their_o defence_n before_o i_o go_v any_o further_o i_o be_o very_o apt_a to_o think_v that_o in_o some_o favour_n especial_o pestilential_a and_o malignant_a the_o spirit_n be_v primary_o affect_v according_a to_o the_o hypothesis_n of_o the_o ingenious_a dr._n morton_n witness_v those_o symptom_n which_o attend_v the_o genus_fw-la nervosum_fw-la immediate_o upon_o the_o first_o seizure_n but_o you_o must_v not_o admit_v this_o notion_n the_o soil_n which_o you_o must_v lodge_v in_o the_o blood_n and_o thence_o be_v communicate_v to_o the_o spirit_n well_o let_v it_o be_v so_o i_o will_v not_o dispute_v it_o the_o difficulty_n on_o your_o side_n will_v be_v great_a still_o for_o though_o i_o shall_v ready_o grant_v the_o globule_n to_o be_v break_v in_o the_o aforesaid_a favour_n yet_o it_o will_v be_v a_o hard_a matter_n to_o convict_v alkaly_n of_o those_o tragical_a disorder_n for_o first_o experience_n show_v that_o nothing_o be_v more_o proper_a in_o those_o case_n malignant_a i_o shall_v adventure_v to_o use_v the_o term_n notwithstanding_o it_o have_v be_v so_o scout_v of_o late_a than_o pulu._n è_fw-fr chel_n rad_a serpentar_n nay_o sp._n c._n c._n itself_o give_v in_o a_o proper_a vehicle_n but_o second_o nothing_o do_v so_o ready_o dissolve_v the_o mass_n of_o bood_n or_o separate_v its_o principle_n as_o acid_n which_o i_o shall_v prove_v by_o and_o by_o when_o i_o come_v to_o speak_v something_o of_o dropsy_n but_o this_o long_a discourse_n of_o the_o heat_n of_o the_o blood_n do_v natural_o lead_v i_o to_o consider_v somewhat_o of_o its_o flame_n first_o and_o here_o the_o life_n of_o man_n you_o take_v to_o be_v a_o fire_n or_o flame_n and_o all_o we_o eat_v and_o drink_v together_o with_o the_o air_n we_o draw_v in_o to_o be_v fuel_n for_o this_o flame_n the_o chief_a argument_n you_o bring_v to_o confirm_v this_o doctrine_n be_v take_v from_o the_o excrement_n of_o this_o flame_n and_o its_o fuel_n the_o excrement_n be_v alkaly_n which_o be_v near_o of_o kind_a to_o ash_n the_o relic_n of_o other_o flame_n and_o for_o it_o be_v pabulum_fw-la it_o be_v acid_n and_o sulphur_n the_o common_a pabulum_fw-la of_o all_o flame_n here_o i_o must_v confess_v you_o talk_v very_o ingenious_o and_o high_o improve_v the_o notion_n of_o that_o great_a philosopher_n but_o let_v we_o examine_v this_o hypothesis_n a_o little_a as_o for_o alkaly_n i_o confess_v they_o be_v of_o the_o same_o nature_n with_o ash_n and_o soot_n yet_o it_o do_v not_o follow_v that_o because_o alkaly_n be_v find_v in_o the_o blood_n there_o must_v be_v a_o flame_n too_o we_o extract_v alkaly_n out_o of_o several_a herb_n it_o be_v true_a the_o herb_n must_v be_v calcine_v first_o but_o certain_o the_o salt_n be_v pre-existent_a in_o the_o herb_n before_o the_o calcination_n or_o else_o the_o fire_n produce_v it_o de_fw-fr novo_fw-la which_o you_o will_v by_o no_o mean_n admit_v the_o inference_n than_o be_v plain_a i_o will_v not_o adventure_v to_o say_v any_o thing_n of_o crabs-claw_n oyster-shell_n etc._n etc._n lest_o you_o shall_v make_v they_o the_o recrement_n of_o a_o vital_a flame_n come_v we_o next_o to_o the_o pabulum_fw-la and_o that_o be_v acid_n and_o sulphur_n that_o body_n in_o which_o sulphur_n be_v predominant_a be_v inflammable_a no_o body_n question_n but_o that_o