o safe_a from_o danger_n of_o death_n but_o of_o these_o thing_n more_o hereafter_o by_o god_n help_n chap._n vi_o the_o effect_n of_o a_o long_a and_o lavish_a use_n of_o crude_a opium_n 1._o relaxation_n and_o weakness_n of_o all_o part_n 2._o inhability_n or_o listlesness_n to_o do_v any_o thing_n except_o it_o be_v while_o the_o opium_n operate_v 3._o inhability_n or_o listlesness_n to_o get_v up_o in_o the_o morning_n 4._o a_o dull_a moapish_a and_o heavy_a disposition_n as_o in_o old_a drunkard_n except_o it_o be_v during_o the_o operation_n of_o opium_n 5._o diminution_n of_o appetite_n as_o be_v observable_a in_o old_a drunkard_n 6._o weakness_n of_o digestion_n as_o be_v observable_a in_o old_a drunkard_n 7._o dropsy_n as_o be_v observable_a in_o old_a drunkard_n 8._o decay_n of_o part_n as_o be_v observable_a in_o old_a drunkard_n 9_o weakness_n of_o memory_n as_o be_v observable_a in_o old_a drunkard_n 10._o stoop_v in_o the_o back_n as_o be_v observable_a in_o old_a drunkard_n 11._o early_o decrepiteness_n as_o be_v observable_a in_o old_a drunkard_n 12._o shortness_n of_o life_n as_o be_v observable_a in_o old_a drunkard_n 13._o acrimony_n of_o blood_n 14._o inclination_n to_o venery_n 15._o frequent_a inclination_n to_o make_v water_n 16._o priapism_n and_o frequent_a erection_n 17._o nocturnal_a pollution_n the_o effect_n of_o sudden_a leave_v off_o the_o use_n of_o opium_n after_o a_o long_a and_o lavish_a use_v thereof_o 1._o great_a and_o even_o intolerable_a distress_n anxiety_n and_o depression_n of_o spirit_n which_o in_o few_o day_n common_o end_v in_o a_o most_o miserable_a death_n attend_v with_o strange_a agony_n unless_o man_n return_v to_o the_o use_v of_o opium_n which_o soon_o raise_v they_o again_o and_o certain_o restore_v they_o if_o it_o have_v time_n to_o operate_v before_o they_o die_v which_o it_o soon_o do_v in_o a_o liquid_a form_n or_o if_o they_o have_v not_o opium_n or_o will_v not_o take_v it_o they_o must_v use_v wine_n very_o plentiful_o and_o often_o as_o a_o substitute_n to_o the_o opium_n though_o it_o do_v not_o perform_v half_a as_o well_o as_o opium_n 2._o a_o return_n of_o all_o disease_n pain_n and_o disaster_n that_o be_v palliate_v by_o the_o take_n of_o opium_n 3._o dangerous_a looseness_n 4._o death_n follow_v the_o leave_v it_o off_o after_o
a_o very_o long_o and_o lavish_a use_n thereof_o the_o inconvenience_n of_o leave_v off_o the_o use_n of_o opium_n do_v bear_v a_o certain_a proportion_n to_o the_o time_n and_o quantity_n that_o it_o have_v be_v use_v in_o 1._o note_v that_o the_o turk_n do_v drink_v some_o water_n always_o after_o the_o take_n of_o opium_n as_o be_v the_o best_a menstruum_fw-la to_o dissolve_v it_o 2._o note_v that_o it_o be_v usual_a with_o they_o to_o take_v a_o drachm_n in_o the_o morning_n and_o so_o much_o in_o the_o afternoon_n and_o so_o may_v we_o as_o well_o as_o they_o if_o use_v to_o it_o and_o it_o be_v a_o very_a silly_a say_n that_o you_o will_v find_v in_o author_n that_o they_o be_v better_a able_a to_o bear_v it_o because_o of_o the_o climate_n etc._n etc._n whereas_o the_o more_o northern_a person_n be_v better_a able_a to_o take_v it_o than_o the_o southern_a as_o will_v hereafter_o appear_v most_o plain_o i_o be_o tell_v of_o one_o near_o banbury_n that_o take_v two_o ounce_n a_o day_n 3._o note_v that_o among_o the_o effect_n of_o opium_n may_v be_v observe_v many_o seem_a contradiction_n yet_o be_v there_o nothing_o more_o certain_a than_o the_o several_a different_a matter_n of_o fact_n which_o no_o doubt_n have_v be_v a_o great_a cause_n to_o puzzle_v the_o world_n about_o it_o and_o to_o run_v man_n into_o strange_a absurdity_n concern_v its_o operation_n and_o all_o to_o deviate_v so_o far_o from_o the_o truth_n that_o nothing_o in_o nature_n can_v be_v far_o unless_o you_o will_v say_v that_o heat_n cool_v or_o what_o please_v the_o sensitive_a soul_n be_v at_o the_o same_o time_n abhor_v by_o it_o now_o because_o these_o seem_a contradiction_n in_o the_o effect_n of_o opium_n be_v the_o great_a rub_n to_o be_v meet_v with_o and_o that_o the_o reader_n may_v take_v the_o better_a estimate_n of_o the_o undertake_n and_o my_o explication_n of_o its_o effect_n when_o i_o come_v to_o it_o i_o shall_v not_o fear_v to_o enumerate_v they_o distinct_o though_o they_o will_v make_v the_o strange_a catalogue_n of_o riddle_n that_o ever_o be_v see_v trust_v in_o he_o that_o create_v this_o wonderful_a medicament_n that_o he_o will_v enable_v i_o to_o explain_v all_o its_o effect_n the_o seem_a contradiction_n in_o the_o effect_n of_o opium_n 1._o it_o cause_v sleep_v and_o watch_v 2._o it_o cause_n and_o prevent_v sweat_n 3._o it_o relax_n and_o stop_v looseness_n 4._o it_o stop_v flux_n and_o cause_n that_o of_o sweat_n etc._n etc._n 5._o it_o stupefy_v the_o sense_n of_o feel_v yet_o irritate_v by_o that_o sense_n to_o venery_n 6._o it_o cause_v stupidity_n and_o promptitude_n in_o business_n cloudiness_n and_o serenity_n of_o mind_n 7._o it_o excite_v the_o spirit_n and_o quiet_v they_o 8._o it_o be_v very_o hot_a yet_o cool_v in_o fever_n 9_o it_o be_v hot_a and_o bitter_a yet_o lessen_v appetite_n even_o in_o cold_a stomach_n 10._o it_o stop_v and_o promote_v urine_n 11._o it_o relax_n and_o weaken_v yet_o enable_v we_o to_o undergo_v labour_n journey_n etc._n etc._n 12._o it_o cause_n and_o prevent_v abortion_n 13._o it_o stop_v vomit_v above_o all_o thing_n yet_o cause_n most_o violent_a tedious_a and_o dangerous_a vomit_n 14._o it_o stop_v purge_v in_o a_o most_o eminent_a manner_n yet_o sometime_o cause_v it_o 15._o it_o be_v very_o acrimonious_a yet_o as_o all_o say_v obtund_v acrimony_n however_o it_o allay_v pain_n proceed_v from_o acrimony_n 16._o it_o cause_v a_o furious_a madness_n yet_o compose_v the_o spirit_n above_o all_o thing_n 17._o it_o cause_v 〈◊〉_d yet_o sometime_o cure_v they_o as_o willis_n say_v 18._o it_o cause_v palsy_n yet_o have_v i_o know_v it_o to_o cure_v a_o palsy_n 19_o it_o cause_v dryness_n in_o the_o mouth_n yet_o take_v off_o thirst_n in_o fever_n 20._o it_o cure_v and_o cause_v a_o hiccough_n 21._o it_o stanche_n blood_n yet_o cause_v the_o blood_n to_o come_v outward_a as_o appear_v by_o the_o efflorescence_n or_o redness_n of_o the_o skin_n that_o it_o cause_n yet_o move_v the_o menses_fw-la and_o lochia_n 22._o we_o have_v many_o instance_n of_o it_o promote_a and_o hinder_v critical_a motion_n 23._o it_o raise_v very_o weak_a people_n when_o nothing_o beside_o will_v do_v it_o yet_o it_o kill_v other_o weak_a people_n 24._o it_o cause_n and_o cure_n convulsion_n 25._o it_o cause_v relaxation_n and_o contraction_n of_o the_o same_o part_n 26._o it_o relax_n yet_o cause_v rigidity_n tension_n and_o erection_n of_o the_o penis_n priapism_n etc._n etc._n thus_o have_v i_o fair_o and_o faithful_o lay_v the_o whole_a onus_fw-la of_o the_o operation_n effect_n and_o contradictory_n phenomena_n of_o opium_n upon_o my_o shoulder_n however_o i_o come_v off_o and_o clear_v myself_o of_o the_o intricacy_n maze_n and_o cross_a effect_n thereof_o by_o explain_v they_o which_o none_o upon_o the_o view_n thereof_o will_v think_v possible_a and_o none_o before_o i_o dare_v as_o much_o as_o enumerate_v for_o that_o end_n chap._n vii_o the_o author_n contrive_v a_o compendious_a way_n of_o examine_v all_o opinion_n concern_v the_o operation_n of_o opium_n have_v without_o any_o sly_a or_o sordid_a evasion_n or_o considerable_a omission_n which_o have_v be_v the_o perfidious_a course_n of_o author_n in_o this_o case_n full_o and_o true_o enumerate_v the_o sensible_a and_o certain_a effect_n of_o opium_n in_o humane_a body_n and_o thereby_o empanneled_a a_o just_a jury_n for_o the_o trial_n of_o hypothesise_n which_o must_v be_v judge_v by_o the_o effect_n or_o phenomena_n of_o opium_n i_o will_v now_o proceed_v to_o their_o examination_n but_o because_o it_o will_v be_v endless_a to_o take_v every_o one_o particular_o into_o consideration_n i_o will_v use_v their_o stratagem_n who_o blow_v up_o foundation_n to_o save_v the_o tedious_a peck_v at_o all_o the_o part_n of_o the_o superstructure_n which_o in_o this_o case_n will_v require_v a_o age_n and_o take_v up_o all_o my_o time_n in_o demolish_n they_o which_o may_v be_v better_o employ_v in_o erect_v something_o that_o may_v be_v useful_a i_o have_v consider_v and_o find_v that_o the_o foundation_n in_o which_o all_o author_n both_o ancient_a and_o modern_a agree_v and_o whereupon_o they_o have_v hitherto_o endeavour_v to_o build_v look_v upon_o it_o as_o firm_a and_o warrantable_a in_o all_o age_n be_v this_o viz._n that_o opium_n operate_v by_o diminish_v or_o disable_n the_o spirit_n mean_v the_o animal_n spirit_n the_o ancient_n affirm_v that_o it_o do_v so_o by_o a_o extreme_a cold_a quality_n etc._n etc._n and_o the_o modern_n who_o observe_v it_o to_o act_n while_o it_o be_v at_o stomach_n by_o affect_v the_o brain_n nerve_n animal_n spirit_n etc._n etc._n and_o conclude_v no_o action_n be_v perform_v without_o contact_n infer_v and_o agree_v because_o no_o visible_a passage_n can_v be_v find_v from_o the_o stomach_n to_o the_o head_n that_o it_o must_v of_o absolute_a necessity_n act_v by_o fume_n vapour_n auras_fw-la or_o effluvium_n send_v up_o out_o of_o the_o stomach_n to_o the_o brain_n nerve_n etc._n etc._n so_o that_o all_o the_o remain_a question_n among_o the_o modern_n be_v which_o way_n those_o fume_n or_o vapour_n do_v the_o feat_n all_o allow_v the_o fume_n do_v it_o one_o say_v that_o they_o stuff_v the_o pore_n of_o the_o brain_n and_o so_o hinder_v the_o generation_n of_o animal_n spirit_n a_o second_o that_o they_o constringed_a and_o close_v the_o pore_n together_o thereby_o hinder_v the_o say_a generation_n a_o three_o that_o they_o fix_v and_o coagulate_v the_o animal_n spirit_n as_o wedelius_n and_o other_o a_o four_o that_o they_o cloud_v the_o animal_n spirit_n a_o five_o that_o they_o act_v as_o a_o poison_n as_o willis_n and_o many_o other_o a_o six_o that_o they_o clog_v the_o animal_n spirit_n by_o adhere_v to_o they_o etc._n etc._n not_o know_v nor_o i_o think_v care_v what_o they_o say_v so_o they_o humour_a their_o own_o imagination_n and_o hypothesise_n though_o utter_o incapable_a of_o solve_v the_o effect_n of_o opium_n especial_o be_v most_o constant_a proper_a and_o genuine_a effect_n for_o how_o can_v a_o cold_a quality_n which_o opium_n never_o have_v cause_v a_o gay_a and_o brisk_a humour_n bravery_n magnanimity_n euphory_n in_o labour_n promptitude_n to_o venus_n etc._n etc._n and_o how_o can_v cloud_n of_o vapour_n hinder_v the_o generation_n of_o animal_n spirit_n by_o stuff_v or_o constr_v the_o pore_n of_o the_o brain_n poison_v fix_v coagulate_v clog_a or_o cloud_v the_o animal_n spirit_n cause_v a_o fine_a ovation_n thereof_o a_o gay_a brave_a courageous_a and_o magnanimous_a disposition_n euphory_n promptitude_n to_o venery_n serenity_n expediteness_n in_o management_n etc._n etc._n which_o be_v as_o have_v be_v say_v the_o constant_a and_o proper_a effect_n of_o opium_n nor_o indeed_o be_v any_o of_o those_o author_n so_o foolhardy_a as_o to_o attempt_v it_o
that_o include_v the_o glandule_n must_v as_o in_o sleep_n which_o relax_n they_o stop_v or_o moderate_v all_o defluxion_n catarrh_n etc._n etc._n because_o they_o be_v not_o sensible_a oâ—_n the_o irritation_n of_o the_o humour_n by_o quantity_n or_o quality_n which_o irritation_n cause_v the_o defluxion_n or_o catarrh_n by_o exciting_a the_o membrane_n to_o contract_v and_o thereby_o to_o squeeze_v out_o the_o humour_n contain_v in_o the_o glandule_n four_o the_o composure_n of_o the_o spirit_n be_v procure_v main_o by_o sleep_n which_o all_o loss_n of_o spirit_n as_o be_v show_v incline_v we_o to_o so_o bleed_v which_o diminish_v the_o spirit_n compose_v their_o fury_n in_o fever_n delirium_n madness_n etc._n etc._n five_o perspiration_n be_v cause_v by_o nothing_o more_o than_o sleep_v for_o we_o perspire_v twice_o as_o much_o in_o sleep_n as_o when_o we_o watch_v as_o be_v most_o manifest_o demonstrable_a by_o the_o statick_a experiment_n of_o weigh_v people_n nor_o be_v perspiration_n ever_o so_o great_a as_o in_o deliquium_n syncopes_fw-la leipothymy_n and_o such_o like_a deadish_fw-mi case_n which_o be_v cause_v by_o diminish_v or_o disable_n of_o the_o spirit_n nay_o it_o be_v so_o in_o animal_n quite_o dead_a for_o a_o little_a time_n while_o they_o be_v hot_a as_o be_v evident_a by_o like_a statick_a demonstration_n the_o true_a cause_n of_o which_o be_v relaxation_n of_o the_o pore_n skin_n etc._n etc._n for_o want_n of_o spirit_n to_o contract_n and_o constringe_v they_o as_o shall_v be_v full_o prove_v hereafter_o by_o god_n help_n these_o thing_n be_v doubtless_o the_o occasion_n of_o that_o hypothesis_n of_o diminish_v or_o disable_n the_o spirit_n by_o opium_n but_o how_o likely_a be_v they_o to_o err_v by_o establish_v it_o without_o any_o consideration_n of_o its_o enliven_a encourage_v and_o brisk_a effect_n as_o ovation_n of_o the_o spirit_n gaity_n bravery_n magnanimity_n euphory_n promptitude_n to_o venery_n etc._n etc._n which_o can_v never_o be_v solve_v by_o diminution_n or_o disability_n of_o the_o spirit_n till_o depression_n and_o elevation_n thereof_o be_v reconcilable_a and_o consistent_a at_o the_o same_o time_n in_o the_o same_o subject_n which_o can_v never_o be_v till_o disable_n and_o not_o disable_n be_v the_o same_o thing_n have_v not_o we_o then_o good_a reason_n to_o suspect_v that_o general_a foundation_n of_o diminish_v or_o disable_n the_o spirit_n by_o opium_n which_o be_v lay_v by_o such_o as_o never_o consider_v any_o thing_n of_o its_o generous_a and_o sprightly_a effect_n which_o as_o have_v be_v show_v be_v its_o constant_a and_o therefore_o most_o proper_a and_o genuine_a effect_n who_o can_v doubt_v then_o but_o they_o must_v err_v in_o lay_v a_o foundation_n quite_o contrary_a to_o the_o very_a property_n of_o opium_n 5._o i_o observe_v that_o all_o our_o modern_a author_n and_o physician_n receive_v the_o knowledge_n of_o opium_n its_o effect_n and_o uses_n from_o those_o ancient_n do_v use_v it_o only_o for_o the_o same_o end_n and_o purpose_v as_o they_o do_v and_o that_o our_o modern_a author_n live_v in_o these_o western_a part_n of_o the_o world_n very_o remote_a from_o the_o eastern_a country_n where_o it_o be_v use_v common_o and_o in_o large_a dose_n by_o people_n in_o health_n in_o the_o daytime_n to_o enliven_v invigorate_a and_o encourage_v they_o and_o cause_v the_o brave_a generous_a and_o magnanimous_a effect_n aforemention_v viz._n courage_n euphory_n etc._n etc._n and_o find_v no_o physician_n that_o go_v before_o they_o to_o mention_v these_o noble_a cordial_a and_o glorious_a effect_n and_o if_o they_o do_v at_o any_o time_n slight_o touch_v they_o to_o do_v it_o with_o all_o imaginable_a disregard_n neglect_v and_o contempt_n as_o if_o there_o be_v no_o heed_n to_o be_v take_v of_o they_o but_o as_o idle_a tale_n and_o improbable_a story_n be_v contrary_a and_o utter_o as_o they_o think_v inconsistent_a and_o irreconcilable_a with_o the_o daily_a and_o most_o notorious_a effect_n of_o opium_n observe_v among_o we_o and_o to_o the_o universal_a opinion_n of_o all_o author_n who_o state_v opium_n to_o be_v a_o diminisher_n or_o disabler_n of_o the_o spirit_n which_o can_v not_o produce_v as_o they_o conclude_v such_o contradictory_n and_o therefore_o to_o they_o utter_o incredible_a effect_n and_o fabulons_a flam_n arise_v as_o they_o fancy_v from_o some_o silly_a error_n as_o want_v of_o due_a observation_n in_o traveller_n mistake_a discourse_n and_o the_o like_a so_o that_o as_o the_o say_n be_v they_o let_v they_o in_o at_o one_o ear_n and_o out_o at_o the_o other_o there_o be_v no_o such_o contrary_a effect_n of_o any_o one_o thing_n to_o be_v observe_v in_o the_o whole_a creation_n and_o they_o be_v well_o assure_v of_o the_o other_o effect_n by_o daily_a experience_n and_o have_v never_o observe_v those_o lively_a effect_n for_o the_o several_a plain_a reason_n that_o you_o will_v meet_v in_o the_o follow_a paragraph_n have_v no_o cause_n to_o alter_v their_o opinion_n when_o all_o thing_n seem_v to_o they_o to_o make_v for_o their_o hypothesis_n for_o want_v of_o a_o notion_n of_o those_o brisk_a effect_n 6._o i_o observe_v that_o those_o brisk_a effect_n of_o opium_n be_v not_o take_v notice_n of_o by_o our_o physician_n nor_o indeed_o all_o thing_n consider_v do_v i_o well_o see_v how_o they_o shall_v without_o get_v out_o of_o the_o common_a road_n of_o observe_v which_o be_v sometime_o as_o i_o have_v find_v very_o useful_a upon_o such_o occasion_n for_o first_o opium_n be_v seldom_o if_o ever_o give_v in_o these_o western_a nation_n but_o to_o sick_a people_n as_o the_o ancient_n do_v who_o be_v utter_o incapable_a of_o those_o brisk_a effect_n or_o at_o least_o to_o any_o remarkable_a degree_n that_o may_v call_v for_o a_o particular_a or_o special_a advertency_n or_o attention_n without_o which_o they_o pass_v off_o as_o they_o come_v without_o any_o reflection_n thereupon_o and_o so_o signify_v nothing_o as_o if_o they_o have_v never_o happen_v second_o we_o as_o the_o ancient_n do_v general_o give_v opium_n when_o people_n be_v go_v to_o bed_n by_o which_o mean_v all_o opportunity_n of_o observation_n be_v lose_v because_o darkness_n and_o be_v alone_o hide_v or_o hinder_v the_o show_v of_o any_o such_o effect_n and_o the_o physician_n who_o only_a business_n it_o be_v to_o be_v more_o curious_a in_o such_o matter_n be_v go_v to_o his_o own_o rest_n though_o if_o he_o be_v present_a not_o likely_a to_o take_v any_o observation_n of_o such_o matter_n whereof_o he_o have_v least_o thought_n or_o belief_n as_o be_v in_o his_o opinion_n contrary_a to_o all_o reason_n sense_n experience_n and_o the_o opinion_n of_o all_o author_n of_o the_o stupefactive_a quality_n of_o opium_n in_o which_o they_o all_o agree_v three_o opium_n be_v as_o be_v say_v give_v in_o these_o country_n to_o cause_n sleep_n or_o such_o effect_n to_o which_o sleep_n conduce_v as_o compose_v the_o spirit_n cause_v indolence_n stop_v flux_n and_o promote_a perspiration_n and_o therefore_o always_o give_v with_o all_o careful_a direction_n and_o injunction_n that_o may_v conduce_v to_o that_o end_n as_o go_v to_o bed_n lie_v still_o put_v out_o light_n keep_v silence_n etc._n etc._n which_o concur_v with_o the_o opium_n cause_n sleep_n which_o be_v utter_o inconsistent_a with_o show_v any_o of_o those_o lively_a effect_n that_o belong_v only_o to_o a_o wake_a person_n to_o do_v so_o that_o all_o opportunity_n of_o observation_n be_v utter_o preclude_v now_o all_o the_o premise_n consider_v it_o can_v be_v conceive_v that_o such_o as_o set_v their_o mind_n upon_o contrary_a effect_n and_o expect_v no_o other_o much_o less_o contrary_a one_o against_o which_o also_o they_o be_v high_o prejudice_v by_o their_o reason_n experience_n and_o read_v shall_v observe_v such_o brisk_a effect_n if_o they_o do_v happen_v and_o how_o can_v a_o brisk_a humour_n courage_n easy_a undergo_n of_o labour_n promptitude_n to_o venus_n etc._n etc._n be_v observe_v in_o sick_a and_o infirm_a people_n lie_v in_o bed_n alone_z and_o in_o the_o dark_a or_o which_o render_v it_o utter_o impossible_a while_o they_o be_v asleep_a and_o the_o thing_n itself_o disbelieved_a and_o esteem_v contrary_a to_o common_a sense_n and_o the_o universal_a sentiment_n of_o the_o learned_a and_o all_o other_o therefore_o 7._o if_o after_o all_o any_o such_o brisk_a effect_n do_v ever_o happen_v it_o must_v be_v either_o not_o regard_v or_o if_o observe_v which_o be_v no_o way_n likely_a as_o be_v show_v you_o may_v be_v sure_a for_o the_o many_o plain_a reason_n and_o cause_n aforesaid_a that_o it_o be_v not_o impute_v to_o stupify_a opium_n as_o all_o esteem_v it_o but_o to_o any_o other_o cause_n or_o accident_n rather_o than_o to_o a_o thing_n well_o know_v to_o have_v quite_o contrary_a effect_n for_o instance_n if_o the_o sick_a person_n happen_v to_o be_v
good_a humour_a of_o which_o he_o be_v seldom_o capable_a and_o utter_o incapable_a of_o all_o or_o most_o of_o the_o other_o brisk_a effect_n as_o euphory_n promptitude_n to_o venus_n exertion_n of_o courage_n etc._n etc._n it_o be_v either_o pass_v by_o as_o a_o ordinary_a thing_n of_o course_n and_o so_o not_o heed_v or_o else_o impute_v to_o refreshment_n by_o sleep_n ease_n from_o pain_n or_o some_o amendment_n as_o to_o the_o disease_n or_o indeed_o to_o any_o thing_n rather_o than_o dispiriting_n and_o stupify_a opium_n that_o be_v so_o far_o in_o all_o opinion_n from_o exciting_a the_o spirit_n that_o all_o affirm_v conclude_v and_o agree_v that_o it_o diminish_v or_o disable_v they_o the_o like_a be_v to_o be_v say_v of_o any_o of_o the_o lively_a effect_n in_o case_n they_o happen_v and_o be_v observe_v though_o i_o do_v not_o see_v how_o they_o can_v so_o at_o least_o as_o any_o slander_n by_o will_v refer_v it_o to_o opium_n beside_o that_o as_o to_o some_o of_o the_o brisk_a effect_n especial_o that_o of_o venery_n great_a dose_n be_v requisite_a to_o render_v it_o any_o thing_n remarkable_a than_o be_v use_v in_o these_o western_a part_n and_o that_o modesty_n will_v much_o hinder_v the_o discovery_n of_o this_o effect_n be_v it_o not_o therefore_o very_o manifest_a that_o i_o have_v great_a cause_n to_o suspect_v that_o both_o ancient_n and_o modern_a physician_n consider_v thing_n by_o half_n since_o they_o do_v not_o take_v the_o most_o genuine_a property_n into_o their_o consideration_n and_o that_o they_o lay_v their_o foundation_n upon_o the_o most_o contrary_a effect_n to_o they_o it_o follow_v then_o that_o the_o general_a supposition_n of_o all_o the_o learned_a can_v no_o more_o solve_v the_o true_a property_n of_o opium_n in_o any_o probability_n than_o give_v the_o reason_n why_o fire_n harden_v clay_n can_v explain_v why_o it_o soften_v wax_n the_o reason_n do_v i_o say_v i_o shall_v have_v say_v than_o give_v the_o wrong_a reason_n why_o it_o harden_v clay_n show_v how_o it_o soften_v wax_n for_o it_o will_v appear_v in_o the_o follow_a chapter_n that_o they_o give_v no_o right_a reason_n for_o any_o effect_n of_o opium_n even_o those_o they_o ever_o allow_v to_o be_v its_o effect_n nor_o lay_v any_o true_a foundation_n to_o explain_v the_o least_o mean_a and_o plain_a effect_n thereof_o forasmuch_o as_o all_o their_o supposition_n be_v so_o false_a that_o there_o never_o be_v any_o such_o thing_n as_o they_o lie_v down_o to_o explain_v the_o effect_n of_o opium_n viz._n 1._o no_o such_o thing_n as_o a_o cold_a quality_n in_o opium_n 2._o no_o such_o thing_n as_o fume_n etc._n etc._n fly_v from_o opium_n to_o the_o brain_n while_o it_o be_v at_o stomach_n 3._o no_o such_o thing_n as_o diminish_v or_o disable_n the_o animal_n spirit_n by_o opium_n any_o way_n whatsoever_o of_o which_o in_o their_o order_n in_o the_o follow_a chapter_n chap._n ix_o it_o be_v prove_v that_o opium_n have_v no_o cold_a quality_n to_o diminish_v or_o disable_v the_o spirit_n thereby_o have_v show_v just_a cause_n of_o my_o suspicion_n of_o that_o universal_a foundation_n of_o opium_n diminish_v or_o disable_n the_o spirit_n i_o will_v now_o proceed_v to_o a_o more_o strict_a examination_n thereof_o beginning_n with_o the_o opinion_n of_o the_o ancient_n who_o affirm_v that_o opium_n diminish_v or_o disable_v the_o spirit_n by_o a_o extreme_a cold_a quality_n i_o confess_v that_o much_o may_v be_v do_v towards_o the_o diminish_n or_o disable_n the_o spirit_n by_o opium_n if_o it_o have_v such_o a_o cold_a quality_n as_o the_o ancient_n attribute_v to_o it_o for_o than_o it_o must_v be_v such_o a_o coldness_n as_o the_o cold_a thing_n either_o actual_a or_o potential_a bear_v no_o proportion_n to_o for_o ice_n snow_n etc._n etc._n bear_v no_o proportion_n to_o it_o in_o cause_v the_o same_o effect_n by_o a_o cold_a quality_n it_o be_v the_o manner_n of_o the_o ancient_n implicit_o to_o believe_v and_o subscribe_v to_o what_o their_o great_a author_n and_o master_n in_o physic_n or_o philosophy_n teach_v they_o who_o they_o adore_v as_o infallible_a god_n as_o soon_o as_o their_o mortality_n prove_v the_o contrary_a which_o be_v as_o absurd_a as_o assert_v tha_z opium_n which_o be_v one_o of_o the_o hot_a thing_n that_o vegetable_n afford_v be_v extreme_a cold_a bless_a be_v god_n for_o our_o light_n in_o religion_n and_o liberty_n in_o philosophy_n therefore_o some_o such_o admire_a author_n or_o great_a master_n in_o physic_n have_v assert_v that_o opium_n act_v by_o a_o extreme_a cold_a quality_n all_o do_v implicit_o subscribe_v to_o it_o the_o devil_n who_o they_o worship_v can_v not_o though_o a_o deceiver_n from_o the_o beginning_n impose_v more_o upon_o their_o faith_n than_o in_o cause_v they_o for_o i_o can_v think_v but_o it_o be_v some_o such_o evil_a power_n to_o believe_v that_o opium_n be_v cold_a against_o all_o the_o evidence_n of_o sense_n and_o experience_n he_o may_v have_v as_o well_o tell_v they_o that_o hell_n fire_n have_v all_o the_o property_n of_o common_a culinary_a fire_n and_o yet_o nothing_o more_o refresh_v by_o its_o cold_a quality_n for_o as_o many_o of_o our_o sense_n as_o can_v take_v notice_n of_o heat_n and_o cold_a do_v plain_o inform_v we_o that_o it_o be_v very_o hot_a in_o itself_o and_o effect_n for_o 1._o it_o be_v taste_n be_v very_o bitter_a rank_a vehement_o hot_a burn_a and_o bite_v all_o which_o quality_n be_v infallible_a sign_n of_o great_a heat_n and_o the_o better_a the_o opium_n be_v the_o more_o intense_a be_v those_o quality_n nay_o it_o be_v observe_v that_o its_o very_a virtue_n be_v strict_o combine_v to_o or_o consist_v in_o those_o quality_n especial_o bitterness_n which_o if_o lose_v the_o virtue_n be_v go_v as_o be_v common_o observe_v and_o easy_o observable_a it_o be_v a_o wise_a fetch_v of_o amatus_fw-la lusitanus_n in_o defence_n of_o its_o cold_a quality_n to_o attribute_v all_o its_o bitterness_n to_o glaucium_fw-la that_o be_v mix_v therewith_o whereas_o glaucium_fw-la always_o give_v a_o yellow_a tincture_n to_o water_n and_o opium_n a_o red_a but_o the_o opium_n that_o give_v no_o yellow_a tincture_n be_v bitter_a also_o yea_o that_o be_v most_o bitter_a that_o give_v the_o red_a tincture_n how_o come_v theban_a opium_n and_o indeed_o all_o other_o opium_n to_o be_v bitter_a before_o any_o thing_n be_v mix_v with_o it_o how_o inadvertent_o absurd_a people_n will_v be_v to_o defend_v absurdity_n it_o be_v pretty_a to_o see_v how_o they_o will_v expose_v themselves_o to_o defend_v a_o false_a opinion_n 2._o it_o be_v smell_n which_o be_v very_a rank_n strong_a hot_a and_o such_o as_o thing_n high_o impregnate_v with_o volatile_a salt_n and_o sulphur_n the_o two_o hot_a principle_n in_o nature_n do_v afford_v it_o be_v from_o volatile_a salt_n that_o cantharides_n pismire_n spear-wort_n crowsfoot_n etc._n etc._n be_v so_o very_o hot_a as_o to_o blister_v or_o exulcerate_v and_o be_v not_o all_o hot_a spirit_n such_o upon_o the_o account_n of_o their_o sulphur_n as_o spirit_n of_o wine_n brandy_n etc._n etc._n 3._o the_o best_a and_o strong_a opium_n will_v also_o exulcerate_v as_o all_o author_n agree_v which_o only_a fire_n or_o such_o thing_n as_o have_v the_o particle_n of_o fire_n lodge_v in_o they_o as_o lixiviate_n etc._n etc._n or_o the_o hot_a thing_n in_o nature_n will_v do_v as_o cantharides_n spear-wort_n etc._n etc._n it_o be_v 4._o for_o the_o like_a reason_n a_o psilothrick_n or_o causer_n of_o hair_n to_o fall_v which_o only_a lime_n orpâ—ment_n and_o the_o hot_a thing_n do_v cause_n 5._o it_o be_v inflammable_a which_o only_o sulphurecus_fw-la thing_n be_v 6._o it_o cause_v a_o sense_n of_o a_o vehement_a heat_n at_o stomach_n though_o take_v but_o in_o the_o quantity_n of_o a_o drachm_n 7._o it_o cause_v dryness_n of_o the_o mouth_n and_o thirst_v though_o take_v but_o in_o the_o quantity_n of_o 3_o grain_n which_o nothing_o do_v but_o hot_a thing_n 8._o it_o discuss_n and_o all_o discusser_n be_v hot_a for_o it_o be_v by_o heat_n that_o they_o do_v discuss_v as_o spirit_n of_o wine_n cummin-seed_n volatile_a salt_n and_o all_o hot_a spirit_n 9_o it_o soon_o operate_v and_o in_o a_o small_a quantity_n which_o be_v a_o infallible_a proof_n of_o the_o activity_n of_o its_o part_n which_o argue_v heat_n not_o cold._a 10._o it_o cause_v a_o gay_a pleasant_a and_o merry_a humour_n which_o only_a wine_n and_o hot_a liquor_n etc._n etc._n do_v and_o one_o grain_n of_o opium_n will_v cause_v they_o as_o much_o as_o several_a glass_n of_o wine_n which_o argue_v that_o its_o heat_n be_v much_o great_a 11._o i_o will_v fain_o know_v how_o or_o see_v any_o instance_n of_o any_o cold_a thing_n raise_v the_o spirit_n cause_v courage_n magnanimity_n enable_v people_n to_o labour_n journey_n etc._n