such_o in_o which_o acid_n be_v the_o chief_a ingredient_n shall_v burn_v look_v like_o a_o paradox_n to_o instance_n in_o a_o few_o acet_fw-la spirit_n of_o vitriol_n suc._n limon_n etc._n etc._n be_v so_o far_o from_o promote_a flame_n that_o they_o immediate_o quench_v it_o and_o indeed_o i_o know_v but_o one_o acid_n in_o nature_n which_o be_v inflammable_a and_o that_o be_v nitre_n but_o then_o this_o vital_a flame_n be_v not_o of_o a_o nature_n with_o culinary_a flame_n answer_v since_o the_o pabulum_fw-la be_v the_o same_o methinks_v the_o flame_n shall_v be_v so_o too_o again_o though_o you_o speak_v so_o much_o of_o this_o vital_a flame_n yet_o you_o do_v not_o as_o i_o remember_v much_o care_n to_o fix_v the_o place_n of_o its_o existence_n i_o suppose_v it_o must_v be_v in_o the_o blood_n if_o any_o where_o now_o it_o be_v very_o hard_a to_o suppose_v a_o flame_n in_o that_o body_n of_o which_o no_o part_n be_v inflammable_a if_o you_o open_v a_o vein_n and_o the_o blood_n spout_v out_o reek_v hot_a on_o the_o fire_n it_o will_v immediate_o quench_v it_o so_o that_o methinks_v these_o notion_n seem_v to_o be_v a_o little_a too_o fine_o spin_v acid_n and_o sulphur_n do_v support_v human_a life_n man_n live_v upon_o coal_n brimstone_n etc._n etc._n in_o which_o there_o be_v store_n of_o acid_n and_o sulphur_n that_o we_o can_v subsist_v without_o air_n be_v evident_a for_o though_o there_o be_v no_o fire_n in_o the_o blood_n there_o be_v motion_n undoubted_o now_o the_o nitro-acreal_a particle_n give_v a_o fresh_a fermentation_n or_o motion_n to_o it_o and_o free_v it_o from_o coagulation_n if_o you_o be_v not_o satisfy_v with_o this_o consult_v the_o ingenious_a dr._n mayow_o but_o then_o the_o blood_n have_v heat_n and_o warmth_n and_o these_o be_v the_o property_n of_o fire_n answ_n may_v they_o not_o be_v excite_v by_o its_o motion_n no_o you_o reply_v we_o be_v much_o warm_a in_o bed_n when_o we_o use_v no_o exercise_n then_o when_o we_o be_v up_o and_o in_o motion_n answ_n the_o body_n indeed_o be_v in_o no_o motion_n there_o but_o the_o blood_n be_v great_a than_o when_o we_o be_v out_o of_o our_o bed_n and_o it_o be_v impossible_a shall_v be_v otherwise_o for_o do_v not_o the_o bedclothe_n protect_v we_o from_o the_o coldness_n of_o the_o ambient_fw-la air_n and_o be_v not_o a_o great_a many_o of_o the_o volatile_a alkaly_n detain_v by_o they_o which_o reflect_v upon_o the_o body_n warm_v it_o and_o accelerate_v the_o motion_n of_o the_o blood_n but_o after_o all_o if_o we_o move_v violent_o when_o out_o of_o our_o bed_n we_o be_v much_o warm_a than_o when_o in_o they_o you_o be_v please_v to_o object_n it_o be_v impossible_a mere_a motion_n shall_v cause_v any_o heat_n in_o fluid_a body_n how_o so_o let_v a_o man_n put_v spirit_n corn_n ceru._n and_o spirit_n vitrioli_fw-la together_o and_o observe_v their_o effect_n they_o will_v soon_o grow_v warm_a it_o be_v evident_a they_o do_v not_o stand_v still_o but_o move_v very_o brisk_o before_o they_o be_v warm_a and_o what_o be_v the_o heat_n of_o these_o body_n occasion_v by_o but_o their_o fermentation_n or_o intestine_a motion_n sure_o it_o can_v be_v by_o accension_n my_o three_o objection_n be_v this_o but_o three_o if_o alkaly_n be_v the_o original_a of_o distemper_n whence_o be_v it_o that_o in_o dropsy_n catarrh_n some_o gout_n and_o other_o disease_n we_o find_v the_o texture_n of_o the_o blood_n so_o thin_a it_o be_v observable_a that_o those_o particle_n you_o term_v alkaly_n the_o more_o the_o blood_n be_v saturate_v with_o they_o of_o the_o more_o thick_a consistence_n it_o be_v as_o we_o see_v in_o pleurisy_n rheumatism_n and_o other_o inflamatory_n case_n in_o which_o distemper_n if_o in_o any_o the_o alkaly_n abound_v be_v not_o then_o it_o be_v tenuity_n rather_o to_o be_v impute_v to_o acid_n do_v not_o acid_n immediate_o put_v the_o blood_n in_o a_o fusion_n and_o render_v it_o thin_a your_o answer_n to_o this_o be_v that_o it_o be_v not_o the_o thinness_n of_o the_o blood_n be_v the_o only_a cause_n of_o these_o distemper_n but_o a_o destruction_n of_o the_o tone_n of_o the_o part_n here_o methinks_v you_o do_v not_o argue_v so_o fair_o for_o you_o mention_v little_a or_o nothing_o of_o the_o destruction_n of_o the_o tone_n of_o the_o part_n in_o your_o etymology_n of_o distemper_n till_o now_o and_o why_o may_v i_o not_o as_o well_o say_v in_o inflamatory_n case_n the_o blood_n be_v not_o affect_v with_o any_o alkaline_a particle_n these_o inflammation_n only_o arise_v from_o a_o destruction_n of_o the_o tone_n of_o the_o part_n especial_o if_o you_o consider_v what_o you_o assert_v in_o your_o notion_n of_o favour_n for_o there_o the_o emunctory_n be_v very_o much_o out_o of_o order_n but_o you_o object_n since_o acid_n will_v reduce_v the_o blood_n to_o it_o be_v due_a consistence_n it_o be_v not_o reasonable_a to_o suppose_v they_o shall_v be_v the_o cause_n of_o its_o fusion_n answ_n whether_o acid_n will_v restore_v the_o consistence_n of_o the_o blood_n i_o shall_v examine_v by_o and_o by_o i_o fear_v they_o will_v not_o but_o this_o i_o be_o certain_a of_o they_o will_v put_v it_o in_o a_o fusion_n it_o be_v well_o know_v that_o your_o celebrate_a oil_n of_o vitriol_n take_v alone_o or_o though_o in_o a_o vehicle_n if_o in_o too_o great_a quantity_n kill_v now_o how_o do_v it_o kill_v do_v it_o not_o by_o dissolve_v the_o mass_n of_o blood_n by_o separate_v the_o grumou_n
part_n from_o the_o serous_a and_o break_v its_o texture_n after_o the_o same_o manner_n as_o it_o do_v that_o of_o milk_n sure_o i_o be_o that_o blood_n coagulate_v by_o the_o aforesaid_a oil_n do_v much_o more_o resemble_v whey_n and_o curd_n than_o jelly_n of_o hartshorn_n now_o then_o what_o be_v all_o this_o but_o a_o extraordinary_a fusion_n and_o if_o a_o large_a dose_n will_v make_v such_o mad_a work_n and_o put_v the_o blood_n into_o so_o great_a a_o fusion_n certain_o a_o less_o do_v must_v cause_v somewhat_o of_o a_o fusion_n and_o it_o be_v rational_a to_o believe_v that_o oil_n of_o vitriol_n be_v proper_a only_o in_o those_o distemper_n where_o the_o blood_n be_v too_o thick_a very_o pernicious_a in_o such_o as_o have_v it_o too_o thin_a and_o here_o i_o be_o very_o glad_a that_o you_o so_o opportune_o give_v we_o your_o sentiment_n of_o dropsy_n a_o dropsy_n say_v you_o or_o the_o thinness_n of_o blood_n in_o that_o disease_n do_v not_o proceed_v from_o acid_n but_o over_o much_o drink_v answ_n that_o large_a draught_n there_o be_v little_a evacuation_n by_o urinal_n render_v the_o blood_n more_o thin_a be_v very_o obvious_a but_o now_o the_o