or_o vapour_n do_v ready_o and_o free_o pass_v from_o the_o stomach_n to_o the_o brain_n because_o the_o gross_a fume_n as_o they_o call_v they_o of_o a_o grain_n or_o two_o of_o opium_n always_o operate_v before_o it_o be_v out_o of_o the_o stomach_n but_o they_o never_o see_v such_o fume_n pass_v nor_o their_o passage_n only_o suppose_v both_o and_o that_o mere_o upon_o a_o imagination_n that_o it_o must_v be_v so_o because_o they_o forsooth_o can_v conceive_v any_o other_o way_n by_o which_o opium_n can_v affect_v the_o head_n nerve_n etc._n etc._n while_o it_o be_v at_o stomach_n whereas_o i_o can_v and_o shall_v god_n will_v show_v they_o another_o mean_n or_o way_n to_o do_v it_o that_o be_v sensible_a and_o not_o whole_o precarious_a as_o they_o be_v and_o that_o in_o the_o mean_a manner_n because_o all_o their_o ground_n to_o suppose_v it_o be_v their_o inability_n to_o conceive_v or_o apprehend_v what_o be_v as_o i_o shall_v show_v very_o sensible_a nay_o obvious_a also_o second_o they_o suppose_v that_o such_o fume_n will_v serve_v to_o solve_v all_o the_o phoenomena_n and_o operation_n of_o opium_n whereas_o it_o be_v utter_o impossible_a they_o shall_v solve_v the_o enliven_a and_o invigorate_n effect_n thereof_o as_o have_v be_v show_v and_o shall_v be_v further_o prove_v if_o god_n permit_v it_o be_v easy_a to_o evidence_n but_o that_o it_o will_v be_v tedious_a and_o needless_a for_o their_o incompetency_n to_o solve_v the_o most_o proper_a effect_n of_o opium_n be_v more_o than_o enough_o that_o such_o fume_n or_o vapour_n can_v true_o solve_v no_o effect_n of_o opium_n unless_o it_o be_v that_o of_o death_n or_o some_o deadly_a symptom_n nay_o they_o will_v not_o solve_v the_o most_o likely_a to_o be_v cause_v by_o vapour_n viz._n sleep_v which_o all_o man_n as_o wedelius_n say_v allow_v to_o be_v the_o effect_n of_o fume_n or_o vapour_n in_o his_o opiologia_fw-la c._n 11._o p._n 35._o somnum_fw-la naturalem_fw-la say_v he_o omnes_fw-la concedunt_fw-la producere_fw-la suaviores_fw-la &_o blandas_fw-la 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d seu_fw-la vapores_fw-la primum_fw-la 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d demulcentes_fw-la qui_fw-la cum_fw-la spiritibus_fw-la animalibus_fw-la mixti_fw-la torpidos_fw-la quasi_fw-la illos_fw-la reddunt_fw-la that_o be_v all_o grant_v that_o kind_n and_o gentle_a fume_n do_v cause_n natural_a sleep_n etc._n etc._n which_o be_v most_o certain_o false_a though_o i_o very_o much_o doubt_n that_o this_o groundless_a presumption_n which_o as_o he_o intimate_v all_o embrace_n have_v be_v a_o great_a cause_n of_o this_o airy_a imagination_n of_o fume_n in_o the_o case_n of_o opium_n because_o man_n look_v upon_o sleep_n agree_v upon_o to_o be_v cause_v by_o fume_n to_o be_v the_o prime_n lead_v and_o most_o proper_a effect_n of_o opium_n which_o be_v also_o false_a it_o be_v but_o a_o mere_a accident_n as_o have_v be_v show_v and_o when_o it_o happen_v general_o require_v lie_v or_o sit_v still_o to_o assist_v it_o whereas_o the_o watch_a that_o be_v the_o effect_n of_o opium_n require_v no_o help_n and_o can_v be_v put_v off_o as_o sleep_n can_v by_o motion_n action_n etc._n etc._n notwithstanding_o all_o endeavour_n to_o the_o contrary_n now_o i_o will_v know_v of_o any_o man_n which_o be_v the_o most_o proper_a and_o natural_a effect_n of_o any_o cause_n that_o which_o nothing_o can_v hinder_v or_o that_o which_o every_o action_n can_v but_o i_o run_v too_o far_o upon_o this_o matter_n which_o belong_v more_o apt_o to_o that_o part_n of_o this_o book_n that_o explain_v all_o the_o effect_n of_o opium_n and_o so_o must_v return_v to_o that_o of_o fume_n which_o do_v not_o cause_v natural_a sleep_n as_o manifest_o appear_v 1._o because_o that_o which_o cause_v natural_a sleep_n must_v in_o all_o reason_n as_o it_o be_v always_o in_o the_o wise_a work_n of_o nature_n bear_v a_o proportion_n thereto_o but_o fume_n suppose_v their_o be_v bear_v no_o proportion_n to_o our_o sleep_n certain_o a_o work_a labourer_n that_o toil_v all_o the_o day_n must_v spend_v the_o fume_n of_o his_o body_n in_o the_o high_a degree_n and_o feed_v upon_o dry_a bread_n and_o cheese_n must_v breed_v few_o fume_n yet_o none_o sleep_v better_a or_o sweet_a than_o he_o the_o like_a be_v to_o be_v say_v of_o a_o travel_a man_n a_o tire_a person_n etc._n etc._n who_o often_o fall_v asleep_a before_o they_o eat_v or_o drink_v to_o renew_v their_o fume_n which_o they_o have_v spend_v in_o a_o extraordinary_a manner_n why_o sleep_n that_o be_v design_v for_o refreshment_n and_o recruit_v shall_v depend_v upon_o fume_n no_o man_n can_v tell_v for_o than_o our_o refreshment_n will_v whole_o depend_v thereon_o and_o no_o man_n have_v any_o recruit_v by_o sleep_n but_o in_o proportion_n thereunto_o who_o dare_v accuse_v our_o wise_a and_o good_a maker_n of_o such_o contrivance_n who_o in_o nature_n always_o proportion_n thing_n to_o the_o exigency_n thereof_o and_o therefore_o sleep_v not_o to_o fume_n but_o to_o that_o which_o be_v impair_v in_o we_o for_o want_v thereof_o which_o be_v always_o contrive_v by_o wise_a nature_n if_o you_o will_v observe_v it_o to_o be_v the_o prompt_a cause_n to_o the_o recruit_v and_o then_o proportion_n be_v due_o observe_v because_o we_o be_v prompt_v exact_o according_a to_o the_o exigence_n or_o necessity_n of_o nature_n as_o become_v the_o wisdom_n of_o our_o creator_n and_o preserver_n this_o rule_n if_o due_o attend_v to_o will_v easy_o speedy_o and_o certain_o lead_v you_o to_o the_o knowledge_n of_o the_o true_a natural_a cause_n of_o hunger_n thirst_v inclination_n to_o sleep_n and_o all_o such_o call_v for_o restauration_n all_o which_o i_o can_v soon_o satisfy_v you_o in_o but_o that_o it_o be_v not_o my_o business_n at_o present_a and_o that_o it_o will_v too_o much_o anticipate_v my_o design_a tract_n of_o animal_n mechanism_n nor_o do_v labour_v itself_o bear_v any_o exact_a proportion_n thereunto_o because_o many_o healthy_a people_n that_o be_v idle_a all_o day_n sleep_v long_o sound_o and_o sweet_o every_o night_n as_o well_o as_o labourer_n so_o that_o in_o short_a it_o must_v be_v somewhat_o that_o belong_v to_o watch_v as_o such_o for_o sleep_v general_o bear_v the_o best_a proportion_n to_o watch_v if_o we_o watch_v much_o or_o little_a our_o sleep_n bear_v some_o proportion_n thereto_o though_o there_o may_v be_v in_o this_o as_o well_o as_o in_o hunger_n thirst_v etc._n etc._n accident_n that_o cause_n the_o promptitude_n to_o be_v more_o or_o less_o and_o so_o vary_v the_o true_a natural_a proportion_n all_o which_o have_v the_o nature_n of_o disease_n as_o canine_a appetite_n coma_n caros_n preternatural_a thrists_z etc._n etc._n what_o it_o be_v that_o watch_a cause_n to_o prompt_v we_o to_o sleep_n must_v be_v some_o impair_v make_v thereby_o as_o such_o and_o not_o the_o foolish_a conceit_n of_o fume_n and_o it_o be_v easy_a for_o i_o to_o illustrate_v what_o it_o be_v but_o that_o it_o will_v require_v some_o sheet_n of_o paper_n and_o as_o i_o say_v before_o anticipate_v my_o discourse_n of_o animal_n mechanism_n which_o i_o hope_v to_o have_v publish_v before_o this_o book_n and_o will_v have_v be_v most_o convenient_a because_o the_o principle_n therein_o state_v may_v serve_v to_o explain_v the_o effect_n of_o opium_n but_o that_o the_o want_n of_o a_o few_o experiment_n have_v to_o my_o grief_n hitherto_o delay_v it_o and_o therefore_o i_o must_v be_v put_v to_o much_o trouble_v in_o this_o work_n for_o want_v thereof_o because_o i_o be_o resolve_v not_o to_o spare_v myself_o in_o order_n to_o satisfy_v the_o reader_n in_o this_o great_a and_o unexplicate_v mystery_n 2._o if_o vapour_n be_v the_o cause_n of_o natural_a sleep_n it_o be_v impossible_a that_o the_o prick_n of_o a_o pin_n or_o a_o sharp_a sound_n etc._n etc._n shall_v awake_v one_o ten_o or_o twenty_o time_n in_o a_o hour_n for_o either_o the_o prick_n must_v in_o a_o instant_n discuss_v all_o the_o fume_n in_o be_v which_o be_v impossible_a to_o be_v imagine_v and_o they_o as_o often_o return_v to_o cause_n sleep_v again_o or_o intercept_v their_o motion_n from_o the_o stomach_n to_o the_o head_n which_o no_o man_n can_v have_v any_o conception_n of_o the_o efficacy_n of_o the_o pin_n or_o sound_v so_o to_o do_v or_o they_o must_v both_o discuss_v and_o intercept_v the_o fume_n which_o indeed_o if_o the_o case_n be_v such_o will_v be_v necessary_a to_o make_v a_o clear_a awake_v which_o be_v yet_o far_o more_o unconceivable_a what_o paltry_a trifle_n do_v the_o world_n embrace_v instead_o of_o truth_n and_o reason_n 3._o several_a person_n whereof_o i_o be_o one_o do_v awake_a in_o a_o minute_n or_o two_o after_o they_o first_o fall_v asleep_a in_o bed_n at_o night_n which_o will_v be_v absolute_o impossible_a if_o fume_n cause_v sleep_n for_o the_o fume_n will_v
increase_v more_o and_o more_o and_o make_v one_o more_o and_o more_o remote_a from_o wake_v 4._o why_o shall_v warm_a bath_n fomentation_n feetwash_n head-washes_a warm_a moist_a wether_n the_o act_n of_o venery_n the_o pleasure_n of_o sweet_a melody_n gentle_a rub_v of_o the_o head_n in_o a_o pleasant_a manner_n scratch_v the_o back_n where_o it_o itch_v and_o all_o gentle_a pleasure_n that_o be_v consistent_a with_o lie_v or_o sit_v still_o which_o do_v all_o cause_n a_o very_a free_a perspiration_n of_o fume_n at_o the_o pore_n that_o be_v then_o most_o certain_o open_v by_o all_o those_o cause_n as_o may_v be_v prove_v by_o statick_a demonstration_n magnify_v glass_n etc._n etc._n cause_n sleep_n see_v they_o all_o cause_n a_o spend_v of_o the_o fume_n obj._n some_o half-witted_a unthinking_a caviller_n may_v say_v that_o such_o thing_n stir_v up_o the_o vapour_n etc._n etc._n answ._n what_o such_o mean_a by_o vapour_n stir_v be_v not_o easy_o determinable_a but_o this_o i_o know_v that_o all_o stir_n of_o humour_n or_o any_o other_o thing_n hinder_v sleep_n and_o that_o the_o long_o such_o cause_n of_o open_v the_o pore_n and_o consequent_o of_o perspire_a fume_n do_v last_o the_o more_o we_o be_v incline_v by_o they_o to_o sleep_n so_o that_o the_o more_o our_o fume_n have_v be_v spend_v the_o more_o we_o be_v incline_v to_o sleep_v which_o be_v a_o strange_a contradiction_n if_o fume_n be_v the_o cause_n of_o sleep_n i_o can_v but_o smile_v to_o think_v how_o most_o physician_n come_v to_o call_v several_a thing_n vapour_n first_o they_o say_v that_o sleep_n be_v from_o vapour_n then_o call_v every_o thing_n vapour_n right_a or_o wrong_n that_o incline_v we_o to_o sleep_v by_o reason_n of_o that_o false_a supposition_n how_o then_o come_v camphire_n not_o to_o be_v a_o great_a causer_n of_o sleep_n that_o be_v so_o apt_a to_o evaporate_v 5._o fear_v sorrow_n grief_n melancholy_n depression_n of_o spirit_n cold_a etc._n etc._n do_v most_o certain_o close_v the_o pore_n as_o appear_v by_o statick_a experiment_n by_o which_o mean_v vapour_n be_v much_o crowd_v in_o the_o body_n yet_o all_o such_o grievance_n do_v hinder_v sleep_n as_o they_o also_o do_v the_o effect_n of_o opium_n and_o drunkenness_n therefore_o they_o do_v not_o proceed_v from_o fume_n as_o the_o world_n imagine_v for_o then_o these_o thing_n that_o crowd_v in_o the_o fume_n and_o vapour_n will_v promote_v not_o hinder_v sleep_n 6._o if_o fume_n be_v the_o cause_n of_o sleep_n then_o be_v the_o cause_n of_o sleep_n and_o vertigo_n as_o the_o vaporanians_n allow_v the_o same_o it_o follow_v then_o that_o we_o can_v never_o sleep_v without_o a_o vertigo_n 7._o many_o as_o dr._n willis_n say_v eat_v their_o meat_n take_v their_o drink_n etc._n etc._n as_o other_o people_n yet_o do_v not_o sleep_v at_o all_o for_o many_o week_n together_o which_o be_v impossible_a if_o the_o fume_n of_o meat_n and_o drink_v cause_v sleep_n for_o they_o by_o eat_v and_o drink_v must_v have_v those_o fume_n and_o consequent_o sleep_v as_o other_o people_n if_o that_o be_v true_a three_o they_o suppose_v and_o take_v it_o for_o grant_v which_o i_o do_v not_o for_o i_o know_v the_o contrary_a that_o opium_n while_o it_o be_v at_o stomach_n can_v affect_v the_o brain_n etc._n etc._n no_o other_o way_n but_o by_o fume_n which_o be_v a_o most_o groundless_a supposition_n for_o 1._o how_o shall_v a_o lump_n of_o curd_n at_o stomach_n or_o the_o have_v of_o a_o knife_n swallow_v and_o many_o such_o thing_n which_o can_v send_v no_o fume_n to_o the_o head_n cause_n convulsion_n headache_n vertigo_n syncopes_fw-la leipothymy_n of_o the_o whole_a man_n manias_fw-la furor_n etc._n etc._n if_o there_o be_v not_o another_o way_n for_o thing_n to_o affect_v the_o nervosum_fw-la genus_fw-la etc._n etc._n while_n at_o stomach_n beside_o send_v up_o vapour_n to_o do_v it_o but_o of_o this_o matter_n to_o show_v how_o a_o thing_n at_o stomach_n may_v affect_v the_o brain_n and_o the_o whole_a system_n of_o the_o nerve_n etc._n etc._n and_o how_o opium_n do_v it_o without_o fume_n the_o 17_o 18_o 19_o 20_o etc._n etc._n chapter_n will_v show_v you_o at_o large_a therefore_o i_o shall_v say_v no_o more_o of_o this_o at_o present_a for_o it_o be_v fit_a for_o we_o first_o to_o overthrow_v that_o supposition_n of_o fume_n and_o vapour_n before_o we_o establish_v our_o own_o for_o far_a satisfaction_n then_o as_o to_o that_o general_a supposition_n of_o fume_n let_v we_o due_o and_o full_o consider_v thing_n for_o it_o be_v not_o a_o slight_a matter_n to_o proceed_v against_o a_o general_n opinion_n that_o have_v continue_v through_o all_o age_n or_o to_o wipe_v off_o the_o prejudices_fw-la acquire_v thereby_o observe_v 1._o that_o the_o brain_n be_v a_o principal_a part._n 2._o that_o it_o be_v very_o soft_a tender_a and_o next_o to_o a_o fluid_a 3._o that_o very_o small_a fine_a and_o gentle_a thing_n do_v high_o offend_v it_o as_o the_o effluvia_n of_o sweet_a or_o ill-scented_n thing_n cause_v hysterick_a and_o epileptical_a fit_n syncopes_fw-la faint_n etc._n etc._n it_o be_v also_o notorious_a among_o we_o physician_n that_o a_o little_a fume_v scarce_o sensible_a as_o to_o quantity_n or_o quality_n rise_v from_o a_o toe_n finger_n &c_n &c_n and_o arrive_v at_o the_o brain_n cause_v dreadful_a epileptical_a fit_n vertigo_n &c._n &c._n 4._o that_o our_o wise_a and_o provident_a creator_n have_v therefore_o secure_v and_o fortify_v all_o the_o avenue_n of_o the_o brain_n in_o a_o more_o particular_a manner_n by_o several_a circumvallation_n viz._n first_o with_o the_o pia_fw-la mater_fw-la second_o with_o the_o dura_n mater_n call_v so_o from_o its_o hardness_n solidity_n and_o strength_n three_o with_o a_o strong_a skull_n of_o a_o round_a or_o arch_a figure_n four_o with_o the_o pericranium_n all_o which_o belong_v to_o it_o particular_o beside_o other_o integument_n common_a to_o it_o with_o other_o part_n as_o 1._o the_o skin_n 2._o the_o cuticle_n 3._o the_o membrana_fw-la carnosa_fw-la 4._o the_o periostium_fw-la all_o which_o do_v surround_v it_o and_o after_o all_o it_o be_v thatch_v as_o it_o be_v with_o hair_n 5._o that_o the_o same_o providence_n have_v take_v care_n which_o be_v very_o observable_a that_o none_o of_o the_o object_n of_o sensation_n nor_o probable_o any_o particle_n or_o effluvium_fw-la that_o fly_v from_o they_o shall_v ever_o reach_v the_o brain_n but_o only_o bare_a impulse_n and_o they_o not_o immediate_o convey_v but_o by_o the_o intervention_n of_o a_o fine_a tenuious_a soft_a gentle_a and_o most_o agreeable_a aura_n viz._n the_o animal_n spirit_n lest_o any_o offence_n shall_v be_v give_v in_o the_o least_o manner_n to_o this_o most_o tender_a delicate_a principal_a part_n and_o royal_a seat_n of_o the_o soul_n all_o which_o care_n have_v never_o be_v without_o necessity_n for_o god_n and_o nature_n do_v nothing_o in_o vain_a and_o if_o you_o will_v due_o consider_v the_o organ_n of_o sensation_n that_o be_v near_o the_o brain_n you_o will_v find_v that_o they_o be_v contrive_v as_o shutter_n to_o exclude_v all_o extraneous_a particle_n from_o the_o brain_n for_o impulse_n may_v have_v be_v contrive_v without_o their_o intervention_n because_o they_o do_v not_o alter_v or_o improve_v the_o impulse_n receive_v from_o object_n for_o if_o they_o do_v we_o shall_v not_o have_v true_a notice_n of_o thing_n and_o see_v they_o do_v not_o alter_v or_o improve_v the_o impulse_n of_o what_o use_n shall_v they_o be_v but_o to_o exclude_v extraneous_a particle_n eume_n effluvia_n &c._n &c._n for_o instance_n the_o tremulous_a motion_n of_o the_o air_n in_o the_o case_n of_o sound_n will_v have_v as_o true_o hit_v the_o auditory_a nerve_n or_o membrane_n without_o the_o tympan_n and_o very_o often_o much_o true_a without_o it_o because_o of_o the_o several_a fault_n and_o disorder_n that_o it_o be_v liable_a to_o yet_o so_o necessary_a be_v it_o think_v by_o the_o best_a of_o judge_n who_o can_v err_v that_o it_o be_v rather_o to_o be_v place_v there_o with_o all_o its_o inconvenience_n that_o may_v follow_v than_o any_o way_n expose_v the_o brain_n though_o to_o the_o most_o gentle_a of_o body_n viz._n the_o air_n by_o which_o in_o all_o probability_n the_o animal_n spirit_n themselves_o be_v nourish_v or_o sustain_v be_v it_o not_o that_o extraneous_a particle_n or_o air_n will_v offend_v the_o brain_n what_o need_n be_v there_o of_o the_o tympan_n when_o we_o know_v as_o well_o by_o experience_n as_o by_o the_o aforesaid_a reason_n that_o a_o dog_n etc._n etc._n can_v hear_v as_o well_o without_o it_o upon_o the_o first_o take_v it_o off_o but_o that_o the_o hear_v will_v afterward_o decay_v because_o the_o brain_n etc._n etc._n be_v expose_v will_v be_v injure_v what_o be_v evident_a in_o the_o case_n of_o the_o ear_n may_v be_v make_v so_o
impossible_a it_o shall_v be_v without_o such_o disturbance_n as_o i_o mention_v will_v follow_v if_o they_o pass_v in_o the_o road_n of_o the_o spirit_n it_o be_v not_o common_a sense_n that_o such_o câ—de_a blast_n shall_v meliorate_v or_o enliven_v the_o spirit_n to_o cause_v briskness_n bravery_n serenity_n courage_n magnanimity_n as_o opium_n do_v much_o less_o if_o those_o fume_n stop_v and_o crowd_v in_o the_o brain_n and_o any_o way_n hinder_v the_o generation_n of_o animal_n spirit_n as_o the_o common_a assertion_n be_v the_o like_a be_v to_o be_v say_v of_o their_o pass_v between_o the_o pia_fw-la mater_fw-la and_o the_o medullary_a part_n of_o the_o nerve_n which_o can_v be_v allow_v because_o of_o its_o close_a adherence_n thereto_o with_o this_o addition_n that_o they_o will_v constant_o cause_v a_o violent_a headache_n which_o opium_n and_o meal_n to_o which_o fume_n be_v particular_o attribute_v do_v often_o cure_v so_o if_o they_o get_v up_o to_o the_o head_n between_o the_o pia_n and_o dura_n mater_n it_o be_v headache_n and_o not_o the_o symptom_n of_o opium_n that_o they_o will_v produce_v which_o headache_n as_o be_v say_v opium_n and_o meal_n do_v cure_v 21._o last_o if_o they_o pass_v by_o any_o mean_n quite_o on_o the_o outside_n of_o the_o nerve_n and_o their_o membrane_n viz._n the_o pia_n and_o dura_n mater_n then_o must_v they_o take_v their_o lodgement_n if_o within_o the_o skull_n between_o the_o dura_n mater_n and_o the_o skull_n and_o produce_v no_o other_o symptom_n but_o a_o headache_n which_o as_o be_v say_v opium_n and_o meal_n rather_o cure_v than_o produce_v and_o if_o without_o the_o skull_n it_o be_v quite_o beside_o the_o cushion_n and_o the_o vaporarian_n own_o intention_n for_o in_o all_o these_o last_o case_n they_o can_v not_o affect_v the_o animal_n spirit_n for_o good_a or_o evil_n many_o and_o very_o many_o thing_n may_v be_v add_v to_o show_v the_o impossibility_n inconvenience_n incoherence_n absurdity_n etc._n etc._n that_o attend_v the_o passage_n of_o the_o fume_n and_o vapour_n into_o the_o brain_n head_n etc._n etc._n 22._o i_o have_v forgotâ—_n mention_v the_o absurdity_n of_o its_o pass_v up_o at_o gullet_n and_o so_o to_o the_o head_n because_o i_o can_v not_o imagine_v that_o any_o one_o will_v be_v so_o beastly_a a_o animal_n as_o to_o belch_v up_o a_o argument_n of_o that_o kind_n consider_v our_o very_a sense_n tell_v we_o that_o what_o come_v up_o that_o way_n pass_v out_o at_o mouth_n or_o nostril_n and_o because_o if_o it_o be_v so_o the_o operation_n of_o opium_n etc._n etc._n will_v be_v in_o proportion_n to_o our_o belch_a which_o be_v ridiculous_a 23._o the_o great_a comfort_n of_o a_o cordial_n be_v at_o first_o or_o soon_o after_o it_o be_v take_v but_o if_o '_o its_o comfort_n be_v by_o fume_n or_o essluvia_n pass_v to_o the_o blood_n or_o any_o where_o beside_o the_o comfort_n will_v as_o their_o cause_n of_o fume_n do_v increase_v for_o a_o long_a time_n and_o be_v more_o after_o a_o good_a while_n than_o at_o first_o so_o 24._o if_o opium_n operate_v by_o fume_n while_o at_o stomach_n which_o must_v gradual_o increase_v continual_o how_o come_v opium_n to_o be_v at_o the_o height_n of_o its_o operation_n in_o a_o short_a time_n viz._n in_o about_o half_a a_o hour_n after_o it_o begin_v sensible_o to_o operate_v or_o a_o hour_n at_o far_a and_o not_o increase_v continual_o in_o its_o operation_n as_o their_o pretend_a cause_n the_o fume_n must_v do_v by_o continual_a steam_a 25._o if_o opium_n operate_v by_o send_v fume_n by_o passage_n etc._n etc._n from_o the_o stomach_n to_o the_o brain_n i_o shall_v think_v that_o when_o it_o have_v get_v out_o of_o the_o stomach_n as_o into_o the_o intestine_n lacteal_v vein_n etc._n etc._n there_o shall_v be_v a_o kind_n of_o interval_n of_o its_o operation_n which_o be_v never_o observe_v till_o it_o get_v into_o the_o blood_n again_o therefore_o it_o do_v not_o operate_v by_o fume_n for_o the_o pylorus_n be_v always_o shut_v but_o when_o somewhat_o be_v send_v downward_o which_o will_v hinder_v the_o mount_a of_o the_o vapour_n into_o the_o stomach_n in_o order_n to_o pass_v to_o the_o brain_n 26._o if_o vapour_n be_v the_o cause_n of_o sleep_n after_o meal_n than_o shall_v we_o be_v more_o sleepy_a two_o or_o three_o hour_n after_o meal_n because_o of_o the_o abundance_n of_o the_o fume_n that_o will_v be_v crowd_v into_o the_o brain_n by_o that_o time_n but_o we_o be_v more_o sleepy_a present_o after_o meal_n and_o if_o we_o indulge_v it_o but_o for_o a_o quarter_n of_o a_o hour_n we_o be_v refresh_v and_o far_o from_o sleepiness_n afterward_o though_o the_o fume_n if_o that_o hypothesis_n be_v true_a will_v be_v much_o more_o at_o brain_n two_o or_o three_o hour_n after_o the_o meal_n so_o it_o be_v in_o the_o case_n of_o wine_n if_o one_o take_v a_o short_a nap_n after_o some_o glass_n he_o may_v drink_v a_o great_a many_o afterward_o without_o be_v sleepy_a which_o plain_o prove_v that_o it_o be_v not_o the_o fume_n of_o the_o wine_n be_v the_o cause_n of_o the_o sleep_n because_o he_o be_v not_o at_o all_o sleepy_a when_o there_o must_v be_v more_o fume_n 27._o all_o allow_v that_o hot_a fume_n assault_v the_o brain_n cause_n frenzy_n if_o that_o be_v true_a than_o the_o fume_n of_o wine_n and_o opium_n which_o be_v both_o very_a hot_a must_v always_o do_v so_o but_o opium_n and_o wine_n also_o do_v often_o cause_v composure_n good_a humour_n sleep_v etc._n etc._n which_o be_v contrary_a to_o frenzy_n therefore_o they_o do_v not_o operate_v by_o fume_n 28._o if_o sleep_n say_v helmont_n the_o only_a man_n that_o i_o have_v read_v who_o be_v against_o vapour_n be_v cause_v by_o vapour_n ascend_v from_o the_o stomach_n to_o the_o head_n obstruct_v and_o intercept_n all_o the_o passage_n of_o sensation_n motion_n speech_n judgement_n etc._n etc._n as_o the_o school_n say_v than_o a_o disease_n will_v have_v be_v before_o the_o fall_n of_o adam_n because_o sleep_n will_v have_v be_v a_o disease_n that_o be_v a_o flatulent_a and_o vaporous_a palsy_n 29._o all_o allow_v vomitives_n and_o purger_n to_o operate_v by_o irritation_n or_o a_o grievous_a sensation_n of_o the_o membrane_n of_o the_o stomach_n why_o not_o wine_n cordial_n opium_n etc._n etc._n by_o a_o pleasant_a sensation_n cujus_fw-la est_fw-la dolour_n aut_fw-la gravamen_fw-la ejusdem_fw-la est_fw-la voluptas_fw-la and_o as_o a_o grievous_a sensation_n or_o pain_n cause_v melancholy_a depression_n of_o spirit_n fretfulness_n lassitude_n etc._n etc._n so_o a_o pleasant_a sensation_n cause_v comfort_n elevation_n of_o the_o spirit_n euphory_n etc._n etc._n but_o we_o have_v not_o clear_v the_o way_n sufficient_o for_o these_o matter_n yet_o which_o will_v in_o due_a time_n be_v solemn_o consider_v obj._n it_o may_v be_v say_v that_o both_o vomitives_n and_o purgative_n take_v some_o time_n before_o they_o operate_v unless_o a_o nausea_n upon_o aversion_n cause_v they_o to_o work_v soon_o for_o thing_n must_v have_v time_n to_o insinuate_v themselves_o or_o soak_v through_o the_o crusta_fw-la carnosa_fw-la of_o the_o stomach_n and_o afterward_o to_o affect_v its_o sensile_a coat_n which_o argue_v that_o wine_n and_o cordial_n which_o operate_v immediate_o do_v not_o operate_v that_o way_n but_o by_o fume_n or_o effuvium_n pass_v into_o the_o brain_n or_o blood_n answ._n i_o doubt_v indeed_o that_o this_o difference_n may_v be_v a_o occasion_n of_o refer_v the_o effect_n of_o cordial_n and_o those_o of_o emittick_n and_o cathartic_o to_o different_a cause_n but_o it_o be_v very_o strange_a that_o they_o shall_v go_v so_o far_o as_o the_o blood_n or_o brain_n to_o seek_v for_o the_o cause_n of_o the_o operation_n of_o cordial_n which_o operate_v in_o a_o moment_n and_o go_v no_o far_o than_o the_o stomach_n for_o the_o cause_n of_o the_o operation_n of_o vomatives_n and_o purgative_n which_o take_v more_o time_n to_o operate_v especial_o see_v the_o blood_n and_o brain_n have_v no_o sensation_n and_o that_o all_o sensitive_a comfort_n happen_v by_o that_o mean_n i_o think_v it_o be_v much_o more_o proper_a first_o to_o consider_v the_o immediate_a part_n upon_o which_o they_o insist_v when_o at_o stomach_n especial_o see_v it_o be_v so_o very_o sensible_a before_o we_o run_v rove_a i_o know_v not_o whither_o to_o seek_v for_o the_o cause_n of_o a_o thing_n that_o work_v please_v and_o comfort_v the_o stomach_n as_o soon_o as_o it_o be_v down_o i_o take_v myself_o run_v off_o the_o proper_a subject_a matter_n of_o this_o chapter_n and_o anticipate_v that_o of_o another_o therefore_o i_o will_v be_v short_a and_o deliver_v my_o opinion_n in_o this_o case_n by_o way_n of_o position_n with_o a_o familiar_a instance_n to_o illustrate_v it_o which_o may_v in_o some_o measure_n prepare_v you_o for_o the_o proof_n
the_o spirit_n by_o any_o mean_n for_o there_o be_v nothing_o so_o good_a in_o nature_n but_o will_v do_v it_o if_o use_v undue_o or_o immoderate_o as_o wine_n bread_n milk_n honey_n sugar_n beer_n etc._n etc._n in_o excess_n for_o i_o intend_v that_o it_o do_v not_o do_v it_o when_o due_o and_o moderate_o use_v 1._o that_o which_o refresh_v the_o weary_a and_o high_o prevent_v weariness_n must_v add_v to_o or_o excite_v the_o spirit_n which_o be_v direct_o contrary_a to_o diminish_v or_o disable_n they_o but_o opium_n do_v in_o a_o most_o eminent_a manner_n refresh_v the_o weary_v and_o prevent_v weariness_n therefore_o it_o do_v not_o diminish_v or_o disable_v the_o spirit_n some_o have_v be_v so_o silly_a and_o inadvertent_n as_o to_o object_n that_o it_o refresh_v the_o weary_a only_o by_o sleep_n it_o be_v matter_n of_o fact_n that_o it_o refresh_v they_o whether_o they_o sleep_v or_o no_o and_o that_o without_o fail_v as_o often_o as_o it_o be_v use_v in_o that_o case_n other_o that_o be_v no_o wise_a have_v say_v that_o it_o only_o take_v off_o the_o sense_n of_o weariness_n by_o stupify_a which_o happen_v by_o the_o diminish_n or_o disable_n of_o the_o animal_n spirit_n bare_a insensibleness_n can_v enable_v the_o spirit_n to_o labour_n with_o eminent_a briskness_n and_o alacrity_n as_o man_n most_o certain_o do_v after_o opium_n be_v take_v be_v fine_o enliven_v and_o invigorate_v as_o with_o generous_a wine_n if_o they_o do_v not_o know_v this_o to_o be_v true_a let_v they_o for_o shame_n hold_v their_o tongue_n till_o they_o know_v matter_n of_o fact_n which_o if_o they_o will_v not_o they_o proclaim_v themselves_o to_o be_v idle_a and_o impertinent_a babbler_n but_o if_o they_o will_v patient_o and_o wise_o abstain_v argue_v till_o they_o be_v satisfy_v as_o to_o matter_n of_o fact_n then_o will_v they_o be_v past_a opinion_n and_o hypothesis_n in_o that_o case_n for_o they_o will_v have_v sensible_a and_o certain_a knowledge_n of_o the_o contrary_a and_o the_o truth_n of_o what_o i_o say_v which_o will_v end_v all_o controversy_n and_o precarious_a squabble_n upon_o false_a supposition_n as_o the_o manner_n be_v that_o can_v lead_v they_o to_o what_o be_v right_o but_o by_o mere_a chance_n and_o never_o to_o a_o true_a knowledge_n that_o they_o be_v in_o the_o right_n which_o make_v it_o none_o in_o effect_n for_o they_o can_v do_v nothing_o with_o assurance_n but_o only_o suppose_v and_o hope_v they_o be_v in_o the_o right_n when_o they_o be_v as_o much_o out_o to_o their_o patient_n sorrow_n as_o physician_n have_v be_v in_o the_o cold_a quality_n and_o fume_n of_o opium_n it_o be_v true_a that_o a_o grain_n or_o two_o of_o opium_n will_n if_o a_o man_n compose_v himself_o sit_v or_o lie_v still_o cause_n a_o sleepiness_n equal_a to_o that_o cause_v by_o spend_v the_o spirit_n by_o a_o day_n be_v labour_n but_o spend_v of_o the_o spirit_n be_v not_o the_o only_a no_o nor_o best_a proportion_v or_o more_o adequate_a cause_n thereof_o as_o i_o have_v show_v if_o loss_n of_o spirit_n be_v the_o adequate_a cause_n of_o sleep_n how_o shall_v good_a and_o generous_a wine_n cause_n sleepiness_n after_o that_o eminent_a rate_n as_o it_o do_v in_o most_o people_n how_o shall_v the_o most_o please_a music_n incline_v such_o as_o lie_v or_o sit_v still_o to_o sleep_v but_o if_o one_o dance_n thereto_o it_o make_v he_o more_o lively_a and_o brisk_a than_o ordinary_a the_o like_a exact_o do_v wine_n and_o opium_n if_o man_n lie_v or_o sit_v still_o but_o otherwise_o they_o make_v they_o much_o more_o brisk_a and_o lively_a and_o able_a to_o undergo_v labour_n action_n etc._n etc._n which_o note_n that_o you_o may_v not_o any_o more_o wonder_n that_o enlivener_n and_o exciter_n of_o the_o spirit_n do_v cause_n sleep_v as_o well_o as_o diminisher_n thereof_o and_o observe_v that_o they_o be_v all_o please_a thing_n as_o music_n wine_n and_o opium_n which_o cause_n pleasant_a dream_n pleasant_a watch_n pleasant_a humour_n etc._n etc._n expect_v more_o of_o this_o matter_n in_o the_o follow_a chapter_n and_o all_o by_o degree_n according_a as_o i_o judge_v the_o prejudice_v world_n will_v bear_v thing_n for_o a_o great_a paradox_n how_o true_a soever_o must_v not_o be_v abrupt_o obtrude_v but_o gentle_o and_o gradual_o usher_v in_o by_o insinuate_v reason_v otherwise_o it_o will_v be_v entertain_v like_o a_o rude_a stranger_n that_o contradict_v a_o multitude_n in_o fashion_n and_o custom_n that_o they_o have_v always_o use_v and_o judge_v to_o be_v the_o very_o best_o however_o unblamable_a consider_v that_o if_o opium_n diminish_v or_o disable_v the_o spirit_n proportionable_a to_o the_o sleepiness_n that_o it_o cause_n as_o a_o hard_a day_n be_v labour_n do_v then_o if_o opium_n be_v give_v a_o man_n after_o a_o hard_a day_n be_v labour_n it_o will_v be_v as_o it_o be_v add_v another_o hard_a day_n be_v labour_v to_o cure_v it_o the_o day_n be_v labour_n and_o opium_n impair_n the_o spirit_n alike_o think_v what_o a_o miserable_a condition_n the_o poor_a man_n will_v be_v in_o especial_o if_o sleep_n do_v not_o make_v he_o some_o amends_o it_o will_v be_v such_o as_o be_v utter_o intolerable_a but_o so_o far_o be_v opium_n from_o any_o such_o effect_n that_o it_o refresh_v he_o though_o he_o sleep_v not_o at_o all_o after_o the_o hard_a day_n be_v labour_n and_o not_o only_o so_o but_o will_v enable_v he_o to_o work_v all_o the_o follow_a night_n with_o great_a alacrity_n if_o need_n require_v it_o what_o a_o condition_n will_v those_o be_v in_o who_o take_v a_o drachm_n of_o it_o twice_o a_o day_n for_o 10_o 20_o or_o 30_o year_n nay_o how_o can_v any_o possible_o do_v it_o for_o half_a 10_o day_n if_o a_o grain_n or_o two_o destroy_v the_o spirit_n so_o much_o as_o to_o cause_v sleepiness_n thereby_o as_o hard_a labour_n do_v which_o they_o must_v allow_v that_o assert_v it_o cause_n sleep_v by_o diminish_v or_o disable_n the_o spirit_n but_o some_o may_v say_v though_o very_o inconsiderate_o that_o it_o only_o disable_v they_o for_o the_o time_n of_o its_o operation_n that_o be_v strange_a indeed_o consider_v that_o even_o during_o that_o time_n they_o be_v most_o enable_v to_o work_n or_o labour_n though_o tire_v before_o and_o that_o it_o 2._o cause_n comfort_n refreshment_n ovation_n of_o the_o spirit_n all_o the_o time_n of_o its_o operation_n as_o wine_n moderate_o take_v do_v especial_o if_o people_n keep_v themselves_o in_o action_n labour_n etc._n etc._n otherwise_o indeed_o they_o may_v fall_v asleep_a upon_o the_o comfortable_a satisfaction_n contentation_n of_o mind_n and_o acquiescence_n of_o spirit_n that_o it_o occasion_n as_o wine_n do_v 3._o the_o first_o effect_n that_o we_o find_v of_o opium_n which_o may_v therefore_o probable_o be_v a_o very_a lead_n fundamental_a and_o significant_a effect_n be_v that_o it_o cause_v a_o most_o agreeable_a pleasant_a and_o charm_a sensation_n about_o the_o region_n of_o the_o stomach_n which_o if_o one_o lie_v or_o sit_v still_o incline_v he_o to_o sleep_n if_o not_o it_o make_v he_o gay_a good_a humour_a brave_a etc._n etc._n it_o be_v a_o pleasure_n so_o sweet_a and_o delicious_a that_o though_o i_o endeavour_v to_o express_v it_o by_o the_o ovation_n of_o the_o spirit_n upon_o joy_n a_o good_a genius_n inform_v a_o man_n or_o the_o helmâ—sians_n archaeus_n in_o his_o best_a humour_n or_o a_o continual_a vâ—real_a pleasure_n wine_n drink_v ad_fw-la hilaritatem_fw-la etc._n etc._n yet_o i_o doubt_v all_o my_o way_n of_o express_v it_o do_v come_v short_a of_o the_o charm_a complacency_n that_o it_o cause_n therefore_o if_o wine_n music_n a_o good_a meal_n agreeable_a frication_n of_o the_o head_n or_o back_o the_o sound_n of_o water_n etc._n etc._n do_v incline_v we_o to_o sleep_v by_o the_o pleasure_n thereof_o which_o lull_v and_o soothe_v we_o to_o it_o as_o be_v most_o certain_a if_o we_o sit_v or_o lie_v still_o much_o more_o must_v the_o high_a charm_n of_o opium_n cause_n it_o that_o it_o be_v a_o pleasure_n that_o affect_v by_o one_o of_o our_o sense_n namely_o by_o feel_v be_v indisputable_a for_o it_o be_v not_o a_o pleasure_n of_o the_o eye_n nose_n tongue_n or_o ear_n and_o it_o must_v be_v sensitive_a because_o cause_v by_o matter_n and_o that_o opium_n have_v doubtless_o the_o like_a effect_n upon_o brute_n who_o have_v no_o other_o pleasure_n but_o what_o be_v sensitive_a that_o it_o be_v at_o stomach_n be_v also_o evident_a where_o we_o can_v be_v please_v only_o by_o the_o sense_n of_o feel_v that_o it_o be_v involuntary_a and_o please_v we_o whether_o we_o will_v or_o no_o and_o that_o the_o same_o particle_n excite_v venery_n itch_a etc._n etc._n now_o all_o the_o sense_n especial_o feel_v and_o particular_o that_o at_o stomach_n be_v give_v we_o for_o