patient_n have_v no_o such_o desire_n for_o drink_v till_o the_o distemper_n be_v actual_o upon_o he_o so_o that_o the_o question_n be_v what_o first_o bring_v on_o the_o distemper_n be_v it_o not_o a_o weakness_n of_o blood_n or_o want_n of_o due_a consistence_n i_o do_v not_o see_v how_o you_o can_v well_o deny_v it_o but_o then_o you_o reply_v let_v it_o be_v so_o it_o be_v impossible_a acid_n shall_v occasion_v this_o ill_a habit_n of_o blood_n for_o hydropical_a people_n be_v thirsty_a and_o it_o be_v ridiculous_a to_o imagine_v that_o acid_n shall_v excite_v thirst_n when_o they_o be_v the_o only_a thing_n in_o the_o world_n that_o will_v quench_v it_o answ_n this_o i_o confess_v at_o first_o sight_n look_v like_o a_o invincible_a argument_n but_o i_o must_v crave_v leave_n to_o weigh_v it_o a_o little_a that_o acid_n drink_v or_o hold_v in_o the_o mouth_n usual_o quench_v thirst_n be_v a_o undeniable_a truth_n though_o it_o will_v hardly_o hold_v good_a in_o all_o case_n for_o let_v a_o man_n drink_n brine_n which_o be_v very_o much_o impregnate_v with_o acid_n or_o eat_v highseasoned_n meat_n i_o believe_v though_o he_o be_v a_o stoic_a he_o will_v immediate_o grow_v thirsty_a but_o common_a salt_n be_v not_o a_o acid_n of_o a_o right_a nature_n well_o admit_v this_o the_o most_o famous_a acid_n that_o i_o know_v for_o suppress_v thirst_n be_v oil_n vitriol_n spirit_n vitriol_n etc._n etc._n now_o i_o hope_v to_o make_v it_o appear_v that_o these_o or_o acid_n of_o the_o same_o nature_n abound_v in_o the_o blood_n may_v provoke_v thirst_n i_o prove_v just_a now_o that_o oil_n of_o vitriol_n have_v a_o ugly_a faculty_n of_o coagulate_v the_o blood_n or_o separate_v its_o serum_n that_o there_o be_v a_o separation_n of_o the_o serum_n in_o dropsy_n be_v evident_a if_o any_o man_n shall_v deny_v it_o let_v he_o look_v upon_o the_o abdomen_fw-la and_o extreme_a part_n and_o his_o eye_n be_v enough_o to_o convince_v he_o well_o then_o the_o serum_n be_v thus_o separate_v pray_v observe_v and_o the_o mass_n of_o blood_n not_o enough_o dilute_v the_o oral_a gland_n must_v necessary_o be_v defraud_v of_o their_o due_a moisture_n and_o consequent_o thirst_v excite_v but_o still_o you_o harp_n upon_o the_o same_o string_n those_o medicine_n which_o restore_v the_o consistence_n of_o the_o blood_n can_v well_o be_v suppose_v to_o impair_v it_o now_o acid_v restore_v it_o and_o steel_n in_o particular_a answ_n that_o steel_n be_v of_o excellent_a use_n and_o a_o very_a great_a restaurative_a be_v not_o to_o be_v deny_v but_o under_o favour_n though_o you_o discourse_v very_o ingenious_o of_o the_o nature_n of_o steel_n yet_o all_o you_o have_v say_v will_v not_o amount_v to_o a_o proof_n of_o its_o be_v a_o acid._n i_o be_o still_o incline_v to_o think_v it_o be_v a_o alkaly_n for_o though_o it_o do_v not_o discover_v itself_o to_o be_v such_o by_o its_o colour_n yet_o it_o plain_o do_v by_o its_o effect_n viz._n it_o be_v fermentation_n with_o acid_n if_o notwithstanding_o this_o phaenomenon_n you_o will_v needs_o have_v it_o to_o be_v a_o acid_n why_o then_o one_o acid_n will_v ferment_n with_o another_o and_o so_o one_o alkaly_n with_o another_o wherefore_o though_o we_o shall_v subscribe_v to_o the_o hypothesis_n that_o alkaly_n be_v the_o original_a of_o