watch_n and_o sentinel_n to_o discover_v and_o give_v notice_n of_o what_o be_v or_o be_v not_o good_a and_o agreeable_a to_o our_o animal_n nature_n that_o upon_o notice_n of_o what_o be_v good_a and_o agreeable_a pleasure_n comfort_n satisfaction_n etc._n etc._n be_v conceive_v otherwise_o displeasure_n discomfort_n and_o dissatisfaction_n what_o diminish_v or_o disable_v our_o spirit_n do_v we_o the_o great_a evil_n that_o can_v be_v and_o consequent_o sensation_n will_v according_a to_o its_o office_n give_v we_o such_o notice_n thereof_o as_o will_v cause_v displeasure_n etc._n etc._n otherwise_o these_o sentinel_n that_o god_n and_o nature_n have_v appoint_v for_o faithful_a notice_n will_v instead_o of_o trusty_a service_n which_o be_v the_o end_n they_o be_v make_v for_o deceive_v we_o and_o consequent_o do_v we_o mischief_n rather_o than_o good_a which_o be_v very_o profane_a if_o not_o blasphemous_a to_o assert_v as_o be_v high_o abusive_a of_o god_n goodness_n and_o wisdom_n to_o make_v thing_n in_o nature_n that_o will_v not_o only_o not_o answer_n but_o act_n quite_o contrary_a to_o their_o end_n it_o follow_v then_o that_o what_o cause_v such_o a_o mighty_a agreeable_a and_o pleasant_a sensation_n at_o stomach_n which_o be_v the_o great_a and_o most_o accurate_a judge_n of_o what_o be_v or_o be_v not_o agreeable_a to_o the_o animal_n can_v be_v destructive_a or_o disable_n of_o its_o spirit_n which_o be_v the_o most_o excellent_a and_o useful_a thing_n that_o belong_v thereto_o therefore_o opium_n which_o so_o mighty_o recommend_v itself_o to_o please_v and_o comfort_v the_o great_a judge_n that_o god_n have_v give_v to_o a_o sensible_a creature_n to_o discern_v what_o be_v good_a and_o evil_a for_o it_o can_v diminish_v or_o disable_v our_o spirit_n one_o may_v say_v what_o i_o dare_v not_o that_o the_o sensation_n at_o stomach_n may_v deceive_v we_o we_o may_v deceive_v ourselves_o and_o say_v so_o when_o that_o which_o please_v the_o stomach_n do_v not_o please_v our_o pervert_v imagination_n which_o make_v no_o argument_n let_v we_o therefore_o consider_v thing_n where_o there_o be_v no_o such_o vain_a imagination_n to_o contradict_v the_o good_a end_n of_o nature_n if_o the_o stomach_n and_o sense_n in_o a_o brute_n or_o mere_a animal_n which_o have_v no_o other_o mean_n to_o judge_n of_o what_o be_v good_a or_o evil_n for_o it_o shall_v not_o judge_v aright_o all_o the_o animal_n in_o the_o whole_a world_n will_v soon_o perish_v it_o be_v the_o vain_a opinion_n of_o man_n that_o persuade_v they_o that_o thing_n be_v cold_a when_o hot_a etc._n etc._n as_o in_o the_o case_n of_o opium_n when_o the_o sense_n true_o inform_v that_o it_o be_v hot_a if_o you_o will_v stand_v to_o your_o imagination_n and_o supposition_n for_o such_o all_o must_v be_v without_o the_o information_n of_o sense_n against_o the_o dictate_v of_o sensation_n you_o must_v inevitable_o err_v but_o one_o may_v say_v be_v the_o sense_n at_o stomach_n such_o a_o infallible_a guide_n always_o i_o believe_v it_o will_v be_v very_o hard_a to_o give_v many_o instance_n to_o the_o contrary_a and_o prove_v it_o well_o however_o if_o we_o do_v or_o may_v allow_v something_o of_o this_o kind_a to_o a_o pervert_v stomach_n at_o certain_a time_n to_o avoid_v a_o squabble_n about_o it_o it_o be_v never_o to_o be_v allow_v that_o all_o the_o stomach_n in_o the_o whole_a world_n shall_v be_v please_v with_o one_o and_o the_o same_o thing_n at_o all_o time_n and_o yet_o that_o this_o thing_n shall_v be_v so_o high_o pernicious_a to_o the_o animal_n as_o to_o diminish_v or_o disable_v its_o spirit_n then_o indeed_o it_o will_v follow_v that_o the_o most_o exquisite_a sense_n at_o stomach_n to_o discern_v what_o be_v or_o be_v not_o agreeable_a to_o the_o animal_n be_v absolute_o in_o vain_a which_o no_o man_n of_o reason_n that_o have_v any_o apprehension_n of_o the_o wisdom_n of_o god_n and_o nature_n can_v assert_v 3._o what_o be_v more_o notorious_a than_o that_o pleasure_n or_o be_v please_v raise_v and_o displeasure_n or_o be_v grieve_v depress_n the_o spirit_n be_v not_o all_o people_n pleasant_a gay_a and_o good_a humour_a brisk_a prompt_a etc._n etc._n when_o please_v do_v not_o man_n travel_v or_o labour_n with_o more_o ease_n in_o pleasant_a company_n etc._n etc._n but_o of_o these_o matter_n and_o the_o reason_n thereof_o more_o in_o the_o follow_a chapter_n 4._o how_o can_v opium_n that_o revive_v people_n when_o they_o be_v so_o dispirited_a that_o they_o be_v even_o almost_o die_v as_o when_o opium_n be_v want_v by_o such_o as_o use_v to_o take_v it_o in_o deliquiâ—ms_n and_o agony_n from_o paiâ—_n etc._n etc._n diminish_v or_o disable_v the_o spirit_n it_o be_v plain_a contradiction_n to_o say_v that_o it_o shall_v next_o to_o opium_n nothing_o revive_v people_n in_o such_o case_n better_o than_o wine_n and_o those_o thing_n that_o produce_v the_o same_o or_o like_a effect_n have_v like_o nature_n and_o who_o can_v say_v that_o wine_n that_o be_v make_v to_o glad_a the_o heart_n of_o man_n diminish_v or_o disable_v the_o spirit_n or_o that_o opium_n which_o produce_v all_o the_o sprightly_a enliven_a and_o encourage_v effect_n of_o generous_a wine_n in_o a_o more_o eminent_a manner_n than_o wine_n and_o in_o the_o 10000th_o part_n of_o its_o quantity_n and_o for_o a_o long_a time_n than_o wine_n cause_v they_o shall_v diminish_v or_o disable_v the_o spirit_n for_o instance_n wine_n and_o opium_n in_o a_o due_a quantity_n but_o opium_n in_o a_o far_o less_o quantity_n as_o be_v say_v cause_v a_o pleasant_a gay_a and_o good_a humour_n courage_n bravery_n magnanimity_n promptitude_n in_o business_n expediteness_n in_o management_n serenity_n euphory_n or_o easy_a undergo_n of_o labour_n journey_n fatigue_n etc._n etc._n both_o take_v away_o sadness_n grief_n melancholy_n fear_v depression_n of_o spirit_n etc._n etc._n both_o cause_n promptitude_n to_o venery_n sine_fw-la cerere_fw-la &_o baccho_fw-la friget_fw-la venus_n so_o wine_n and_o opium_n prevent_v and_o cure_v cold_a open_v the_o pore_n promote_v perspiration_n and_o sweat_n especial_o the_o follow_a morning_n as_o sir_n theodore_n mayern_n myself_o and_o other_o have_v observe_v of_o opium_n and_o be_v notorious_a as_o to_o wine_n both_o cause_n sleep_n and_o take_v away_o the_o sense_n of_o pain_n and_o require_v a_o great_a dose_n than_o ordinary_a in_o proportion_n to_o the_o pain_n both_o take_v off_o shivering_n from_o fear_n cold_a or_o ague_n fit_n and_o cause_n mirth_n contentation_n and_o acquiescence_n dryness_n of_o the_o mouth_n thirst_v a_o sense_n of_o heat_n within_o we_o a_o dream_v condition_n pleasant_a dream_n if_o the_o quantity_n of_o wine_n be_v not_o grievous_a by_o its_o heat_n load_n etc._n etc._n nocturnal_a pollution_n and_o in_o some_o constitution_n both_o cause_n vigilancy_n but_o wine_n and_o opium_n cause_v that_o more_o rare_o than_o sleep_n both_o stop_n and_o cause_n vomit_v if_o they_o stay_v too_o long_o at_o stomach_n both_o moderate_a hunger_n 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d and_o be_v good_a in_o a_o canine_a appetite_n both_o cause_n swim_v in_o the_o head_n etc._n etc._n so_o both_o in_o a_o excessive_a do_v do_v cause_n at_o first_o mirth_n and_o afterward_o a_o kind_n of_o drunken_a soper_n in_o some_o in_o other_o fury_n or_o madness_n sardonick_a laughter_n and_o weight_n at_o stomach_n vomit_n hiccough_n great_a heat_n at_o stomach_n debility_n and_o laxity_n of_o all_o part_n falter_v of_o the_o tongue_n scotomy_n and_o darkness_n of_o the_o eye_n vertigo_n laxity_n of_o the_o cornea_n of_o the_o eye_n dilatation_n of_o the_o papilla_fw-la deadness_n of_o the_o eye_n to_o the_o view_n loss_n of_o memory_n venereal_a fury_n a_o high_a colour_n profuse_a sweat_v purge_v sometime_o alienation_n of_o the_o mind_n loss_n of_o memory_n and_o last_o great_a or_o lesser_a effect_n according_a to_o the_o do_v constitution_n etc._n etc._n so_o a_o long_a and_o lavish_a use_n of_o both_o cause_n a_o dull_a and_o moapish_a disposition_n dropsy_n fall_v of_o humour_n upon_o weaken_v part_n a_o sleepy_a disposition_n want_v of_o appetite_n weakness_n of_o digestion_n aptitude_n to_o sterility_n and_o abortion_n early_a decrepiteness_n stoop_v in_o the_o back_n tremble_v of_o the_o hand_n weakness_n of_o memory_n shortness_n of_o life_n difficulty_n and_o danger_n in_o sudden_o leave_v they_o off_o revive_v such_o as_o sink_v for_o want_n of_o either_o and_o supply_v the_o want_n of_o each_o other_o how_o can_v any_o have_v the_o face_n to_o say_v that_o a_o thing_n which_o agree_v so_o with_o generous_a wine_n in_o effect_n can_v be_v a_o diminisher_n or_o disabler_n of_o the_o spirit_n the_o mischief_n of_o excessive_a dose_n and_o lavish_a use_n of_o either_o be_v no_o argument_n against_o their_o inspirit_a nature_n if_o it_o be_v than_o wine_n be_v no_o cordial_n though_o make_v to_o glad_a the_o heart_n
of_o man_n because_o of_o its_o ill_a effect_n lavish_o use_v therefore_o none_o can_v argue_v from_o that_o that_o opium_n diminish_v or_o disable_v the_o spirit_n any_o more_o than_o wine_n or_o bread_n do_v a_o surfeit_n of_o which_o be_v most_o dangerous_a omnis_fw-la repletio_fw-la mala_fw-la panis_n vero_fw-la pessima_fw-la &_o corruptio_fw-la optimi_fw-la est_fw-la pessima_fw-la that_o be_v all_o repletion_n be_v bad_a but_o that_o of_o bread_n be_v the_o worst_a and_o the_o corruption_n of_o the_o best_a be_v the_o worst_a the_o short_a be_v this_o wine_n and_o opium_n agree_v in_o all_o their_o effect_n save_v such_o as_o be_v consequence_n of_o their_o different_a accident_n as_o the_o quantity_n of_o wine_n that_o must_v be_v use_v to_o cause_v the_o same_o effect_n with_o a_o little_a opium_n and_o wine_n have_v be_v ferment_v and_o opium_n as_o may_v be_v show_v have_v some_o crude_a and_o viscid_a rosin_n in_o it_o which_o sometime_o stick_v to_o the_o crusta_fw-la carnosa_fw-la etc._n etc._n of_o the_o stomach_n whence_o it_o happen_v that_o wine_n load_v one_o more_o heat_v more_o and_o be_v more_o troublesome_a upon_o those_o account_n and_o that_o opium_n offend_v the_o stomach_n often_o even_o in_o a_o moderate_a do_v cause_v vomit_n hiccough_n anxiety_n distress_n at_o stomach_n deliquium_n etc._n etc._n because_o of_o the_o indigestible_a rosin_n stick_v to_o the_o side_n of_o the_o most_o sensile_a stomach_n as_o i_o shall_v far_o prove_v hereafter_o by_o god_n help_n show_v very_o easy_a way_n and_o mean_n to_o separate_v that_o rosin_n and_o so_o make_v it_o as_o safe_a and_o less_o troublesome_a as_o it_o be_v more_o effectual_a than_o wine_n opium_n can_v diminish_v or_o disable_v the_o spirit_n because_o as_o have_v be_v prove_v it_o send_v no_o part_n fume_v or_o effluvium_fw-la to_o the_o brain_n or_o animal_n spirit_n to_o cause_v such_o bad_a effect_n while_o it_o be_v at_o stomach_n yet_o do_v it_o produce_v they_o while_o it_o be_v there_o for_o as_o the_o vaporarians_n themselves_o and_o indeed_o all_o man_n allow_v there_o can_v be_v no_o destruction_n without_o contact_n sanctorius_n do_v well_o and_o true_o observe_v by_o the_o help_n of_o his_o static_o that_o nothing_o cause_v liberal_a perspiration_n but_o it_o raise_v the_o spirit_n it_o be_v most_o certain_a that_o nothing_o in_o nature_n open_v the_o pore_n and_o cause_n perspiration_n more_o than_o opium_n therefore_o nothing_o shall_v according_a to_o his_o observation_n elevate_v the_o spirit_n more_o and_z indeed_o nothing_o do_v as_o appear_v by_o all_o that_o have_v be_v say_v and_o will_v yet_o more_o plain_o appear_v loss_n of_o memory_n by_o opium_n as_o some_o argue_v be_v not_o so_o much_o a_o loss_n of_o spirit_n as_o lanity_n of_o the_o brain_n for_o people_n in_o drink_n do_v not_o want_v spirit_n but_o there_o be_v a_o great_a relaxation_n of_o the_o brain_n and_o its_o membrane_n and_o of_o the_o whole_a jenus_fw-la 〈◊〉_d which_o relaxation_n cause_v a_o soft_a loose_a and_o labile_fw-la brain_n that_o like_o liquid_a thing_n retain_v no_o impression_n beside_o that_o i_o shall_v god_n will_v show_v you_o hereafter_o that_o impression_n can_v be_v so_o well_o make_v upon_o the_o sensitive_a soul_n by_o the_o animal_n spirit_n upon_o relaxation_n of_o the_o sensible_a part_n as_o in_o sleep_n etc._n etc._n for_o a_o very_a plain_a mechanical_a reason_n to_o be_v show_v in_o due_a time_n thus_o have_v i_o by_o the_o assistance_n of_o its_o maker_n who_o best_o know_v it_o clear_v opium_n from_o the_o false_a aspersion_n of_o a_o extreme_a cold_a quality_n and_o parcotick_a fume_n both_o which_o be_v common_o call_v venomous_a fatal_a and_o by_o all_o the_o ill_a name_n imaginable_a but_o as_o good_a luck_n be_v they_o abuse_v nothing_o because_o it_o be_v manifest_a that_o there_o be_v no_o such_o thing_n nor_o have_v it_o any_o quality_n by_o which_o it_o diminish_v or_o disable_v the_o spirit_n as_o be_v most_o evident_a from_o the_o premise_n so_o that_o all_o that_o have_v be_v say_v of_o opium_n by_o way_n of_o hypothesis_n to_o explain_v its_o effect_n depend_v upon_o its_o diminish_n or_o disable_n the_o spirit_n by_o a_o cold_a quality_n or_o fume_n be_v come_v to_o nothing_o i_o wish_v it_o have_v be_v as_o innocent_a chap._n xii_o show_v what_o must_v be_v the_o true_a cause_n of_o the_o operation_n of_o opium_n all_o the_o general_a foundation_n upon_o which_o author_n either_o ancient_a or_o modern_a erect_v their_o several_a hypothesise_n concern_v the_o operation_n of_o opium_n have_v as_o manifest_o appear_v no_o real_a existence_n what_o enchant_a castle_n in_o the_o air_n or_o vain_a phantasm_n must_v their_o structure_n be_v and_o how_o like_a delude_a wizzard_n must_v they_o appear_v while_o they_o seem_v to_o take_v high_a flight_n and_o glorious_a prospect_n of_o cause_n that_o have_v no_o reality_n thus_o be_o i_o leave_v utter_o destitute_a of_o either_o foundation_n or_o model_n unless_o i_o find_v out_o that_o and_o frame_v this_o which_o i_o hope_v may_v be_v easy_o do_v because_o the_o cloudy_a supposition_n of_o vapour_n have_v vanish_v away_o there_o now_o remain_v but_o two_o way_n by_o which_o a_o internal_a medicament_n can_v operate_v viz._n 1._o as_o a_o alterative_a of_o the_o blood_n etc._n etc._n or_o 2._o as_o affect_v the_o sense_n of_o feel_v either_o grievous_o as_o vomit_n purger_n etc._n etc._n or_o pleas_o as_o cordial_n generous_a wine_n titillate_v amphrodisiack_n comfortable_a warmth_n anodynes_n and_o such_o like_a that_o please_v the_o nerve_n and_o membrane_n which_o way_n of_o operate_n be_v too_o little_o observe_v by_o physician_n though_o they_o take_v great_a notice_n of_o the_o operation_n of_o thing_n by_o grievous_a sensation_n as_o irritative_n to_o vomit_n purge_v salivate_a etc._n etc._n by_o their_o acrimony_n whereas_o the_o pleaser_n of_o sensation_n which_o must_v as_o contrary_n have_v contrary_a operation_n be_v little_o regard_v or_o think_v of_o 1._o opium_n do_v not_o operate_v as_o a_o alterative_a of_o the_o blood_n etc._n etc._n first_o because_o it_o operate_v while_o it_o be_v at_o stomach_n or_o at_o least_o before_o it_o arrive_v at_o the_o blood_n which_o manifest_o appear_v several_a way_n as_o 1._o because_o it_o often_o operate_v in_o a_o liquid_a form_n in_o few_o minute_n and_o very_o common_o in_o a_o quarter_n of_o a_o hour_n in_o which_o time_n it_o must_v be_v at_o stomach_n or_o at_o least_o far_o from_o arrive_v at_o the_o blood_n 2._o because_o it_o have_v be_v very_o often_o vomit_v up_o after_o it_o have_v operate_v and_o produce_v its_o usual_a effect_n for_o 1_o 2_o 3_o 4_o 5_o 6_o 8_o 10_o and_o sometime_o more_o hour_n as_o evident_o appear_v by_o the_o smell_n colour_n taste_v etc._n etc._n of_o what_o be_v vomit_v and_o by_o its_o operation_n cease_v after_o such_o vomit_v of_o which_o common_a experience_n and_o author_n do_v inform_v we_o see_v helmont_n ius_n duumvir_fw-la 62._o where_o he_o tell_v of_o opium_n operate_a at_o night_n and_o vomit_v up_o next_o morning_n 3._o it_o be_v bare_a cause_v vomit_v after_o it_o have_v operate_v for_o a_o good_a while_n be_v of_o itself_o though_o its_o taste_n smell_v etc._n etc._n do_v not_o discover_v it_o a_o infallible_a argument_n of_o its_o operate_n while_o it_o be_v at_o stomach_n for_o it_o be_v against_o all_o reason_n to_o imagine_v that_o thing_n shall_v irritate_fw-la it_o to_o vomit_n after_o they_o be_v go_v into_o the_o blood_n and_o not_o do_v it_o while_o they_o be_v in_o the_o stomach_n itself_o as_o all_o vomitory_n do_v the_o reason_n why_o it_o stay_v so_o long_o at_o stomach_n be_v 1._o it_o be_v indigestibleness_n which_o plain_o appear_v by_o stool_n urine_n and_o sweat_v smell_v of_o it_o when_o take_v in_o any_o considerable_a quantity_n all_o the_o coction_n digestion_n circulation_n etc._n etc._n that_o it_o pass_v in_o the_o body_n signify_v very_o little_a to_o it_o which_o its_o cause_v itch_n in_o the_o skin_n and_o affect_v the_o venereal_a membrane_n after_o its_o pass_v the_o blood_n do_v also_o argue_v 2._o the_o clamminess_n of_o its_o resinous_a part_n stick_v to_o the_o stomach_n cause_n as_o i_o shall_v plain_o prove_v hereafter_o its_o long_a stay_n in_o it_o for_o if_o the_o rosin_n be_v separate_v from_o it_o it_o will_v not_o then_o make_v such_o a_o long_a stay_n at_o stomach_n as_o i_o have_v often_o experience_v 4._o we_o actual_o feel_v it_o cause_v a_o sense_n of_o pleasure_n at_o stomach_n during_o its_o operation_n therefore_o it_o be_v then_o in_o it_o 5._o it_o have_v be_v carry_v off_o by_o stool_n after_o it_o have_v produce_v its_o usual_a effect_n therefore_o it_o operate_v before_o it_o arrive_v at_o the_o blood_n 6._o all_o observer_n do_v allow_v that_o opium_n operate_v while_o it_o be_v at_o stomach_n
which_o give_v the_o occasion_n as_o you_o may_v remember_v to_o the_o hypothesis_n of_o its_o operate_n by_o fume_n rise_v out_o of_o the_o stomach_n because_o they_o can_v not_o think_v of_o any_o other_o mean_v by_o which_o it_o may_v affect_v the_o head_n brain_n animal_n spirit_n nerve_n etc._n etc._n while_o it_o be_v at_o stomach_n but_o by_o the_o way_n of_o fume_n or_o vapour_n it_o be_v therefore_o past_a all_o doubt_n that_o opium_n produce_v its_o common_a effect_n while_o it_o be_v at_o stomach_n and_o before_o it_o arrive_v at_o the_o blood_n and_o therefore_o do_v not_o operate_v as_o a_o alterative_a thereof_o second_o because_o a_o grain_n of_o opium_n which_o operate_v very_o remarkable_o bear_v as_o etmuller_n well_o observe_v so_o small_a a_o proportion_n to_o the_o blood_n that_o it_o can_v produce_v such_o great_a and_o notable_a effect_n as_o a_o alterative_a thereof_o for_o a_o grain_n of_o opium_n to_o 20_o pound_n of_o blood_n which_o a_o ordinary_a man_n have_v in_o his_o body_n be_v but_o as_o 1_o to_o 115200_o or_o if_o 16_o oucne_n be_v allow_v to_o the_o pound_n as_o 1_o to_o 153600._o but_o it_o be_v no_o wonder_n if_o a_o grain_n shall_v affect_v the_o membrane_n at_o stomach_n since_o the_o 1000_o part_n of_o a_o grain_n of_o the_o vomitory_n particle_n of_o crocus_n metallorum_fw-la or_o regulus_n of_o antimony_n do_v affect_v it_o so_o eminent_o as_o many_o other_o thing_n will_v in_o a_o very_a small_a quantity_n whereas_o the_o alter_n of_o the_o blood_n to_o any_o observable_a degree_n require_v the_o use_n of_o alterative_n in_o great_a quantity_n for_o several_a week_n which_o confirm_v the_o former_a conclusion_n that_o opium_n do_v not_o operate_v as_o a_o alterative_a as_o to_o its_o common_a and_o usual_a effect_n ii_o opium_n do_v not_o operate_v by_o grievous_a sensation_n or_o irritation_n as_o vomit_n purger_n errhine_n salivator_n or_o apophlegmatizer_n etc._n etc._n do_v first_o because_o it_o manifest_o cause_v a_o very_a agreeable_a pleasant_a and_o even_o charm_a sensation_n second_o because_o it_o take_v away_o grievous_a sensation_n or_o pain_n thereby_o stop_v vomit_v purge_v and_o all_o other-effect_n of_o grievous_a sensation_n by_o acrimony_n etc._n etc._n as_o for_o the_o vomit_v that_o opium_n sometime_o cause_n it_o be_v only_o as_o shall_v be_v show_v by_o its_o resinous_n part_n stick_v to_o the_o coat_n of_o the_o stomach_n which_o be_v separate_v from_o it_o opium_n have_v no_o such_o effect_n though_o all_o its_o good_a effect_n remain_v so_o its_o purge_v which_o happen_v most_o rare_o and_o only_o when_o a_o great_a quantity_n be_v give_v to_o man_n of_o strong_a digestion_n it_o be_v only_o from_o its_o rosin_n digest_v and_o resolve_v in_o strong_a stomach_n hence_o it_o be_v that_o dog_n and_o such_o as_o have_v canine_a appetite_n do_v general_o purge_v after_o a_o great_a quantity_n of_o crude_a or_o rosinous_n opium_n whereas_o such_o as_o be_v not_o rosinous_n cause_v no_o such_o effect_n but_o of_o these_o matter_n more_o to_o your_o satisfaction_n hereafter_o three_o because_o it_o cause_v all_o effect_n that_o be_v quite_o contrary_a to_o those_o of_o grievous_a sensation_n it_o cause_v a_o ovation_n of_o the_o sensitive_a soul_n and_o spirit_n pain_n or_o grievous_a sensation_n a_o depression_n of_o spirit_n it_o cause_v euphory_n and_o pain_n weariness_n for_o what_o tire_v more_o than_o pain_n or_o labour_v in_o pain_n it_o cause_v good_a humour_n pain_n peevishness_n fretfulness_n and_o ill_a humour_n opium_n cause_v relaxation_n of_o all_o part_n pain_n contraction_n that_o cause_v free_a perspiration_n this_o check_v it_o that_o cause_v sleep_n this_o hinder_v it_o that_o cause_v contentation_n acquiescence_n this_o discontent_n and_o uneasiness_n that_o compose_v this_o discompose_v the_o spirit_n blood_n etc._n etc._n that_o cause_v flux_n by_o irritation_n etc._n etc._n this_o moderate_n or_o stop_v they_o that_o open_v the_o pore_n pain_n constr_v they_o opium_n prevent_v the_o shake_v fit_n in_o ague_n pain_n bring_v they_o on_o that_o cause_v a_o large_a and_o slow_a pulse_n this_o a_o quick_a hard_a and_o narrow_a pulse_n that_o cause_v a_o efflorescence_n of_o the_o skin_n this_o paleness_n that_o pleasant_a this_o unpleasant_a dream_n that_o still_v hiccough_n this_o cause_n they_o that_o take_v off_o contraction_n convulsion_n etc._n etc._n this_o cause_v they_o to_o be_v short_a opium_n cause_v all_o the_o effect_n of_o pleasant_a sensation_n and_o take_v off_o all_o the_o effect_n of_o grievous_a sensation_n what_o can_v be_v a_o more_o evident_a proof_n of_o its_o act_n by_o cause_v a_o pleasant_a sensation_n it_o be_v endless_a to_o mention_v all_o the_o proof_n that_o may_v be_v make_v to_o the_o same_o purpose_n from_o pleaser_n and_o displeaser_n of_o sensation_n therefore_o we_o fair_o conclude_v that_o opium_n do_v not_o operate_v by_o cause_v a_o grievovi_fw-la sensation_n and_o there_o be_v no_o other_o way_n leave_v by_o which_o it_o may_v operate_v it_o must_v operate_v by_o cause_v a_o pleasant_a sensation_n which_o be_v the_o true_a and_o plain_a reason_n why_o as_o have_v be_v show_v it_o take_v off_o pain_n and_o cause_v all_o effect_n quite_o contrary_a to_o that_o of_o grievous_a sensation_n irritation_n by_o acrimony_n etc._n etc._n which_o be_v most_o eminent_a upon_o the_o most_o sensible_a part_n as_o the_o stomach_n intestine_n venereal_a membrane_n skin_n etc._n etc._n as_o you_o may_v observe_v where_o the_o effect_n of_o opium_n be_v enumerate_v now_o gentle_a reader_n consider_v that_o contrary_n be_v the_o true_a cure_n of_o contrary_n what_o can_v then_o cure_v pain_n and_o all_o its_o effect_n better_a than_o pleasure_n it_o be_v very_o strange_a then_o that_o million_o for_o many_o age_n find_v opium_n cure_v or_o take_v off_o pain_n and_o all_o its_o effect_n above_o all_o thing_n shall_v not_o attribute_v its_o so_o do_v to_o its_o cause_v a_o pleasant_a sensation_n which_o be_v the_o direct_a contrary_n to_o pain_n especial_o since_o every_o man_n that_o take_v opium_n feel_v a_o actual_a pleasure_n upon_o take_v thereof_o pleasant_a dream_n a_o pleasant_a humour_n etc._n etc._n it_o may_v be_v say_v what_o if_o it_o be_v grant_v that_o opium_n operate_v by_o a_o please_a sensation_n which_o i_o will_v thank_v none_o for_o that_o have_v feel_v at_o stomach_n or_o reason_n at_o brain_n how_o be_v it_o possible_a that_o such_o pleasant_a sensation_n shall_v cause_v and_o explicate_v all_o the_o various_a strange_a wonderful_a mysterious_a and_o very_o often_o seem_o contradictory_n phenomena_n and_o effect_n of_o opium_n answer_n as_o easy_o as_o ever_o i_o explain_v any_o thing_n in_o nature_n especial_o if_o my_o tract_n of_o animal_n mechanism_n be_v publish_v but_o it_o be_v my_o misfortune_n that_o it_o be_v not_o however_o it_o shall_v not_o be_v the_o reader_n though_o it_o will_v put_v i_o to_o a_o great_a trouble_n to_o evade_v which_o be_v none_o of_o my_o intention_n by_o those_o word_n but_o rather_o to_o bespeak_v the_o reader_n be_v patience_n while_n i_o be_o premise_v some_o necessary_a praecognita_fw-la requisite_a to_o be_v know_v before_o i_o enter_v upon_o the_o explication_n of_o the_o wonderful_a and_o seem_o inexplicable_a effect_n of_o opium_n i_o therefore_o desire_v the_o reader_n be_v leave_v to_o premise_v some_o thing_n of_o the_o nature_n of_o sensation_n and_o sensitive_a pleasure_n in_o order_n to_o his_o more_o clear_a and_o ready_a understanding_n my_o explication_n of_o this_o mysterious_a and_o momentous_a matter_n look_v upon_o as_o so_o dark_a and_o abstruse_a a_o business_n to_o this_o day_n that_o some_o have_v not_o only_o yield_v it_o up_o as_o a_o thing_n hide_v from_o mankind_n but_o have_v earnest_o and_o serious_o argue_v that_o it_o act_v absolute_o by_o a_o occult_a quality_n reserve_v in_o a_o special_a manner_n as_o be_v the_o nature_n of_o spirit_n from_o our_o knowledge_n that_o it_o have_v be_v so_o hitherto_o i_o think_v none_o can_v deny_v as_o the_o circulation_n of_o the_o blood_n be_v for_o thousand_o of_o year_n though_o the_o very_a motion_n be_v see_v by_o million_o so_o as_o the_o cause_n of_o the_o operation_n of_o opium_n have_v be_v feel_v by_o a_o far_o great_a number_n it_o therefore_o will_v if_o i_o fail_v not_o in_o explain_v it_o appear_v so_o clear_a that_o it_o will_v be_v much_o wonder_v at_o like_o that_o of_o the_o circulation_n of_o the_o blood_n why_o so_o obvious_a a_o thing_n be_v not_o find_v by_o every_o one_o that_o use_v opium_n but_o whatever_o opium_n be_v god_n method_n be_v unsearchable_a and_o often_o his_o wise_a providence_n bestow_v good_a gift_n upon_o the_o unworthy_a that_o his_o free_a goodness_n may_v appear_v to_o who_o be_v all_o glory_n praise_n and_o thanksgiving_n for_o ever_o and_o ever_o amen_n note_v that_o while_o i_o be_o upon_o the_o
sensation_n of_o the_o sensile_a part_n which_o can_v well_o happen_v in_o that_o sound_a sleep_n wherein_o there_o be_v so_o little_a feel_v by_o reason_n of_o the_o say_a relaxation_n and_o because_o relaxation_n oppose_v contraction_n by_o which_o that_o shiver_a be_v promote_v such_o a_o relaxation_n and_o failure_n of_o feel_v thereupon_o be_v the_o true_a cause_n why_o opium_n put_v off_o ague_n fit_n etc._n etc._n so_o 20._o the_o relaxation_n in_o sleep_n stop_v vomit_v by_o take_v away_o the_o sense_n of_o the_o irritate_v cause_n and_o quiet_v as_o i_o have_v intimate_v all_o motion_n in_o general_a so_o sleep_v stop_n hiccough_n hemorrhage_n diary_n fever_n etc._n etc._n 21._o why_o watch_v labour_n or_o what_o impair_v the_o spirit_n and_o tire_v the_o sensitive_a soul_n incline_v we_o to_o sleep_v that_o be_v dispose_v the_o sensitive_a soul_n the_o only_a feeler_n of_o lassitude_n to_o give_v over_o contract_n the_o sensile_a part_n which_o as_o will_v plain_o appear_v by_o and_o by_o spend_v the_o spirit_n as_o sleep_v by_o relax_v they_o cause_v a_o recruit_v thereof_o to_o be_v short_a though_o one_o can_v hardly_o be_v too_o long_o in_o solve_v phenomena_n which_o be_v the_o proof_n of_o the_o truth_n of_o a_o man_n assertion_n the_o mechanical_a demonstration_n that_o i_o have_v make_v of_o the_o state_n of_o sleep_v and_o wake_v do_v so_o evident_o explicate_v all_o the_o phenomena_n of_o both_o that_o i_o be_o even_o ashamed_a to_o run_v any_o far_o upon_o such_o plain_a matter_n so_o obvious_a be_v thing_n when_o the_o truth_n be_v know_v and_o therefore_o have_v mention_v those_o circumstance_n and_o effect_n of_o sleep_n that_o main_o concern_v we_o i_o must_v give_v over_o lest_o the_o world_n shall_v think_v that_o i_o take_v all_o my_o reader_n to_o be_v idiot_n by_o use_v too_o many_o word_n in_o so_o obvious_a a_o thing_n or_o that_o i_o be_o no_o better_o for_o use_v they_o without_o cause_n for_o the_o truth_n of_o this_o matter_n seem_v to_o i_o to_o outshine_v all_o the_o argument_n i_o can_v make_v for_o it_o such_o splendour_n do_v truth_n show_v upon_o the_o first_o glimpse_n thereof_o as_o i_o take_v the_o account_n i_o give_v of_o sleep_n and_o watch_v to_o be_v for_o the_o opinion_n i_o have_v meet_v concern_v they_o be_v quite_o contrary_a to_o or_o very_o remote_a from_o what_o i_o have_v state_v 1._o they_o go_v quite_o contrary_a to_o it_o that_o say_v that_o the_o animal_n spirit_n be_v expanded_a and_o the_o pore_n of_o the_o brain_n etc._n etc._n more_o open_a and_o consequent_o more_o lax_n in_o watch_v as_o willis_n and_o several_a other_o who_o therefore_o say_v that_o coffee_n volatile_a salt_n etc._n etc._n be_v antihypnotick_n or_o good_a against_o too_o much_o sleepiness_n because_o they_o cause_v a_o expansion_n of_o the_o spirit_n and_o open_v the_o pore_n of_o the_o brain_n suppose_v forsooth_o that_o they_o march_v up_o and_o down_o and_o so_o keep_v the_o great_a stir_n upon_o the_o false_a imagination_n of_o their_o road_n be_v more_o open_a which_o as_o be_v prove_v be_v real_o more_o close_a coffee_n keep_v we_o from_o sleep_n by_o dry_v bind_a and_o both_o way_n constr_v the_o vessel_n as_o also_o by_o a_o wide_a grate_a quality_n which_o therefore_o do_v irritate_fw-la they_o to_o contract_v beside_o that_o the_o saline_n particle_n cause_v a_o agitation_n may_v contribute_v thereto_o so_o that_o by_o constr_v and_o agitate_v it_o direct_o oppose_v sleep_n which_o proceed_v from_o relaxation_n and_o quietness_n 2._o they_o be_v very_o remote_a from_o the_o mark_n that_o say_v as_o wedeliâ—s_a assert_n all_o do_v that_o vapour_n be_v the_o cause_n of_o natural_a sleep_n which_o bear_v no_o manner_n of_o proportion_n thereto_o as_o be_v show_v as_o they_o be_v also_o who_o mâ—dly_o talk_v that_o the_o animal_n spirit_n which_o have_v neither_o life_n sense_n motion_n or_o election_n do_v of_o themselves_o retire_v very_o know_o to_o the_o brain_n in_o sâ—eep_n and_o leave_v the_o limb_n etc._n etc._n destitute_a of_o they_o whereas_o as_o have_v be_v mechanical_o prove_v they_o have_v more_o room_n than_o that_o at_o other_o time_n in_o 〈◊〉_d limb_n and_o all_o the_o sensile_a part_n but_o i_o will_v not_o argue_v against_o such_o senseless_a and_o precarious_a absurdity_n it_o be_v not_o worth_a the_o while_n especial_o since_o the_o truth_n be_v manifest_o discover_v it_o will_v not_o have_v be_v so_o silly_a to_o have_v affirm_v the_o quite_o contrary_a viz._n that_o the_o animal_n spirit_n be_v force_v into_o the_o soft_a and_o yield_a brain_n in_o watch_v by_o the_o vigilative_a contraction_n of_o all_o the_o senfile_v part_n repel_v they_o as_o when_o cold_a repel_v they_o by_o a_o strong_a contraction_n of_o the_o part_n and_o cause_v a_o stupor_n or_o sleep_n thereof_o as_o they_o call_v it_o but_o what_o have_v we_o to_o do_v with_o such_o insufferable_a trash_n therefore_o bid_v it_o adieu_n let_v we_o pursue_v our_o business_n that_o it_o be_v the_o sensitive_a soul_n and_o nothing_o but_o it_o have_v that_o contract_n power_n be_v evident_a 1._o because_o it_o be_v the_o original_a of_o all_o motion_n in_o the_o animal_n as_o such_o and_o that_o nothing_o beside_o it_o have_v any_o life_n perception_n motion_n or_o power_n and_o therefore_o must_v rest_v till_o they_o be_v move_v 2._o because_o that_o when_o the_o sensitive_a soul_n be_v divert_v by_o intense_a pleasure_n from_o attend_v his_o business_n immediate_o relaxation_n follow_v as_o in_o the_o pleasure_n of_o the_o act_n of_o venery_n by_o wine_n joy_n etc._n etc._n in_o which_o you_o have_v all_o the_o effect_n of_o relaxation_n as_o deadness_n of_o the_o eye_n dilatation_n of_o the_o pupilla_fw-la plentiful_a perspiration_n floridity_n of_o the_o skin_n a_o large_a pulse_n and_o sometime_o a_o considerable_a failure_n of_o sense_n and_o motion_n as_o in_o the_o most_o pleasant_a time_n of_o the_o venereal_a act_n deliquiums_n drunkenness_n syncopes_fw-la or_o ecstasy_n upon_o intense_a pleasure_n which_o be_v very_o proper_o call_v ecstasy_n leipothymy_n leipopsychy_n etc._n etc._n which_o signify_v the_o soul_n leave_v we_o without_o his_o help_n by_o contraction_n which_o he_o then_o do_v not_o exercise_n as_o be_v charm_v and_o whole_o take_v up_o with_o pleasure_n this_o be_v the_o true_a cause_n of_o all_o deliquium_n etc._n etc._n upon_o pleasure_n joy_n etc._n etc._n all_o which_o cause_n great_a relaxation_n and_o thereby_o loss_n of_o sense_n and_o motion_n as_o be_v its_o necessary_a consequence_n 3._o because_o grievous_a sensation_n which_o belong_v only_o to_o the_o sensitive_a soul_n put_v we_o immediate_o out_o of_o sleep_n into_o a_o vigilative_a contraction_n 4._o because_o the_o sensitive_a soul_n can_v when_o we_o be_v sleepy_a oppose_v it_o by_o continue_v the_o vigilative_a contraction_n which_o prove_v vigilative_a contraction_n to_o be_v in_o his_o power_n note_v that_o there_o be_v also_o other_o sort_n of_o leipothymy_n deliquium_n etc._n etc._n upon_o the_o sensitive_a soul_n be_v overtired_n whereof_o natural_a sleep_n be_v but_o a_o common_a and_o ordinary_a degree_n that_o happen_v of_o course_n for_o our_o relief_n or_o overbear_v with_o some_o fatigue_n etc._n etc._n as_o when_o somewhat_o grieve_v at_o stomach_n and_o that_o it_o have_v lay_v about_o it_o all_o manner_n of_o way_n by_o vomit_v convulsive_a motion_n etc._n etc._n to_o be_v rid_v of_o it_o till_o it_o can_v work_v no_o long_o whereupon_o it_o lay_v down_o the_o cudgel_n desi_v from_o all_o further_a endeavour_n by_o contraction_n yield_v itself_o to_o ease_n see_v all_o strive_v be_v to_o no_o effect_n so_o that_o though_o this_o deliquium_fw-la and_o the_o former_a differ_v in_o their_o first_o cause_n yet_o do_v they_o agree_v in_o the_o last_o and_o immediate_a viz._n the_o sensitive_a soul_n be_v not_o attend_v his_o business_n of_o contraction_n whereupon_o follow_v a_o mighty_a relaxation_n as_o appear_v by_o the_o deadness_n or_o relaxation_n of_o the_o cornea_n dilatation_n of_o the_o pupil_n a_o great_a laxity_n of_o all_o part_n a_o large_a pulse_n or_o none_o very_o plentiful_a perspiration_n stop_v of_o hemorrhage_n and_o all_o flux_n that_o require_v contraction_n etc._n etc._n which_o happen_v both_o upon_o the_o account_n of_o the_o great_a relaxation_n itself_o as_o have_v be_v show_v and_o the_o almost_o absolute_a rest_n of_o all_o thing_n by_o the_o sensitive_a soul_n withdraw_a himself_n from_o business_n more_o than_o in_o sleep_n itself_o i_o therefore_o observe_v the_o degree_n of_o sleep_n etc._n etc._n do_v note_n that_o god_n and_o nature_n use_v a_o due_a proportion_n in_o all_o thing_n the_o sensitive_a soul_n use_v several_a degree_n of_o relaxation_n according_a as_o he_o be_v tire_v and_o refection_n be_v want_v hence_o it_o be_v that_o such_o as_o be_v much_o tire_v sleep_n more_o profound_o that_o our_o first_o
titillation_n and_o actuate_a of_o our_o spirit_n nor_o too_o full_a of_o volatile_a salt_n as_o mustard_n asarabacca_n etc._n etc._n nor_o have_v too_o accrimonious_a a_o volatile_a salt_n with_o too_o little_a oleous_a part_n to_o correct_v it_o for_o in_o both_o these_o last_o case_n the_o irritation_n will_v be_v grievous_a nor_o have_v the_o oleous_a and_o volatile_a loose_o combine_v but_o that_o it_o shall_v be_v a_o sal_fw-la volatile_a oleosum_fw-la wherein_o the_o volatile_a part_n be_v brisk_a and_o somewhat_o more_o active_a than_o we_o yet_o so_o correct_v by_o oleous_a part_n intimate_o combine_v therewith_o as_o to_o render_v it_o of_o a_o most_o agreeable_a and_o pleasant_a titillation_n such_o as_o will_v please_v all_o membrane_n but_o especial_o those_o that_o have_v most_o acute_a sensation_n as_o the_o stomach_n and_o venereal_a membrane_n both_o which_o opium_n most_o sensible_o please_v which_o be_v order_v so_o to_o be_v for_o preservation_n of_o the_o individuum_fw-la and_o species_n the_o one_o to_o invite_v we_o to_o eat_v and_o the_o other_o to_o procreate_v but_o to_o satisfy_v you_o yet_o far_o as_o to_o the_o stomach_n which_o concern_v we_o most_o note_v 1._o that_o the_o more_o exalt_v and_o intense_a the_o pleasure_n be_v the_o high_a be_v its_o effect_n upon_o the_o sensitive_a soul_n in_o please_v comfort_a and_o elevate_a it_o and_o upon_o the_o body_n in_o relax_v all_o the_o sensile_a part_n thereof_o as_o that_o of_o wine_n be_v high_a than_o that_o of_o mustum_fw-la etc._n etc._n note_v 2._o that_o the_o better_a the_o organ_n be_v dispose_v for_o sensation_n the_o high_a the_o pleasure_n or_o displeasure_n be_v for_o he_o that_o have_v his_o nose_n tongue_n ear_n membrane_n etc._n etc._n ill_o dispose_v for_o smell_a taste_v hear_v feel_v etc._n etc._n have_v not_o so_o much_o pleasure_n in_o sweet_a odour_n good_a taste_n music_n pleaser_n of_o the_o feel_n etc._n etc._n nor_o so_o much_o displeasure_n in_o bad_a scent_n etc._n etc._n it_o follow_v note_v 3_o that_o cujus_fw-la est_fw-la dolour_n ejusdem_fw-la est_fw-la voluptas_fw-la that_o be_v the_o part_n or_o membrane_n that_o be_v capable_a of_o intense_a pleasure_n be_v so_o of_o intense_a pain_n or_o displeasure_n for_o instance_n if_o the_o stomach_n be_v capable_a of_o great_a grievance_n it_o be_v so_o of_o great_a pleasure_n god_n have_v distribute_v they_o also_o equal_o note_v 4._o that_o since_o the_o great_a use_n end_v and_o business_n of_o sensation_n be_v to_o give_v notice_n and_o inform_v the_o animal_n of_o what_o be_v or_o be_v not_o good_a and_o agreeable_a to_o it_o it_o follow_v that_o the_o wisdom_n that_o make_v we_o will_v place_v the_o most_o exquisite_o and_o critical_o dispose_v organ_n or_o membrane_n of_o sensation_n where_o such_o notice_n be_v most_o requisite_a and_o useful_a and_o consequent_o there_o must_v be_v more_o pleasure_n or_o displeasure_n conceive_v at_o thing_n agreeable_a or_o disagreeable_a that_o the_o descend_v and_o relieve_v motion_n and_o comfort_n may_v be_v proportionable_a note_v 5._o that_o such_o exquisite_a exact_a and_o nice_a notice_n be_v most_o requisite_a at_o stomach_n first_o because_o all_o our_o nutriment_n good_a and_o bad_a be_v to_o pass_v that_o way_n to_o be_v judge_v of_o second_o because_o it_o be_v the_o last_o part_n that_o it_o arrive_v at_o before_o it_o receive_v a_o considerable_a change_n for_o when_o it_o be_v change_v no_o such_o true_a and_o sincere_a judgement_n can_v be_v give_v thereof_o as_o can_v be_v before_o three_o because_o the_o fault_n defect_n or_o negligence_n of_o the_o taste_n and_o the_o external_n sense_n be_v to_o be_v remedy_v and_o correct_v there_o or_o no_o where_o therefore_o the_o stomach_n be_v as_o the_o last_o judge_n of_o appeal_n and_o shall_v be_v most_o exact_a and_o infallible_a in_o judge_v or_o as_o the_o last_o inner_a or_o main_a guard_n in_o a_o fort_n town_n or_o castle_n which_o if_o the_o enemy_n pass_v the_o whole_a be_v endanger_v if_o not_o lose_v four_o because_o the_o concern_v be_v so_o great_a sensation_n shall_v be_v the_o more_o exquisite_a there_o to_o excite_v the_o animal_n power_n to_o make_v defence_n by_o repel_v reject_v or_o detrude_a the_o enemy_n which_o power_n as_o have_v be_v intimate_v be_v excite_v according_a to_o the_o degree_n of_o sensation_n especial_o see_v there_o be_v no_o voluntary_a power_n or_o contraction_n of_o the_o stomach_n but_o only_o the_o natural_a which_o be_v always_o excite_v by_o sensation_n in_o such_o case_n or_o not_o at_o all_o five_o sensation_n shall_v be_v critical_a and_o accurate_a at_o stomach_n to_o inform_v we_o precise_o when_o we_o shall_v eat_v or_o drink_v six_o to_o inform_v we_o exact_o when_o we_o have_v eat_v or_o drink_v enough_o for_o all_o this_o be_v do_v by_o sensation_n therefore_o god_n have_v place_v a_o most_o sensile_a membrane_n at_o the_o stomach_n as_o most_o manifest_o appear_v first_o by_o its_o take_n and_z giving_z notice_n of_o such_o minute_n thing_n that_o no_o sense_n part_n organ_n or_o membrane_n can_v for_o it_o take_v notice_n of_o and_o inform_v the_o sensitive_a soul_n as_o have_v be_v say_v of_o the_o vomitory_n particle_n of_o the_o crocus_n and_o regulus_n of_o antimony_n which_o be_v so_o indefinite_o small_a that_o no_o other_o membrane_n or_o organ_n of_o sensation_n but_o that_o at_o stomach_n can_v take_v notice_n thereof_o because_o the_o crocus_n and_o regulus_n after_o they_o have_v afford_v 1000_o vomit_n from_o their_o body_n be_v not_o sensible_o diminish_v either_o in_o weight_n or_o bulk_n nor_o do_v the_o stomach_n take_v and_o give_v a_o slight_a but_o very_o remarkable_a notice_n thereof_o that_o be_v sufficient_o powerful_a to_o excite_v not_o only_o all_o the_o natural_a power_n of_o the_o part_n and_o of_o all_o the_o auxiliary_a muscle_n that_o usual_o assist_v to_o vomit_v but_o to_o cause_v a_o contraction_n and_o that_o very_a often_o strong_o convulsive_a of_o all_o or_o most_o of_o the_o muscle_n and_o membrane_n of_o the_o whole_a body_n so_o great_a be_v the_o sway_n or_o regimen_n of_o the_o stomach_n by_o virtue_n of_o its_o exquisite_a sensility_n second_o by_o its_o give_a notice_n of_o inimicous_a particle_n and_o very_o tenuious_a effluvias_fw-la that_o fly_v in_o the_o air_n which_o no_o organ_n of_o sensation_n or_o membrane_n but_o that_o at_o stomach_n can_v observe_v for_o instance_n some_o that_o hate_v cat_n very_o much_o will_v know_v that_o there_o be_v a_o cat_n in_o the_o same_o room_n with_o they_o though_o silent_a and_o shut_v up_o in_o a_o trunk_n or_o cupboard_n where_o neither_o the_o eye_n ear_n nose_n taste_n or_o immediate_a feel_n can_v be_v at_o all_o concern_v or_o affect_v that_o it_o be_v the_o stomach_n that_o be_v affect_v be_v apparent_a though_o a_o thing_n not_o think_v of_o 1._o because_o the_o first_o notice_n they_o have_v be_v plain_o at_o stomach_n by_o a_o kind_n of_o faint_a distress_n not_o unlike_o a_o beginning_n nausea_n if_o the_o curious_a will_v inquire_v they_o will_v find_v it_o to_o be_v as_o i_o say_v 2._o because_o all_o perception_n of_o material_a thing_n be_v by_o sensation_n and_o that_o it_o be_v evident_a no_o other_o organ_n of_o sensation_n or_o membrane_n be_v concern_v 3._o because_o if_o the_o cat_n continue_v in_o the_o room_n and_o be_v not_o remove_v they_o fall_v a_o vomit_v or_o into_o anxiety_n or_o great_a distress_n at_o stomach_n or_o faint_n and_o syncopes_fw-la which_o be_v the_o common_a and_o know_v effect_n of_o a_o grieve_a or_o oppress_a stomach_n just_o so_o do_v it_o though_o these_o thing_n be_v not_o or_o not_o due_o observe_v take_v and_o give_v notice_n of_o pestilential_a effluvias_fw-la which_o cause_n the_o like_a faint_n or_o a_o kind_n of_o nausea_n at_o stomach_n thus_o people_n discern_v that_o they_o be_v as_o they_o call_v it_o plague_v strike_v and_o often_o fall_v as_o in_o the_o case_n of_o the_o effluvias_fw-la of_o the_o cat_n into_o dangerous_a deliquium_n and_o syncopes_fw-la of_o which_o many_o in_o plague_n time_n sudden_o die_v as_o cat_n hater_n will_v for_o aught_o i_o know_v if_o they_o continue_v long_o in_o the_o same_o room_n with_o a_o cat_n as_o they_o do_v with_o pestilential_a effluvias_fw-la therefore_o it_o be_v good_a present_o to_o remove_v they_o from_o the_o place_n wherein_o they_o be_v strike_v because_o the_o air_n as_o the_o room_n wherein_o the_o cat_n be_v be_v fill_v with_o the_o pernicious_a particle_n for_o you_o see_v in_o the_o case_n of_o the_o cat_n that_o remove_v the_o man_n or_o the_o cat_n give_v relief_n and_o it_o be_v better_a remove_v the_o man_n but_o that_o he_o be_v more_o cumbersome_a because_o the_o room_n be_v already_o taint_v with_o the_o effluvias_fw-la and_o in_o the_o case_n of_o the_o plague_n it_o be_v only_o the_o person_n that_o can_v
be_v well_o remove_v this_o prove_v how_o useful_a removal_n may_v be_v and_o how_o convenient_a in_o plague_n time_n it_o will_v be_v to_o remove_v to_o the_o wind-side_n of_o a_o town_n or_o city_n that_o be_v taint_v according_a as_o the_o wind_n change_v and_o how_o convenient_a wind_n be_v to_o convey_v away_o the_o effluviams_n and_o good_a stomachick_a cordial_n that_o be_v warm_a and_o pleasant_a to_o fortify_v the_o stomach_n and_o open_v the_o pore_n which_o all_o thing_n that_o cause_v a_o sense_n of_o pleasure_n do_v as_o wine_n spirit_n etc._n etc._n to_o which_o if_o some_o good_a preparation_n of_o opium_n be_v add_v it_o will_v be_v most_o convenient_a how_o many_o story_n have_v we_o of_o person_n well_o fill_v with_o wine_n who_o wonderful_o escape_v infection_n i_o pray_v god_n this_o hint_n may_v be_v improve_v to_o the_o preservation_n of_o mankind_n therefore_o i_o add_v that_o much_o may_v be_v in_o a_o good_a quantity_n of_o wine_n in_o this_o case_n 1._o because_o quod_fw-la intus_fw-la est_fw-la prohibet_fw-la alienum_fw-la that_o be_v what_o be_v within_o hinder_v ingress_n of_o another_o thing_n 2._o because_o the_o perspiration_n will_v be_v the_o great_a both_o upon_o the_o account_n of_o the_o great_a open_n of_o the_o pore_n by_o the_o pleasure_n of_o the_o wine_n and_o the_o great_a quantity_n of_o matter_n to_o be_v perspire_v carry_v off_o the_o venomous_a particle_n 3._o because_o the_o sensitive_a soul_n be_v thereby_o much_o comfort_v refresh_v and_o invigorate_v but_o i_o will_v have_v the_o wine_n so_o use_v as_o to_o keep_v a_o continual_a warmth_n pleasure_n and_o comfort_n at_o stomach_n which_o be_v the_o main_a cause_n of_o all_o the_o good_a i_o think_v a_o glass_n every_o hour_n after_o take_v 2_o or_o 3_o at_o first_o may_v hit_v the_o mark_n best_o the_o reason_n of_o which_o will_v appear_v hereafter_o three_o the_o stomach_n be_v exquisite_a disposition_n to_o sensation_n above_o all_o other_o organ_n and_o membrane_n appear_v by_o this_o viz._n that_o the_o offence_n of_o the_o other_o organ_n of_o sensation_n even_o by_o their_o proper_a object_n do_v often_o affect_v the_o stomach_n more_o than_o those_o very_a sense_n or_o organ_n themselves_o for_o instance_n if_o we_o smell_v a_o great_a stench_n the_o stomach_n be_v often_o more_o offend_v thereat_o than_o the_o nose_n as_o be_v manifest_a from_o the_o vomit_n faint_n and_o deliquium_n that_o be_v cause_v by_o the_o stomach_n upon_o that_o account_n so_o the_o bare_a see_v feel_v and_o taste_v of_o a_o nasty_a thing_n do_v cause_n nauseas_fw-la etc._n etc._n at_o stomach_n yea_o the_o very_a name_n of_o such_o thing_n have_v much_o offend_v it_o and_o cause_v such_o effect_n which_o may_v be_v think_v very_o strange_a consider_v that_o there_o pass_v no_o effluvias_fw-la from_o the_o sound_n of_o word_n but_o the_o reason_n will_v appear_v in_o the_o follow_a paragraph_n four_o all_o passion_n commotion_n and_o perturbation_n that_o happen_v in_o the_o body_n do_v often_o affect_v the_o stomach_n and_o sometime_o so_o grievous_o as_o to_o cause_n nauseas_fw-la vomit_n great_a anxiety_n at_o stomach_n faint_n etc._n etc._n thus_o fear_v terror_n surprise_v anger_n grief_n pain_n in_o other_o part_n etc._n etc._n cause_v some_o motion_n in_o the_o animal_n more_o than_o ordinary_a of_o which_o the_o stomach_n be_v sensible_a do_v cause_n the_o aforesaid_a disturbance_n therefore_o it_o be_v no_o wonder_n if_o the_o hear_v one_o mention_n a_o nasty_a thing_n which_o cause_v a_o abhorrence_n and_o the_o motion_n consequent_a thereunto_o shall_v as_o be_v say_v in_o the_o precedent_n paragraph_n cause_v the_o nice_a stomach_n to_o be_v offend_v it_o be_v most_o manifest_a from_o the_o premise_n that_o no_o organ_n or_o membrane_n can_v compare_v with_o the_o stomach_n as_o to_o its_o exquisite_a disposition_n for_o sensation_n it_o follow_v then_o that_o grievance_n or_o pleasure_n at_o stomach_n must_v have_v the_o great_a effect_n 1._o because_o the_o intenseness_n of_o either_o will_v be_v proportionable_a to_o the_o sensation_n 2._o because_o the_o power_n of_o the_o animal_n that_o be_v to_o defend_v it_o which_o be_v contraction_n be_v affect_v according_a to_o the_o sensation_n and_o that_o it_o be_v there_o most_o requisite_a sensible_o to_o affect_v they_o 3._o because_o what_o affect_v the_o stomach_n influence_n the_o whole_a animal_n more_o than_o the_o sensation_n of_o any_o other_o part._n 4._o because_o of_o the_o considerable_a stay_v that_o thing_n make_v at_o stomach_n to_o cause_n grievance_n or_o pleasure_n whereas_o that_o of_o pleasure_n be_v general_o very_o momentary_a in_o other_o case_n 5._o because_o be_v within_o the_o body_n we_o carry_v our_o pleasure_n or_o grievance_n with_o we_o as_o a_o vade_fw-la mecum_fw-la wherever_o we_o go_v and_o therefore_o 6._o it_o be_v a_o pleasure_n etc._n etc._n that_o can_v so_o well_o be_v take_v away_o from_o we_o as_o that_o of_o the_o tongue_n ear_n nose_n eye_n etc._n etc._n may_v by_o remove_v the_o object_n and_o therefore_o it_o remain_v with_o we_o in_o our_o very_a sleep_n as_o far_o as_o we_o be_v capable_a of_o sensation_n at_o that_o time_n cause_v pleasant_a dream_n etc._n etc._n and_o so_o agreeable_o entertain_v we_o sleep_v or_o wake_v when_o the_o pleasure_n of_o all_o the_o other_o sense_n fail_v we_o which_o will_v appear_v far_o hereafter_o the_o pleasure_n at_o stomach_n excel_v even_o that_o of_o venery_n if_o not_o in_o intenseness_n yet_o in_o several_a other_o respect_n viz._n 1._o because_o of_o its_o duration_n that_o of_o venus_n be_v momentary_a but_o that_o of_o wine_n at_o stomach_n last_v a_o good_a while_n and_o that_o of_o opium_n many_o hour_n it_o be_v therefore_o that_o the_o effect_n of_o these_o two_o be_v more_o remarkable_a and_o take_v notice_n of_o 2._o because_o that_o at_o stomach_n may_v be_v continue_v as_o long_o as_o we_o please_v by_o a_o new_a supply_n of_o wine_n opium_n cordial_n etc._n etc._n 3._o because_o it_o may_v be_v excite_v when_o and_o as_o often_o as_o we_o please_v if_o we_o have_v those_o cordial_n at_o hand_n 4._o because_o it_o be_v not_o attend_v with_o any_o expense_n of_o strength_n depression_n of_o spirit_n etc._n etc._n as_o that_o of_o venery_n but_o the_o quite_o contrary_a viz._n with_o more_o vigour_n elevation_n of_o the_o spirit_n etc._n etc._n one_o be_v by_o emission_n and_o the_o other_o upon_o admission_n of_o what_o be_v agreeable_a it_o be_v for_o the_o several_a reason_n contain_v in_o the_o premise_n that_o the_o effect_n of_o grievance_n as_o hunger_n etc._n etc._n or_o pleasure_n be_v more_o considerable_a and_o remarkable_a at_o stomach_n and_o that_o thing_n agreeable_a thereto_o have_v by_o way_n of_o eminence_n gain_v the_o name_n of_o cordial_n that_o wine_n spirit_n opium_n etc._n etc._n do_v cause_n a_o more_o permanent_a and_o notable_a gaity_n pleasantness_n good_a humour_n serenity_n promptitude_n ovation_n of_o the_o spirit_n or_o sensitive_a soul_n bravery_n courage_n magnanimity_n euphory_n or_o easy_a undergo_n of_o business_n relaxation_n with_o all_o its_o effect_n as_o deadness_n of_o the_o eye_n dilatation_n of_o the_o papilla_fw-la perspiration_n etc._n etc._n which_o be_v hardly_o note_v in_o other_o short_a pleasure_n unless_o it_o be_v in_o that_o eminent_a though_o short_a one_o of_o venus_n which_o be_v a_o pleasure_n of_o the_o same_o sense_n of_o feel_v as_o that_o of_o opium_n and_o wine_n be_v therefore_o please_v the_o stomach_n be_v one_o of_o the_o great_a thing_n to_o be_v regard_v in_o the_o practice_n of_o physic_n to_o comfort_n satisfy_v or_o compose_v the_o spirit_n by_o which_o mean_n i_o have_v often_o perform_v such_o cure_n that_o neither_o i_o nor_o i_o suppose_v any_o other_o can_v otherwise_o perform_v namely_o dejection_n of_o appetite_n untowardness_n at_o stomach_n etc._n etc._n when_o all_o the_o ordinary_a and_o usual_a mean_n have_v fail_v by_o ask_v they_o what_o they_o most_o desire_a or_o long_v for_o and_o let_v they_o have_v it_o or_o if_o they_o can_v not_o tell_v of_o any_o thing_n that_o they_o long_v for_o i_o have_v mention_v to_o they_o all_o the_o relish_v thing_n that_o i_o can_v think_v of_o and_o such_o as_o be_v grateful_a to_o the_o stomach_n till_o they_o fasten_v upon_o somewhat_o that_o they_o like_v or_o fancy_v and_o then_o be_v give_v they_o it_o general_o have_v the_o desire_a success_n the_o stomach_n be_v grieve_v for_o it_o will_v concern_v we_o to_o know_v how_o because_o opium_n cause_v vomit_v etc._n etc._n general_o speak_v 1._o by_o thing_n hard_a of_o digestion_n as_o heavy_a bread_n mushroom_n rosin_n and_o such_o like_a 2._o by_o thing_n acrimonious_a or_o pungent_a as_o vomitory_n of_o asarabacca_n groundsil_n squill_n etc._n etc._n which_o abound_v with_o volatile_a salt_n 3._o by_o thing_n that_o stick_v to_o the_o stomach_n which_o