all_o distemper_n yet_o it_o be_v hard_a to_o exclude_v the_o use_n of_o they_o in_o general_a in_o distemper_n for_o some_o alkaly_n or_o other_o may_v be_v find_v out_o that_o shall_v dispute_v it_o with_o these_o offend_a alkaly_n you_o be_v please_v to_o quote_v beeker_n for_o a_o confirmation_n of_o the_o acidity_n of_o steel_n the_o chief_a sentence_n of_o the_o citation_n seem_v to_o be_v this_o hoc_fw-la tantum_fw-la hic_fw-la loci_fw-la allegabo_o omne_fw-la acidum_fw-la substantiae_fw-la martialis_fw-la esse_fw-la in_fw-la quocunque_fw-la oleo_fw-la pinguedine_fw-la fuligine_fw-la limo_fw-la silice_fw-la &_o arenâ_fw-la imo_fw-la etiam_fw-la ipsâ_fw-la flammâ_fw-la reperibile_fw-la &_o ad_fw-la oculum_fw-la demonstrari_fw-la posse_fw-la quaecunque_fw-la ergo_fw-la naturae_fw-la acidae_fw-la &_o martialis_fw-la sunt_fw-la illa_fw-la potestatem_fw-la habent_fw-la alkali_fw-la tanquam_fw-la substantiam_fw-la metallorum_fw-la mercurialem_fw-la alterandi_fw-la &_o transmutandi_fw-la if_o i_o apprehend_v the_o sense_n of_o the_o author_n this_o do_v not_o make_v so_o much_o for_o you_o but_o suppose_v it_o do_v beeker_n be_v never_o reckon_v infallible_a and_o though_o chalybs_fw-la be_v a_o acid_n it_o do_v not_o follow_v because_o one_o acid_n will_v renew_v the_o state_n of_o the_o blood_n that_o other_o will_v do_v so_o too_o but_o since_o we_o have_v so_o happy_o fall_v on_o this_o subject_a viz._n the_o strengthen_v the_o mass_n of_o blood_n let_v we_o see_v what_o other_o medicine_n beside_o chalybs_fw-la be_v subservient_fw-fr to_o this_o end_n and_o here_o i_o suppose_v your_o bitter_a herb_n may_v not_o be_v infimi_fw-la subsellii_fw-la it_o be_v needless_a to_o prove_v it_o for_o hardly_o any_o physician_n but_o what_o have_v experience_v it_o i_o do_v not_o believe_v you_o will_v dare_v to_o say_v there_o be_v any_o thing_n of_o a_o acid_n in_o these_o since_o you_o know_v very_o well_o that_o alkaly_n may_v be_v extract_v from_o most_o if_o not_o all_o of_o they_o so_o that_o poor_a alkaly_n be_v effectual_a in_o some_o case_n you_o see_v but_o then_o you_o say_v oak-bark_n bistort_v tormentile_a comfrey-root_n and_o other_o of_o that_o tribe_n will_v reduce_v the_o blood_n to_o consistence_n answ_n that_o they_o be_v astringent_a i_o grant_v whether_o they_o will_v reduce_v the_o blood_n or_o invigorate_v its_o depauperated_a principle_n i_o much_o question_n it_o be_v very_o rare_a to_o see_v they_o prescribe_v in_o dropsy_n cackexy_n and_o the_o like_a distemper_n where_o the_o blood_n be_v poor_a and_o low_a they_o be_v proper_a indeed_o in_o flux_n by_o virtue_n of_o their_o astringent_a faculty_n but_o then_o they_o owe_v this_o astringency_n to_o acid_n whether_o they_o do_v or_o not_o it_o matter_n not_o much_o but_o why_o may_v not_o this_o quality_n be_v derive_v as_o well_o from_o the_o terrestrious_a as_o the_o salt_n particle_n of_o these_o vegetable_n since_o bol._n arm._n terra_fw-la lemnia_n and_o other_o plain_a earth_n be_v very_o styptic_a i_o do_v not_o say_v these_o earth_n be_v so_o simple_a as_o to_o have_v no_o manner_n of_o salt_n in_o they_o but_o sure_o they_o have_v very_o little_a acid._n another_o object_n be_v if_o alkaly_n do_v always_o offend_v and_o cause_v pain_n it_o must_v follow_v that_o acid_n must_v give_v ease_n but_o i_o assure_v you_o i_o have_v often_o experience_v the_o contrary_a for_o upon_o the_o exhibition_n of_o rhenish_n white-wine_n and_o other_o acid_n i_o have_v find_v the_o gouty_a pain_n immediate_o exasperate_v and_o many_o time_n it_o have_v be_v a_o long_a while_n ere_o they_o go_v off_o i_o shall_v not_o repeat_v your_o whole_a answer_n to_o this_o but_o sum_v up_o the_o most_o material_a part_n of_o it_o answ_n it_o be_v not_o improbable_a but_o upon_o give_v a_o small_a quantity_n of_o acid_n where_o there_o be_v a_o large_a quantity_n of_o alkaly_n lodge_v on_o any_o part_n so_o as_o to_o cause_v pain_n it_o may_v only_o in_o part_n dissolve_v the_o alkaly_n which_o be_v before_o more_o fix_v and_o so_o by_o accident_n exasperate_v the_o pain_n whereas_o by_o continue_v the_o use_n of_o the_o acid_n the_o alkaly_n will_v be_v perfect_o dissolve_v and_o extirpate_v and_o so_o the_o pain_n will_v altogether_o vanish_v but_o pain_n be_v sometime_o exasperate_v more_o upon_o the_o first_o give_v of_o they_o in_o too_o small_a quantity_n have_v i_o doubt_v not_o ben_z one_o
their_o nature_n when_o you_o make_v they_o whole_o excrementitious_a be_v there_o a_o more_o noble_a juice_n in_o human_a body_n than_o bile_n than_o alkalizate_v bile_n sure_o i_o be_o no_o true_a concoction_n can_v be_v perform_v without_o it_o a_o thousand_o other_o good_a office_n may_v be_v attribute_v to_o it_o this_o be_v all_o sir_n i_o have_v to_o offer_v in_o maintenance_n of_o my_o objection_n if_o i_o have_v express_v myself_o indecent_o any_o where_n do_v not_o impute_v it_o to_o rudeness_n or_o disrespect_n your_o good_a nature_n can_v but_o easy_o find_v out_o the_o true_a occasion_n of_o it_o god_n forbid_v i_o shall_v treat_v you_o as_o a_o gentleman_n have_v late_o do_v i_o think_v we_o be_v all_o of_o we_o oblige_v to_o you_o for_o your_o care_n and_o industry_n whether_o acid_n be_v of_o universal_a use_n will_v be_v determine_v in_o time_n i_o believe_v they_o will_v never_o prove_v so_o but_o certain_o they_o be_v of_o some_o use_n and_o in_o this_o you_o have_v gain_v a_o considerable_a point_n and_o do_v the_o world_n very_o eminent_a service_n for_o many_o of_o our_o old_a galenical_a brethren_n have_v a_o great_a antipathy_n to_o they_o nay_o the_o most_o moderate_a use_n of_o that_o mild_a acid_n vinegar_n have_v be_v declaim_v against_o for_o sour_v the_o blood_n and_o for_o other_o acid_n of_o a_o strong_a nature_n they_o have_v represent_v they_o to_o their_o patient_n as_o hurtful_a as_o the_o venom_n of_o a_o mad-dog_n your_o enemy_n can_v but_o acknowledge_v the_o generosity_n of_o your_o temper_n in_o your_o not_o be_v discourage_v at_o the_o snarl_v of_o such_o cynic_n nor_o even_o at_o the_o base_a and_o villainous_a practice_n of_o some_o surgeon_n who_o have_v meditate_a against_o your_o life_n because_o you_o have_v put_v they_o in_o a_o fair_a way_n to_o save_v that_o of_o other_o i_o shall_v here_o conclude_v and_o make_v no_o far_o observation_n on_o your_o hypothesis_n but_o that_o you_o desire_v i_o and_o every_o one_o else_o before_o we_o take_v up_o with_o any_o thing_n that_o come_v from_o you_o to_o examine_v it_o in_o the_o balance_n of_o reason_n and_o experience_n pardon_v i_o therefore_o if_o i_o adventure_v to_o examine_v