only_o the_o open_n of_o the_o pore_n so_o that_o i_o need_v add_v no_o more_o word_n about_o it_o for_o the_o fame_n cause_o must_v have_v the_o same_o effect_n therefore_o a_o intense_a and_o permanent_a pleasure_n must_v have_v all_o or_o much_o of_o the_o effect_n of_o sleep_n in_o general_n as_o have_v be_v show_v it_o can_v therefore_o be_v any_o wonder_n that_o opium_n cause_v sleep_n yet_o be_v there_o difference_n between_o sleep_n and_o pleasure_n upon_o other_o account_n though_o not_o upon_o the_o account_n of_o relaxation_n viz._n because_o 1._o that_o sleep_n require_v also_o a_o rest_n of_o spirit_n or_o the_o sensitive_a soul_n whereas_o relaxation_n by_o pleasure_n be_v consistent_a with_o motion_n of_o the_o spirit_n either_o by_o outward_a action_n or_o internal_a motion_n thereof_o by_o some_o inward_a cause_n hence_o it_o be_v first_o that_o we_o can_v labour_v travel_v dance_n etc._n etc._n and_o enjoy_v pleasure_n and_o its_o relaxation_n volantary_a motion_n which_o require_v only_o a_o particular_a contraction_n of_o some_o part_n by_o the_o dictate_v of_o the_o will_n or_o appetite_n be_v consistent_a with_o the_o general_a relaxation_n by_o reason_n of_o the_o prerogative_n of_o the_o will._n thus_o do_v we_o move_v though_o more_o relax_v or_o when_o most_o merry_a and_o please_v with_o wine_n nay_o some_o will_v walk_v in_o their_o sleep_n when_o extreme_o intâ—t_v upon_o a_o thing_n as_o when_o awake_a which_o show_v the_o roll_a power_n of_o intentive_a contraction_n that_o may_v be_v exercise_v with_o relaxation_n and_o other_o contraction_n as_o the_o will_n itself_o may_v or_o intentive_a appetite_n second_o that_o pain_n be_v often_o take_v away_o by_o opium_n by_o the_o diversion_n and_o relaxation_n cause_v by_o pleasure_n and_o its_o inconsistence_n with_o pain_n without_o sleep_n which_o require_v the_o aforesaid_a rest_n that_o bare_a relaxation_n as_o such_o do_v not_o include_v though_o relaxation_n suffice_v to_o take_v away_o pain_n three_o that_o opium_n do_v by_o its_o heat_n active_a particle_n etc._n etc._n hinder_v some_o person_n to_o sleep_n yet_o have_v you_o in_o both_o these_o last_o case_n all_o other_o effect_n of_o opium_n as_o pleasure_n indolence_n relaxation_n etc._n etc._n which_o show_v how_o far_o sleep_v be_v from_o be_v a_o constant_a and_o the_o most_o genuine_a effect_n of_o opium_n as_o be_v general_o imagine_v however_o we_o must_v allow_v it_o as_o have_v be_v show_v to_o be_v a_o mighty_a disposer_n of_o we_o towards_o sleep_n because_o of_o the_o relaxation_n that_o it_o cause_n which_o be_v the_o main_a requisite_a of_o sleep_n ii_o that_o pleasure_n do_v without_o nutritive_a refection_n by_o the_o complacency_n it_o cause_v in_o the_o sensitive_a soul_n produce_v comfort_n satisfaction_n composure_n elevation_n of_o the_o spirit_n euphory_n etc._n etc._n of_o which_o sleep_n be_v either_o not_o at_o all_o capable_a or_o but_o in_o a_o low_a degree_n proportionable_a to_o the_o sensation_n that_o it_o have_v which_o be_v but_o little_a however_o a_o pleasure_n that_o remain_v within_o we_o even_o in_o our_o sleep_n as_o that_o of_o opium_n may_v well_o cause_v pleasant_a dream_n etc._n etc._n the_o reader_n may_v observe_v that_o in_o all_o place_n where_o i_o mention_v that_o relaxation_n cause_v the_o open_n of_o the_o pore_n that_o i_o speak_v only_o of_o perspiration_n as_o the_o effect_n thereof_o without_o mention_v sweat_n 1._o because_o perspiration_n be_v the_o only_a constant_a and_o infallible_a effect_n thereof_o by_o reason_n that_o the_o levity_n of_o the_o fume_n cause_v they_o as_o certain_o to_o pass_v at_o the_o pore_n when_o open_a as_o smoke_n pass_v up_o at_o a_o open_a chimney_n 2._o because_o sweat_n be_v a_o uncertain_a effect_n thereof_o for_o it_o require_v that_o the_o body_n be_v well_o fill_v with_o moisture_n though_o there_o be_v a_o relaxation_n or_o open_v of_o the_o pore_n as_o hypocrates_n very_o right_o intimate_v in_o that_o aphorism_n of_o his_o that_o i_o cite_v in_o the_o last_o chapter_n 1._o because_o sweat_n have_v not_o that_o levity_n that_o the_o fume_n have_v to_o cause_v it_o ready_o to_o move_v as_o soon_o as_o the_o pore_n be_v open_a 2._o because_o relaxation_n be_v more_o apt_a to_o receive_v detain_v and_o suspend_v humour_n 3._o because_o the_o protrusive_a motion_n of_o the_o heart_n be_v weak_a in_o all_o relaxation_n and_o all_o see_v how_o much_o its_o vigorous_a protrusion_n contribute_v to_o sweat_v upon_o action_n 4._o because_o a_o heartful_a of_o blood_n do_v not_o make_v such_o a_o push_v forward_o when_o the_o artery_n be_v widen_v by_o relaxation_n 5._o sweat_n have_v more_o of_o continuity_n consistence_n and_o viscidity_n can_v flow_v out_o so_o ready_o at_o the_o pore_n as_o a_o mere_a vapour_n however_o if_o the_o body_n be_v full_a of_o moisture_n and_o the_o pore_n open_a there_o be_v a_o natural_a course_n that_o way_n and_o the_o heart_n continual_o protrude_a it_o far_o and_o far_o a_o sweat_n follow_v and_o that_o whether_o they_o sleep_v or_o not_o 3._o because_o sweat_v as_o be_v in_o some_o sort_n intimate_v be_v sometime_o cause_v by_o the_o strong_a protrusion_n of_o the_o heart_n as_o in_o motion_n etc._n etc._n and_o upon_o that_o account_n come_v more_o under_o the_o title_n of_o flux_n cause_v by_o contraction_n than_o relaxation_n of_o which_o perspiration_n be_v a_o constant_a effect_n 4._o because_o sweat_n be_v sometime_o cause_v by_o another_o sort_n of_o contraction_n viz._n the_o compression_n of_o the_o whole_a body_n by_o a_o violent_a defensive_a contraction_n as_o in_o great_a terror_n agony_n and_o the_o like_a cause_v thereby_o as_o be_v show_v by_o the_o comparison_n of_o a_o wet_a sheet_n wring_v who_o out_o side_n be_v cold_a a_o cold_a sweat_n which_o that_o of_o alum_n or_o vitriol_n cause_v a_o exudation_n of_o the_o spital_n into_o the_o mouth_n by_o constr_v the_o part_n do_v illustrate_v very_o plain_o therefore_o you_o see_v i_o have_v just_a cause_n not_o to_o mention_v sweat_n as_o a_o certain_a and_o proper_a effect_n of_o relaxation_n without_o good_a distinction_n first_o make_v though_o unwary_a author_n that_o talk_v any_o thing_n one_o after_o another_o not_o know_v what_o they_o say_v make_v it_o their_o common_a say_n that_o sleep_n and_o opium_n stop_v all_o flux_n but_o sweat_n whereas_o they_o shall_v have_v rather_o say_v but_o perspiration_n for_o opium_n and_o sleep_n also_o will_v sometime_o hinder_v sweat_n viz._n that_o from_o pain_n terror_n etc._n etc._n and_o that_o as_o happen_v just_a upon_o awake_v by_o the_o strong_a systole_n of_o the_o heart_n and_o contraction_n of_o the_o whole_a body_n and_o that_o also_o upon_o motion_n unless_o the_o body_n be_v as_o be_v say_v full_a of_o humour_n or_o moisture_n therefore_o it_o be_v a_o vulgar_a error_n to_o say_v sweat_n instead_o of_o perspiration_n in_o the_o case_n aforesaid_a you_o may_v remember_v that_o in_o the_o beginning_n of_o this_o chapter_n i_o conclude_v that_o a_o sal-volatile-oleosum_a such_o as_o semen_n humanum_fw-la wherein_o the_o oily_a and_o volatile_a part_n be_v strict_o combine_v and_o the_o volatile_a somewhat_o more_o active_a or_o acrimonious_a than_o that_o in_o our_o membrane_n in_o general_a must_v be_v most_o please_v to_o the_o membrane_n by_o a_o fine_a titillation_n etc._n etc._n therefore_o if_o opium_n shall_v prove_v to_o be_v such_o we_o need_v not_o wonder_v at_o its_o titillate_v to_o venery_n nor_o indeed_o its_o cause_v a_o high_a sense_n of_o pleasure_n upon_o any_o membrane_n they_o be_v all_o of_o the_o same_o nature_n but_o especial_o upon_o the_o most_o exquisite_o dispose_v membrane_n of_o the_o stomach_n and_o the_o venereal_a part_n nor_o consequent_o its_o cause_v all_o the_o aforementioned_a effect_n of_o intense_a pleasure_n as_o comfort_n satisfaction_n ovation_n etc._n etc._n of_o the_o sensitive_a soul_n or_o spirit_n and_o relaxation_n of_o all_o the_o sensile_a part_n which_o will_v easy_o solve_v all_o the_o phenomenas_n of_o opium_n however_o numerous_a mysterious_a and_o seem_o contradictory_n as_o you_o will_v find_v let_v we_o therefore_o now_o see_v whether_o opium_n be_v such_o a_o sal-volatile-oleosum_a wherein_o the_o volatile_a particle_n be_v somewhat_o more_o active_a or_o acrimonious_a than_o we_o and_o the_o oily_a and_o volatile_a part_n strict_o combine_v if_o so_o the_o business_n be_v do_v the_o nail_n be_v hit_v on_o the_o head_n and_o i_o may_v say_v 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d chap._n xv._o show_v what_o be_v the_o principle_n of_o opium_n and_o which_o cause_n the_o good_a and_o bad_a effect_n thereof_o have_v try_v if_o not_o tire_v your_o patience_n and_o premise_v what_o i_o think_v necessary_a in_o the_o forego_n chapter_n i_o now_o reassume_v the_o thread_n of_o my_o discourse_n as_o for_o the_o passive_a principle_n of_o opium_n which_o do_v or_o signify_v little_a or_o nothing_o
spoon_n and_o cause_n no_o more_o effect_n than_o oil_n of_o olive_n and_o spirit_n of_o sal_fw-la amenoniack_a take_v inward_o one_o act_v too_o soft_o lazy_o and_o greasy_o to_o cause_v any_o brisk_a and_o agreeable_a ovation_n of_o the_o spirit_n and_o the_o other_o too_o rude_o sting_v the_o membrane_n therefore_o we_o must_v proceed_v in_o our_o enquiry_n four_o opium_n have_v a_o sort_n of_o resinous_n sulphur_n that_o be_v loose_a and_o not_o unite_v with_o the_o volatile_a salt_n which_o plain_o appear_v 1._o because_o if_o you_o dissolve_v opium_n in_o water_n cold_a or_o hot_a or_o any_o watery_a menstruum_fw-la you_o will_v find_v a_o good_a quantity_n of_o rosin_n undissolved_a at_o bottom_n while_o the_o volatile_a salt_n be_v all_o or_o most_o dissolve_v in_o the_o water_n especial_o if_o the_o water_n be_v often_o repeat_v and_o quite_o separate_v from_o the_o resinous_n part_v which_o subside_v without_o any_o more_o trouble_n which_o show_v that_o the_o volatile_a salt_n and_o it_o be_v not_o combine_v but_o in_o a_o very_a loose_a and_o distinct_a manner_n 2._o because_o if_o you_o first_o dissolve_v opium_n in_o spirit_n of_o wine_n which_o imbibe_v the_o rosin_n it_o be_v easy_o again_o precipitate_v by_o plain_a water_n leave_v behind_o it_o all_o or_o most_o of_o the_o volatile_a salt_n in_o the_o form_n of_o a_o red_a tincture_n in_o the_o menstruum_fw-la as_o it_o do_v also_o in_o the_o former_a case_n note_v that_o the_o resinous_n part_n of_o opium_n have_v no_o effect_n as_o a_o opiate_n for_o if_o it_o be_v well_o wash_v with_o water_n as_o be_v say_v it_o have_v no_o operation_n of_o that_o kind_n or_o so_o little_a that_o it_o be_v not_o worth_a the_o mind_v but_o all_o the_o virtue_n specific_a taste_n smell_v etc._n etc._n be_v carry_v away_o in_o that_o red_a tincture_n which_o have_v all_o the_o good_a effect_n of_o opium_n as_o experience_n assure_v we_o 3._o because_o if_o opium_n be_v very_o much_o torrefy_v most_o of_o the_o volatile_a salt_n be_v evaporate_v and_o with_o it_o most_o if_o not_o all_o the_o virtue_n of_o opium_n but_o the_o rosin_n remain_v as_o a_o deadish_a stuff_n in_o respect_n of_o the_o good_a effect_n of_o opium_n though_o it_o be_v as_o shall_v be_v prove_v the_o producer_n of_o the_o ill_a effect_n thereof_o therefore_o this_o rosin_n must_v be_v whole_o reject_v five_o the_o red_a tincture_n aforesaid_a have_v all_o or_o most_o of_o the_o volatile_a salt_n in_o it_o 1._o because_o water_n be_v the_o proper_a menstruum_fw-la for_o saline_n thing_n and_o that_o the_o tincture_n reduce_v to_o a_o extract_n give_v very_o much_o in_o moist_a wether_n which_o quality_n it_o must_v have_v from_o the_o volatile_a salt_n because_o it_o have_v very_o little_o fix_v salt_n 2._o because_o the_o specific_a bitterness_n which_o proceed_v from_o volatile_a salt_n and_o oily_a part_n be_v whole_o in_o that_o red_a tincture_n 3._o because_o that_o tincture_n have_v also_o the_o specific_a rankness_n of_o smell_n that_o the_o volatile_a salt_n as_o be_v show_v give_v the_o opium_n by_o the_o help_n of_o some_o oily_a part_n 4._o because_o that_o tincture_n reduce_v to_o a_o extract_n have_v the_o bite_a taste_n of_o opium_n which_o as_o be_v show_v proceed_v from_o its_o volatile_a salt_n 5._o because_o that_o extract_n incides_fw-la discuss_n resolve_n be_v psilothrick_n titillate_n to_o venery_n cause_v itch_n in_o the_o skin_n acrimonious_a sweat_v etc._n etc._n all_o which_o be_v as_o be_v show_v the_o effect_n of_o volatile_a salt_n but_o what_o need_v i_o insist_v so_o much_o upon_o its_o effect_n to_o prove_v it_o when_o 6._o it_o appear_v by_o crystalization_n of_o the_o say_a tincture_n after_o it_o have_v be_v evaporate_v to_o a_o due_a degree_n that_o it_o contain_v the_o volatile_a salt_n in_o it_o which_o in_o a_o cool_a place_n shoot_v to_o elegant_a crystal_n and_o that_o 7._o it_o be_v find_v therein_o by_o chemical_a operation_n by_o fire_n six_o the_o say_a tincture_n be_v oleose_v 1._o because_o the_o redness_n of_o the_o tincture_n must_v be_v from_o oily_a part_n for_o pure_a sincere_a volatile_a salt_n give_v no_o such_o tincture_n 2._o because_o it_o be_v bitter_a one_o ingredient_n of_o which_o taste_n be_v ever_o oily_a part_n as_o be_v say_v 3._o because_o of_o its_o rank_a smell_n like_o sem._n viril_n which_o prove_v it_o to_o be_v sulphureous_a for_o the_o volatile_a salt_n alone_o have_v only_o a_o quick_a smell_n or_o urinous_a at_o far_a 4._o because_o it_o be_v of_o a_o hot_a taste_n when_o reduce_v to_o a_o extract_n which_o heat_v of_o taste_n consider_v distinct_o from_o its_o pungent_a or_o bite_a taste_n must_v be_v from_o sulphureous_a or_o oily_a part_n 5._o because_o spirit_n of_o wine_n and_o other_o spirituosulphureous_a menstruum_n do_v ready_o dissolve_v it_o when_o reduce_v to_o a_o extract_n 6._o because_o the_o extract_n soften_v with_o dry_a warmth_n as_o sulphureous_a or_o oily_a thing_n do_v 7._o because_o a_o true_a sal-volatile-oleosum_a wherein_o the_o volatile_a salt_n and_o oily_a part_n be_v intimate_o combine_v as_o you_o find_v in_o all_o blood_n tincture_n of_o several_a plant_n that_o have_v such_o a_o sal-volatile-oleosum_a be_v red_a 8._o because_o it_o can_v not_o otherwise_o so_o fine_o please_v the_o membrane_n cause_n sleep_n compose_v the_o spirit_n etc._n etc._n if_o it_o be_v all_o volatile_a salt_n which_o be_v whole_o pungent_a and_o acrimonious_a mighty_o oppose_v sleep_n and_o cause_v a_o great_a stir_n in_o the_o blood_n and_o spirit_n but_o as_o i_o say_v as_o to_o its_o volatile_a salt_n what_o need_v i_o insist_v upon_o its_o effect_n when_o 10._o it_o be_v inflammability_n after_o it_o be_v reduce_v to_o a_o extract_n and_o dry_v put_v it_o out_o of_o all_o question_n and_o that_o 11._o a_o oil_n may_v be_v separate_v from_o the_o volatile_a salt_n though_o not_o without_o trouble_n because_o that_o as_o be_v requisite_a to_o complete_a it_o in_o the_o high_a degree_n seven_o the_o oily_a part_n and_o volatile_a salt_n be_v very_o intimate_o and_o strict_o combine_v as_o fair_o appear_v 1._o by_o the_o difficulty_n to_o separate_v they_o 2._o by_o the_o redness_n of_o the_o tincture_n as_o in_o blood_n etc._n etc._n for_o when_o oily_a or_o sulphureous_a particle_n be_v loose_a therein_o they_o make_v either_o a_o white_a colour_n as_o the_o rosin_n do_v in_o the_o drop_n that_o fall_v out_o of_o the_o incision_n in_o the_o head_n of_o the_o poppy_n which_o be_v milk_n white_a or_o leave_v the_o volatile_a spirit_n perspicuous_a as_o in_o a_o sort_n of_o artificial_a sal._n volatile-oleosum_a that_o be_v sell_v at_o the_o apothecary_n shop_n in_o london_n 3._o because_o it_o impart_v its_o tincture_n which_o depend_v upon_o both_o to_o all_o menstruum_n 4._o because_o it_o impart_v its_o virtue_n which_o depend_v upon_o both_o to_o all_o menstruum_n 5._o because_o it_o impart_v its_o specific_a smell_n which_o depend_v upon_o both_o to_o all_o menstruumt_v 6._o because_o it_o impart_v its_o specific_a hot_a and_o bite_a taste_n which_o depend_v upon_o both_o the_o oily_a and_o volatile_a particle_n to_o all_o menstruum_n 7._o because_o it_o will_v hold_v its_o virtue_n many_o year_n which_o it_o can_v not_o if_o the_o volatile_a salt_n and_o oily_a part_n be_v not_o very_o strict_o combine_v 8._o because_o that_o notwithstanding_o the_o digestion_n at_o stomach_n it_o have_v hold_v its_o specific_a virtue_n smell_v and_o taste_n after_o it_o have_v be_v in_o it_o 4_o 5_o 6_o 7_o 8_o 9_o 10_o 11_o 12_o 18_o or_o more_o hour_n as_o appear_v by_o its_o operate_n so_o long_o and_o afteward_n its_o be_v vomit_v up_o with_o the_o same_o taste_n and_o smell_v that_o it_o have_v at_o first_o than_o which_o there_o can_v be_v a_o great_a argument_n 9_o because_o it_o have_v be_v carry_v off_o by_o stool_n which_o have_v its_o specific_a smell_n after_o many_o hour_n remain_v in_o the_o stomach_n 10._o because_o its_o operation_n in_o general_n last_v long_o charas_fw-la mention_n one_o that_o it_o operate_v with_o for_o about_o 30_o hour_n and_o wedelius_n another_o who_o opium_n cause_v to_o vomit_v constant_o about_o 18_o hour_n after_o it_o be_v take_v 11._o because_o it_o have_v its_o effect_n upon_o the_o venereal_a membrane_n after_o it_o have_v pass_v the_o digestion_n at_o stomach_n the_o effect_n of_o the_o choler_n and_o succus_fw-la pancreatus_fw-la in_o the_o duodenum_fw-la be_v strain_v through_o the_o coat_n of_o the_o intestine_n into_o the_o lacteal_v and_o through_o the_o glandule_n of_o the_o mesentery_n mix_v and_o circulate_v with_o the_o blood_n etc._n etc._n 12._o because_o after_o all_o that_o it_o have_v its_o effect_n upon_o the_o skin_n by_o cause_v a_o itch_a therein_o 13._o because_o it_o not_o only_a cause_n acrimonious_a sweat_v but_o such_o as_o evident_o smell_v thereof_o
by_o diminish_v or_o disable_n the_o spirit_n except_o it_o be_v that_o the_o pernicious_a rosin_n may_v do_v something_o of_o that_o kind_n by_o its_o aforesaid_a ill_a effect_n but_o by_o pleasant_o affect_v the_o membrane_n at_o stomach_n venereal_a part_n etc._n etc._n 2._o that_o sleep_n be_v cause_v by_o relaxation_n and_o quiet_v the_o spirit_n 3._o that_o pleasure_n especial_o if_o intense_a and_o last_a as_o that_o by_o opium_n comfort_n enlivens_fw-la encourage_v and_o cause_v a_o ovation_n of_o the_o sensitive_a soul_n and_o spirit_n and_o displeasure_n cause_v sadness_n dejection_n etc._n etc._n 4._o how_o pleasure_n must_v cause_v complacency_n satisfaction_n content_a acquiescence_n and_o composure_n of_o the_o sensitive_a soul_n and_o spirit_n as_o grievance_n cause_v the_o contrary_n 5._o how_o pleasure_n elevate_a and_o keep_v up_o the_o spirit_n and_o cause_v a_o entire_a relaxation_n of_o the_o defensive_a and_o a_o great_a relaxation_n of_o the_o vigilative_a contraction_n which_o tire_v the_o sensitive_a soul_n must_v cause_v euphory_n or_o easy_a undergo_n of_o labour_n journey_n etc._n etc._n without_o lassitude_n as_o experience_n show_v 6._o how_o pleasure_n cause_v relaxation_n of_o all_o the_o sensile_a part_n 7._o how_o the_o say_a relaxation_n as_o in_o sleep_n do_v by_o suffer_v the_o animal_n spirit_n to_o expand_v and_o thereby_o make_v they_o unfit_a to_o carry_v impression_n smart_o which_o be_v necessary_a to_o convey_v a_o sense_n of_o pain_n for_o a_o smart_a impression_n be_v the_o very_a cause_n of_o it_o take_v away_o pain_n to_o which_o you_o may_v add_v that_o the_o sensitive_a soul_n attend_v willing_o to_o the_o sense_n of_o pleasure_n be_v divert_v from_o pain_n and_o that_o a_o sense_n of_o pain_n can_v be_v in_o the_o same_o subject_a with_o pleasure_n which_o be_v therefore_o once_o excite_v pain_n must_v disappear_v but_o that_o of_o take_v away_o all_o smartness_n of_o impression_n by_o relaxation_n be_v a_o plain_a mechanical_a cause_n 8._o how_o therefore_o all_o flux_n that_o be_v cause_v by_o or_o require_v a_o grievous_a sensation_n or_o irritation_n by_o quantity_n or_o quality_n to_o maintain_v and_o continue_v they_o by_o cause_v a_o contraction_n of_o the_o part_n to_o squeeze_v out_o the_o humour_n must_v be_v moderate_v for_o want_v of_o sensation_n upon_o such_o relaxation_n to_o irritate_fw-la the_o part_n as_o it_o happen_v in_o sleep_n or_o in_o any_o case_n where_o relaxation_n and_o thereby_o expansion_n of_o the_o animal_n spirit_n incapacitates_fw-la they_o to_o carry_v impression_n smart_o which_o be_v of_o the_o essence_n of_o pain_n as_o have_v be_v show_v 9_o how_o perspiration_n must_v be_v promote_v by_o relaxation_n which_o open_v the_o pore_n 10._o how_o that_o by_o the_o same_o mean_n sweat_v also_o must_v be_v promote_v if_o the_o body_n be_v full_a of_o moisture_n 11._o how_o opium_n or_o semen_n animale_a be_v of_o the_o same_o principle_n and_o of_o like_a principle_n with_o cantharides_n pismire_n bee_n garlick_n etc._n etc._n must_v excite_v to_o venery_n cause_n itch_n of_o the_o skin_n etc._n etc._n 12._o how_o opium_n may_v by_o too_o high_a a_o ovation_n of_o the_o spirit_n cause_n watch_v while_o pleasure_n cause_v relaxation_n etc._n etc._n may_v take_v away_o pain_n for_o relaxation_n as_o in_o sleep_n syncopes_fw-la etc._n etc._n be_v enough_o to_o take_v away_o pain_n but_o to_o sleep_v quietness_n of_o the_o spirit_n be_v also_o require_v as_o well_o as_o their_o expansion_n by_o relaxation_n so_o that_o pain_n may_v very_o well_o be_v take_v off_o without_o sleep_n as_o it_o often_o be_v by_o opium_n that_o always_o relax_n 13._o how_o the_o pleasure_n that_o opium_n cause_n be_v as_o be_v say_v by_o the_o same_o principle_n and_o therefore_o of_o the_o same_o nature_n with_o that_o which_o animal_n seed_n cause_v upon_o the_o membrane_n but_o that_o animal_n seed_n cause_v it_o only_o upon_o one_o part_n and_o opium_n upon_o the_o membrane_n of_o the_o stomach_n venereal_a part_n and_o all_o other_o in_o general_n and_o that_o only_a for_o a_o moment_n but_o this_o of_o opium_n for_o many_o hour_n by_o which_o mean_v the_o effect_n of_o relaxtion_n by_o pleasure_n come_v to_o be_v more_o remarkable_a as_o after_o much_o wine_n who_o effect_n be_v somewhat_o last_v and_o internal_a as_o that_o of_o opium_n be_v 14._o how_o the_o rosin_n of_o opium_n cause_v its_o ill_a effect_n by_o its_o indigestibleness_n adhere_v quality_n and_o tedious_a sting_a of_o the_o exquisite_o nice_a coat_n of_o the_o stomach_n by_o continual_o teaze_v and_o urge_v it_o by_o its_o actimony_n and_o acute_a volatile_a point_n or_o spiculâ—_n therefore_o have_v 1._o a_o most_o perfect_a and_o complete_a sol-volatile-oleosum_a in_o opium_n of_o the_o same_o please_a principle_n as_o to_o all_o membrane_n as_o animal_n seed_n be_v to_o the_o membrane_n of_o venus_n whereby_o they_o must_v be_v please_v tickle_v and_o relax_v 2._o a_o pernicious_a rosin_n indigestible_a stick_v and_o arm_v with_o acrimonious_a and_o sting_a point_n which_o must_v high_o offend_v the_o most_o sensile_a coat_n at_o the_o stomach_n i_o be_o now_o ready_a by_o god_n assistance_n to_o explain_v every_o phenomenon_n or_o effect_v of_o opium_n however_o amaze_a and_o mysterious_a hope_v they_o will_v not_o remain_v long_o so_o chap._n xvi_o the_o explication_n of_o the_o effect_n of_o opium_n use_v external_o its_o effect_n external_o use_v be_v of_o two_o sort_n either_o i._o as_o a_o opiate_n or_o please_a tickler_n of_o the_o membrane_n or_o ii_o as_o a_o alterative_a of_o the_o part_n that_o it_o be_v apply_v to_o first_o as_o a_o opiate_n or_o pleaser_n of_o the_o membrane_n it_o have_v the_o same_o effect_n as_o opium_n use_v internal_o and_o for_o the_o same_o reason_n therefore_o the_o cause_n of_o its_o operation_n in_o this_o case_n will_v be_v better_o see_v by_o the_o explication_n of_o its_o internal_a effect_n which_o be_v far_o more_o perfect_a complete_a and_o certain_a second_o as_o a_o alterative_a of_o the_o part_n that_o it_o be_v apply_v to_o which_o be_v the_o follow_v viz._n 1._o it_o incides_fw-la resolve_n and_o discuss_n by_o its_o point_a penetrate_a and_o volatile_a salt_n insinuate_v itself_o into_o the_o part_n and_o humour_n of_o the_o animal_n because_o its_o particle_n be_v fine_a minute_n and_o agreeable_a thereto_o as_o menstruum_n to_o the_o thing_n to_o be_v dissolve_v then_o by_o its_o volatility_n it_o discuss_n what_o it_o have_v so_o incide_v and_o resolve_v 2._o it_o mollefy_v and_o relax_n by_o its_o sal-volatile-oleosum_a so_o resolve_v the_o part_n and_o humour_n and_o thereby_o kindly_a loosen_a they_o thus_o opiate_n as_o solanum_fw-la lethale_n or_o deadly_a night_n shade_n hemlock_n mandrake_n etc._n etc._n come_v to_o be_v of_o excellent_a use_n in_o hard_a tumor_n of_o the_o spleen_n tophousness_n etc._n etc._n 3._o it_o maturate_v and_o suppurate_v for_o the_o aforesaid_a reason_n for_o nothing_o can_v better_v dispose_n towards_o maturation_n and_o suppuration_n than_o relax_v mollefy_a and_o resolve_v 4._o it_o exulcerate_v or_o cause_n blister_n or_o at_o least_o rubify_v tender_a skin_n if_o it_o be_v very_o strong_a because_o of_o its_o volatile_a salt_n as_o cantharides_n spearwort_n and_o other_o thing_n do_v upon_o the_o same_o account_n but_o this_o effect_n belong_v main_o to_o the_o true_a mastack_n or_o 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d 〈◊〉_d that_o drop_n from_o the_o incision_n make_v in_o the_o head_n of_o the_o poppy_n more_o especial_o the_o theban_a which_o afford_v a_o most_o powerful_a juice_n for_o exulcerate_v or_o blister_v be_v but_o a_o strong_a full_a and_o therefore_o painful_a resolution_n as_o you_o see_v by_o the_o cuticle_n upon_o blister_n resolve_v into_o a_o kind_n of_o jelly_n 5._o it_o be_v psilothrick_n for_o the_o same_o reason_n for_o while_o it_o so_o resolve_v the_o part_n it_o loosen_v the_o root_n of_o the_o hair_n and_o so_o cause_v its_o shed_n 6._o it_o hurt_v the_o eye_n because_o of_o its_o acrimony_n by_o reason_n of_o the_o volatile_a salt_n 7._o it_o cause_v itch_a in_o the_o skin_n by_o the_o titillation_n of_o the_o same_o volatile_a salt_n as_o you_o find_v by_o the_o application_n of_o squill_n and_o the_o like_a 8._o it_o excite_v venery_n by_o the_o same_o titillation_n on_o the_o veneral_a membrane_n chap._n xvii_o the_o explication_n of_o the_o effect_n of_o opium_n use_v internal_o in_o a_o moderate_a do_v note_v that_o because_o opium_n have_v be_v general_o hitherto_o use_v either_o crude_a or_o with_o its_o rosin_n in_o it_o the_o effect_n of_o opium_n be_v according_o consider_v as_o common_a experience_n thereupon_o have_v give_v opportunity_n of_o observe_v they_o but_o as_o i_o proceed_v i_o shall_v show_v you_o where_o the_o resinous_n part_n of_o opium_n be_v concern_v in_o the_o effect_n 1._o it_o be_v manifest_a why_o opium_n may_v well_o
operate_v in_o a_o very_a small_a quantity_n as_o it_o usual_o do_v because_o the_o least_o matter_n imaginable_a affect_v the_o sense_n as_o have_v be_v show_v for_o the_o thousand_o part_n of_o a_o grain_n of_o ambergrise_n musk_n etc._n etc._n affect_v the_o smell_a the_o hundred_o part_n of_o a_o grain_n of_o very_a acrimonious_a thing_n the_o taste_n which_o cause_v very_o sensible_a pleasure_n or_o displeasure_n according_a as_o it_o be_v agreeable_a or_o not_o much_o easy_a may_v the_o exquisite_o dispose_v membrane_n at_o stomach_n which_o be_v affect_v with_o thing_n so_o indefinite_o small_a that_o no_o other_o sense_n or_o membrane_n can_v take_v notice_n of_o as_o the_o particle_n of_o crocus_n metallorum_fw-la in_o vomit_n effluvias_fw-la from_o a_o cat_n body_n pestiferous_a effluvias_fw-la and_o the_o like_a of_o all_o which_o the_o stomach_n be_v so_o sensible_a that_o they_o thereby_o cause_v most_o violent_a symptom_n which_o be_v as_o be_v show_v proportion_v to_o the_o sensation_n therefore_o it_o can_v be_v no_o wonder_n that_o a_o grain_n or_o less_o of_o opium_n shall_v affect_v the_o sensile_a coat_n of_o the_o stomach_n and_o thereby_o cause_v a_o sense_n of_o pleasure_n for_o that_o which_o be_v nice_a to_o discern_v grieve_v particle_n be_v so_o to_o discern_v please_v once_o as_o have_v be_v say_v cujus_fw-la est_fw-la dolour_n ejusdem_fw-la est_fw-la voluptus_fw-la that_o be_v pleasure_n and_o displeasure_n belong_v to_o the_o same_o part_n and_o as_o be_v show_v in_o equal_a degree_n this_o prove_v that_o it_o must_v operate_v by_o pleas_o affect_v the_o stomach_n for_o it_o be_v otherwise_o impossible_a that_o so_o little_a a_o quantity_n shall_v cause_v such_o remarkable_a effect_n and_o that_o before_o the_o opium_n be_v out_o of_o the_o stomach_n but_o it_o be_v ordinary_a for_o the_o stomach_n to_o cause_v mighty_a effect_n by_o its_o sensation_n of_o very_a small_a thing_n otherwise_o insensible_a and_o inconsiderable_a as_o to_o the_o production_n of_o any_o observable_a effect_n and_o therefore_o it_o will_v be_v a_o miracle_n if_o it_o do_v any_o other_o way_n cause_n such_o great_a and_o numerous_a effect_n helmont_n observe_v that_o pro_fw-la remedio_fw-la restaurativo_fw-la archaei_n sive_fw-la animae_fw-la sensitivae_fw-la non_fw-la requiritur_fw-la unciarum_fw-la &_o drachmarum_fw-la quantitas_fw-la sed_fw-la pauca_fw-la grana_n that_o be_v very_o little_a serve_v to_o comfort_v the_o archaeus_n or_o sensitive_a soul_n because_o it_o be_v do_v by_o sensation_n as_o i_o have_v prove_v 2._o it_o be_v as_o evident_a how_o a_o hot_a brisk_a and_o salino-volatile_a thing_n as_o opium_n be_v must_v affect_v the_o sensile_a coat_n of_o the_o stomach_n in_o a_o short_a time_n as_o vomit_n purger_n etc._n etc._n do_v which_o it_o do_v much_o in_o the_o same_o time_n with_o those_o thing_n that_o be_v as_o soon_o as_o they_o insinuate_v themselves_o through_o the_o crusta_fw-la carnosa_fw-la of_o the_o stomach_n and_o reach_v its_o sensile_a coat_n which_o be_v the_o reason_n that_o opium_n vomit_n purger_n etc._n etc._n make_v some_o and_o like_o delay_n before_o they_o operate_v which_o be_v also_o a_o proof_n that_o all_o of_o they_o operate_v by_o affect_v the_o sensile_a coat_n of_o the_o stomach_n all_o the_o difference_n be_v that_o one_o affect_v pleasant_o as_o wine_n meat_n and_o cordial_n and_o the_o other_o by_o a_o grievous_a sensation_n the_o explication_n of_o the_o constant_a effect_n of_o opium_n use_v internal_o etc._n etc._n 1._o the_o first_o and_o lead_v effect_n of_o opium_n be_v cause_v a_o most_o agreeable_a pleasant_a and_o charm_a sensation_n about_o the_o region_n of_o the_o stomach_n this_o be_v a_o property_n that_o belong_v to_o it_o omni_n &_o semper_fw-la and_o indeed_o soli_fw-la to_o opiate_n if_o the_o degree_n duration_n and_o fineness_n of_o the_o pleasure_n be_v consider_v how_o manifest_a be_v it_o from_o what_o have_v be_v say_v of_o the_o most_o complete_a and_o consummate_v sal-volatile-oleosum_a of_o opium_n which_o exact_o agree_v in_o principle_n etc._n etc._n with_o semen_n animale_a that_o so_o high_o please_v and_o titillate_n the_o membrane_n with_o which_o it_o not_o only_o agree_v in_o principle_n as_o be_v show_v but_o have_v they_o more_o active_a actuate_a and_o titillate_v than_o any_o membrane_n that_o it_o must_v of_o necessity_n high_o please_v all_o membrane_n more_o especial_o such_o as_o be_v most_o exquisite_o dispose_v for_o sensation_n as_o the_o most_o sensile_a membrane_n at_o stomach_n be_v not_o only_o by_o its_o agreeableness_n but_o by_o a_o most_o charm_a and_o captivate_a titillation_n that_o actuate_v and_o cause_v a_o fine_a ovation_n and_o serene_a glow_a of_o the_o spiritus_fw-la insiti_fw-la of_o the_o stomach_n which_o make_v it_o please_v in_o the_o high_a manner_n have_v all_o the_o requisite_n to_o cause_n a_o sense_n of_o pleasure_n and_o that_o be_v not_o all_o but_o it_o be_v take_v into_o the_o body_n it_o cause_v a_o long_a continue_a and_o permanent_a sense_n of_o pleasure_n which_o we_o must_v necessary_o carry_v along_o with_o we_o as_o a_o vade_fw-la mecum_fw-la even_o sleep_v or_o wake_v rest_a or_o move_a or_o whatever_o we_o do_v or_o wherever_o we_o be_v by_o which_o mean_n it_o far_o excel_v all_o other_o pleasure_n and_o consequent_o produce_v such_o mighty_a effect_n all_o other_o pleasure_n be_v momentary_a transitory_a desultory_n or_o interrupt_v except_o that_o of_o wine_n and_o cordial_n at_o stomach_n which_o therefore_o have_v the_o like_a effect_n to_o that_o of_o opium_n though_o they_o do_v not_o equal_v it_o in_o the_o intenseness_n or_o duration_n of_o the_o pleasure_n unless_o they_o be_v repeat_v as_o indeed_o they_o may_v be_v which_o make_v i_o to_o intimate_v that_o drink_v a_o good_a glass_n of_o wine_n every_o hour_n and_o by_o that_o mean_n keep_v the_o fresh_a pleasure_n thereof_o continual_o at_o the_o stomach_n like_o that_o of_o opium_n be_v the_o best_a way_n to_o cause_v a_o long_a euphory_n of_o labour_n journey_n etc._n etc._n which_o may_v come_v near_o the_o performance_n of_o our_o divine_a sal-volatile-oleosum_a of_o opium_n though_o never_o equal_v it_o for_o reason_n already_o sufficient_o hint_v viz._n because_o wine_n want_v its_o most_o agreeable_a composition_n and_o fine_a titillation_n of_o the_o volatile_a salt_n that_o opium_n and_o animal_n seed_n have_v note_v that_o the_o pleasure_n of_o opium_n may_v to_o some_o inadvertent_n person_n seem_v very_o indefinite_a though_o it_o be_v at_o stomach_n as_o it_o must_v be_v because_o the_o pleasure_n immediate_o relax_v all_o part_n and_o gratify_v the_o sensitive_a soul_n which_o inform_v the_o whole_a seem_v to_o be_v general_a though_o original_o only_a at_o stomach_n 2._o our_o consummate_v sal-volatile-oleosum_a must_v cause_v a_o blithe_a gay_a and_o good_a humour_n for_o be_v please_v with_o any_o thing_n as_o be_v the_o vulgar_a observation_n cause_v a_o good_a humour_n how_o much_o more_o must_v such_o a_o intense_a agreeable_a and_o continual_a pleasure_n that_o we_o always_o and_o every_o where_o carry_v along_o with_o we_o so_o do_v how_o common_a a_o say_v be_v it_o he_o be_v please_v with_o somewhat_o for_o i_o find_v he_o in_o a_o good_a humour_n 3._o the_o like_a be_v to_o be_v say_v of_o its_o cause_v promptitude_n serenity_n alacrity_n and_o expediteness_n in_o dispatch_v and_o manage_n of_o business_n for_o these_o be_v but_o natural_a and_o necessary_a consequence_n of_o a_o blithe_a gay_a and_o good_a humour_n and_o therefore_o always_o go_v together_o for_o the_o sensitive_a soul_n be_v put_v in_o a_o fine_a ovation_n by_o the_o continual_a pleasure_n be_v more_o active_a and_o have_v thereupon_o as_o be_v show_v whole_o excuse_v himself_o from_o the_o care_n and_o solicitude_n of_o the_o defensive_a contraction_n and_o in_o great_a measure_n of_o the_o vigilative_a contraction_n also_o be_v more_o at_o leisure_n to_o attend_v the_o managery_n of_o other_o affair_n without_o distraction_n beside_o that_o he_o be_v actuate_v and_o enliven_v by_o the_o aforesaid_a ovation_n of_o the_o spirit_n and_o please_a titillation_n into_o a_o alacrity_n and_o promptitude_n for_o any_o business_n with_o which_o also_o he_o be_v less_o tire_v because_o he_o have_v as_o be_v say_v rid_v himself_o of_o the_o fatigue_n of_o the_o contraction_n that_o as_o be_v manifest_o prove_v do_v cause_n lassitude_n which_o otherwise_o can_v hardly_o touch_v or_o affect_v he_o at_o all_o in_o the_o state_n of_o relaxation_n 4._o it_o must_v cause_v assurance_n ovation_n of_o the_o spirit_n courage_n magnanimity_n as_o wine_n do_v by_o elevate_n the_o sensitive_a soul_n by_o pleasure_n and_o a_o high_a titillation_n of_o the_o spiritus_fw-la insiti_fw-la by_o its_o volatile_a part_n actuate_a they_o as_o the_o animal_n semen_n do_v all_o creature_n in_o time_n of_o copulation_n though_o it_o immediate_o affect_v only_o the_o venereal_a membrane_n but_o we_o do_v actuate_v they_o not_o
only_o in_o those_o membrane_n but_o also_o in_o the_o more_o exquisite_o dispose_v membrane_n for_o sensation_n at_o stomach_n and_o soon_o after_o all_o over_o the_o body_n 5._o it_o prevent_v and_o take_v away_o grief_n fear_v anxiety_n peevishness_n fretfulness_n etc._n etc._n for_o the_o aforesaid_a reason_n which_o cause_n a_o blithe_a gay_a and_o good_a humour_n promptitude_n courage_n etc._n etc._n for_o it_o be_v impossible_a to_o be_v gay_a and_o good_a humour_a serene_a cheerful_a courageous_a and_o magnanimous_a and_o at_o the_o same_o time_n sorrowful_a fearful_a peevish_a fretful_a etc._n etc._n if_o the_o bare_a sense_n of_o a_o ordinary_a meal_n of_o meat_n at_o stomach_n which_o cause_v but_o a_o slow_a pleasure_n in_o comparison_n with_o opium_n take_v off_o the_o peevishness_n fretfulness_n etc._n etc._n that_o the_o grievous_a sensation_n of_o hunger_n cause_n how_o much_o more_o must_v the_o intense_a and_o charm_a pleasure_n cause_v by_o opium_n that_o be_v so_o agreeable_a even_o far_o beyond_o wine_n itself_o as_o have_v be_v set_v forth_o take_v away_o all_o ill_a humour_n fretfulness_n peevishness_n etc._n etc._n obj._n but_o it_o may_v be_v say_v that_o sleepiness_n which_o depend_v also_o upon_o relaxation_n as_o the_o effect_n of_o pleasure_n do_v cause_v a_o peevish_a fretful_a humour_n as_o be_v common_o observe_v ans._n it_o be_v so_o far_o otherwise_o in_o the_o case_n of_o opium_n that_o it_o be_v quite_o contrary_a for_o 1._o the_o sleepy_a be_v not_o peevish_a unless_o you_o put_v they_o by_o some_o mean_v out_o of_o the_o pleasure_n of_o enjoy_v sleep_n or_o relaxation_n for_o if_o you_o let_v they_o alone_o they_o will_v not_o trouble_v you_o with_o peevishness_n nor_o any_o ill_a humour_n but_o it_o be_v the_o call_v they_o from_o their_o relaxed_a condition_n to_o the_o grievous_a task_n of_o contraction_n that_o vex_v they_o so_o that_o it_o be_v the_o want_n of_o continue_v under_o the_o relaxation_n that_o fret_v they_o and_o the_o more_o because_o the_o fatigue_n and_o tedium_n of_o contraction_n do_v put_v they_o upon_o the_o relief_n of_o sleep_n of_o which_o if_o disappoint_v they_o be_v much_o vex_v but_o in_o the_o case_n of_o opium_n you_o can_v so_o easy_o rob_v they_o of_o their_o pleasure_n which_o they_o carry_v continual_o within_o they_o in_o a_o uninterrupted_a manner_n unless_o some_o very_a grievous_a thing_n happen_v which_o cause_v more_o defensive_a contraction_n than_o the_o opium_n cause_v relaxation_n though_o even_o this_o also_o be_v general_o soon_o overcome_v by_o the_o pleasure_n continual_o invite_v the_o relaxation_n and_o promote_a it_o whereas_o the_o interruption_n thereof_o be_v transitory_a but_o at_o the_o worst_a it_o be_v but_o take_v more_o opium_n and_o the_o work_n be_v do_v for_o i_o observe_v that_o the_o do_v of_o opium_n must_v be_v sufficient_a to_o introduce_v such_o a_o sense_n of_o pleasure_n as_o cause_v a_o relaxation_n of_o the_o contraction_n cause_v by_o the_o grievance_n hence_o it_o be_v certain_a that_o a_o great_a pain_n require_v a_o large_a do_v of_o opium_n as_o have_v be_v intimate_v 6._o all_o know_v that_o pleasant_a diversion_n as_o music_n pleasant_a jest_n and_o story_n fine_a sight_n etc._n etc._n do_v cause_n euphory_n and_o a_o easy_a undergo_n of_o journey_n labour_n etc._n etc._n therefore_o if_o such_o interrupt_v transient_a and_o slight_a pleasure_n do_v it_o so_o much_o it_o will_v be_v easy_o grant_v i_o that_o a_o continual_a and_o more_o intense_a pleasure_n that_o be_v always_o present_a without_o any_o interruption_n or_o intermission_n as_o that_o of_o opium_n must_v cause_v a_o more_o eminent_a and_o permanent_a euphory_n proportion_v to_o the_o pleasure_n which_o cause_v relaxation_n prevent_v the_o fatigue_n or_o lassitude_n that_o be_v cause_v only_o by_o contraction_n either_o vigilative_a defensive_a or_o intentive_a as_o i_o have_v prove_v so_o that_o i_o do_v not_o conceive_v how_o the_o noctambuli_n or_o such_o as_o walk_v in_o their_o sleep_n can_v ever_o be_v tire_v if_o they_o travel_v ever_o so_o far_o if_o they_o can_v eat_v and_o drink_v because_o the_o relaxation_n of_o the_o sleep_v recruit_n they_o as_o much_o as_o they_o spend_v of_o spirit_n etc._n etc._n so_o person_n that_o cause_v such_o relaxation_n by_o opium_n and_o so_o repeat_v it_o as_o to_o maintain_v the_o relaxation_n can_v hardly_o be_v weary_a which_o be_v the_o true_a plain_a and_o mechanical_a reason_n why_o the_o turk_n and_o other_o eastern_a people_n do_v by_o the_o help_n of_o opium_n perform_v prodigious_a journey_n without_o be_v tire_v which_o may_v therefore_o in_o allusion_n to_o the_o noctambuli_n be_v call_v opiambuli_n or_o opambuli_n as_o be_v a_o kind_n of_o artificial_a noctambuli_n because_o they_o be_v much_o relax_v by_o the_o pleasure_n that_o opium_n cause_n as_o the_o other_o be_v by_o sleep_n qui_fw-la laetitiâ_fw-la aâ—iciuntur_fw-la say_v sanctorius_n nuâ—lam_n in_o itinere_fw-la defatigationem_fw-la sentiunt_fw-la that_o be_v the_o merry_a be_v not_o weary_a as_o the_o say_v be_v because_o mirth_n be_v pleasant_a cause_v relaxation_n as_o opium_n do_v in_o some_o measure_n note_v that_o as_o to_o all_o the_o forego_n serene_a and_o brisk_a effect_n a_o full_a and_o liberal_a perspiration_n which_o it_o also_o cause_n as_o will_v be_v show_v contribute_v much_o thereto_o a_o posteriori_fw-la for_o as_o fire_n burn_v slow_o and_o dull_o if_o the_o smoke_n do_v by_o any_o mean_n return_v upon_o it_o and_o very_o serene_a if_o not_o so_o it_o be_v with_o the_o flame_n of_o life_n if_o cloud_v with_o or_o clear_v from_o vapour_n by_o perspiration_n sanctor_n sect._n 7._o aph._n 17._o mâ—lancholia_fw-la superatur_fw-la liberâ_fw-la perspiratione_fw-la &_o aph._n 30._o 31._o edulia_n aperientia_fw-la gaudium_fw-la movent_fw-la that_o be_v such_o as_o open_v the_o pore_n and_o cause_n perspiration_n cause_n joy_n or_o mirth_n 7._o it_o lull_v soothe_v and_o as_o it_o be_v charm_v the_o mind_n with_o consent_n and_o acquiescence_n for_o the_o several_a reason_n couch_v in_o the_o premise_n and_o because_o the_o fine_a continual_a and_o charm_a pleasure_n of_o opium_n such_o as_o some_o glass_n of_o generous_a wine_n cause_v must_v needs_o have_v such_o a_o effect_n 8._o it_o quiet_v allay_v and_o compose_v all_o perturbation_n and_o commotion_n of_o the_o sensitive_a soul_n spirit_n etc._n etc._n 1._o because_o it_o so_o lull_v soothe_v and_o charm_n the_o sensitive_a soul_n as_o be_v aforesaid_a who_o be_v the_o original_a of_o all_o motion_n in_o the_o animal_n 2._o because_o all_o motion_n be_v by_o the_o relaxation_n proportionable_o abate_v as_o be_v demonstrate_v thus_o opium_n take_v off_o hysterick_n fit_v fever_n from_o commotion_n of_o the_o spirit_n convulsion_n stop_v hemerrhage_n or_o bleed_v &c._n &c._n 9_o it_o cause_v a_o relaxation_n of_o all_o the_o sensile_a part_n of_o the_o body_n by_o reason_n of_o the_o great_a and_o continual_a pleasure_n that_o it_o cause_n and_o how_o pleasure_n cause_v relaxation_n i_o have_v show_v in_o chap._n 14._o 10._o it_o cause_v indolence_n or_o exemption_n from_o pain_n by_o cause_v so_o high_a and_o last_a a_o pleasure_n 1._o because_o that_o pleasure_n take_v up_o the_o attention_n of_o the_o sensitive_a soul_n who_o delight_v in_o it_o 2._o because_o a_o sense_n of_o pleasure_n and_o pain_n can_v be_v at_o the_o same_o time_n in_o the_o same_o subject_a be_v they_o be_v contrary_n 3._o because_o the_o membrane_n be_v relax_v and_o the_o animal_n spirit_n expanded_a the_o impression_n of_o pain_n can_v be_v carry_v to_o the_o sensitive_a soul_n because_o they_o can_v convey_v impression_n smart_o be_v thus_o relax_v and_o expanded_a as_o have_v be_v demonstrate_v by_o the_o comparison_n of_o a_o gut_n half_n full_a of_o air_n etc._n etc._n and_o all_o impression_n of_o pain_n must_v be_v smart_n or_o else_o they_o be_v not_o impression_n of_o pain_n for_o gentle_a impression_n be_v such_o as_o belong_v to_o oil_n smooth_a and_o soft_a thing_n or_o when_o the_o animal_n spirit_n can_v hardly_o carry_v any_o impression_n but_o gentle_o as_o in_o sleep_n and_o other_o relaxation_n as_o that_o upon_o pleasure_n etc._n etc._n which_o be_v our_o case_n note_v that_o it_o will_v cause_v indolence_n without_o cause_v sleep_n because_o sleep_n require_v relaxation_n and_o quiet_a of_o the_o spirit_n but_o indolence_n require_v only_a relaxation_n as_o be_v show_v which_o always_o follow_v the_o charm_a pleasure_n of_o opium_n 11._o it_o stop_v moderate_v or_o palliate_n most_o flux_n and_o promote_v perspiration_n because_o the_o relaxation_n take_v away_o the_o sense_n of_o the_o irritation_n of_o humour_n which_o cause_v a_o contraction_n to_o squeeze_v they_o out_o and_o that_o the_o same_o relaxation_n open_v the_o pore_n to_o let_v the_o foam_n out_o which_o pass_v by_o their_o own_o levity_n upon_o the_o open_n of_o the_o pore_n nihil_fw-la magis_fw-la say_v sanctorius_n
sect._n 7._o aph._n 6._o reddit_fw-la liberam_fw-la perspirationem_fw-la quam_fw-la animi_fw-la consolatio_fw-la aut_fw-la voluptas_fw-la &_o aph._n 19_o animi_fw-la consolatio_fw-la quacunque_fw-la de_fw-la causâ_fw-la aperit_fw-la meatus_fw-la &_o largam_fw-la perspirationem_fw-la facit_fw-la now_o you_o may_v perceive_v why_o opium_n and_o good_a cordial_n do_v moderate_a flux_n by_o stool_n even_o before_o they_o be_v out_o of_o the_o stomach_n because_o the_o pleasure_n there_o cause_v relax_n all_o part_n and_o thereby_o cause_v a_o expansion_n of_o the_o animal_n spirit_n the_o sense_n of_o the_o irritation_n be_v lose_v because_o the_o expand_v spirit_n can_v carry_v the_o impression_n smart_o to_o the_o sensitive_a soul_n which_o must_v be_v to_o cause_v a_o sense_n of_o irritation_n or_o grievous_a sensation_n by_o the_o same_o reason_n only_o warm_a trencher_n apply_v to_o the_o belly_n or_o sit_v upon_o a_o warm_a stool_n etc._n etc._n moderate_v a_o looseness_n because_o the_o pleasure_n of_o the_o warmth_n relax_n and_o so_o take_v away_o a_o sense_n of_o the_o irritation_n by_o the_o aforesaid_a expansion_n of_o the_o spirit_n 12._o i_o have_v just_a now_o show_v how_o it_o promote_v insensible_a perspiration_n viz._n by_o the_o relaxation_n open_v the_o pore_n and_o let_v out_o the_o fume_n which_o i_o need_v not_o have_v mention_v again_o but_o for_o order_n sake_n that_o all_o may_v thereby_o see_v that_o i_o evade_v the_o explication_n of_o no_o effect_n nor_o indeed_o need_v i_o for_o they_o be_v now_o obvious_a enough_o even_o without_o my_o explication_n to_o any_o sagacious_a person_n so_o that_o the_o plainness_n may_v give_v great_a cause_n to_o pass_v over_o some_o untouched_a than_o the_o difficulty_n but_o it_o be_v not_o sit_v that_o either_o shall_v cause_v any_o omission_n in_o such_o a_o mighty_a concern_v that_o be_v never_o explicate_v and_o scarce_o ever_o think_v possible_a 13._o opium_n prevent_v shivering_n in_o ague_n fit_n because_o that_o for_o the_o reason_n aforesaid_a it_o take_v away_o the_o sense_n of_o the_o irritate_v humour_n that_o cause_v they_o 14._o it_o prevent_v and_o cure_v cold_n by_o the_o relaxation_n that_o its_o pleasure_n cause_n whereby_o the_o pore_n be_v keep_v very_o open_a and_o perspiration_n as_o be_v show_v promote_v beside_o that_o it_o prevent_v the_o sensation_n of_o hinder_v it_o to_o constringe_v the_o pore_n by_o cause_v a_o grievous_a sensation_n 15._o it_o cause_v a_o large_a and_o slow_a pulse_n because_o of_o the_o relaxation_n that_o the_o intense_a and_o continual_a pleasure_n cause_n by_o which_o the_o artery_n be_v widen_v and_o the_o motion_n make_v slow_a 1._o because_o the_o animal_n spirit_n be_v weaken_v by_o the_o relaxation_n of_o their_o vessel_n and_o their_o expansion_n thereupon_o 2._o because_o the_o sense_n of_o irritation_n by_o which_o the_o heart_n be_v solicit_v to_o move_v fast_o be_v lose_v 16._o it_o cause_v dryness_n in_o the_o mouth_n as_o sleep_n do_v 1._o because_o the_o dilatation_n of_o the_o glandule_n by_o the_o relaxation_n detain_v and_o suspend_v the_o humour_n and_o 2._o because_o the_o sensation_n be_v lessen_v the_o membrane_n that_o include_v the_o salival_n glandule_n be_v not_o irritate_v to_o contraction_n to_o squeeze_v out_o the_o saliva_n or_o spital_n 3._o because_o the_o pulse_n be_v slow_a to_o cause_v a_o extrusion_n of_o the_o humour_n 17._o it_o have_v most_o effect_n in_o warm_a and_o moist_a wether_n because_o both_o warmth_n and_o moisture_n promote_v relaxation_n by_o which_o opium_n do_v upon_o the_o account_n of_o the_o pleasure_n it_o cause_v perform_v its_o effect_n 18._o it_o have_v more_o effect_n upon_o fine_a and_o lax_n texture_n for_o the_o same_o reason_n and_o because_o their_o sensation_n be_v more_o nice_a and_o affect_v more_o with_o please_a or_o grieve_v thing_n therefore_o it_o affect_v child_n and_o woman_n especial_o the_o nice_n and_o delicate_a more_o than_o man_n which_o may_v be_v the_o reason_n why_o woman_n do_v not_o use_v opium_n in_o the_o eastern_a country_n as_o much_o as_o men._n 19_o it_o cause_v a_o efflorescence_n or_o redness_n of_o the_o skin_n as_o sleep_n or_o wine_n do_v because_o the_o skin_n be_v relax_v admit_v the_o blood_n to_o come_v into_o it_o very_o free_o as_o cold_a fear_v etc._n etc._n contract_v the_o part_n of_o the_o skin_n repel_v it_o or_o squeeze_v it_o out_o or_o back_o again_o thus_o person_n that_o drink_v much_o get_v red_a nose_n by_o frequent_a relaxation_n of_o the_o skin_n which_o widen_v the_o road_n of_o the_o blood_n more_o and_o more_o hence_o it_o be_v that_o the_o bag_n at_o a_o turky-cock_n neck_n be_v red_a when_o he_o be_v please_v and_o soon_o pale_a again_o when_o displease_v 20._o it_o affect_v the_o genus_fw-la nervosum_fw-la or_o animal_n spirit_n which_o be_v a_o common_a observation_n more_o than_o the_o blood_n because_o it_o operate_v by_o affect_v sensation_n wherein_o the_o nerve_n and_o membrane_n be_v most_o concern_v and_o not_o by_o alter_v the_o blood_n to_o which_o it_o bear_v no_o proportion_n to_o cause_v any_o remarkable_a effect_n note_v how_o plain_o this_o concession_n of_o all_o author_n confirm_v what_o i_o say_v viz._n that_o it_o do_v not_o operate_v as_o a_o alterative_a of_o the_o blood_n etc._n etc._n but_o by_o affect_v sensation_n as_o i_o have_v prove_v 21._o it_o increase_v seed_n in_o some_o measure_n because_o it_o administer_v a_o sal-volatile-oleosum_a of_o the_o same_o nature_n with_o it_o and_o by_o its_o titillation_n solicit_v and_o invite_v the_o send_n of_o its_o matter_n that_o way_n as_o be_v observable_a in_o such_o as_o use_v much_o titillation_n but_o to_o speak_v plain_o and_o mechanical_o i_o think_v that_o this_o main_o happen_v because_o of_o the_o relaxation_n of_o the_o part_n admit_v as_o be_v say_v of_o the_o efflorescence_n of_o the_o skin_n by_o relaxation_n the_o blood_n or_o material_n of_o seed_n more_o free_o into_o the_o testicle_n and_o all_o the_o seminary_n vessel_n especial_o be_v that_o the_o titillation_n cause_v a_o ostener_o empty_v of_o the_o same_o in_o order_n to_o receive_v those_o material_n with_o less_o opposition_n for_o quod_fw-la intus_fw-la est_fw-la prohibet_fw-la alienum_fw-la that_o be_v what_o be_v within_o hinder_v the_o entrance_n of_o other_o matter_n nothing_o can_v receive_v more_o than_o what_o it_o can_v contain_v but_o what_o be_v often_o empty_v can_v successive_o receive_v much_o 22._o it_o cause_v a_o great_a promptitude_n to_o venery_n erection_n etc._n etc._n especial_o if_o the_o do_v be_v large_a than_o ordinary_a because_o be_v of_o the_o same_o principle_n with_o animal_n seed_n and_o in_o all_o probability_n somewhat_o more_o titillate_v and_o of_o like_a principle_n though_o more_o gentle_a than_o cantharides_n it_o must_v high_o titillate_v those_o part_n and_o consequent_o cause_v a_o great_a promptitude_n to_o venery_n chap._n xviii_o the_o explication_n of_o the_o frequent_a though_o not_o constant_a effect_n of_o opium_n in_o a_o moderate_a do_v 1._o it_o cause_v sleep_n because_o it_o high_o dispose_v thereto_o by_o the_o relaxation_n that_o its_o pleasure_n cause_n thus_o music_n agreeable_a frication_n and_o many_o other_o pleasure_n nay_o all_o that_o be_v consistent_a with_o lie_v or_o sit_v still_o and_o silent_a incline_v we_o to_o sleep_n but_o none_o can_v compare_v with_o the_o sweet_a continual_a and_o transcendent_a pleasure_n of_o opium_n that_o we_o carry_v along_o with_o we_o for_o many_o hour_n whereas_o other_o pleasure_n be_v either_o remiss_a or_o interrupt_v or_o transient_a in_o their_o nature_n for_o continuance_n in_o gentle_a pleasure_n as_o the_o fall_n of_o water_n whistle_v of_o wind_n effect_n much_o towards_o sleep_n so_o intenseness_n do_v also_o though_o momentary_a as_o that_o of_o venus_n how_o much_o than_o must_v a_o continual_a and_o intense_a pleasure_n cause_n it_o especial_o when_o rest_n silence_n etc._n etc._n be_v add_v thereto_o note_v that_o sleep_n be_v so_o far_o from_o be_v a_o property_n of_o opium_n that_o it_o do_v not_o belong_v to_o it_o omni_n soli_fw-la or_o semper_fw-la yet_o people_n have_v general_o look_v upon_o sleep_n as_o such_o which_o cause_v many_o error_n 2._o it_o cause_v pleasant_a dream_n because_o the_o very_a sleep_n be_v cause_v and_o continue_v by_o pleasure_n when_o it_o be_v by_o opium_n which_o pleasure_n be_v all_o the_o time_n we_o sleep_v within_o we_o must_v needs_o suggest_v pleasant_a dream_n or_o none_o for_o how_o can_v sad_a and_o melancholy_a dream_n seize_v one_o that_o be_v in_o a_o gay_a and_o pleasant_a condition_n as_o far_o as_o one_o in_o sleep_n be_v capable_a thereof_o 3._o it_o stop_v vomit_v 1._o as_o it_o do_v other_o flux_n by_o take_v away_o the_o sense_n of_o irritation_n 2._o by_o high_o please_v and_o thereby_o quiet_v and_o compose_v the_o commotion_n of_o the_o stomach_n 3._o by_o relax_v it_o which_o oppose_v the_o
the_o pleasure_n yet_o be_v neither_o discover_v for_o many_o thousand_o of_o year_n especial_o consider_v also_o that_o in_o the_o case_n of_o opium_n thousand_o of_o ingenious_a man_n have_v diligent_o inquire_v after_o the_o cause_n of_o its_o operation_n who_o make_v no_o far_a step_n in_o it_o then_o to_o state_n thing_n that_o have_v not_o as_o much_o as_o existence_n viz._n a_o cold_a quality_n and_o 〈◊〉_d fly_v from_o the_o stomach_n to_o the_o head_n to_o be_v the_o cause_n thereof_o therefore_o it_o be_v plain_a that_o neither_o be_v he_o that_o plant_n any_o thing_n neither_o he_o that_o water_v but_o god_n that_o give_v the_o increase_n of_o knowledge_n and_o of_o other_o thing_n to_o who_o be_v all_o glory_n chap._n xx._n the_o explication_n of_o the_o effect_n of_o the_o declination_n of_o the_o operation_n of_o opium_n in_o a_o moderate_a do_v 1._o a_o general_n return_v of_o all_o disease_n and_o disaster_n when_o the_o operation_n of_o opium_n be_v over_o because_o it_o do_v not_o as_o be_v show_v operate_v as_o a_o alterative_a but_o a_o please_a diverter_n of_o the_o sensitive_a soul_n for_o some_o time_n during_o which_o it_o cause_v a_o general_a relaxation_n of_o all_o the_o sensile_a part_n whereby_o the_o animal_n spirit_n be_v expanded_a grow_v unfit_a to_o convey_v impression_n smart_o which_o be_v requisite_a to_o cause_v a_o sense_n of_o pain_n etc._n etc._n as_o have_v be_v often_o say_v but_o it_o cure_v several_a distemper_n viz._n such_o as_o please_v and_o comfort_v the_o sensitive_a soul_n compose_v the_o spirit_n relaxation_n perspiration_n sweat_v etc._n etc._n can_v quite_o take_v away_o of_o which_o more_o particular_o when_o we_o come_v to_o speak_v of_o the_o use_n of_o opium_n in_o cure_n 2._o sweat_n happen_v in_o the_o declination_n of_o its_o operation_n as_o sir_n theodore_n mayern_n myself_o and_o other_o have_v observe_v because_o that_o now_o all_o the_o parâ—s_a contract_n which_o by_o their_o relaxation_n suspend_v all_o humour_n during_o its_o operation_n do_v mechanical_o squeeze_v out_o the_o congest_a humour_n there_o be_v less_o room_n in_o the_o body_n as_o be_v say_v of_o sweat_n upon_o awake_v by_o the_o return_n of_o the_o vigilative_a contraction_n after_o relaxation_n during_o the_o sleep_n which_o be_v to_o be_v compare_v to_o the_o relaxation_n during_o the_o operation_n of_o opium_n and_o the_o return_v of_o the_o contraction_n when_o it_o be_v end_v beside_o that_o both_o upon_o the_o go_v off_o of_o the_o operation_n and_o awake_v the_o motion_n of_o the_o heart_n grow_v more_o vigorous_a as_o it_o do_v upon_o motion_n by_o the_o intentive_a contraction_n do_v more_o powerful_o propell_v the_o humour_n out_o at_o the_o pore_n as_o happen_v in_o sweat_n upon_o motion_n 3._o frequent_v make_v of_o water_n happen_v partly_o by_o the_o titillation_n of_o the_o volatile_a salt_n as_o by_o cantharides_n etc._n etc._n that_o be_v now_o separate_v from_o the_o blood_n partly_o by_o the_o contraction_n of_o the_o whole_a body_n squeese_v it_o out_o at_o the_o kidney_n as_o when_o people_n be_v cold_a they_o make_v more_o water_n for_o that_o reason_n 4._o a_o looseness_n may_v and_o do_v happen_v sometime_o from_o the_o like_a contraction_n squeese_v out_o the_o humour_n that_o be_v suspend_v during_o the_o relaxation_n by_o the_o opium_n which_o be_v common_a for_o such_o contraction_n to_o cause_n as_o by_o cold_a terror_n etc._n etc._n and_o because_o sensation_n grow_v more_o nice_a and_o irritable_a by_o the_o humour_n by_o reason_n of_o the_o contraction_n which_o be_v the_o more_o for_o the_o grievance_n of_o fail_v of_o the_o pleasure_n of_o opium_n therefore_o 5._o disease_n pain_n etc._n etc._n seem_v worse_o upon_o the_o return_n of_o the_o grievance_n because_o of_o the_o great_a ease_n they_o have_v during_o the_o operation_n of_o the_o opium_n contraria_fw-la inter_fw-la se_fw-la magis_fw-la elucescunt_fw-la and_o it_o be_v particular_o observe_v of_o pleasure_n that_o it_o leave_v man_n worse_o than_o it_o find_v they_o thus_o a_o man_n be_v worse_a more_o sad_a etc._n etc._n post_fw-la coitum_fw-la more_o melancholy_a after_o all_o sort_n of_o pleasure_n insomuch_o that_o it_o be_v grow_v to_o a_o proverb_n viz._n after_o merry_a come_v sorry_a or_o after_o mirth_n come_v sorrow_n as_o also_o minus_n gaudebis_fw-la minus_fw-la dolebis_fw-la therefore_o 6._o melaneholy_n do_v often_o if_o not_o always_o happen_v in_o some_o degree_n after_o its_o operation_n be_v end_v 1._o because_o of_o the_o return_n of_o the_o contraction_n or_o toil_n of_o the_o sensitive_a soul_n 2._o because_o as_o be_v say_v the_o sense_n of_o pleasure_n new_o lose_v aggravate_v the_o sorrow_n as_o have_v be_v show_v after_o coition_n etc._n etc._n 7._o the_o pulse_n be_v narrow_a because_o the_o contraction_n return_v with_o melancholy_a and_o return_v of_o disaster_n improve_v when_o that_o so_o happen_v as_o it_o general_o do_v 8._o itch_a of_o the_o skin_n happen_v about_o this_o time_n because_o that_o now_o the_o volatile_a salt_n which_o cause_v tuillation_n be_v arrive_v as_o far_o as_o the_o skin_n upon_o its_o march_n out_o of_o the_o body_n chap._n xxi_o the_o explication_n of_o the_o effect_n of_o opium_n in_o a_o excessive_a do_v the_o cause_n of_o most_o of_o these_o effect_n will_v be_v evident_a from_o the_o explication_n of_o the_o former_a because_o the_o difference_n be_v only_o in_o the_o quantity_n of_o the_o opium_n therefore_o i_o be_o often_o necessitate_v to_o speak_v much_o the_o same_o as_o i_o have_v do_v before_o you_o can_v expect_v any_o good_a effect_n from_o its_o excess_n any_o more_o than_o you_o have_v from_o wine_n though_o the_o best_a of_o cordial_n next_o to_o the_o sal._n volatile_a oleosum_fw-la of_o opium_n but_o rather_o less_o because_o opium_n be_v join_v to_o a_o pernicious_a rosin_n which_o you_o may_v be_v sure_o will_v be_v very_o grievous_a to_o the_o stomach_n in_o great_a quantity_n if_o it_o be_v so_o in_o little_a the_o evil_a effect_n in_o this_o case_n do_v main_o proceed_v either_o from_o too_o much_o relaxation_n as_o in_o drunkenness_n or_o from_o the_o rosin_n at_o stomach_n 1._o a_o heat_n at_o stomach_n be_v cause_v by_o the_o intense_a heat_n of_o the_o opium_n in_o a_o great_a quantity_n it_o be_v sensible_o a_o very_a hot_a thing_n 2._o the_o sense_n of_o weight_n at_o stomach_n be_v cause_v by_o the_o great_a relaxation_n that_o it_o cause_n which_o render_v the_o stomach_n proportionable_o weak_a and_o unable_a to_o endeavour_v its_o own_o relief_n so_o that_o the_o rosin_n etc._n etc._n lie_v heavy_a upon_o it_o thus_o we_o find_v a_o great_a heaviness_n at_o stomach_n when_o any_o thing_n grieve_v it_o that_o it_o can_v reject_v or_o discharge_v 3._o gaity_n of_o humour_n be_v cause_v at_o first_o as_o by_o the_o pleasure_n of_o a_o great_a quantity_n of_o wine_n by_o its_o please_a agreeableness_n to_o the_o membrane_n at_o stomach_n till_o the_o relaxation_n grow_v enormous_a as_o by_o a_o great_a do_v of_o wine_n sudden_o drink_v to_o which_o it_o be_v very_o like_a in_o all_o its_o effect_n except_o such_o as_o proceed_v from_o the_o rosin_n stick_v at_o stomach_n which_o wine_n have_v not_o 4._o sardonick_a laughter_n be_v cause_v as_o you_o see_v in_o drunken_a people_n when_o they_o be_v disable_v by_o the_o great_a relaxation_n that_o they_o can_v well_o express_v themselves_o by_o the_o fail_a tongue_n they_o endeavour_v it_o by_o a_o silly_a kind_n of_o feign_a or_o make_v laughter_n as_o they_o call_v it_o while_o the_o please_a titillation_n at_o stomach_n much_o incline_v they_o to_o mirth_n if_o they_o know_v how_o to_o manage_v and_o carry_v it_o on_o 5._o laxity_n and_o consequent_o debility_n of_o all_o part_n be_v cause_v by_o the_o extraordinary_a relaxation_n of_o they_o by_o a_o continual_a and_o permanent_a sense_n of_o pleasure_n which_o happen_v considerable_o in_o the_o momentary_a pleasure_n of_o venus_n much_o more_o in_o this_o continual_a and_o last_a pleasure_n when_o a_o great_a do_v make_v it_o intense_a as_o in_o drunkenness_n 6._o alienation_n of_o the_o mind_n be_v cause_v as_o in_o drunkenness_n by_o a_o over_o relaxation_n of_o the_o brain_n and_o its_o membrane_n 7._o loss_n of_o memory_n happen_v by_o the_o same_o mean_n as_o in_o drunkenness_n so_o 8._o darkness_n of_o eye_n be_v cause_v by_o a_o relaxation_n of_o the_o coat_n and_o membrane_n of_o the_o eye_n but_o main_o by_o the_o expansion_n of_o the_o animal_n spirit_n by_o that_o relaxation_n which_o as_o in_o sleep_n render_v they_o unfit_a to_o convey_v the_o impression_n of_o light_n etc._n etc._n 9_o laxity_n of_o the_o cornea_n be_v from_o the_o same_o relaxation_n 10._o appearance_n of_o various_a colour_n happen_v by_o as_o be_v say_v the_o unevenness_n of_o the_o cornea_n etc._n etc._n when_o so_o relax_v whereas_o when_o it_o be_v due_o