some_o passage_n in_o your_o essay_n of_o alkaly_n and_o acid._n of_o the_o smallpox_n the_o first_o thing_n that_o occur_v there_o be_v the_o smallpox_n you_o suppose_v it_o in_o page_n 3_o and_o 13_o to_o proceed_v from_o a_o intromission_n of_o heterogeneous_a particle_n or_o particle_n of_o a_o different_a nature_n and_o texture_n from_o the_o blood_n into_o it_o by_o mean_n of_o which_o particle_n the_o blood_n be_v put_v into_o a_o very_a great_a hurry_n and_o disorder_n in_o order_n to_o throw_v off_o its_o enemy_n and_o that_o the_o place_v that_o nature_n design_n the_o discharge_v of_o these_o particle_n by_o be_v the_o cutaneous_a gland_n now_o the_o inconvenience_n that_o you_o observe_v to_o attend_v the_o use_n of_o alkaly_n where_o the_o throw_v out_o of_o more_o pustles_a than_o nature_n design_v the_o destroy_v the_o globule_n of_o the_o blood_n and_o a_o waste_n of_o too_o great_a quantity_n of_o serum_n this_o hypothesis_n how_o ingenious_o soever_o contrive_v i_o fear_v will_v look_v somewhat_o strange_a by_o and_o by_o especial_o when_o compare_v with_o your_o practice_n well_o then_o the_o occasion_n of_o the_o smallpox_n be_v a_o intromission_n of_o heterogeneous_a particle_n here_o you_o term_v the_o morbific_a particle_n heterogeneous_a but_o do_v not_o much_o care_n to_o fix_v the_o nature_n of_o they_o i_o suppose_v they_o must_v be_v of_o a_o alkaline_n if_o any_o for_o nothing_o but_o alkaly_n with_o you_o be_v the_o principal_a of_o destruction_n now_o i_o shall_v endeavour_v to_o prove_v that_o these_o intromit_v particle_n can_v well_o be_v of_o a_o alkaline_a nature_n and_o though_o they_o be_v so_o that_o a_o moderate_a use_n of_o they_o can_v not_o be_v always_o prejudicial_a but_o sometime_o of_o great_a advantage_n first_o then_o these_o particle_n can_v be_v alkaline_n because_o no_o tolerable_a account_n can_v be_v give_v from_o the_o rule_n of_o your_o hypothesis_n how_o these_o alkaly_n shall_v excite_v such_o a_o disorderly_a motion_n in_o the_o blood_n the_o globule_v you_o say_v be_v break_v but_o you_o explain_v not_o the_o manner_n of_o their_o be_v break_v they_o must_v either_o be_v break_v by_o accension_n the_o vital_a flame_n burn_v very_o furious_o or_o by_o fermentation_n it_o will_v be_v very_o difficult_a to_o find_v out_o another_o way_n now_o alkaly_n can_v well_o accend_v the_o blood_n acid_n and_o sulphur_n with_o you_o be_v the_o only_a pabulum_fw-la of_o flame_n ash_n or_o alkaly_n shall_v rather_o choke_v it_o but_o here_o i_o only_o argue_v against_o your_o hypothesis_n of_o accension_n i_o do_v not_o deny_v but_o alkaly_n may_v raise_v some_o slight_a disorder_n in_o the_o blood_n they_o may_v occasion_v some_o fevour_n but_o they_o be_v never_o so_o ill_o nature_a as_o to_o break_v the_o globule_n acid_n be_v much_o better_o arm_v to_o do_v this_o work_n neither_o second_o can_v they_o be_v so_o easy_o find_v guilty_a of_o fermentation_n since_o you_o exclude_v all_o acid_n from_o the_o blood_n these_o salt_n do_v not_o use_v to_o be_v so_o nimble_a they_o be_v dull_a enough_o of_o themselves_o unless_o a_o acid_n antagonist_n rouse_v their_o courage_n but_o second_o grant_v these_o intromit_v particle_n be_v alkaline_n which_o you_o have_v not_o prove_v hitherto_o yet_o alkaly_n can_v not_o be_v always_o improper_a in_o this_o distemper_n indeed_o when_o the_o blood_n run_v hy_o and_o its_o motion_n be_v very_o violent_a then_o to_o add_v alkaly_n to_o the_o intromit_v alkaly_n will_v be_v high_o pernicious_a but_o if_o this_o motion_n be_v natural_o weak_a or_o be_v accidental_o check_v so_o as_o to_o be_v unable_a to_o promote_v a_o excretion_n of_o the_o particle_n what_o harm_n be_v it_o to_o help_v it_o on_o with_o alkaly_n there_o be_v nothing_o more_o usual_a than_o upon_o take_v cold_a or_o by_o too_o liberal_a a_o use_n of_o cool_a liquor_n for_o the_o pox_n as_o soon_o as_o they_o appear_v to_o strike_v in_o again_o as_o they_o call_v it_o or_o vanish_v and_o if_o they_o do_v not_o strike_v in_o they_o maturate_a very_o slow_o the_o patient_n be_v feverish_a all_o the_o while_n in_o such_o a_o case_n as_o this_o you_o may_v give_v acids_n ad_fw-la infinitum_fw-la too_o no_o purpose_n or_o allow_v your_o patient_n as_o much_o small-beer_n as_o you_o please_v it_o shall_v not_o fill_v up_o the_o pustules_fw-la it_o will_v be_v a_o hard_a matter_n for_o dame_n nature_n to_o escape_v a_o drown_n and_o i_o appeal_v to_o your_o learned_a society_n if_o upon_o such_o accident_n as_o these_o pulv_v e_o chel_n mark_fw-mi pp._n and_o above_o all_o ead_n serpentar_n virgin_n be_v not_o of_o wonderful_a use_n indeed_o in_o a_o confluent-pox_n you_o may_v bleed_v indulge_v small-beer_n liberal_o give_v acid_n and_o all_o will_v not_o stop_v they_o will_v but_o regulate_v the_o motion_n of_o the_o blood_n but_o if_o you_o shall_v observe_v the_o same_o method_n in_o more_o gentle_a pox_n it_o be_v much_o but_o the_o patient_n pay_v dear_a for_o it_o and_o therefore_o you_o act_n like_o a_o honest_a good_a physician_n be_v more_o tender_a of_o other_o life_n than_o your_o own_o hypothesis_n in_o prescribe_v nothing_o of_o acid_n in_o variolis_n benignis_fw-la neither_o be_v it_o good_a i_o confess_v to_o tamper_v too_o much_o with_o alkaly_n here_o but_o this_o i_o assure_v you_o have_v often_o engage_v with_o this_o distemper_n that_o i_o never_o see_v the_o testaceous_a powder_n moderate_o administer_v produce_v any_o ill_a effect_n even_o in_o the_o most_o favourable_a pox_n which_o be_v more_o i_o very_o believe_v than_o can_v be_v say_v of_o acid_n and_o here_o i_o can_v but_o take_v notice_n of_o one_o thing_n which_o i_o omit_v in_o its_o proper_a place_n alkaly_n you_o acknowledge_v be_v good_a medicine_n for_o child_n because_o they_o be_v of_o a_o mild_a nature_n be_v there_o not_o acid_n of_o a_o mild_a nature_n as_o well_o as_o alkaly_n why_o then_o do_v you_o not_o exhibit_v those_o mild_a acid_n indeed_o you_o prescribe_v they_o in_o some_o particular_a case_n not_o without_o success_n but_o they_o will_v hardly_o ever_o be_v find_v so_o general_o effectual_a as_o alkalies_n but_o to_o return_v to_o the_o smallpox_n you_o displease_v i_o in_o give_v syrup_n de_fw-fr meconio_fw-la even_o upon_o their_o first_o invasion_n methinks_v it_o shall_v hinder_v their_o eruption_n the_o worthy_a sydenham_n that_o true_a patron_n of_o a_o cold_a regimen_n seem_v to_o be_v sensible_a of_o this_o and_o therefore_o never_o prescribe_v it_o till_o they_o be_v all_o come_v out_o one_o word_n more_o and_o i_o have_v do_v with_o this_o if_o the_o pox_n be_v