and_o frequent_a erection_n be_v and_o must_v be_v from_o the_o same_o cause_n 17._o nocturnal_a pollution_n be_v necessary_a consequence_n of_o the_o relaxation_n and_o the_o titillation_n cause_v by_o those_o volatile_a salt_n as_o be_v say_v chap._n xxiii_o the_o explication_n of_o the_o effect_n of_o leave_v off_o opium_n after_o a_o long_a and_o lavish_a use_v thereof_o i._o great_a and_o even_o intolerable_a distress_n anxiety_n and_o depression_n of_o spirit_n do_v happen_v 1._o because_o the_o sensitive_a soul_n who_o be_v so_o much_o comfort_v divert_v and_o support_v by_o the_o habitual_a and_o dear_o belove_a pleasure_n that_o opium_n cause_n be_v sudden_o deprive_v thereof_o by_o which_o it_o be_v main_o sustain_v be_v exceed_o disappoint_v and_o cast_v down_o 2._o because_o he_o now_o labour_v under_o the_o sore_a burden_n of_o the_o three_o contraction_n so_o that_o every_o thing_n seem_v and_o be_v real_o more_o grievous_a â—o_o he_o for_o now_o it_o act_v as_o one_o in_o pain_n or_o grief_n and_o every_o thing_n affect_v he_o more_o smart_o proportionable_a to_o the_o compression_n cause_v thereby_o of_o the_o animal_n spirit_n unless_o he_o return_v to_o the_o pleasure_n of_o opium_n which_o elevate_v it_o again_o or_o use_v generous_a wine_n as_o its_o substitute_n though_o it_o do_v not_o equal_v it_o either_o in_o the_o intenseness_n or_o duration_n of_o the_o pleasure_n unless_o repeat_v as_o i_o have_v some_o where_o direct_v once_o in_o half_a a_o hour_n or_o a_o hour_n in_o a_o moderate_a manner_n which_o cause_v a_o continuance_n of_o the_o pleasure_n though_o it_o can_v equal_v the_o intenseness_n of_o that_o of_o opium_n which_o therefore_o have_v the_o great_a effect_n ii_o a_o return_n of_o all_o disease_n pain_n and_o disaster_n must_v happen_v general_o because_o the_o opium_n take_v they_o off_o by_o a_o bare_a diversion_n of_o the_o sense_n thereof_o by_o pleasure_n iii_o dangerous_a looseness_n happen_v sometime_o because_o the_o sensation_n grow_v more_o grievous_a for_o as_o the_o pleasant_a sensation_n cause_v by_o opium_n take_v away_o the_o perception_n of_o the_o irritation_n of_o humour_n so_o the_o grievance_n of_o lose_v that_o pleasure_n cause_v contraction_n make_v all_o sensation_n smart_a and_o consequent_o more_o irritate_v so_o that_o the_o humour_n have_v thereby_o more_o of_o the_o effect_n of_o purger_n which_o operate_v as_o all_o agree_v by_o irritation_n beside_o that_o the_o humour_n before_o detain_v and_o suspend_v by_o relaxation_n as_o in_o sleep_n be_v now_o therefore_o pour_v down_o in_o great_a quantity_n by_o the_o advance_a contraction_n squeese_v they_o out_o as_o the_o return_n of_o the_o vigilative_a contraction_n after_o sleep_n cause_n man_n to_o be_v more_o apt_a to_o go_v to_o stool_n upon_o awake_v or_o get_v up_o in_o the_o morning_n which_o may_v be_v well_o compare_v in_o some_o measure_n to_o purge_v after_o leave_v off_o the_o use_n of_o opium_n since_o it_o relax_n as_o sleep_n do_v and_o that_o for_o a_o much_o long_a time_n by_o a_o continue_a use_n thereof_o iv_o death_n common_o follow_v for_o all_o the_o reason_n aforesaid_a especial_o the_o great_a and_o intolerable_a distress_n of_o soul_n that_o they_o be_v under_o unless_o opium_n be_v use_v which_o soon_o set_v they_o right_o or_o wine_n its_o substitute_n so_o frequent_o use_v as_o to_o continue_v its_o cordial_a pleasure_n at_o stomach_n nothing_o now_o remain_v but_o to_o take_v a_o short_a review_n to_o see_v whether_o i_o have_v explain_v all_o the_o amaze_a contradiction_n that_o seem_v to_o be_v in_o the_o effect_n of_o opium_n for_o though_o it_o be_v real_o do_v yet_o may_v it_o not_o so_o well_o appear_v as_o when_o set_v one_o against_o the_o other_o it_o will_v be_v tautology_n to_o repeat_v all_o the_o reason_n therefore_o i_o shall_v only_o mention_v they_o in_o the_o close_a order_n i_o at_o first_o enumerate_v they_o that_o you_o may_v see_v that_o they_o be_v all_o explicate_v in_o the_o former_a discourse_n you_o may_v well_o remember_v that_o i_o have_v show_v 1._o how_o it_o cause_v sleep_v and_o watch_v in_o divers_a person_n 2._o how_o it_o cause_v and_o prevent_v sweat_n 3._o how_o it_o relax_n and_o stop_n looseness_n even_o by_o relax_v 4._o how_o it_o stop_v flux_n and_o promote_v sweat_v and_o perspiration_n 5._o how_o it_o stupefy_v the_o sense_n of_o feel_v yet_o irritate_v it_o 6._o how_o it_o cause_v stupidity_n if_o you_o sit_v or_o lie_v still_o otherwise_o promptitude_n in_o business_n 7._o how_o it_o cause_v cloudiness_n and_o serenity_n that_o if_o one_o lie_v still_o and_o doze_n this_o if_o he_o keep_v in_o action_n that_o by_o a_o excessive_a and_o lavish_a use_v thereof_o which_o cause_v moapishness_n this_o by_o a_o temperate_a occasional_a take_v thereof_o especial_o in_o the_o morning_n upon_o journey_n etc._n etc._n 8._o how_o it_o excite_v the_o spirit_n yet_o quiet_v and_o compose_v they_o in_o hysterick_n fit_v diary_n fever_n from_o pain_n commotion_n etc._n etc._n 9_o how_o that_o it_o be_v very_o hot_a and_o take_v of_o fever_n 10._o how_o though_o it_o be_v hot_a and_o bitter_a yet_o it_o lessen_v appetite_n and_o hunger_n which_o be_v a_o grievous_a sensation_n by_o cause_v a_o pleasant_a one_o 11._o how_o it_o sometime_o stop_v urine_n by_o relax_v the_o bladder_n suspending_a humour_n etc._n etc._n and_o promote_v it_o by_o its_o tickle_a volatile_a salt_n as_o cantharides_n bee_n aunt_n etc._n etc._n do_v 12._o how_o it_o relax_n and_o thereby_o weaken_v as_o in_o sleep_n etc._n etc._n yet_o enable_v to_o perform_v labour_n journey_n etc._n etc._n with_o great_a euphory_n by_o divertive_a pleasure_n 13._o how_o it_o cause_v and_o prevent_v abortion_n that_o by_o over-relaxing_a this_o by_o allay_a pain_n terror_n etc._n etc._n that_o may_v cause_v it_o 14._o how_o it_o stop_v vomit_v by_o take_v off_o irritation_n etc._n etc._n and_o cause_v it_o by_o the_o adherence_n of_o its_o indigestible_a and_o viscid_a rosin_n 15._o how_o it_o stop_v purge_v and_o sometime_o cause_v it_o by_o the_o dissolution_n of_o its_o rosin_n by_o a_o strong_a digestion_n fix_a salt_n etc._n etc._n when_o its_o quantity_n be_v considerable_a which_o make_v it_o happen_v but_o rare_o 16._o how_o though_o acrimonious_a it_o take_v away_o the_o sense_n of_o acrimony_n 17._o how_o it_o cause_v madness_n and_o cure_v it_o by_o compose_v the_o spirit_n etc._n etc._n 18._o how_o it_o cause_v palsy_n by_o relax_v the_o part_n and_o make_v they_o susceptible_a of_o humour_n cause_v ill_a digestion_n etc._n etc._n and_o may_v cure_v they_o as_o dr._n willis_n give_v a_o instance_n by_o open_v the_o pore_n 19_o how_o it_o cause_v palsy_n and_o cure_n stupor_n etc._n etc._n that_o proceed_v from_o cold_a and_o contract_n cause_n 20._o how_o it_o cause_v dryness_n in_o the_o mouth_n yet_o by_o take_v off_o fever_n often_o cure_v it_o 21._o how_o it_o take_v off_o hiccough_n and_o cause_v they_o as_o it_o do_v vomit_v and_o for_o the_o same_o cause_n 22._o how_o it_o stanch_v blood_n by_o quiet_v its_o motion_n yet_o promote_v the_o menses_fw-la and_o lochia_n by_o relax_v open_v and_o widen_v the_o vessel_n and_o pore_n 23._o how_o it_o stop_v critical_a motion_n that_o depend_v upon_o irritation_n and_o contraction_n and_o promote_v such_o as_o depend_v upon_o open_v the_o pore_n 24._o how_o it_o revive_v people_n that_o be_v at_o the_o point_n of_o death_n for_o want_n of_o opium_n or_o by_o violent_a contraction_n and_o convulsion_n and_o be_v fatal_a to_o other_o weak_a person_n 25._o how_o it_o cause_v convulsion_n by_o its_o grieve_v rosin_n and_o cure_v they_o by_o quiet_v and_o compose_v the_o spirit_n by_o please_v they_o 26._o how_o it_o cause_v contraction_n by_o the_o grievous_a sensation_n that_o its_o rosin_n cause_n and_o relaxation_n by_o the_o pleasant_a sensation_n that_o its_o salvolatile_a oleosum_fw-la cause_n by_o that_o it_o cause_v many_o ill_a effect_n not_o here_o name_v and_o by_o this_o it_o cure_v they_o for_o how_o can_v such_o contrary_a cause_n according_a as_o one_o or_o the_o other_o prevail_v not_o cause_v contrary_a and_o seem_o contradictory_n effect_n at_o divers_a time_n and_o in_o divers_a person_n 27._o how_o it_o relax_n yet_o cause_v the_o tension_n rigidity_n and_o erection_n of_o the_o penis_n priapism_n etc._n etc._n by_o its_o titillation_n thus_o have_v you_o all_o even_o the_o most_o mysterious_a and_o seem_o contradictory_n effect_n of_o opium_n explain_v and_o reconcile_v and_o that_o so_o easy_o that_o if_o there_o be_v no_o other_o proof_n of_o the_o truth_n of_o my_o foundation_n it_o be_v sufficient_a to_o convince_v any_o man_n of_o its_o validity_n consider_v the_o vastness_n of_o the_o number_n and_o perplexity_n of_o the_o nature_n of_o those_o effect_n that_o be_v all_o with_o such_o facility_n explain_v be_v able_a even_o
with_o bean_n trefoil_n some_o with_o centaury_n other_o with_o gentian_n etc._n etc._n and_o the_o famous_a dr._n lower_n practice_n run_v almost_o altogether_o upon_o bitter_a thing_n which_o do_v he_o great_a service_n in_o his_o tincture_n of_o steel_n as_o he_o call_v it_o that_o he_o often_o make_v in_o distil_v water_n that_o can_v take_v little_a or_o nothing_o to_o purpose_n of_o the_o tincture_n of_o steel_n whether_o out_o of_o ignorance_n or_o design_n i_o will_v not_o though_o i_o may_v determine_v which_o show_v that_o it_o be_v the_o bitter_a thing_n that_o do_v the_o good_a and_o make_v it_o as_o a_o panacea_fw-la and_o not_o the_o steel_n however_o certain_a it_o be_v that_o promote_a the_o dissolution_n of_o meat_n at_o stomach_n which_o the_o bitter_a salia-volatalia-oleosa_a do_v be_v a_o great_a foundation_n for_o cure_n and_o no_o doubt_n our_o sal-volatile-oleosum_a do_v by_o its_o incide_v divide_v and_o resolve_v quality_n contribute_v very_o much_o to_o a_o due_a solution_n thereof_o at_o stomach_n by_o connaturalness_n as_o all_o menstruum_n do_v especial_o if_o it_o be_v flesh_n which_o we_o use_v most_o and_o require_v most_o help_n to_o be_v resolve_v which_o may_v very_o well_o be_v though_o it_o lessen_v appetite_n by_o please_a sensation_n for_o as_o be_v show_v it_o be_v quite_o another_o thing_n to_o cause_n appetite_n or_o a_o grievous_a sensation_n and_o resolution_n or_o digestion_n of_o the_o meat_n at_o stomach_n for_o wine_n help_v digestion_n yet_o by_o the_o please_a sensation_n that_o it_o cause_n at_o stomach_n it_o cure_v a_o canine_a appetite_n and_o at_o any_o time_n if_o you_o will_v observe_v it_o take_v off_o the_o eagerness_n of_o appetise_n for_o the_o present_a you_o can_v better_o stay_v without_o meat_n after_o a_o whet_v before_o dinner_n than_o you_o can_v without_o it_o so_o that_o the_o wine_n answer_v that_o of_o a_o whet_v as_o to_o digestion_n though_o not_o to_o appetite_n or_o hunger_n which_o be_v a_o grievous_a sensation_n that_o wine_n must_v rather_o cure_v than_o cause_n it_o be_v true_a that_o wine_n or_o opium_n may_v by_o cause_v a_o sense_n of_o pleasure_n at_o stomach_n cause_n some_o stay_n of_o the_o meat_n at_o stomach_n but_o it_o do_v not_o thence_o follow_v but_o the_o digestion_n may_v be_v the_o true_a because_o more_o gentle_a and_o gradual_a as_o it_o may_v and_o do_v happen_v in_o sleep_n when_o thing_n that_o be_v not_o very_o hard_a of_o digestion_n be_v eat_v which_o be_v not_o good_a at_o any_o time_n you_o may_v remember_v how_o blister_n to_o which_o opium_n be_v near_o of_o kind_a as_o have_v be_v show_v do_v quick_o by_o their_o resolve_v nature_n turn_v the_o cuticle_n as_o if_o digest_v into_o a_o sort_n of_o jelly_n what_o a_o mighty_a help_n will_v such_o a_o degree_n of_o resolution_n be_v to_o the_o digestion_n at_o stomach_n when_o it_o be_v by_o that_o mean_n like_o the_o skin_n of_o a_o well_o boil_a cow-heel_n half_o turn_v to_o a_o jelly_n and_o from_o a_o thing_n that_o be_v very_o hard_a of_o digestion_n to_o be_v very_o easy_a as_o be_v also_o a_o boar_n skin_n in_o brawn_n by_o reason_n of_o the_o prior_n resolution_n in_o the_o boil_n if_o as_o sanctorius_n say_v insensible_a perspiration_n hinder_v be_v the_o cause_n of_o most_o disease_n what_o be_v more_o proper_a to_o prevent_v or_o cure_v they_o than_o this_o sal-volatile-oleosum_a which_o cause_v perspiration_n above_o all_o thing_n i_o have_v be_v late_o inform_v that_o in_o some_o part_n of_o the_o most_o eastern_a country_n they_o use_v opium_n as_o a_o general_a medicament_n or_o panacea_fw-la dr._n willis_n and_o silvius_n say_v it_o hinder_v the_o coagulation_n of_o the_o blood_n how_o many_o chronical_a disease_n may_v it_o then_o prevent_v or_o cure_v that_o be_v the_o great_a effect_n of_o the_o alcahest_n and_o that_o be_v it_o that_o main_o qualify_v a_o medicament_n for_o a_o panacea_fw-la as_o courvee_a assert_n and_o all_o ingenious_a man_n allow_v wedelius_n say_v that_o it_o happy_o restore_v the_o tone_n of_o the_o blood_n what_o be_v then_o want_v to_o the_o preservation_n of_o health_n paracelsus_n say_v that_o tam_fw-la homini_fw-la quam_fw-la morbo_fw-la somnum_fw-la conciliat_fw-la that_o be_v that_o it_o put_v the_o disease_n asleep_o as_o well_o as_o the_o man._n ☞_o platerius_n cure_v the_o gout_n with_o it_o safe_o quick_o and_o pleasant_o and_o i_o know_v one_o that_o can_v do_v it_o especial_o if_o it_o be_v at_o the_o first_o come_v of_o the_o fit_n willis_n give_v a_o instance_n of_o one_o perfect_o cure_v of_o a_o dropsy_n and_o pocky_a pain_n by_o the_o use_n of_o laudanum_n ☞_o horstius_fw-la perfect_o cure_v a_o hypochondriacal_a person_n that_o be_v trouble_v with_o stupidity_n watch_n loss_n of_o appetite_n tremble_v and_o direful_a epileptical_a convulsion_n and_o past_o all_o hope_n by_o the_o use_n of_o opiate_n i_o myself_o have_v often_o see_v defluxion_n and_o catarrh_n cure_v by_o the_o use_n of_o opiate_n and_o one_o of_o a_o inveterate_a ill_a habit_n of_o body_n of_o many_o year_n stand_v wedelius_n say_v that_o it_o resolve_v the_o grumescence_n of_o the_o blood_n alter_v and_o dissipate_v the_o tenuious_a part_n of_o it_o temper_n the_o acrimonious_a etc._n etc._n the_o ancient_n use_v it_o against_o ague_n with_o great_a success_n you_o may_v to_o confirm_v this_o matter_n far_a observe_v that_o among_o the_o constant_a and_o frequent_a effect_n of_o opium_n there_o be_v no_o bad_a one_o unless_o there_o be_v 2_o or_o 3_o pure_o upon_o the_o account_n of_o its_o rosin_n as_o have_v be_v show_v therefore_o when_o it_o be_v separate_v from_o it_o there_o be_v no_o cause_n to_o fear_v the_o use_n of_o the_o sal-volatile-oleosum_a unless_o it_o be_v as_o in_o the_o case_n of_o wine_n when_o it_o be_v take_v in_o a_o excessive_a do_v or_o use_v too_o long_o in_o a_o lavish_a intemperate_a manner_n so_o that_o when_o i_o have_v show_v how_o due_o to_o prepare_v it_o and_o the_o moderate_a and_o safe_a dose_n thereof_o it_o may_v be_v use_v altogether_o as_o safe_o as_o wine_n in_o a_o proportionable_a do_v for_o what_o harm_n can_v there_o be_v in_o moderate_o please_v the_o membrane_n particular_o at_o stomach_n which_o all_o the_o best_a thing_n we_o use_v as_o wine_n cordial_n meat_n and_o drink_v do_v which_o be_v therefore_o all_o opiate_n in_o some_o degree_n thereby_o assure_v we_o of_o their_o goodness_n and_o agreeableness_n to_o our_o body_n though_o they_o do_v it_o not_o in_o so_o high_a a_o dgree_n as_o our_o sal-volatile-oleosum_a do_v which_o be_v the_o more_o authentic_a certificate_n of_o its_o excellency_n though_o it_o be_v to_o be_v still_o confess_v that_o excess_n of_o the_o best_a thing_n as_o joy_n comfort_n pleasure_n wine_n cordial_n etc._n etc._n have_v and_o may_v do_v mischief_n but_o what_o need_v excess_n therein_o any_o more_o than_o in_o wine_n meat_n cordial_n etc._n etc._n which_o then_o like_v it_o be_v all_o inconvenient_a and_o injurious_a to_o the_o body_n all_o this_o i_o have_v say_v to_o administer_v cause_n to_o improve_v the_o practice_n of_o physic_n by_o the_o use_n of_o this_o panacea_fw-la now_o that_o it_o be_v know_v by_o introduce_v its_o noble_a use_n as_o a_o alterative_a to_o cure_n as_o well_o as_o former_o to_o palliate_v disease_n it_o be_v a_o far_o more_o beneficial_a thing_n to_o cure_v than_o palliate_v remember_v how_o the_o cortex_fw-la mercury_n antimony_n and_o other_o the_o most_o effectual_a and_o glorious_a medicament_n have_v be_v traduce_v and_o scandalize_v by_o the_o ignorant_a imagination_n of_o the_o unlearned_a who_o have_v no_o true_a knowledge_n of_o the_o virtue_n of_o thing_n whole_o depend_v upon_o fear_n and_o jealousy_n to_o guard_v they_o from_o their_o imagine_a ill_a effect_n which_o general_o speak_v only_o the_o same_o ignorance_n fear_n and_o jealousy_n give_v a_o fantastical_a be_v to_o it_o remain_v that_o i_o in_o the_o next_o place_n show_v you_o 1._o the_o true_a preparation_n of_o this_o panacea_fw-la or_o sal-volatile-oleosum_a 2._o other_o preparation_n of_o opium_n that_o be_v next_o it_o in_o safety_n and_o good_a effect_n and_o why_o they_o be_v so_o 3._o the_o moderate_a and_o true_o safe_a dose_v of_o they_o all_o there_o be_v no_o danger_n in_o well_o prepare_v opium_n but_o from_o excess_n in_o the_o use_v thereof_o chap._n xxv_o of_o the_o preparation_n of_o the_o panacea_fw-la or_o true_a sal-volatile-oleosum_a of_o opium_n see_v that_o the_o sal-volatile-oleosum_a of_o opium_n must_v be_v such_o a_o effectual_a generous_a and_o general_a medicament_n that_o be_v both_o cordial_a and_o alterative_a in_o so_o transcendent_a a_o manner_n it_o well_o deserve_v a_o careful_a and_o curious_a preparation_n therefore_o i_o will_v be_v very_o particular_a therein_o to_o that_o end_n 1._o it_o must_v be_v separate_v from_o all_o the_o
have_v spend_v month_n in_o prepare_v the_o sapo_n tartareus_fw-la to_o correct_v opium_n when_o they_o may_v with_o the_o hundred_o part_n of_o the_o trouble_v and_o forty_o part_n of_o the_o time_n whole_o have_v take_v away_o the_o pernicious_a part_n by_o aqueous_a menstruum_n which_o they_o only_o pretend_v to_o correct_v by_o the_o sapo_n tartareus_fw-la though_o i_o allow_v it_o for_o the_o reason_n aforesaid_a to_o be_v a_o good_a corrector_n yet_o can_v it_o equal_v the_o total_a separation_n of_o the_o pernicious_a part_n i_o be_o of_o opinion_n upon_o my_o best_a thought_n and_o some_o experience_n that_o intimate_o mix_v and_o subdue_a opium_n with_o good_a white_a soap_n may_v for_o the_o reason_n aforesaid_a prove_v a_o good_a and_o ready_a corrector_n or_o preventer_n of_o the_o adhesion_n of_o the_o resinous_a part_n of_o opium_n to_o the_o stomach_n much_o conduce_v to_o its_o dissolution_n or_o digestion_n therein_o and_o nimble_a slip_n out_o of_o it_o and_o thereby_o prevent_v all_o the_o ill_a effect_n of_o opium_n which_o it_o cause_v by_o the_o adhesion_n and_o indigestibleness_n of_o its_o rosin_n of_o the_o second_o sort_n of_o preparation_n of_o opium_n wherein_o its_o rosin_n remain_v whole_o unaltered_a in_o its_o nature_n yet_o become_v safe_a by_o divide_v it_o etc._n etc._n this_o be_v main_o if_o not_o altogether_o do_v by_o a_o fine_a and_o through_o division_n of_o the_o resinous_a part_n of_o opium_n and_o keep_v they_o afterward_o from_o a_o coalescence_n in_o and_o adhesion_n to_o the_o stomach_n by_o which_o mean_n they_o become_v digestible_a or_o at_o least_o passable_a without_o offence_n this_o may_v be_v do_v 1._o by_o torrefaction_n till_o the_o opium_n be_v very_o friable_a and_o then_o fine_o powder_a it_o and_o mix_v it_o with_o such_o thing_n as_o be_v of_o good_a consistence_n etc._n etc._n to_o keep_v the_o part_n of_o opium_n from_o a_o coalescence_n as_o in_o venice_n treacle_n mithridate_n diascordium_n the_o philonium_n etc._n etc._n this_o be_v the_o way_n and_o method_n that_o the_o ancient_n use_v which_o cause_v galen_n to_o say_v that_o opium_n alone_o that_o be_v undivided_a and_o unmixed_a with_o other_o thing_n to_o prevent_v its_o coalescence_n etc._n etc._n be_v dangerous_a but_o mix_v with_o other_o thing_n be_v salutiferous_a which_o they_o find_v by_o experience_n not_o know_v the_o cause_n but_o attribute_v the_o safety_n thereof_o to_o something_o among_o the_o many_o ingredient_n as_o a_o corrector_n of_o the_o opium_n hence_o it_o be_v that_o they_o put_v small_a quantity_n thereof_o into_o electuary_n make_v of_o many_o and_o much_o other_o thing_n that_o keep_v the_o particle_n asunder_o which_o they_o do_v so_o common_o that_o at_o last_o all_o electuary_n be_v call_v opiate_n thus_o we_o have_v those_o composition_n above_o name_v which_o be_v safe_o use_v for_o the_o reason_n aforesaid_a not_o that_o any_o thing_n therein_o correct_v i_o know_v not_o what_o poisonous_a or_o narcotick_a quality_n in_o opium_n but_o that_o the_o other_o ingredient_n divide_v its_o rosin_n and_o afterward_o keep_v its_o particle_n from_o coalescence_n and_o adhesion_n 2._o dissolution_n of_o opium_n in_o spirit_n of_o wine_n or_o such_o sulphureous_a spirit_n which_o fine_o divide_v the_o rosin_n and_o use_v the_o bare_a tincture_n before_o the_o resinous_a particle_n be_v again_o compact_v as_o in_o extract_n etc._n etc._n may_v be_v of_o use_n if_o due_o administer_v but_o here_o a_o caution_n be_v to_o be_v use_v that_o you_o take_v it_o not_o in_o or_o drink_v any_o aqueous_a or_o phlegmatic_a liquid_a with_o it_o or_o before_o or_o after_o it_o in_o two_o or_o three_o hour_n which_o if_o you_o do_v the_o resinous_a particle_n will_v be_v precipitate_v thereby_o and_o so_o stick_v to_o the_o bottom_n tom_fw-mi of_o the_o stomach_n cause_v thereby_o the_o usual_a ill_a effect_n of_o vomit_v anxiety_n etc._n etc._n therefore_o it_o shall_v be_v give_v only_o in_o a_o spirituous_a liquid_a note_v also_o that_o if_o you_o give_v a_o solution_n thereof_o in_o any_o lixivium_n you_o take_v care_v not_o to_o dilate_v it_o by_o any_o mean_n by_o aqueous_a liquid_n in_o two_o hour_n before_o or_o after_o you_o take_v it_o for_o then_o there_o be_v but_o little_a lixivial_a salt_n in_o proportion_n to_o the_o liquid_a the_o resinous_a part_n be_v let_v go_v and_o precipitate_v to_o the_o bottom_n of_o the_o stomach_n as_o in_o the_o case_n of_o the_o spirit_n of_o wine_n so_o dilate_v of_o which_o i_o have_v see_v a_o very_a convince_a instance_n for_o one_o that_o have_v a_o esteem_n of_o lixivial_o in_o this_o case_n not_o only_o according_a to_o helmont_n and_o the_o common_a cry_n to_o correct_v opium_n but_o also_o to_o extract_v its_o virtue_n the_o more_o effectual_o make_v a_o tincture_n of_o opium_n in_o water_n lixiviate_v with_o salt_n of_o wormwood_n whereof_o he_o take_v the_o quantity_n that_o he_o have_v see_v i_o give_v of_o my_o liquid_a panacea_fw-la in_o a_o coffee-dish_n full_a of_o water_n which_o precipitate_v the_o rosin_n in_o the_o stomach_n cause_v he_o to_o vomit_v in_o about_o a_o hour_n after_o and_o continue_v so_o to_o do_v for_o about_o 15_o hour_n by_o which_o you_o plain_o see_v that_o the_o great_a secret_a of_o lixivial_o to_o correct_v opium_n lie_v mere_o in_o its_o division_n of_o the_o rosin_n thereof_o as_o in_o the_o case_n of_o spirit_n of_o wine_n and_o powder_a it_o and_o afterward_o keep_v its_o particle_n asunder_o during_o its_o stay_n at_o stomach_n which_o the_o sapo_n tartareus_fw-la do_v and_o probable_o other_o soap_n may_v do_v very_o well_o for_o the_o several_a reason_n aforesaid_a 3._o dissolution_n of_o opium_n in_o the_o yolk_n of_o a_o rear_n new_o lay_v egg_n by_o pound_v the_o dose_n that_o you_o intend_v to_o take_v with_o a_o little_a quantity_n of_o the_o yolk_n till_o both_o be_v thorough_o mix_v and_o then_o take_v it_o in_o the_o remain_a part_n of_o the_o yolk_n by_o which_o mean_v you_o not_o only_o fine_o divide_v the_o resinous_a part_n of_o the_o opium_n while_o the_o yolk_n of_o the_o egg_n intimate_o mix_v with_o they_o as_o it_o do_v with_o other_o rosin_n and_o turpentine_n but_o send_v along_o with_o it_o into_o the_o stomach_n what_o be_v digestible_a in_o itself_o and_o more_o and_o more_o divide_v and_o separate_v the_o resinous_a part_n and_o high_o contribute_v to_o their_o final_a dissolution_n and_o digestion_n so_o that_o i_o doubt_v not_o but_z you_o will_v find_v this_o new_a ready_a and_o agreeable_a mean_n as_o good_a if_o not_o better_o all_o thing_n consider_v than_o the_o former_a and_o even_o equal_a to_o the_o sapo_n tartareus_fw-la by_o what_o be_v say_v though_o short_a you_o may_v because_o it_o be_v the_o clear_a truth_n of_o thing_n judge_v of_o the_o goodness_n of_o all_o preparation_n of_o opium_n and_o 1._o that_o resinous_a thing_n shall_v not_o be_v add_v to_o opium_n because_o such_o like_o its_o own_o rosin_n render_v it_o more_o indigestible_a and_o apt_a to_o stick_v at_o stomach_n hence_o it_o be_v that_o the_o styrax_fw-mi pill_n have_v resinous_a thing_n in_o it_o and_o crude_a opium_n do_v so_o often_o cause_v dismal_a effect_n though_o forsooth_o much_o esteem_v for_o the_o lung_n cough_n defluxion_n etc._n etc._n for_o have_v such_o balsamic_a resinous_a thing_n as_o styrax_n and_o olibanum_n in_o it_o whereas_o the_o benefit_n be_v from_o the_o opium_n have_v dr._n bates_n know_v the_o cause_n of_o the_o mischief_n of_o opium_n he_o will_v never_o have_v put_v benjamin_n in_o his_o pacifick_n pill_n 2._o that_o all_o preparation_n make_v of_o extract_n in_o spirit_n of_o wine_n be_v to_o be_v reject_v such_o extract_v be_v much_o worse_a than_o crude_a opium_n and_o experimental_o find_v to_o be_v so_o therefore_o our_o common_a london_n laudanum_n be_v make_v of_o opium_n prepare_v in_o spirit_n of_o wine_n be_v no_o commendable_a preparation_n though_o so_o much_o use_v and_o cry_v up_o which_o also_o experience_n prove_v in_o that_o it_o sometime_o cause_v the_o ill_a effect_n of_o opium_n when_o give_v alone_o in_o a_o good_a do_v you_o will_v find_v more_o of_o these_o matter_n when_o you_o come_v to_o chap._n 29._o which_o consist_v of_o general_a rule_n and_o caution_n concern_v the_o use_n of_o opium_n therefore_o though_o i_o may_v add_v some_o useful_a observation_n i_o put_v a_o end_n to_o this_o matter_n at_o present_a for_o that_o reason_n and_o because_o what_o be_v to_o be_v true_o do_v in_o the_o preparation_n of_o opium_n be_v very_o evident_a from_o what_o be_v say_v since_o the_o cause_n of_o the_o ill_a effect_n of_o opium_n be_v now_o certain_o know_v to_o be_v its_o rosin_n to_o the_o separation_n or_o due_a alteration_n of_o which_o so_o as_o to_o cause_v it_o to_o pass_v the_o stomach_n without_o adhesion_n or_o offence_n by_o
the_o say_a column_n three_o sort_n of_o dose_n the_o low_a on_o the_o left_a hand_n the_o high_a on_o the_o right_a hand_n and_o the_o moderate_a do_v between_o they_o as_o suppose_v you_o be_v about_o to_o give_v a_o middle_n do_v of_o the_o liquid_a panacea_fw-la to_o a_o strong_a man_n see_v for_o strong_a man_n in_o the_o upper_a space_n and_o for_o liquid_a panacea_fw-la in_o the_o first_o column_n on_o the_o left_a hand_n under_o the_o word_n opiate_n and_o where_o the_o column_n that_o belong_v to_o strong_a man_n and_o the_o space_n that_o belong_v to_o liquid_a panacea_fw-la do_v meet_v there_o you_o will_v find_v qt_n 20_o 30_o 40_o for_o the_o least_o middle_a and_o high_a do_v give_v which_o you_o think_v fit_a according_a to_o your_o intention_n so_o if_o you_o be_v about_o to_o give_v the_o high_a do_v of_o the_o solid_a panacea_fw-la to_o a_o strong_a woman_n you_o will_v find_v under_o the_o word_n strong_a woman_n over_o against_o solid_a panacea_fw-la gr_fw-la i_o gr_n i¼_n gr_n i_o ss_z which_o show_v you_o that_o gr_n i_o ss_z be_v the_o high_a do_v for_o a_o strong_a woman_n and_o so_o of_o all_o the_o rest_n 4._o note_v that_o i_o have_v be_v so_o cautious_a in_o dose_v all_o the_o opiate_n that_o you_o may_v very_o safe_o give_v the_o high_a dose_n to_o all_o but_o very_o weak_a person_n to_o who_o it_o be_v hardly_o fit_a to_o give_v any_o thing_n by_o reason_n of_o extreme_a weakness_n 5._o note_v that_o if_o you_o give_v any_o to_o young_a person_n under_o the_o age_n of_o 20._o you_o shall_v proportion_v the_o dose_n not_o so_o much_o as_o idle_a custom_n direct_v according_a to_o their_o year_n as_o bulk_n and_o strength_n for_o instance_n allow_v strong_a man_n to_o be_v 200_o pound_n weight_n you_o must_v give_v a_o strong_a youth_n of_o 100_o pound_v weight_n half_o the_o do_v of_o the_o strong_a man_n and_o so_o of_o all_o other_o only_o allow_v somewhat_o less_o the_o young_a they_o be_v because_o of_o the_o softness_n fineness_n or_o laxity_n of_o their_o texture_n especial_o if_o they_o be_v very_o young_a to_o who_o opiate_n must_v be_v cautious_o give_v or_o only_o diacodium_fw-la which_o be_v best_a in_o that_o case_n and_o that_o in_o a_o small_a proportion_n also_o for_o young_a child_n can_v bear_v opiate_n as_o well_o as_o grow_v person_n no_o not_o in_o proportion_n to_o their_o bulk_n or_o weight_n place_v this_o between_o p._n 294_o and_o p._n 295._o a_o table_n of_o the_o dose_n of_o the_o best_a and_o safe_a opiate_n opiate_n do_v do_v do_v do_v liquid_a to_o strong_a man_n to_o middling_a man_n &_o strong_a woman_n to_o weak_a man_n &_o middling_a woman_n to_o weak_a woman_n the_o liquid_a panacea_fw-la gt_fw-mi 20_o 30_o 40_o 16_o 23_o 30_o 12_o 18_o 24_o 10_o 15_o 20_o laudanum_n liquidum_fw-la cydoniatum_n gt_fw-fr 20_o 30_o 40_o 16_o 23_o 30_o 12_o 18_o 24_o 10_o 15_o 20_o sydenham_n laudanum_n gt_v 20_o 30_o 40_o 16_o 23_o 30_o 12_o 18_o 24_o 10_o 15_o 20_o diacodium_fw-la or_o syr._n e_fw-it mecon_fw-mi ☞_o i_o Ê’x_o ☞_o ss_z ☞_o ss_z Ê’vi_fw-la ☞_o i_o ☞_o ss_z Ê’v_o Ê’vi_fw-la Ê’iii_fw-la ☞_o ss_z Ê’v_v solid_n  _fw-fr  _fw-fr  _fw-fr  _fw-fr the_o solid_a panacea_fw-la gr_n i_o iss_v two_o gr_n i_o i¼_n iss_v gr_n ss_z ay_o i¼_n gr_n ss_z ¾_n i_o wedelius_n laudanum_n gr_n i_o iss_v two_o gr_n i_o i¼_n iss_v gr_n ss_z ay_o i¼_n gr_n ss_z ¾_n i_z le_fw-fr mort_n extract_n gr_n i_o iss_v two_o gr_n i_o i¼_n iss_v gr_n ss_z ay_o i¼_n gr_n ss_z ¾_n i_o dr._n bate_n pacific_a pill_n gr_n two_o iiss_n three_o gr_n i_o iss_v two_o gr_n i_o i¼_n iss_v gr_n ss_z ¾_n ay_o starkey_n or_o matthew_n pill_n gr_n vi_fw-la ix_o twelve_o gr_n v_o seven_o ix_o gr_n four_o vi_fw-la viij_o gr_n three_o four_o v_a philonium_fw-la romanum_fw-la Ê’ss_n ℈_o two_o Ê’i_fw-la ℈_o i_o Ê’ss_n ℈_o two_o gr_n xviii-xxiv_a Ê’ss_v gr_n xuj_o xx_o xxiv_o philonium_fw-la persicum_fw-la Ê’ss_n ℈_o two_o Ê’i_fw-la ℈_o i_o Ê’ss_o ℈_o two_o gr_n xviii-xxiv_a Ê’ss_v gr_n xuj_o xx_o xxiv_o venice_n treacle_n Ê’i_fw-it Ê’ii_fw-la Ê’iii_fw-la Ê’i_fw-la Ê’iss_v Ê’ii_fw-la ℈_o two_o Ê’i_fw-la ℈_o iiii_o Ê’ss_n ℈_o two_o Ê’i_fw-la mithridate_n ☞_o ss_z Ê’vi_fw-la ☞_o i_o Ê’iii_fw-la Ê’v_o Ê’vii_fw-la Ê’ii_fw-la ☞_o ss_z Ê’vi_fw-la Ê’ii_fw-la Ê’iii_fw-la ☞_o ss_z diascordium_fw-la ☞_o ss_z Ê’vi_fw-la ☞_o i_o Ê’iii_fw-la Ê’v_o Ê’vii_fw-la Ê’ii_fw-la ☞_o ss_z Ê’vi_fw-la Ê’ii_fw-la Ê’ii_fw-la ☞_o ss_z the_o dose_n of_o london_n laudanum_n which_o i_o mention_v rather_o for_o its_o general_a use_n than_o laudableness_n may_v be_v the_o same_o with_o that_o of_o the_o pacifick_n pill_n a_o table_n of_o mark_n very_o necessary_a for_o the_o better_a understanding_n of_o the_o table_n of_o dose_n gt_fw-fr signify_v a_o drop_n 〈◊〉_d signify_v a_o grain_n 〈◊〉_d signify_v a_o scruple_n which_o be_v 20_o grainâ—_n 〈◊〉_d or_o ☜_o signify_v a_o dram_n which_o be_v 3_o scruple_n 〈◊〉_d signify_v a_o ounce_n which_o be_v 8_o dramâ—_n or_o drachm_n â—_o â—_o signifieâ—_n a_o quarter_n of_o any_o to_n â—_o â—_o â—_o â—_o ss_z or_o ss_z signifieâ—_n half_a of_o any_o to_n â—_o â—_o signifieâ—_n 3_o quarter_n of_o any_o to_a chap._n xxviii_o the_o cure_n of_o the_o ill_a effect_n of_o opium_n have_v show_v how_o to_o prepare_v opium_n so_o as_o to_o render_v it_o safe_a and_o innocent_a in_o a_o moderate_a do_v and_o how_o much_o that_o moderate_a do_v be_v one_o may_v be_v apt_a to_o think_v that_o this_o chapter_n be_v needless_a but_o when_o you_o consider_v how_o many_o there_o be_v that_o may_v be_v negligent_a wilful_a want_v time_n skill_n etc._n etc._n to_o prepare_v it_o or_o take_v too_o much_o or_o too_o long_o of_o it_o and_o that_o the_o physician_n must_v be_v able_a to_o answer_n and_o remedy_n all_o ill_a accident_n that_o may_v happen_v you_o will_v find_v it_o very_o requisite_a that_o i_o shall_v show_v how_o to_o cure_v the_o ill_a effect_n of_o opium_n which_o proceed_v either_o 1._o from_o its_o rosin_n at_o stomach_n or_o 2._o from_o too_o much_o relaxation_n by_o a_o excessive_a do_v or_o 3._o from_o a_o long_a and_o lavish_a use_n of_o it_o or_o 4._o from_o a_o sudden_a leave_v it_o off_o after_o a_o long_a and_o lavish_a use_v thereof_o i._o to_o cure_v the_o ill_a effect_n of_o the_o rosin_n at_o stomach_n you_o be_v first_o to_o know_v whether_o that_o be_v the_o cause_n which_o you_o may_v learn_v 1._o by_o consider_v whether_o crude_a opium_n or_o some_o resinous_a preparation_n thereof_o be_v take_v especial_o by_o itself_o in_o the_o form_n of_o a_o pill_n or_o pill_n as_o a_o extract_v thereof_o out_o of_o spirit_n of_o wine_n or_o pilâ—e_a styrace_n or_o london_n laudanum_n or_o the_o like_a not_o due_o prepare_v as_o have_v be_v direct_v 2._o by_o the_o symptom_n which_o be_v these_o viz._n a_o nausea_n puke_v vomit_v hiccough_n convulsion_n distress_n and_o anxiety_n about_o the_o stomach_n particular_o the_o part_n call_v the_o pit_n of_o the_o stomach_n swimmings_n in_o the_o head_n vertigo_n palpitation_n and_o tremble_n of_o the_o heart_n agitation_n uneasiness_n a_o turbulent_a pulse_n and_o after_o a_o struggle_v of_o nature_n under_o those_o symptom_n faint_n leipothymy_n syncopes_fw-la etc._n etc._n which_o last_o you_o must_v not_o take_v for_o certain_a sign_n and_o symptom_n unless_o the_o former_a have_v precede_v they_o because_o it_o be_v not_o impossible_a but_o they_o may_v happen_v from_o the_o quantity_n of_o the_o opium_n condition_n or_o constitution_n of_o the_o person_n etc._n etc._n but_o this_o when_o all_o thing_n be_v compare_v together_o will_v be_v easy_o judge_v of_o especial_o if_o you_o observe_v 1._o whether_o those_o faint_n or_o leipothymy_n be_v not_o more_o like_o the_o failure_n and_o stupor_n of_o drunkard_n than_o bare_a faint_n if_o they_o be_v of_o the_o first_o sort_n then_o do_v they_o proceed_v from_o a_o over_o relaxation_n occasion_v by_o the_o opium_n and_o not_o from_o its_o rosin_n the_o cure_n of_o which_o belong_v to_o the_o second_o particular_a 2._o whether_o they_o be_v more_o attend_v with_o the_o sign_n of_o relaxation_n as_o deadness_n of_o the_o eye_n falter_v of_o the_o tongue_n darkness_n before_o the_o eye_n dilatation_n of_o the_o pupilla_fw-la efflorescence_n of_o the_o skin_n laxity_n of_o the_o limb_n want_v of_o feel_v stupidity_n sleepiness_n failure_n of_o the_o sense_n or_o of_o make_v water_n loss_n of_o memory_n or_o understanding_n a_o dry_a mouth_n a_o slow_a and_o wide_a pulse_n and_o other_o thing_n much_o like_o the_o state_n of_o a_o deadish_a drunkenness_n for_o then_o those_o failure_n be_v the_o effect_n of_o relaxation_n by_o the_o pleasant_a sensation_n that_o the_o opium_n cause_n but_o after_o all_o it_o be_v the_o sort_n of_o opium_n that_o be_v take_v and_o
of_o opium_n of_o which_o i_o be_o go_v to_o speak_v chap._n xxx_o the_o method_n contrive_v to_o show_v the_o use_n of_o well-prepared_n opiate_n more_o especial_o the_o panacea_fw-la of_o opium_n have_v show_v the_o nature_n and_o principle_n of_o opium_n which_o produce_v the_o good_a which_o the_o bad_a effect_n how_o and_o why_o they_o do_v so_o how_o to_o separate_v subdue_v and_o correct_v the_o bad_a principle_n the_o due_a dose_n of_o good_a preparation_n how_o to_o cure_v all_o the_o ill_a effect_n of_o opium_n and_o general_a rule_n and_o caution_n concern_v it_o and_o in_o what_o case_n it_o may_v not_o be_v convenient_a i_o have_v now_o nothing_o to_o do_v but_o to_o shâ—w_v the_o beneficial_a use_n of_o the_o panacea_fw-la or_o well_o prepare_v opiate_n to_o make_v it_o more_o agreeable_a to_o rational_a mind_n and_o fix_v its_o uses_n better_a in_o memory_n i_o will_v so_o proceed_v by_o its_o effect_n that_o the_o very_a title_n of_o every_o chapter_n may_v imply_v the_o reason_n of_o its_o use_n which_o be_v either_o internal_a or_o external_a and_o both_o of_o they_o either_o i._o as_o it_o be_v a_o pleaser_n of_o sensation_n or_o a_o opiate_n special_o so_o call_v by_o which_o mean_v it_o produce_v all_o the_o good_a effect_n that_o be_v notorious_o observe_v which_o be_v mention_v in_o chap._n 4_o 5_o 6._o or_o ii_o as_o it_o be_v a_o alterative_a of_o the_o blood_n etc._n etc._n which_o be_v all_o improvement_n because_o almost_o whole_o disregard_v and_o never_o bring_v into_o any_o method_n to_o this_o day_n though_o it_o be_v the_o far_o noble_a use_n by_o how_o much_o cure_v excel_v bare_a please_a or_o palliate_a though_o these_o last_o uses_n have_v already_o render_v it_o the_o most_o general_a medicament_n that_o be_v in_o be_v insomuch_o that_o silvius_n say_v have_v only_a respect_n to_o this_o use_n that_o he_o have_v rather_o not_o be_v a_o physician_n than_o not_o know_v the_o use_n of_o opium_n iii_o as_o a_o evacuative_a by_o relax_v and_o open_v the_o pore_n its_o effect_n and_o use_v as_o a_o pleaser_n of_o sensation_n be_v fair_o reducible_a to_o these_o general_a head_n viz._n 1._o it_o be_v comfort_v gratify_a encourage_v and_o invigorate_n of_o the_o sensitive_a soul_n and_o spirit_n 2._o it_o be_v compose_v the_o sensitive_a soul_n spirit_n etc._n etc._n 3._o it_o be_v relax_v all_o the_o senfile_v part_n of_o the_o body_n 4._o it_o be_v cause_v sleep_n 5._o it_o be_v cause_v indolence_n or_o take_v away_o pain_n 6._o it_o be_v stop_v flux_n that_o depend_v upon_o irritation_n grievous_a sensation_n contraction_n etc._n etc._n 7._o its_o promote_a flux_n that_o depend_v upon_o relaxation_n 8._o it_o be_v cause_v titillation_n 9_o it_o be_v cause_v vigilancy_n or_o watch_v in_o some_o person_n its_o effect_n and_o use_v as_o a_o alterative_a be_v 1._o to_o invigorate_v nature_n or_o the_o sensitive_a soul_n and_o spirit_n which_o be_v the_o principle_n of_o all_o motion_n and_o alteration_n for_o the_o preservation_n of_o the_o animal_n 2._o to_o give_v nature_n or_o the_o sensitive_a soul_n a_o euphory_n in_o that_o work_n of_o preservation_n alteration_n etc._n etc._n 3._o to_o administer_v fresh_a and_o most_o agreeable_a principle_n for_o that_o end_n 4._o to_o administer_v such_o as_o be_v more_o vigorous_a and_o powerful_a than_o our_o own_o in_o order_n 5._o to_o resolve_v all_o ill_a humour_n as_o vigorous_a and_o agreeable_a menstrunm_n do_v 6._o to_o compose_v combine_v concentrate_v or_o unite_v the_o good_a and_o agreeable_a part_n of_o those_o humour_n and_o by_o its_o agreeableness_n to_o join_v with_o they_o and_o cause_v a_o strict_a combination_n of_o part_n to_o intercede_v and_o as_o it_o be_v cement_v they_o 7._o to_o discuss_v the_o separate_a and_o effete_a part_n of_o those_o humour_n by_o its_o brisk_a volatile_a salt_n and_o its_o effect_n and_o use_v as_o a_o evacuative_a be_v 1._o to_o cause_v a_o liberal_a perspiration_n to_o give_v those_o effete_a part_n their_o exit_fw-la in_o the_o most_o natural_a plentiful_a kind_a and_o universal_a manner_n 2._o to_o cause_n sweat_n when_o there_o be_v sufficient_a matter_n for_o that_o end_n 3._o to_o relax_v and_o open_v the_o pore_n for_o the_o menses_fw-la and_o lochia_n etc._n etc._n chap._n xxxi_o of_o the_o use_n of_o the_o panacea_fw-la or_o well-prepared_n opiate_n to_o comfort_v and_o invigorate_v the_o sensitive_a soul_n and_o spirit_n i_o have_v show_v how_o and_o why_o it_o cause_v a_o blithe_a gay_a and_o good_a humour_n serenity_n ovation_n of_o the_o sensitive_a soul_n and_o spirit_n alacrity_n promptitude_n assurance_n courage_n magnanimity_n euphory_n or_o easy_a undergo_n of_o labour_n journey_n etc._n etc._n it_o therefore_o follow_v 1._o that_o it_o must_v prevent_v or_o take_v off_o sadness_n melancholy_a cloudiness_n slowness_n dulness_n listlesness_n laziness_n bashfulness_n cowardice_n fear_v pusillanimity_n lassitude_n distress_n anxiety_n solicitude_n and_o all_o such_o grievous_a passion_n as_o wine_n ad_fw-la hilaritatem_fw-la do_v 2._o that_o by_o fortify_v the_o sensitive_a soul_n and_o spirit_n it_o must_v prevent_v contagious_a infection_n and_o mighty_o enable_v and_o invigorate_v nature_n to_o subdue_v and_o conquer_v what_o be_v inimicous_a to_o it_o in_o all_o respect_n 3._o that_o it_o prevent_v and_o take_v off_o faint_n and_o leipothymy_n that_o happen_v from_o the_o aforesaid_a cause_n as_o those_o upon_o fear_n tâ—rour_n hard_a labour_n be_v plague-struck_a and_o the_o like_a i._o the_o form_n that_o it_o be_v to_o be_v give_v in_o be_v indifferent_a unless_o a_o very_a sudden_a effect_n be_v require_v as_o may_v happen_v in_o faint_v fit_n etc._n etc._n for_o then_o as_o be_v say_v a_o liquid_a form_n in_o wine_n or_o hot_a cordial_n be_v best_a ii_o the_o do_v in_o these_o case_n must_v be_v moderate_a and_o sometime_o in_o great_a case_n the_o high_a for_o great_a grievance_n cause_v proportionable_a defensive_a contraction_n which_o oppose_v the_o good_a effect_n of_o the_o panacea_fw-la etc._n etc._n iii_o the_o vehicle_n shall_v be_v a_o glass_n of_o generous_a wine_n cordial_a fermented_a liquor_n comfortable_a spirit_n or_o suchlike_a to_o which_o you_o may_v add_v if_o you_o please_v pleasant_a and_o comfortable_a thing_n as_o tincture_n of_o saffron_n or_o its_o spirit_n chemical_a oil_n as_o of_o cinnamon_n nutmeg_n sassaphras_n cloves_n etc._n etc._n drop_v into_o sugar_n ambergrise_v musk_n etc._n etc._n iv_o the_o time_n of_o give_v it_o be_v at_o such_o a_o convenient_a distance_n before_o the_o time_n that_o you_o will_v have_v it_o operate_v that_o it_o may_v produce_v its_o effect_n at_o the_o time_n desire_v see_v the_o general_n rule_v as_o to_o time_n when_o it_o be_v requisite_a to_o continue_v its_o effect_n as_o in_o long_a journey_n or_o the_o like_a repeat_v it_o as_o soon_o as_o you_o find_v the_o effect_n of_o the_o former_a do_v begin_v sensible_o to_o decay_v because_o it_o take_v some_o time_n to_o operate_v v._o the_o regimen_n when_o action_n or_o business_n be_v intend_v be_v to_o keep_v in_o motion_n discourse_n or_o the_o like_a lest_o you_o sleep_n or_o grow_v drowsy_a but_o when_o you_o intend_v sleep_n observe_v the_o regimen_n direct_v in_o the_o chapter_n of_o its_o use_n to_o cause_v sleep_n though_o less_o sustenance_n will_v serve_v when_o you_o use_v it_o yet_o must_v it_o not_o be_v omit_v in_o a_o moderate_a manner_n the_o kind_a must_v be_v such_o as_o be_v easy_a of_o digestion_n and_o apt_a to_o promote_v perspiration_n as_o light_a bread_n mutton_n lamb_n neat's-tongue_n sweetbread_n and_o lamb-stone_n with_o agreeable_a sauce_n that_o may_v help_v digestion_n and_o perspiration_n which_o be_v a_o great_a cause_n of_o serenity_n and_o alacrity_n as_o sanctorius_n observe_v because_o that_o thereby_o fume_n and_o vapour_n which_o cloud_n and_o clog_v the_o spirit_n be_v evaporate_v and_o the_o spirit_n become_v serene_a and_o expedite_a it_o be_v to_o be_v observe_v that_o parsley_n selery_n onion_n horseradish_n garlic_n and_o such_o warm_a and_o volatile_a plant_n promote_v perspiration_n your_o drink_n shall_v be_v good_a stomach-wine_n or_o wine_n and_o water_n or_o fine_a clear_a drink_n not_o too_o new_a 1._o note_v that_o as_o have_v be_v intimate_v drink_v good_a acceptable_a and_o generous_a wine_n so_o often_o yet_o moderate_o as_o to_o keep_v a_o continual_a sense_n of_o its_o pleasure_n at_o stomach_n be_v the_o best_a substitute_n to_o it_o that_o can_v be_v use_v for_o it_o will_v thereby_o answer_v much_o of_o the_o permanent_a effect_n of_o well-prepared_n opium_n though_o not_o quite_o so_o convenient_a in_o many_o respect_n as_o 1._o because_o it_o must_v be_v so_o often_o repeat_v 2._o because_o its_o effect_n be_v not_o so_o fine_a and_o charm_a 3._o because_o the_o wine_n heat_v more_o 4._o because_o it_o wash_v the_o stomach_n too_o often_o and_o the_o like_a 2._o note_v
chapter_n of_o its_o use_n to_o cause_v sleep_n v._o the_o regimen_n must_v be_v exact_a temperance_n and_o moderation_n in_o all_o thing_n and_o 1._o as_o to_o diet_n let_v it_o be_v appropriate_v to_o the_o disease_n and_o always_o of_o such_o thing_n as_o the_o stomach_n digest_v without_o any_o difficulty_n or_o disturbance_n 2_o as_o to_o sleep_v it_o shall_v be_v moderate_a yet_o so_o much_o as_o full_o recruit_n and_o refresh_v 3._o as_o to_o rest_n and_o motion_n the_o like_a moderation_n must_v be_v use_v for_o motion_n must_v not_o be_v violent_a or_o over-wasting_a of_o the_o spirit_n in_o any_o respect_n yet_o must_v gentle_a motion_n and_o exercise_n be_v use_v ride_v on_o horseback_n to_o such_o as_o can_v do_v it_o be_v a_o very_a wholesome_a exercise_n 4._o as_o to_o excretion_n and_o retension_n you_o shall_v never_o purge_v or_o vomit_n during_o its_o use_n unless_o there_o be_v a_o very_a special_a cause_n and_o then_o i_o will_v have_v the_o vomit_n to_o be_v only_o carduate_v water_n and_o for_o stool_n only_o so_o much_o of_o the_o scot_n pill_n or_o stomach_n pill_n as_o will_v serve_v to_o open_v the_o body_n to_o be_v take_v at_o bedtime_n or_o at_o such_o time_n of_o the_o night_n as_o to_o cause_v no_o disturbance_n before_o you_o be_v up_o in_o the_o morning_n but_o general_o speak_v cause_v not_o evacuation_n be_v best_a but_o what_o be_v the_o consequence_n of_o the_o panacea_fw-la itself_o which_o cause_v the_o best_a most_o natural_a universal_a and_o considerable_a evacuation_n by_o the_o pore_n 5._o as_o to_o the_o air_n the_o dry_a and_o temperate_a as_o to_o heat_n and_o cold_a but_o rather_o incline_v to_o coldness_n be_v the_o best_a for_o you_o can_v so_o well_o err_v on_o this_o hand_n because_o the_o pore_n will_v be_v keep_v open_a and_o cold_n prevent_v in_o a_o high_a manner_n by_o the_o use_n of_o the_o panacea_fw-la beside_o that_o coolness_n be_v most_o agreeable_a to_o digestion_n 6._o as_o to_o passion_n of_o the_o mind_n all_o the_o grievous_a one_o shall_v be_v avoid_v and_o a_o fine_a even_a cheerfulness_n maintain_v as_o mâ—ch_v as_o may_v be_v it_o will_v be_v very_o easy_o continue_v by_o the_o help_n of_o the_o panacea_fw-la which_o cause_v it_o above_o all_o thing_n 1._o note_v that_o these_o direction_n do_v general_o concern_v its_o use_n in_o chronical_a case_n for_o as_o to_o acute_a disease_n and_o particular_a gas_n it_o must_v be_v leave_v to_o the_o management_n of_o the_o present_a physician_n 2._o note_v that_o its_o use_n as_o a_o evacuative_a have_v be_v sufficient_o treat_v of_o in_o the_o chapter_n of_o its_o use_n to_o cause_v flux_n and_o evacuation_n 3._o note_n that_o notwithstanding_o all_o i_o have_v say_v of_o the_o most_o excellent_a qualification_n of_o the_o panacea_fw-la of_o opium_n i_o submit_v all_o to_o far_a experience_n at_o the_o introduction_n of_o which_o i_o main_o aim_v by_o endeavour_v to_o take_v off_o people_n fear_n and_o jealousy_n which_o have_v ever_o be_v the_o great_a hinderer_n of_o improvement_n in_o cure_n more_o especial_o in_o reference_n to_o the_o use_v of_o opiate_n which_o without_o doubt_n will_v cure_v many_o disease_n more_o than_o ever_o they_o be_v use_v for_o at_o least_o as_o alteratives_n which_o if_o my_o discourse_n do_v occasion_n i_o shall_v thank_v and_o praise_v the_o author_n of_o all_o good_a for_o make_v i_o instrumental_a thereto_o chap._n xli_o of_o the_o external_n use_v of_o opium_n it_o be_v external_n use_v be_v as_o the_o internal_a either_o i._o as_o a_o pleaser_n of_o sensation_n or_o a_o opiate_n spe_fw-mi cial_o so_o call_v or_o ii_o as_o a_o alterative_a first_o as_o a_o pleaser_n of_o sensation_n or_o a_o opiate_n proper_o and_o special_o so_o call_v it_o be_v scarce_o worth_a while_n to_o treat_v of_o it_o because_o of_o the_o uncertainty_n ineffectualness_n and_o sometime_o danger_n thereof_o unless_o it_o be_v to_o caution_n man_n concern_v it_o for_o my_o part_n i_o seldom_o or_o never_o use_v it_o external_o unless_o it_o be_v in_o venice-treacle_n diascordium_n or_o mithridate_n which_o have_v but_o little_a quantity_n thereof_o nor_o can_v i_o see_v why_o it_o shall_v be_v at_o all_o use_v external_o as_o a_o opiate_n except_o it_o be_v when_o opiate_n can_v be_v use_v internal_o where_o they_o have_v more_o even_o certain_a and_o better_a effect_n or_o in_o very_o â—ew_a case_n which_o will_v be_v mention_v the_o main_a therefore_o that_o i_o can_v do_v in_o this_o case_n be_v to_o acquaint_v you_o what_o other_o have_v sound_a by_o experience_n concern_v its_o external_a use._n 1._o it_o have_v be_v find_v dangerous_a to_o apply_v opiate_n to_o the_o suture_n of_o the_o head_n it_o have_v kill_v some_o and_o galen_n be_v against_o it_o l._n 2._o de_fw-fr comp._n med._n i_o have_v somewhere_o read_v of_o a_o man_n who_o after_o a_o certain_a contest_v for_o victory_n be_v very_o hot_a take_v off_o his_o helmet_n to_o refresh_v himself_o after_o the_o victory_n he_o have_v obtain_v which_o helmet_n his_o emulator_n smear_v on_o the_o inside_n with_o opium_n he_o afterward_o put_v it_o on_o and_o soon_o die_v 2._o it_o be_v apply_v more_o safe_o to_o the_o forehead_n or_o temple_n but_o the_o quantity_n of_o half_a a_o scruple_n shall_v not_o be_v exceed_v in_o this_o case_n fernelius_n commend_v the_o application_n of_o it_o to_o the_o forehead_n in_o headache_n frenzy_n &c_n &c_n mix_v with_o ointment_n wedelius_n do_v also_o use_n venice_n treacle_n and_o extract_v of_o opium_n to_o the_o temple_n with_o good_a success_n in_o pain_n of_o the_o head_n he_o also_o find_v the_o like_a success_n in_o apply_v it_o behind_o the_o ear_n note_v that_o the_o continuance_n and_o constancy_n of_o its_o operation_n where_o it_o take_v effect_v apply_v external_o may_v be_v very_o beneficial_a in_o some_o case_n but_o even_o that_o may_v be_v answer_v by_o internal_a use_n if_o it_o be_v repeat_v 3._o all_o or_o most_o do_v agree_v that_o it_o be_v too_o acrimonious_a to_o be_v apply_v to_o the_o eye_n 4._o geigâ—rus_n fernelius_n heurnius_n etc._n etc._n do_v commend_v its_o use_n to_o smell_v to_o be_v make_v into_o a_o ball_n etc._n etc._n with_o odoriferous_a thing_n and_o i_o have_v a_o opinion_n that_o this_o way_n of_o use_v it_o may_v be_v excellent_a condition_v that_o not_o above_o half_a a_o scruple_n of_o opium_n be_v use_v 1._o because_o but_o a_o small_a quantity_n and_o that_o of_o its_o fine_a part_n be_v thus_o receive_v into_o the_o body_n 2._o because_o it_o may_v be_v remove_v at_o pleasure_n and_o then_o as_o some_o say_v the_o effect_v immediate_o cease_v this_o be_v very_o well_o worth_a the_o experiment_n for_o it_o will_v be_v very_o neat_a to_o be_v able_a to_o cause_v sleep_n and_o its_o other_o effect_n with_o safety_n as_o long_o or_o as_o short_a a_o time_n as_o we_o please_v and_o no_o long_o for_o this_o can_v be_v do_v when_o it_o be_v internal_o give_v but_o its_o operation_n will_v have_v its_o course_n without_o extraordinary_a mean_n and_o trouble_n but_o when_o external_o use_v the_o very_a cause_n of_o the_o danger_n if_o any_o shall_v hâ—ppen_v can_v be_v immediate_o remove_v by_o take_v of_o the_o opiate_n from_o the_o nose_n 5._o that_o of_o geigerus_fw-la and_o langius_n use_v only_o one_o 〈◊〉_d of_o opium_n to_o the_o puncture_n or_o little_a wound_n make_v by_o a_o leecâ—_n behind_o the_o ear_n to_o cause_v sleep_n and_o that_o with_o effect_n seem_v to_o i_o to_o he_o attribute_v more_o to_o the_o bleed_a which_o always_o incline_v man_n to_o sleep_v than_o to_o the_o opium_n 6._o crude_a opium_n have_v kill_v people_n by_o put_v it_o in_o hollow_a tooth_n as_o some_o observer_n aver_v 7._o apply_v to_o the_o ear_n it_o relax_n and_o as_o it_o be_v resolve_v the_o tympan_n and_o other_o delicate_a membrane_n concern_v and_o thereby_o offend_v the_o hear_v 9_o galen_n seem_v to_o be_v against_o the_o application_n of_o it_o to_o the_o nape_n of_o the_o neck_n because_o so_o near_o the_o original_a of_o the_o nerve_n note_v that_o it_o be_v not_o convenient_a to_o use_v it_o where_o resolution_n and_o relaxation_n may_v do_v any_o harm_n as_o be_v say_v of_o the_o tympan_n of_o the_o ear_n etc._n etc._n 10._o venice_n treacle_n mithridate_n and_o diascordium_n be_v safe_o apply_v external_o to_o the_o region_n of_o the_o stomach_n to_o appease_v vomit_v and_o hiccough_n moderate_a looseness_n etc._n etc._n 11._o savanarola_n and_o octavius_n horatianus_n use_v it_o to_o the_o navel_n to_o cause_v sleep_n and_o with_o rue_n myrrh_n frankincense_n and_o wax_v to_o move_v to_o stool_n which_o it_o perform_v as_o the_o last_o mention_v author_n say_v 12._o silvius_n use_v it_o in_o his_o carminative_a plaster_n to_o discuss_v wind_n which_o be_v rational_a
benefit_n as_o in_o many_o of_o the_o former_a to_o be_v short_a it_o be_v good_a and_o useful_a in_o all_o pain_n and_o grievous_a sensation_n 1._o eecept_n all_o such_o as_o tend_v to_o the_o speedy_a and_o timely_a benefit_n of_o person_n as_o those_o in_a woman_n labour_n grievance_n at_o stomach_n that_o cause_n vomit_v upon_o over-repletion_n or_o by_o reason_n of_o somewhat_o that_o grieve_v and_o be_v not_o convenient_a to_o stay_v at_o stomach_n or_o irritation_n to_o expectorate_v when_o much_o want_v as_o happen_v sometime_o in_o vomicas_fw-la pleurisy_n peripneumonias_n etc._n etc._n or_o such_o as_o irritate_fw-la and_o solicit_v to_o make_v water_n go_v to_o stool_n etc._n etc._n when_o evacuation_n of_o urine_n ordure_n ill_a humour_n etc._n etc._n be_v requisite_a 2._o except_o when_o grievous_a sensation_n be_v necessary_a call_n or_o intimation_n for_o supply_v refreshment_n etc._n etc._n as_o hunger_n thirst_v etc._n etc._n which_o shall_v be_v take_v off_o only_o by_o the_o pleasure_n of_o good_a meat_n and_o drink_v lest_o nature_n be_v defraud_v where_o you_o may_v observe_v a_o inconvenience_n that_o may_v happen_v by_o the_o frequent_a use_n of_o opium_n take_v away_o appetite_n without_o nutriment_n though_o this_o be_v much_o compensated_a by_o the_o relaxation_n and_o recruit_v that_o opiate_n give_v and_o their_o moderate_v the_o expense_n of_o spirit_n by_o take_v of_o contraction_n and_o may_v more_o if_o not_o whole_o by_o a_o regular_a and_o constant_a way_n of_o eat_v and_o drink_v temperate_o at_o usual_a time_n though_o the_o hunger_n may_v not_o by_o reason_n of_o the_o opiate_n be_v so_o great_a as_o at_o other_o time_n i._o the_o form_n be_v indifferent_a and_o to_o be_v order_v only_o according_a to_o the_o general_a rule_n remember_v that_o the_o liquid_a be_v best_a for_o speed_n ii_o the_o dose_n must_v be_v proportion_v to_o the_o pain_n or_o grievous_a sensation_n and_o always_o rather_o more_o than_o when_o there_o be_v no_o pain_n because_o its_o contraction_n oppose_v the_o relaxation_n to_o be_v induce_v by_o the_o opiate_n observe_v this_o method_n first_o give_v a_o good_a do_v then_o stay_v about_o 2_o or_o 3_o hour_n and_o if_o the_o pain_n be_v not_o at_o all_o lessen_v you_o may_v safe_o then_o give_v half_a the_o quantity_n again_o and_o afterward_o about_o a_o three_o part_n of_o the_o do_v every_o 2_o or_o 3_o hour_n till_o it_o begin_v to_o abate_v but_o upon_o the_o least_o sensible_a abatement_n you_o must_v forbear_v to_o give_v any_o more_o because_o that_o which_o do_v in_o some_o measure_n abate_v the_o pain_n do_v in_o the_o same_o proportion_n abate_v the_o contraction_n and_o consequent_o it_o have_v less_o to_o contest_v with_o therefore_o will_v be_v sure_a to_o conquer_v it_o for_o the_o same_o power_n that_o can_v subdue_v ten_o in_o some_o measure_n will_v subdue_v nine_o in_o a_o great_a measure_n and_o eight_o more_o easy_o than_o nine_o etc._n etc._n till_o the_o pain_n quite_o cease_v whereas_o if_o you_o add_v more_o power_n to_o the_o opiate_n it_o may_v be_v too_o much_o especial_o when_o the_o pain_n be_v thereby_o conquer_v and_o that_o it_o have_v no_o contraction_n to_o contest_v with_o for_o than_o it_o will_v be_v as_o if_o a_o great_a do_v be_v give_v to_o one_o that_o have_v no_o pain_n but_o if_o the_o pain_n increase_v again_o you_o may_v safe_o repeat_v the_o half_n do_v etc._n etc._n every_o 2_o or_o 3_o hour_n till_o it_o again_o begin_v to_o abate_v and_o no_o long_o which_o you_o have_v better_o observe_v to_o do_v as_o soon_o as_o ever_o the_o pain_n begin_v to_o return_v because_o it_o take_v some_o time_n to_o operate_v it_o sollow_v then_o that_o the_o liquid_a form_n be_v most_o convenient_a in_o this_o case_n for_o expedition_n my_o particular_a and_o effectual_a manner_n of_o use_v it_o in_o the_o gout_n will_v be_v somewhat_o too_o redious_a to_o be_v set_v down_o therefore_o since_o it_o may_v be_v obvious_a enough_o to_o the_o sagacious_a that_o consider_v what_o have_v be_v say_v and_o the_o nature_n of_o the_o distemper_n i_o will_v pass_v that_o by_o at_o this_o time_n iii_o the_o vehicle_n in_o cold_a stomach_n and_o constitution_n may_v be_v a_o glass_n of_o wine_n or_o some_o temperate_a cordial_n but_o in_o hot_a case_n or_o where_o a_o fever_n be_v fear_v emulsion_n milk_n and_o water_n or_o water_n alone_o or_o other_o acceptable_a cool_a thing_n or_o such_o as_o be_v direct_v in_o the_o case_n of_o procure_v relaxation_n in_o the_o last_o chapter_n because_o it_o be_v relaxation_n that_o take_v away_o pain_n as_o have_v be_v mechanical_o demonstrate_v but_o heâ—e_v there_o be_v no_o need_n of_o be_v scrupulous_a as_o to_o the_o vehicle_n unless_o it_o be_v in_o respect_n of_o heat_n and_o cold_a as_o the_o case_n happen_v iv_o the_o time_n may_v be_v any_o hour_n as_o the_o case_n require_v only_o remember_v that_o sleep_n conduce_v much_o to_o relaxation_n and_o therefore_o to_o the_o take_v away_o of_o pain_n v._o the_o regimen_n to_o be_v use_v in_o the_o case_n of_o relax_v in_o the_o last_o chapter_n will_v suffice_v but_o it_o be_v convenient_a as_o be_v say_v to_o regard_v the_o stomach_n and_o hot_a and_o cold_a constitution_n especial_o where_o there_o be_v any_o fear_n of_o fever_n by_o give_v cool_a liquid_n as_o emulsion_n etc._n etc._n and_o avoid_v hot_a or_o solid_a thing_n especial_o such_o as_o be_v hard_a of_o digestion_n as_o flâ—sh_v fish_n egg_n etc._n etc._n 1._o note_v that_o it_o be_v very_o advisable_v not_o to_o defer_v the_o use_n of_o opiate_n too_o long_o till_o people_n be_v very_o weak_a though_o it_o may_v seem_v that_o they_o will_v hinder_v some_o due_a evacuation_n for_o i_o can_v see_v what_o harm_n a_o refreshment_n by_o they_o may_v do_v any_o more_o than_o by_o sleep_n both_o depend_v upon_o the_o same_o cause_n viz._n relaxation_n it_o be_v true_a that_o by_o reason_n of_o sleep_n or_o a_o opiate_n the_o evacuation_n may_v be_v a_o little_a defer_v what_o then_o will_v any_o man_n deny_v sleep_n for_o that_o reason_n why_o then_o shall_v a_o physician_n deny_v a_o opiate_n to_o cause_v it_o respite_n nature_n and_o enable_v it_o to_o bear_v its_o burden_n or_o engage_v with_o difficulty_n the_o better_a 2._o remember_v always_o that_o sleep_n be_v a_o great_a help_n to_o take_v away_o pain_n and_o so_o be_v all_o thing_n that_o conduce_v to_o relaxation_n or_o pleasant_a diversion_n 3._o use_v means_n in_o pain_n of_o the_o hemorrhoid_v furdament_n or_o intestinum_fw-la rectum_fw-la and_o indeed_o in_o any_o pain_n within_o the_o gut_n unless_o it_o proceed_v from_o a_o looseness_n that_o opiate_n may_v not_o bind_v man_n too_o much_o as_o leâ—itives_n internal_o or_o emollient_a 〈◊〉_d or_o which_o of_o they_o may_v be_v most_o easy_o and_o convenient_o do_v and_o most_o to_o the_o purpose_n chap._n xxxv_o of_o the_o use_n of_o the_o panacea_fw-la of_o opium_n etc._n etc._n to_o cause_n sleep_n it_o primary_o cause_n sleep_v by_o relax_v and_o compose_v quiet_v soothe_v please_a and_o lull_v the_o sensitive_a soul_n and_o spirit_n it_o always_o relax_n but_o do_v not_o always_o sufficient_o compose_v or_o quiet_v the_o spirit_n to_o cause_n sleep_n to_o which_o both_o be_v requisite_a secundary_o by_o take_v away_o grievous_a passion_n or_o sensation_n when_o they_o happen_v to_o hinder_v it_o 1._o as_o soporiserous_a it_o be_v of_o incomparable_a use_n in_o all_o troublesome_a watch_n whether_o they_o be_v from_o grievous_a passion_n or_o sensation_n or_o irrequiete_a motion_n of_o the_o spirit_n though_o not_o so_o certain_a in_o this_o last_o case_n as_o in_o the_o former_a and_o therefore_o prove_v sometime_o unsuccessful_a in_o some_o person_n and_o in_o some_o sort_n of_o madness_n as_o the_o merry_a or_o furicus_n though_o it_o be_v effectual_a in_o melancholy_n and_o slow_a manias_fw-la as_o have_v be_v intimate_v for_o bare_a relaxation_n suffice_v in_o the_o two_o first_o case_n where_o sleep_n be_v hinder_v by_o contraction_n which_o it_o never_o fail_v to_o take_v off_o if_o give_v in_o a_o due_a quantity_n as_o have_v be_v direct_v 2._o to_o recruit_v the_o spirit_n as_o when_o people_n be_v tire_v with_o labour_n journey_n disease_n conflict_n of_o nature_n as_o by_o convulsion_n vomit_n purge_n hysteric_a fit_n and_o the_o like_a 3._o to_o relax_v compose_v take_v away_o pain_n moderate_a flux_n that_o depend_v upon_o grievous_a sensation_n or_o irritation_n and_o its_o consequent_a contraction_n or_o from_o motion_n or_o segregation_n of_o humour_n 4._o to_o promote_v flux_n that_o depend_v upon_o relaxation_n as_o perspiration_n sweat_v as_o also_o the_o menses_fw-la and_o lochia_n in_o some_o case_n of_o all_o which_o you_o have_v particular_a chapter_n which_o see_v i._o the_o form_n may_v be_v indifferent_o either_o solid_a or_o liquid_a as_o